Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
C-terminally truncated ALG-2-interacting protein X + H2O
?
limited proteolysis of C-terminally truncated ALG-2-interacting protein X , but not full-length ALIX. Importance of the CHMP4-ALIX interaction for ALIX truncated mutant cleavage, CHMP4 proteins are part of the ESCRT system
-
-
?
domain 1 of calpastatin-Bro1 domain fuion protein + H2O
?
the calpain-7 cleavage site is located between ELLAK (207-211) and KEGIT(212-216) at the C-terminal border of sub-domain B
-
-
?
increased sodium tolerance-1 protein + H2O
?
peptide + H2O
hydrolyzed peptide
additional information
?
-
increased sodium tolerance-1 protein + H2O
?
-
-
-
-
?
increased sodium tolerance-1 protein + H2O
?
-
-
-
?
peptide + H2O
hydrolyzed peptide
-
-
-
?
peptide + H2O
hydrolyzed peptide
-
-
-
?
peptide + H2O
hydrolyzed peptide
-
-
-
?
peptide + H2O
hydrolyzed peptide
-
-
-
?
peptide + H2O
hydrolyzed peptide
-
-
-
-
?
peptide + H2O
hydrolyzed peptide
-
-
-
?
additional information
?
-
-
calpain 7 plays roles in the endosomal pathway by interacting with a subset of ESCRT-III-related proteins
-
-
?
additional information
?
-
-
C-terminal deletion mutants of charged multivesicular body protein 1B enhances autolytic activity of calpain-7 in cells
-
-
?
additional information
?
-
GST-MIM protein enhances the autolysis of purified Strep-tagged monomeric green fluorescent protein-fused calpain 7. Calpain 7 is activated in the endosomal sorting complex required for transport system
-
-
?
additional information
?
-
-
GST-MIM protein enhances the autolysis of purified Strep-tagged monomeric green fluorescent protein-fused calpain 7. Calpain 7 is activated in the endosomal sorting complex required for transport system
-
-
?
additional information
?
-
the enzyme interacts with a subset of endosomal sorting complex required for transport (ESCRT)-III and ESCRT-III-related proteins, including charged multivesicular body protein 1
-
-
?
additional information
?
-
calpain-7 performs autolysis, ESCRT proteins enhance the calpain-7 autolysis. Engineered FLAG-tagged casein-Bro1 domain is no substrate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
increased sodium tolerance-1 protein + H2O
?
additional information
?
-
increased sodium tolerance-1 protein + H2O
?
-
-
-
-
?
increased sodium tolerance-1 protein + H2O
?
-
-
-
?
additional information
?
-
-
calpain 7 plays roles in the endosomal pathway by interacting with a subset of ESCRT-III-related proteins
-
-
?
additional information
?
-
-
C-terminal deletion mutants of charged multivesicular body protein 1B enhances autolytic activity of calpain-7 in cells
-
-
?
additional information
?
-
GST-MIM protein enhances the autolysis of purified Strep-tagged monomeric green fluorescent protein-fused calpain 7. Calpain 7 is activated in the endosomal sorting complex required for transport system
-
-
?
additional information
?
-
-
GST-MIM protein enhances the autolysis of purified Strep-tagged monomeric green fluorescent protein-fused calpain 7. Calpain 7 is activated in the endosomal sorting complex required for transport system
-
-
?
additional information
?
-
the enzyme interacts with a subset of endosomal sorting complex required for transport (ESCRT)-III and ESCRT-III-related proteins, including charged multivesicular body protein 1
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
malfunction
epidermal growth factor receptor degradation is slightly delayed in CAPN7-knockdown HeLa cells, the effect can be reversed by re-expression of wild-type enzyme CAPN7 but not a protease-inactive mutant
physiological function
the enzyme is involved in membrane trafficking. The proteolytic activity of CAPN7 is important for the acceleration of epidermal growth factor receptor degradation via the endosomal sorting pathway utilizing a part of the endosomal sorting complex required for transport, ESCRT, system
additional information
calpain-7 is a unique intracellular cysteine protease that has a tandem repeat of microtubule interacting and trafficking domains and lacks a penta-EF-hand domain. The catalytic residues are C290, H458 and N478
additional information
importance of not only the N-terminal microtubule-interacting and trafficking domains but also the C-terminal C2 domain-like domains for proteolytic activity of the enzyme
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (Q7Z479), Homo sapiens (Q9Y6W3), Mus musculus (Q9R1S8)
brenda
Strausberg R.L.; Feingold E.A.; Grouse L.H.; Derge J.G.; et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Proc. Natl. Acad. Sci. USA
99
16899-16903
2002
Homo sapiens (Q7Z479)
brenda
Futai, E.; Kubo, T.; Sorimachi, H.; Suzuki, K.; Maeda, T.
Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PALB.
Biochim. Biophys. Acta
1517
316-319
2001
Mus musculus (Q9R1S8), Mus musculus, Homo sapiens (Q9Y6W3), Homo sapiens
brenda
Franz, T.; Vingron, M.; Boehm, T.; Dear.T.N.
Capn7: a highly divergent vertebrate calpain with a novel C-terminal domain
Mamm. Genome
10
318-321
1999
Mus musculus (Q9R1S8)
brenda
Yorikawa, C.; Takaya, E.; Osako, Y.; Tanaka, R.; Terasawa, Y.; Hamakubo, T.; Mochizuki, Y.; Iwanari, H.; Kodama, T.; Maeda, T.; Hitomi, K.; Shibata, H.; Maki, M.
Human calpain 7/PalBH associates with a subset of ESCRT-III-related proteins in its N-terminal region and partly localizes to endocytic membrane compartments
J. Biochem.
143
731-745
2008
Homo sapiens
brenda
Osako, Y.; Maemoto, Y.; Tanaka, R.; Suzuki, H.; Shibata, H.; Maki, M.
Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction
FEBS J.
277
4412-4426
2010
Homo sapiens (Q9Y6W3), Homo sapiens
brenda
Maemoto, Y.; Osako, Y.; Goto, E.; Nozawa, E.; Shibata, H.; Maki, M.
Calpain-7 binds to CHMP1B at its second alpha-helical region and forms a ternary complex with IST1
J. Biochem.
150
411-421
2011
Homo sapiens
brenda
Maemoto, Y.; Kiso, S.; Shibata, H.; Maki, M.
Analysis of limited proteolytic activity of calpain-7 using non-physiological substrates in mammalian cells
FEBS J.
280
2594-2607
2013
Homo sapiens (Q9Y6W3)
brenda
Maemoto, Y.; Ono, Y.; Kiso, S.; Shibata, H.; Takahara, T.; Sorimachi, H.; Maki, M.
Involvement of calpain-7 in epidermal growth factor receptor degradation via the endosomal sorting pathway
FEBS J.
281
3642-3655
2014
Homo sapiens (Q9Y6W3)
brenda