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UDP-N-acetyl-alpha-D-glucosamine + [Skp1-protein]-trans-4-hydroxy-L-proline
UDP + [Skp1-protein]-O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-proline
-
-
-
-
?
UDP-N-acetylglucosamine + hydroxyproline-peptide
UDP + (N-acetyl-D-glucosaminyl)hydroxyproline peptide
UDP-N-acetylglucosamine + polypeptide-hydroxyamino acid
UDP + polypeptide-O-(alpha-N-acetyl-D-glucosaminyl)hydroxyamino acid
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(alpha-N-acetyl-D-glucosaminyl)hydroxyproline
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
additional information
?
-
UDP-N-acetylglucosamine + hydroxyproline-peptide
UDP + (N-acetyl-D-glucosaminyl)hydroxyproline peptide
-
synthetic peptide substrate
-
?
UDP-N-acetylglucosamine + hydroxyproline-peptide
UDP + (N-acetyl-D-glucosaminyl)hydroxyproline peptide
-
synthetic peptide substrate
-
?
UDP-N-acetylglucosamine + polypeptide-hydroxyamino acid
UDP + polypeptide-O-(alpha-N-acetyl-D-glucosaminyl)hydroxyamino acid
-
-
-
-
?
UDP-N-acetylglucosamine + polypeptide-hydroxyamino acid
UDP + polypeptide-O-(alpha-N-acetyl-D-glucosaminyl)hydroxyamino acid
-
-
-
-
?
UDP-N-acetylglucosamine + polypeptide-hydroxyamino acid
UDP + polypeptide-O-(alpha-N-acetyl-D-glucosaminyl)hydroxyamino acid
-
-
-
-
?
UDP-N-acetylglucosamine + polypeptide-hydroxyamino acid
UDP + polypeptide-O-(alpha-N-acetyl-D-glucosaminyl)hydroxyamino acid
-
-
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(alpha-N-acetyl-D-glucosaminyl)hydroxyproline
enzyme is involved in O-glycosylation of Skp1-protein and mucin formation
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(alpha-N-acetyl-D-glucosaminyl)hydroxyproline
enzyme is highly specific for the Skp1-protein
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
-
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
enzyme attaches the first sugar of pentasaccharide chain
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
enzyme attaches the first sugar of pentasaccharide chain
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
hydroxyproline143
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
hydroxyproline143
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
transfer to the hydroxyproline, at the Thr-Pro143 dipeptide, preceded by a coil and succeeded by an alpha-helix in Skp1
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
-
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
transfer to the hydroxyproline, at the Thr-Pro143 dipeptide, preceded by a coil and succeeded by an alpha-helix in Skp1
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
hydroxyproline143
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
hydroxyproline143
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
high affinity for UDP-GlcNAc
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
recombinant protein substrate, deficient in GlcNAc
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
recombinant protein substrate, deficient in GlcNAc
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
part of complex O-linked glycosylation, which is necessary for targeting of Skp-1-protein to the nucleus
-
?
additional information
?
-
-
substrate specificity of recombinant Gnt1 hydrid enzyme, although synthetic 13-mer and 23-mer hydroxyproline peptides are substrates, their activities are much lower even at 5000fold higher concentration, the 40-mer hydroxyproline peptide is also a poor substrate, overview
-
-
?
additional information
?
-
-
substrate specificity of recombinant Gnt1 hydrid enzyme, although synthetic 13-mer and 23-mer hydroxyproline peptides are substrates than Skyp1A, their activities are much lower even at 5000fold higher concentration, the 40-mer hydroxyproline peptide is also a poor substrate, overview
-
-
?
additional information
?
-
-
no activity with nonhydroxylated Skp-1-protein or -peptide
-
-
?
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UDP-N-acetylglucosamine + polypeptide-hydroxyamino acid
UDP + polypeptide-O-(alpha-N-acetyl-D-glucosaminyl)hydroxyamino acid
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(alpha-N-acetyl-D-glucosaminyl)hydroxyproline
enzyme is involved in O-glycosylation of Skp1-protein and mucin formation
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
UDP-N-acetylglucosamine + polypeptide-hydroxyamino acid
UDP + polypeptide-O-(alpha-N-acetyl-D-glucosaminyl)hydroxyamino acid
-
-
-
-
?
UDP-N-acetylglucosamine + polypeptide-hydroxyamino acid
UDP + polypeptide-O-(alpha-N-acetyl-D-glucosaminyl)hydroxyamino acid
-
-
-
-
?
UDP-N-acetylglucosamine + polypeptide-hydroxyamino acid
UDP + polypeptide-O-(alpha-N-acetyl-D-glucosaminyl)hydroxyamino acid
-
-
-
-
?
UDP-N-acetylglucosamine + polypeptide-hydroxyamino acid
UDP + polypeptide-O-(alpha-N-acetyl-D-glucosaminyl)hydroxyamino acid
-
-
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
-
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
-
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
-
-
?
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline
UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline
-
part of complex O-linked glycosylation, which is necessary for targeting of Skp-1-protein to the nucleus
-
?
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GNT1_DICDI
423
0
49069
Swiss-Prot
other Location (Reliability: 1)
S8EQK9_TOXGM
Toxoplasma gondii (strain ATCC 50611 / Me49)
1510
0
164651
TrEMBL
other Location (Reliability: 5)
D7FQK5_ECTSI
440
0
50080
TrEMBL
Mitochondrion (Reliability: 4)
A0A084G6T6_PSEDA
527
0
52393
TrEMBL
Secretory Pathway (Reliability: 1)
A0A084GGR3_PSEDA
439
0
42811
TrEMBL
Secretory Pathway (Reliability: 2)
A0A084G2U2_PSEDA
280
0
29973
TrEMBL
Mitochondrion (Reliability: 2)
A0A084GCU8_PSEDA
1044
17
113845
TrEMBL
other Location (Reliability: 4)
A0A086LID8_TOXGO
1510
0
164619
TrEMBL
other Location (Reliability: 5)
A0A084G8P3_PSEDA
689
0
70457
TrEMBL
Secretory Pathway (Reliability: 1)
A0A084GED3_PSEDA
358
1
37160
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2G8Y0S4_TOXGO
1510
0
164489
TrEMBL
other Location (Reliability: 5)
A0A2T6IMW7_TOXGO
1510
0
164619
TrEMBL
other Location (Reliability: 5)
A0A086PNR1_TOXGO
1510
0
164443
TrEMBL
other Location (Reliability: 5)
A0A125YWN5_TOXGV
Toxoplasma gondii (strain ATCC 50861 / VEG)
1510
0
164651
TrEMBL
other Location (Reliability: 5)
A0A6J7ZPD6_PLARU
375
0
43143
TrEMBL
-
A0A086KY81_TOXGO
1510
0
164610
TrEMBL
other Location (Reliability: 5)
A0A139XNB9_TOXGO
1510
0
164682
TrEMBL
other Location (Reliability: 5)
F0VNY2_NEOCL
Neospora caninum (strain Liverpool)
1094
0
117398
TrEMBL
other Location (Reliability: 4)
A0A086R070_TOXGO
1510
0
164664
TrEMBL
other Location (Reliability: 5)
D7G8J8_ECTSI
516
1
59056
TrEMBL
Mitochondrion (Reliability: 5)
A0A3R7YJH1_TOXGO
1510
0
164490
TrEMBL
other Location (Reliability: 5)
A0A653WPC2_9BURK
317
0
35816
TrEMBL
-
D9T0D8_MICAI
Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / BCRC 12538 / CBS 129.76 / JCM 10878 / NBRC 16125 / NRRL B-16091 / INA 9442)
299
0
34142
TrEMBL
-
M5D7M4_STEMA
371
0
42082
TrEMBL
-
A0A086MBY1_TOXGO
1510
0
164628
TrEMBL
other Location (Reliability: 5)
A0A086JX78_TOXGO
1510
0
164651
TrEMBL
other Location (Reliability: 5)
A0A084G8F0_PSEDA
562
0
60483
TrEMBL
Secretory Pathway (Reliability: 1)
S7UM38_TOXGG
Toxoplasma gondii (strain ATCC 50853 / GT1)
1510
0
164640
TrEMBL
other Location (Reliability: 5)
Q8MZN0_DICDI
380
0
43967
TrEMBL
-
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van der Wel, H.; Morris, H.R.; Panico, M.; Paxton, T.; Dell, A.; Kaplan, L.; West, C.M.
Molecular cloning and expression of a UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase that modifies Skp1 in the cytoplasm of Dictyostelium
J. Biol. Chem.
277
46328-46337
2002
Dictyostelium discoideum (Q8T1C6)
brenda
Teng-umnuay, P.; van der Wel, H.; West, C.M.
Identification of a UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase in the cytoplasm of Dictyostelium
J. Biol. Chem.
274
36392-36402
1999
Dictyostelium sp.
brenda
West, C.M.; van der Wel, H.; Gaucher, E.A.
Complex glycosylation of Skp1 in Dictyostelium: implications for the modification of other eukaryotic cytoplasmic and nuclear proteins
Glycobiology
12
17R-27R
2002
Dictyostelium sp., Dictyostelium discoideum (Q8T1C6)
brenda
West, C.M.; van der Wel, H.; Sassi, S.; Gaucher, E.A.
Cytoplasmic glycosylation of protein-hydroxyproline and its relationship to other glycosylation pathways
Biochim. Biophys. Acta
1673
29-44
2004
Chlamydomonas reinhardtii, Phytophthora sojae, Thalassiosira pseudonana, Toxoplasma gondii, Dictyostelium discoideum (Q8MZN0)
brenda
van der Wel, H.; Johnson, J.M.; Xu, Y.; Karunaratne, C.V.; Wilson, K.D.; Vohra, Y.; Boons, G.J.; Taylor, C.M.; Bendiak, B.; West, C.M.
Requirements for Skp1 processing by cytosolic prolyl 4(trans)-hydroxylase and alpha-N-acetylglucosaminyltransferase enzymes involved in O2 signaling in dictyostelium
Biochemistry
50
1700-1713
2011
Dictyostelium discoideum, Dictyostelium purpureum
brenda