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Disease on EC 2.3.1.286 - protein acetyllysine N-acetyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
The SIRT1/HIF2? axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.
Acquired Immunodeficiency Syndrome
New clinical findings on the longevity gene in disease, health, & longevity: Sirtuin 1 often decreases with advanced age & serious diseases in most parts of the human body, while relatively high & constant Sirtuin 1 regardless of age was first found in the hippocampus of supercentenarians.
p53 inhibits the upregulation of sirtuin 1 expression induced by c-Myc.
Acute Coronary Syndrome
Association between the SIRT1 mRNA Expression and Acute Coronary Syndrome.
Acute Kidney Injury
Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney Injury.
Activation of sirtuin1 protects against ischemia/reperfusion-induced acute kidney injury.
Activators of SIRT1 in the kidney and protective effects of SIRT1 during acute kidney injury (AKI) (effect of SIRT1 activators on acute kidney injury).
Acute kidney injury: Sirtuin 3-a master regulator of mitochondrial integrity in AKI.
Calcitonin Gene-Related Peptide Attenuates LPS-Induced Acute Kidney Injury by Regulating Sirt1.
Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney.
Dexmedetomidine attenuation of renal ischaemia-reperfusion injury requires sirtuin 3 activation.
Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-?B signaling pathway.
Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats.
Intestinal SIRT1 Deficiency-Related Intestinal Inflammation and Dysbiosis Aggravate TNF?-Mediated Renal Dysfunction in Cirrhotic Ascitic Mice.
Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function.
Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3.
Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1.
Mitochondrial Sirtuin 3 and Renal Diseases.
Pharmacological Activation of Sirt1 Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing Apoptosis, Oxidative Stress, and Inflammation in Mice.
Porous Se@SiO2 nanospheres attenuate cisplatin-induced acute kidney injury via activation of Sirt1.
Protective effects of sirtuin 3 in a murine model of sepsis-induced acute kidney injury.
Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway.
Renal protective effect of sirtuin 1.
Renoprotective effects of estrogen on acute kidney injury: the role of SIRT1.
Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy.
S-Sulfhydration of SIRT3 by Hydrogen Sulfide Attenuates Mitochondrial Dysfunction in Cisplatin-Induced Acute Kidney Injury.
SIRT1 and Kidney Function.
SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation.
Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury.
SIRT1 Mediates Effects of FGF21 to Ameliorate Cisplatin-Induced Acute Kidney Injury.
SIRT1-mediated HMGB1 deacetylation suppresses sepsis-associated acute kidney injury.
SIRT2 is involved in cisplatin-induced acute kidney injury through regulation of mitogen-activated protein kinase phosphatase-1.
SIRT3 Inactivation Promotes Acute Kidney Injury Through Elevated Acetylation of SOD2 and p53.
Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice.
SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated Autophagy.
Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury.
Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis.
Sirtuin 3 in acute kidney injury.
Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury.
Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response.
Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1.
Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway.
The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury.
Acute Lung Injury
Acute down-regulation of miR-199a attenuates sepsis-induced acute lung injury by targeting SIRT1.
Aloin suppresses lipopolysaccharide-induced acute lung injury by inhibiting NLRP3/NF-?B via activation of SIRT1 in mice.
Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1.
Arbutin attenuates LPS-induced lung injury via Sirt1/ Nrf2/ NF-?Bp65 pathway.
Changed profile of microRNAs in acute lung injury induced by cardio-pulmonary bypass and its mechanism involved with SIRT1.
Depleting microRNA-146a-3p attenuates lipopolysaccharide-induced acute lung injury via up-regulating SIRT1 and mediating NF-?B pathway.
Downregulation of miR-155 attenuates sepsis-induced acute lung injury by targeting SIRT1.
GDF-15 prevents lipopolysaccharide-mediated acute lung injury via upregulating SIRT1.
Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1.
Hydroxytyrosol Attenuates LPS-Induced Acute Lung Injury in Mice by Regulating Autophagy and Sirtuin Expression.
Inhibition of acute lung injury by rubriflordilactone in LPS-induced rat model through suppression of inflammatory factor expression.
Metformin alleviated endotoxemia-induced acute lung injury via restoring AMPK-dependent suppression of mTOR.
MicroRNA-499-5p targets SIRT1 to aggravate lipopolysaccharide-induced acute lung injury.
Nrf2 Activation Induced by Sirt1 Ameliorates Acute Lung Injury After Intestinal Ischemia/Reperfusion Through NOX4-Mediated Gene Regulation.
Propofol reduces renal ischemia/reperfusion-induced acute lung injury by stimulating sirtuin 1 and inhibiting pyroptosis.
Protective effect of SIRT3 on acute lung injury by increasing manganese superoxide dismutase-mediated antioxidation.
Resveratrol alleviates alveolar epithelial cell injury induced by hyperoxia by reducing apoptosis and mitochondrial dysfunction.
Resveratrol reduces acute lung injury in a LPS?induced sepsis mouse model via activation of Sirt1.
Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-?B and HMGB1 pathways through the upregulation of SIRT1.
Silencing angiopoietin-like protein 4 (ANGPTL4) protects against lipopolysaccharide-induced acute lung injury via regulating SIRT1 /NF-kB pathway.
SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury.
Suppression of NLRP3 and NF-?B signaling pathways by ?-Cyperone via activating SIRT1 contributes to attenuation of LPS-induced acute lung injury in mice.
The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia.
Adenocarcinoma
Association of SIRT1 and HMGA1 expression in non-small cell lung cancer.
Cellular molecular and proteomic profiling deciphers the SIRT1 controlled cell death pathways in esophageal adenocarcinoma cells.
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.
Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells.
Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.
Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma.
Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.
High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma.
Hsa-miR-217 Inhibits the Proliferation, Migration, and Invasion in Non-small Cell Lung Cancer Cells Via Targeting SIRT1 and P53/KAI1 Signaling
Hypermethylation of HIC1 Promoter and Aberrant Expression of HIC1/SIRT1 Might Contribute to the Carcinogenesis of Pancreatic Cancer.
Immunohistochemical Characterization of Large Intestinal Adenocarcinoma in the Rhesus Macaque (Macaca mulatta).
Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer.
Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma.
MiR-708-5p inhibits the progression of pancreatic ductal adenocarcinoma by targeting Sirt3.
RAR? acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells.
SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation.
SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of ?-catenin.
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer.
SIRT1 is significantly elevated in mouse and human prostate cancer.
Sirtuin1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions.
Upregulation of SIRT1 gene in gastric adenocarcinoma.
[Effects of resveratrol-mediated inhibition of NOD-like receptor protein 3 inflammasomevia activating silent information regulator 1 on the injury of intestinal mucosal barrier function after sepsis].
Adenocarcinoma of Lung
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients.
E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation.
Expression and role of lncRNAs in the regeneration of skeletal muscle following contusion injury.
Hsa_circ_0006571 promotes spinal metastasis through sponging microRNA-138 to regulate sirtuin 1 expression in lung adenocarcinoma.
Inhibition of SIRT1 signaling sensitizes the antitumor activity of silybin against human lung adenocarcinoma cells in vitro and in vivo.
Prognostic and Predictive Role of Sirtuin1 Expression in Lung Adenocarcinoma.
SIRT1 expression is associated with poor prognosis of lung adenocarcinoma.
Sirt1 is a tumor promoter in lung adenocarcinoma.
Sirt1 protects from K-Ras-driven lung carcinogenesis.
Sirt3 is a tumor suppressor in lung adenocarcinoma cells.
Targeting histone deacetylase SIRT1 selectively eradicates EGFR TKI-resistant cancer stem cells via regulation of mitochondrial oxidative phosphorylation in lung adenocarcinoma.
Adenoma
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.
Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas.
Modulating SIRT1 activity variously affects thymic lymphoma development in mice.
SIRT1 is a useful biomarker for high-grade dysplasia and carcinoma in Barrett's esophagus.
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer.
The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target.
Adenoviridae Infections
SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain.
{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3.
Adrenal Cortex Neoplasms
SIRT1 is involved in adrenocortical cancer growth and motility.
Adrenoleukodystrophy
Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy.
Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration.
Albuminuria
Communication from Tubular Epithelial Cells to Podocytes through Sirt1 and Nicotinic Acid Metabolism.
Decreased Urinary Levels of SIRT1 as Non-Invasive Biomarker of Early Renal Damage in Hypertension.
Diabetic nephropathy: Sirt1 attenuates diabetic albuminuria.
In vivo RNA interference models of inducible and reversible Sirt1 knockdown in kidney cells.
Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury.
Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes.
P53/NRF2 mediates SIRT1's protective effect on diabetic nephropathy.
Reduction in podocyte SIRT1 accelerates kidney injury in aging mice.
Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.
Role of SIRT1 in HIV-associated kidney disease.
SIRT1 and Kidney Function.
SIRT1 Attenuates Kidney Disorders in Male Offspring Due to Maternal High-Fat Diet.
Sirtuin and metabolic kidney disease.
Transcriptional Coactivator p300 and Silent Information Regulator 1 (SIRT1) Gene Polymorphism Associated with Diabetic Kidney Disease in a Chinese Cohort.
Alzheimer Disease
A Label-free Sirtuin 1 Assay based on Droplet-Electrospray Ionization Mass Spectrometry.
A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1.
A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model.
Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi.
Amyloid-? Increases Tau by Mediating Sirtuin 3 in Alzheimer's Disease.
Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway.
Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation.
Association between Sirtuin 2 gene rs10410544 polymorphism and depression in Alzheimer's disease in two independent European samples.
Biophysical interaction of resveratrol with sirtuin pathway: Significance in Alzheimer's disease.
Bisdemethoxycurcumin inhibits oxidative stress and antagonizes Alzheimer's disease by up-regulating SIRT1.
CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease.
Correlation Between SIRT2 3'UTR Gene Polymorphism and the Susceptibility to Alzheimer's Disease.
Design, synthesis of allosteric peptide activator for human SIRT1 and its biological evaluation in cellular model of Alzheimer's disease.
Distinct Patterns of Sirtuin Expression During Progression of Alzheimer's Disease.
Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer's Disease.
Eriodictyol Attenuates LPS-Induced Neuroinflammation, Amyloidogenesis, and Cognitive Impairments via the Inhibition of NF-?B in Male C57BL/6J Mice and BV2 Microglial Cells.
Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents.
Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration.
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.
Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease.
Honokiol Alleviates Cognitive Deficits of Alzheimer's Disease (PS1V97L) Transgenic Mice by Activating Mitochondrial SIRT3.
Icariin ameliorate Alzheimer's disease by influencing SIRT1 and inhibiting A? cascade pathogenesis.
Impact of neural stem cell-derived extracellular vesicles on mitochondrial dysfunction, sirtuin 1 level, and synaptic deficits in Alzheimer's disease.
Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia.
Intracerebroventricular injection of resveratrol ameliorated A?-induced learning and cognitive decline in mice.
miR-200a-3p promotes b-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer's disease.
Mitochondrial Sirt3 Expression is Decreased in APP/PS1 Double Transgenic Mouse Model of Alzheimer's Disease.
Mitophagy in degenerative joint diseases.
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.
Neuroprotection by ethanolic extract of Syzygium aromaticum in Alzheimer's disease like pathology via maintaining oxidative balance through SIRT1 pathway.
Neuroprotective Effect of Resveratrol via Activation of Sirt1 Signaling in a Rat Model of Combined Diabetes and Alzheimer's Disease.
Neuroprotective Mechanisms of Resveratrol in Alzheimer's Disease: Role of SIRT1.
Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau.
Noninvasive 40-Hz Light Flicker Rescues Circadian Behavior and Abnormal Lipid Metabolism Induced by Acute Ethanol Exposure via Improving SIRT1 and the Circadian Clock in the Liver-Brain Axis.
Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease.
Peripheral leukocyte expression of the potential biomarker proteins Bdnf, Sirt1, and Psen1 is not regulated by promoter methylation in Alzheimer's disease patients.
Positive association of a Sirt1 variant and parameters of oxidative stress on Alzheimer's disease.
Potential of chromatin modifying compounds for the treatment of Alzheimer's disease.
Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease.
Rational design of novel sirtuin 1 activators via structure-activity insights from application of QSAR modeling.
Reduced expression of SIRT1 and SOD-1 and the correlation between these levels in various regions of the brains of patients with Alzheimer's disease.
Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease.
Resveratrol--a boon for treating Alzheimer's disease?
Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
RTN4B-mediated suppression of Sirtuin 2 activity ameliorates ?-amyloid pathology and cognitive impairment in Alzheimer's disease mouse model.
SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease.
SIRT1 and neuronal diseases.
SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases.
SIRT1 and SIRT2: emerging targets in neurodegeneration.
SIRT1 as a therapeutic target for Alzheimer's disease.
SIRT1 deacetylase activity and the maintenance of protein homeostasis in response to stress: an overview.
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
SIRT1 Deacetylates SC35 and Suppresses Its Function in Tau Exon 10 Inclusion.
Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice.
SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes.
Sirt1 in cerebral ischemia.
SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms.
Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling.
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease.
SIRT1: new avenues of discovery for disorders of oxidative stress.
SIRT2 polymorphism rs10410544 is associated with Alzheimer's disease in a Han Chinese population.
SIRT3 and mitochondrial metabolism in neurodegenerative diseases.
SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease.
SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model.
Sirtuin 1 and Alzheimer's disease: An up-to-date review.
Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease.
Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-? Protein Precursor Processing in Two Alzheimer's Disease Mouse Models.
Sirtuin 3 mRNA Expression is Downregulated in the Brain Tissues of Alzheimer's Disease Patients: A Bioinformatic and Data Mining Approach.
Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease.
Sirtuin deacetylases in neurodegenerative diseases of aging.
Sirtuin modulators control reactive gliosis in an in vitro model of Alzheimer's disease.
Sirtuin1: a promising serum protein marker for early detection of Alzheimer's disease.
Sirtuins as Novel Targets for Alzheimer's Disease and Other Neurodegenerative Disorders: Experimental and Genetic Evidence.
Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence.
Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva.
Sirtuins in cognitive ageing and Alzheimer's disease.
Sirtuins in Neuroendocrine Regulation and Neurological Diseases.
Small-molecule chromatin-modifying agents: therapeutic applications.
SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's Disease.
Synthesis and Assay of SIRT1-Activating Compounds.
The Effects of SIRT1 on Alzheimer's Disease Models.
The emerging role of alternative splicing in senescence and aging.
The neuroprotective effects of SIRT1 in mice carrying the APP/PS1 double-transgenic mutation and in SH-SY5Y cells over-expressing human APP670/671 may involve elevated levels of ?7 nicotinic acetylcholine receptors.
The probable role of insulin resistance and SIRT1 proteins in the Alzheimer's disease.
The Protective Mechanism of SIRT1 in the Regulation of Mitochondrial Biogenesis and Mitochondrial Autophagy in Alzheimer's Disease.
The relationship between four GWAS-identified loci in Alzheimer's disease and the risk of Parkinson's disease, amyotrophic lateral sclerosis, and multiple system atrophy.
The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity.
The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology.
The SIRT2 polymorphism rs10410544 and risk of Alzheimer's disease in two Caucasian case-control cohorts.
The SIRT2 Polymorphism rs10410544 and Risk of Alzheimer's Disease: A Meta-analysis.
The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations.
Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease.
Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective.
[Neuroprotective role of silent information regulator 1 in Alzheimer's disease].
[SIRT1/PGC-1: a neuroprotective axis?]
[SIRT1].
[Sirt3 gene knockout protects mice from Alzheimer's disease through activating autophagy].
Amyotrophic Lateral Sclerosis
Differential Sirtuin Expression Patterns in Amyotrophic Lateral Sclerosis (ALS) Postmortem Tissue: Neuroprotective or Neurotoxic Properties of Sirtuins in ALS?.
Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration.
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.
Identification and verification of key genes in varicocele rats through high-throughput sequencing and bioinformatics analysis.
Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis.
Reduced sirtuin 1/adenosine monophosphate-activated protein kinase in amyotrophic lateral sclerosis patient-derived mesenchymal stem cells can be restored by resveratrol.
Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis.
Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner.
Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice.
Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.
SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis.
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system.
SIRT3 and mitochondrial metabolism in neurodegenerative diseases.
Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease.
Sirtuin deacetylases in neurodegenerative diseases of aging.
The role of single-nucleotide variants of the energy metabolism-linked genes SIRT3, PPARGC1A and APOE in amyotrophic lateral sclerosis risk.
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
[SIRT1].
Anaphylaxis
Sirt1 negatively regulates Fc?RI-mediated mast cell activation through AMPK- and PTP1B-dependent processes.
Anemia, Aplastic
Sirt1 in the Regulation of Interferon Gamma in Severe Aplastic Anemia.
Aneurysm
Sirt3 Protects Against Thoracic Aortic Dissection Formation by Reducing Reactive Oxygen Species, Vascular Inflammation, and Apoptosis of Smooth Muscle Cells.
Aneurysm, Dissecting
Resveratrol Attenuates Aortic Dissection by Increasing Endothelial Barrier Function Through the SIRT1 Pathway.
SIRT1 protects against aortic dissection by regulating AP-1/decorin signaling-mediated PDCD4 activation.
Sirt3 Protects Against Thoracic Aortic Dissection Formation by Reducing Reactive Oxygen Species, Vascular Inflammation, and Apoptosis of Smooth Muscle Cells.
Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension.
Angiomyolipoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Anhedonia
SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex.
SIRT2 inhibition reverses anhedonia in the VGLUT1+/- depression model.
The role of SIRT1 in the basolateral amygdala in depression-like behaviors in mice.
Anosmia
Recovery of Olfactory Function After Excitotoxic Lesion of the Olfactory Bulbs Is Associated with Increases in Bulbar SIRT1 and SIRT4 Expressions.
Aortic Aneurysm, Abdominal
Abnormal acetylation of FOXP3 regulated by SIRT-1 induces Treg functional deficiency in patients with abdominal aortic aneurysms.
Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm.
Mouse macrophage specific knockout of SIRT1 influences macrophage polarization and promotes angiotensin II-induced abdominal aortic aneurysm formation.
Aortic Valve Stenosis
Modulatory Role of SIRT1 and Resistin as Therapeutic Targets in Patients with Aortic Valve Stenosis.
Sirt1 inhibits resistin expression in aortic stenosis.
Apnea
[The expression of SIRT1 in brainstem of rats in different types of hypoxia and its significance].
Arteriosclerosis
[Sir2 gene]
Arteritis
An Insight into Giant Cell Arteritis Pathogenesis: Evidence for Oxidative Stress and SIRT1 Downregulation.
Arthritis
Helicobacter pylori infection increases sirt2 gene expression in gastric epithelial cells of gastritis patients.
Impact of glucocorticoids on systemic sirtuin 1 expression and activity in rats with adjuvant-induced arthritis.
Implication of the deacetylase sirtuin-1 on synovial angiogenesis and persistence of experimental arthritis.
Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-?B activation.
Quercetin-mediated SIRT1 activation attenuates collagen-induced mice arthritis.
Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts.
Seven sirtuins for seven deadly diseases of aging.
SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study.
SIRT1 Regulation in Ageing and Obesity.
Sirt2 suppresses inflammatory responses in collagen-induced arthritis.
Switching gears to an arthritis gene expression network by SirT1 cleavage.
TNF?-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes.
[The cytokine homeostasis was regulated by over-expression of Sirt1 in collagen-induced arthritis mice].
Arthritis, Experimental
Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation.
Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients.
SIRT1 promotes tumor-like invasion of fibroblast-like synoviocytes in rheumatoid arthritis via targeting TIMP1.
Sirt2 suppresses inflammatory responses in collagen-induced arthritis.
[The cytokine homeostasis was regulated by over-expression of Sirt1 in collagen-induced arthritis mice].
Arthritis, Gouty
Sirt1 inhibits gouty arthritis via activating PPAR?.
Arthritis, Rheumatoid
1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes.
A study of Sirt1 regulation and the effect of resveratrol on synoviocyte invasion and associated joint destruction in rheumatoid arthritis.
An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury.
Changes in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis.
Dysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis.
Emerging epigenetic targets in rheumatoid arthritis.
Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
Inhibition of HMGB1-induced angiogenesis by cilostazol via SIRT1 activation in synovial fibroblasts from rheumatoid arthritis.
MiR-140-3p inhibits the cell viability and promotes apoptosis of synovial fibroblasts in rheumatoid arthritis through targeting sirtuin 3.
Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-?B activation.
Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts.
Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner.
Retraction: Inhibition of HMGB1-Induced Angiogenesis by Cilostazol via SIRT1 Activation in Synovial Fibroblasts from Rheumatoid Arthritis.
Sirt1 activity in peripheral blood mononuclear cells from patients with rheumatoid arthritis.
SIRT1 inhibits differentiation of monocytes to macrophages: amelioration of synovial inflammation in rheumatoid arthritis.
SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-?B pathway.
SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance.
SIRT1 promotes tumor-like invasion of fibroblast-like synoviocytes in rheumatoid arthritis via targeting TIMP1.
The class III histone deacetylase sirtuin 1 in immune suppression and its therapeutic potential in rheumatoid arthritis.
The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis.
[Effect of Warm Needle Moxibustion Intervention on Knee-joint Swelling and Expression of Synovial SIRT 1 and NF-?B in Rats with Rheumatoid Arthritis].
Asthma
Antiasthmatic Effects of Resveratrol in Ovalbumin-Induced Asthma Model Mice Involved in the Upregulation of PTEN.
Bergenin-activated SIRT1 inhibits TNF-?-induced proinflammatory response by blocking the NF-?B signaling pathway.
Effects of SIRT1/Akt pathway on chronic inflammatory response and lung function in patients with asthma.
Histone deacetylase inhibitors: can we consider potent anti-neoplastic agents for the treatment of asthma?
Increases in peripheral SIRT1: a new biological characteristic of asthma.
miR-221 participates in the airway epithelial cells injury in asthma via targeting SIRT1.
Myeloid-specific SIRT1 deletion exacerbates airway inflammatory response in a mouse model of allergic asthma.
SIRT7 regulates the TGF-?1-induced proliferation and migration of mouse airway smooth muscle cells by modulating the expression of TGF-? receptor I.
Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma.
Sirtuin 1: Endocan and Sestrin 2 in Different Biological Samples in Patients with Asthma. Does Severity Make the Difference?
Sirtuin 2 enhances allergic asthmatic inflammation.
Sirtuins as novel targets in the pathogenesis of airway inflammation in bronchial asthma.
Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma.
Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach.
Astrocytoma
Tat-Mediated Induction of miRs-34a & -138 Promotes Astrocytic Activation via Downregulation of SIRT1: Implications for Aging in HAND.
Ataxia
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.
Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.
Dysfunction of endothelial progenitor cells from smokers and COPD patients due to increased DNA damage and senescence.
Ataxia Telangiectasia
Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-X(L) and survivin.
AsSIRTing the DNA damage response.
Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites.
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.
SIRT2 directs the replication stress response through CDK9 deacetylation.
SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma.
The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes.
Atherosclerosis
A Paradigm Shift in the Management of Atherosclerosis: Protective Role of Sirtuins in Atherosclerosis.
A TagSNP in SIRT1 Gene Confers Susceptibility to Myocardial Infarction in a Chinese Han Population.
Acacetin Protects Against High Glucose-Induced Endothelial Cells Injury by Preserving Mitochondrial Function via Activating Sirt1/Sirt3/AMPK Signals.
Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis.
ApoE-/- PGC-1?-/- Mice Display Reduced IL-18 Levels and Do Not Develop Enhanced Atherosclerosis.
Assessing the performance of three resveratrol in binding with SIRT1 by molecular dynamics simulation and MM/GBSA methods: the weakest binding of resveratrol 3 to SIRT1 triggers a possibility of dissociation from its binding site.
Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages.
Ca2+/calmodulin-dependent protein kinase kinase ? phosphorylation of Sirtuin 1 in endothelium is atheroprotective.
Cholesterol Metabolism: A Review of How Ageing Disrupts the Biological Mechanisms Responsible for its Regulation.
Correlation between endothelial cell apoptosis and SIRT3 gene expression in atherosclerosis rats.
Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development.
Does Metformin Protect Diabetic Patients from Oxidative Stress and Leukocyte-Endothelium Interactions?
Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms.
Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial.
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.
Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice.
Enhancement in efferocytosis of oxidized low-density lipoprotein-induced apoptotic RAW264.7 cells through Sirt1-mediated autophagy.
Estrogen modulates vascular smooth muscle cell function through downregulation of SIRT1.
Estrogen-SIRT1 Axis Plays a Pivotal Role in Protecting Arteries Against Menopause-Induced Senescence and Atherosclerosis.
Exercise intervention attenuates hyperhomocysteinemia-induced aortic endothelial oxidative injury by regulating SIRT1 through mitigating NADPH oxidase/LOX-1 signaling.
Impact of Short-Term Hypoxia on Sirtuins as Regulatory Elements in HUVECs.
Impaired SIRT1 promotes the migration of vascular smooth muscle cell-derived foam cells.
Impairment of sirtuin 1-mediated DNA repair is involved in bisphenol A-induced aggravation of macrophage inflammation and atherosclerosis.
In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions.
Loss-of-SIRT1 function during vascular ageing: Hyperphosphorylation mediated by cyclin-dependent kinase 5.
Metformin ameliorates the proinflammatory state in patients with carotid artery atherosclerosis through sirtuin 1 induction.
Methods to investigate the role of SIRT1 in endothelial senescence.
MicroRNA-140-5p aggravates hypertension and oxidative stress of atherosclerosis via targeting Nrf2 and Sirt2.
MicroRNA?217 is involved in the progression of atherosclerosis through regulating inflammatory responses by targeting sirtuin 1.
MiR-132 relieves vascular endothelial inflammation and improve endothelial function in atherosclerosis rats by regulating SIRT1.
miR-92a regulates the expression levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 3 via sirtuin 1 signaling in hydrogen peroxide-induced vascular smooth muscle cells.
Mitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis.
Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span.
mTOR signaling promotes foam cell formation and inhibits foam cell egress through suppressing the SIRT1 signaling pathway.
Peripheral blood monocyte Sirt1 expression is reduced in patients with coronary artery disease.
Poly(ADP-ribose) Polymerase 1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Implications.
Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins.
Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation.
Protective roles of SIRT1 in atherosclerosis.
Regulation of SIRT1 in vascular smooth muscle cells from streptozotocin-diabetic rats.
Resveratrol Blunts the Positive Effects of Exercise Training on Cardiovascular Health in Aged Men.
Role of histone deacetylase Sirt3 in the development and regression of atherosclerosis.
Roles of SIRT1 in High Glucose-induced Endothelial Impairment: Association with Diabetic Atherosclerosis.
Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A randomized trial.
Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients.
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR.
SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis.
SIRT1 improves VSMC functions in atherosclerosis.
SIRT1 in cardiovascular aging.
SIRT1 inhibition promotes atherosclerosis through impaired autophagy.
SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy.
SIRT1 inhibits monocyte adhesion to the vascular endothelium by suppressing Mac-1 expression on monocytes.
SIRT1 mediates the actions of PPAR? on the oxLDL-triggered migration and proliferation of vascular smooth muscle cells.
SIRT1 prevents atherosclerosis via liver?X?receptor and NF??B signaling in a U937 cell model.
SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice.
SIRT1 regulates CD40 expression induced by TNF-? via NF-?B pathway in endothelial cells.
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase.
SIRT1 Regulation in Ageing and Obesity.
SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells.
SIRT1/eNOS Axis as a Potential Target against Vascular Senescence, Dysfunction and Atherosclerosis.
SIRT1: a novel target to prevent atherosclerosis.
SIRT1: new avenues of discovery for disorders of oxidative stress.
SIRT4 suppresses the PI3K/Akt/NF??B signaling pathway and attenuates HUVEC injury induced by oxLDL.
Sulfhydrated Sirtuin-1 Increasing Its Deacetylation Activity Is an Essential Epigenetics Mechanism of Anti-Atherogenesis by Hydrogen Sulfide.
Suppression of microRNA-323-3p restrains vascular endothelial cell apoptosis via promoting sirtuin-1 expression in coronary heart disease.
The Endothelium as a Target for Anti-Atherogenic Therapy: A Focus on the Epigenetic Enzymes EZH2 and SIRT1.
The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin.
The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis.
The Sirt1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE?/? mice through inhibiting vascular inflammatory response.
The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.
The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis.
TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.
Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis.
Vestibular rehabilitation ameliorates chronic dizziness through the SIRT1 axis.
[Sirt1 inhibited oxidized low-density lipoprotein induced smooth muscle cells inflammatory response].
Atrial Fibrillation
A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease.
Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery.
Protective mechanism of SIRT1 on Hcy-induced atrial fibrosis mediated by TRPC3.
[Expression of SIRT1 in right auricle tissues and the relationship with oxidative stress in patients with atrial fibrillation].
Autoimmune Diseases
Decreased SIRT1 expression in the peripheral blood of patients with Graves' disease.
Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology.
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.
SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus.
sirt1-null mice develop an autoimmune-like condition.
Sirtuin 1 in immune regulation and autoimmunity.
The class III histone deacetylase sirtuin 1 in immune suppression and its therapeutic potential in rheumatoid arthritis.
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice.
The Versatility of Sirtuin-1 in Endocrinology and Immunology.
Three novel acetylation sites in the foxp3 transcription factor regulate the suppressive activity of regulatory T cells.
TNF? Regulates SIRT1 Cleavage during Ocular Autoimmune Disease.
Azoospermia
microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials.
Bacteremia
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.
Bacterial Infections
A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection.
Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins.
Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors.
Effects of Resveratrol on the Treatment of Inflammatory Response Induced by Severe Burn.
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.
Barrett Esophagus
SIRT1 is a useful biomarker for high-grade dysplasia and carcinoma in Barrett's esophagus.
Bicuspid Aortic Valve Disease
Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease.
Blast Crisis
Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib.
Bone Diseases
Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration.
Overexpression of SIRT1 prevents hypoxia?induced apoptosis in osteoblast cells.
Bone Diseases, Metabolic
SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress.
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice.
Bone Marrow Failure Disorders
The Sirt1 activator resveratrol improved hematopoiesis in pancytopenia mice induced by irradiation.
Bone Neoplasms
SIRT1 Activation Attenuates Bone Cancer Pain by Inhibiting mGluR1/5.
SIRT1 activation by SRT1720 attenuates bone cancer pain via preventing Drp1-mediated mitochondrial fission.
Bone Resorption
Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1.
Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders?
Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling.
Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency.
Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition.
Particle-induced SIRT1 downregulation promotes osteoclastogenesis and osteolysis through ER stress regulation.
SIRT1 modulates high-mobility group box 1-induced osteoclastogenic cytokines in human periodontal ligament cells.
SIRT1/FOXO3a axis plays an important role in the prevention of mandibular bone loss induced by 1,25(OH)2D deficiency.
Sirtuin 1 inhibits TNF-?-mediated osteoclastogenesis of bone marrow-derived macrophages through both ROS generation and TRPV1 activation.
Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs.
Sirtuins and FoxOs in osteoporosis and osteoarthritis.
The Role of FoxOs in Bone Health and Disease.
Bowen's Disease
Overlapping tumor-specific expression of p53, p16INK4a, and sirtuin 1 in Bowen's disease: A case report.
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Brain Diseases
Heme oxygenase-1 modulates microRNA expression in cultured astroglia: implications for chronic brain disorders.
Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling.
Mitochondrial SIRT3 and neurodegenerative brain disorders.
Modulation of sirtuins: new targets for antiageing.
Brain Edema
Alpha-lipoic acid upregulates SIRT1-dependent PGC-1? expression and protects mouse brain against focal ischemia.
Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha Expression in experimental stroke.
Neuroprotective Effects of Exercise Postconditioning After Stroke via SIRT1-Mediated Suppression of Endoplasmic Reticulum (ER) Stress.
PDGFR-? modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-?B pathway in subarachnoid hemorrhage rats.
SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress.
SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.
SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage.
SIRT3 protects against early brain injury following subarachnoid hemorrhage via promoting mitochondrial fusion in an AMPK dependent manner.
The AMPAR antagonist perampanel protects the neurovascular unit against traumatic injury via regulating Sirt3.
Treatment of Brain Edema by Wogonoside Is Associated with Inhibition of Neuronal Apoptosis and SIRT1 Activation in Rats.
Brain Infarction
Sirt3 inhibits cerebral ischemia-reperfusion injury through normalizing Wnt/?-catenin pathway and blocking mitochondrial fission.
Brain Injuries
Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway.
c-myc protects mice from ischemia stroke through elevating microRNA-200b-5p-regulated SIRT1 expression.
Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling.
Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia.
Exosomes Derived From Adipose-Derived Mesenchymal Stem Cells Ameliorate Radiation-Induced Brain Injury by Activating the SIRT1 Pathway.
Fucoxanthin Mitigates Subarachnoid Hemorrhage-Induced Oxidative Damage via Sirtuin 1-Dependent Pathway.
Honokiol ameliorates radiation-induced brain injury via the activation of SIRT3.
Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha Expression in experimental stroke.
Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo.
Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats.
Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling.
Melatonin Counteracts at a Transcriptional Level the Inflammatory and Apoptotic Response Secondary to Ischemic Brain Injury Induced by Middle Cerebral Artery Blockade in Aging Rats.
Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH).
NAD+ Metabolism and NAD+-Dependent Enzymes: Promising Therapeutic Targets for Neurological Diseases.
Oleanolic acid exerts neuroprotective effects in subarachnoid hemorrhage rats through SIRT1-mediated HMGB1 deacetylation.
Polydatin prevents the induction of secondary brain injury after traumatic brain injury by protecting neuronal mitochondria.
Radiation-Induced Alteration of the Brain Proteome: Understanding the Role of the Sirtuin 2 Deacetylase in a Murine Model.
Resveratrol Relieves Hyperoxia-Induced Brain Injury in Neonatal Rats by Activating Sirt1.
Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats.
SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress.
SIRT1 attenuated oxidative stress induced by methyl tert-butyl ether in HT22 cells.
Sirt1 improves functional recovery by regulating autophagy of astrocyte and neuron after brain injury.
Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury.
Sirt1 Regulates Oxidative Stress in Oxygen-Glucose Deprived Hippocampal Neurons.
SIRT1/PGC-1? Signaling Promotes Mitochondrial Functional Recovery and Reduces Apoptosis after Intracerebral Hemorrhage in Rats.
SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice.
SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.
SIRT3 Expression Decreases with Reactive Oxygen Species Generation in Rat Cortical Neurons during Early Brain Injury Induced by Experimental Subarachnoid Hemorrhage.
SIRT3 protects against early brain injury following subarachnoid hemorrhage via promoting mitochondrial fusion in an AMPK dependent manner.
Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats.
The molecular mechanism of Sirt1 signaling pathway in brain injury of newborn rats exposed to hyperoxia.
The small RNA microRNA-212 regulates sirtuin 2 expression in a cellular model of oxygen-glucose deprivation.
Will Sirtuins Be Promising Therapeutic Targets for TBI and Associated Neurodegenerative Diseases?
Brain Injuries, Traumatic
Batroxobin inhibits astrocyte activation following nigrostriatal pathway injury.
Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo.
Low-Molecular-Weight Fucoidan Attenuates Mitochondrial Dysfunction and Improves Neurological Outcome After Traumatic Brain Injury in Aged Mice: Involvement of Sirt3.
Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1.
Sirt1 improves functional recovery by regulating autophagy of astrocyte and neuron after brain injury.
SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway.
SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-?B p65 acetylation and activation.
SIRT2 inhibition exacerbates p53-mediated ferroptosis in mice following experimental traumatic brain injury.
Sirtuin 1 alleviates neuroinflammation-induced apoptosis after traumatic brain injury.
Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia.
Sirtuins in Neuroendocrine Regulation and Neurological Diseases.
The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases.
Brain Ischemia
Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome.
Brain SIRT1 Mediates Metabolic Homeostasis and Neuroprotection.
Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia.
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Epsilon PKC Increases Brain Mitochondrial SIRT1 Protein Levels via Heat Shock Protein 90 following Ischemic Preconditioning in Rats.
Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice.
Luteolin Protects Against CIRI, Potentially via Regulation of the SIRT3/AMPK/mTOR Signaling Pathway.
Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats.
Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance.
New role of silent information regulator 1 in cerebral ischemia.
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons.
Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning.
Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation.
Protective effects of ex-527 on cerebral ischemia-reperfusion injury through necroptosis signaling pathway attenuation.
Resveratrol and ischemic preconditioning in the brain.
Resveratrol mimics ischemic preconditioning in the brain.
Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway.
Resveratrol relieves ischemia-induced oxidative stress in the hippocampus by activating SIRT1.
Role of SIRT1 in Isoflurane Conditioning-Induced Neurovascular Protection against Delayed Cerebral Ischemia Secondary to Subarachnoid Hemorrhage.
Salidroside attenuates hypoxia/reoxygenation-induced human brain vascular smooth muscle cell injury by activating the SIRT1/FOXO3? pathway.
Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats.
SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.
SIRT1 Activation: A Potential Strategy for Harnessing Endogenous Protection Against Delayed Cerebral Ischemia After Subarachnoid Hemorrhage.
SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow.
Sirt1 in cerebral ischemia.
Sirt1 mediates improvement in cognitive defects induced by focal cerebral ischemia following hyperbaric oxygen preconditioning in rats.
SIRT1 regulation modulates stroke outcome.
Sirt3 confers protection against neuronal ischemia by inducing autophagy: Involvement of the AMPK-mTOR pathway.
Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1?/VEGF Signaling and Blood-Brain Barrier Integrity.
SIRT3 protects cells from hypoxia via PGC-1?- and MnSOD-dependent pathways.
Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels.
Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window.
The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases.
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
The small RNA microRNA-212 regulates sirtuin 2 expression in a cellular model of oxygen-glucose deprivation.
[Acute cerebral ischemia-induced down-regulation of Sirt3 protein expression contributes to neuronal injury via damaging mitochondrial function].
Brain Neoplasms
A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma.
FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2).
Germline copy number variation of genes involved in chromatin remodelling in families suggestive of Li-Fraumeni syndrome with brain tumours.
SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.
SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3? activity in neuroblastoma cells.
Breast Neoplasms
4-Hydroxynonenal promotes growth and angiogenesis of breast cancer cells through HIF-1? stabilization.
A New Synthetic Histone Deacetylase Inhibitor, MHY2256, Induces Apoptosis and Autophagy Cell Death in Endometrial Cancer Cells via p53 Acetylation.
A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo.
A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer.
A novel MeCP2 acetylation site regulates interaction with ATRX and HDAC1.
A novel Ubc9 -dependent pathway regulates SIRT1- ER-? Axis and BRCA1-associated TNBC lung metastasis.
A positive role of DBC1 in PEA3-mediated progression of estrogen receptor-negative breast cancer.
Altered Sirtuin 7 Expression is Associated with Early Stage Breast Cancer.
Altered sirtuin expression is associated with node-positive breast cancer.
AMPK inhibits MTDH expression via GSK3? and SIRT1 activation: potential role in triple negative breast cancer cell proliferation.
Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1.
Assessment of SIRT2 Inhibitors in Mouse Models of Cancer.
Association between SIRT1 Gene Polymorphisms and Breast Cancer in Egyptians.
Balance between SIRT1 and DBC1 expression is lost in breast cancer.
Brachyury promotes tamoxifen resistance in breast cancer by targeting SIRT1.
Branched-chain amino acid transaminase 1 (BCAT1) promotes the growth of breast cancer cells through improving mTOR-mediated mitochondrial biogenesis and function.
BRCA1 inhibits AR-mediated proliferation of breast cancer cells through the activation of SIRT1.
Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer.
Can Sir(2) regulate cancer?
CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1.
CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance.
Characterization of FOXO Acetylation.
Checkpoint suppressor 1 suppresses transcriptional activity of ER? and breast cancer cell proliferation via deacetylase SIRT1.
CHM-1, a novel microtubule-destabilizing agent exhibits antitumor activity via inducing the expression of SIRT2 in human breast cancer cells.
Clinicopathological and prognostic role of SIRT1 in breast cancer patients: a meta-analysis.
Combination of SIRT1 and Src overexpression suggests poor prognosis in luminal breast cancer.
Construction of SIRT1 gene shRNA lentivirus vector and its effect on the proliferation of breast cancer cells.
Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer.
Cyanidin-3-glucoside induces mesenchymal to epithelial transition via activating Sirt1 expression in triple negative breast cancer cells.
DBC1 Functions as a Tumor Suppressor by Regulating p53 Stability.
DBC1/CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor.
De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment.
Deacetylation of cortactin by SIRT1 promotes cell migration.
Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer.
Decreased sirtuin 4 expression is associated with poor prognosis in patients with invasive breast cancer.
Defining the Role of Histone Deacetylases in the Inhibition of Mammary Carcinogenesis by Dietary Energy Restriction (DER): Effects of Suberoylanilide Hydroxamic Acid (SAHA) and DER in a Rat Model.
Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis.
Development of activity-based probes for the protein deacylase Sirt1.
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients.
Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype.
Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer.
Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness.
Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells.
Effect of the BRCA1-SIRT1-EGFR axis on cisplatin sensitivity in ovarian cancer.
Emerging role of sirtuins in breast cancer metastasis and multidrug resistance: Implication for novel therapeutic strategies targeting sirtuins.
Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer.
Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent ?-H2AX and telomerase regulation in triple-negative breast cancer.
Expression and sequence of canine SIRT2 and p53 genes in canine mammary tumour cells - effects on downstream targets Wip1 and p21/Cip1.
Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma.
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.
Expression of DBC1 is associated with nuclear grade and HER2 expression in breast cancer.
Expression of FOXM1 and related proteins in breast cancer molecular subtypes.
Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer.
Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma.
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas.
Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer.
Expression of SIRT1, SIRT3 and SIRT6 Genes for Predicting Survival in Triple-Negative and Hormone Receptor-Positive Subtypes of Breast Cancer.
Extracellular NAMPT/visfatin causes p53 deacetylation via NAD production and SIRT1 activation in breast cancer cells.
Frizzled 7 expression is positively regulated by SIRT1 and ?-catenin in breast cancer cells.
HDAC2 overexpression correlates with aggressive clinicopathological features and DNA-damage response pathway of breast cancer.
High Expression of SIRT1 Associates with the Doxorubicin Resistance of Breast Cancer through Activating of Akt.
High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients.
High-throughput screening of Sirtuin family of genes in breast cancer.
Histone/protein deacetylase SIRT1 is an anticancer therapeutic target.
hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1.
Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells.
I157172, a novel inhibitor of cystathionine ?-lyase, inhibits growth and migration of breast cancer cells via SIRT1-mediated deacetylation of STAT3.
Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity.
Identification of novel SIRT3 inhibitor scaffolds by virtual screening.
Identification of Sirtuin 3, a mitochondrial protein deacetylase, as a new contributor to tamoxifen resistance in breast cancer cells.
Impact of structurally diverse BET inhibitors on SIRT1.
Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3.
Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells.
Inhibition of sirtuin 1 deacetylase by miR-211-5p provides a mechanism for the induction of cell death in breast cancer cells.
Isoalantolactone induces apoptosis in human breast cancer cells via ROS-mediated mitochondrial pathway and downregulation of SIRT1.
Lemon Juice as a Biocatalyst Under Ultrasound Irradiation: Synthesis and Pharmacological Evaluation of 2-amino 1,3,4-thiadiazoles.
Loss of SIRT4 promotes the self-renewal of Breast Cancer Stem Cells.
Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.
Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence.
Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of ?-tubulin acetylation and inhibition of breast cancer cell migration.
Mesenchymal stem cells with Sirt1 overexpression suppress breast tumor growth via chemokine-dependent natural killer cells recruitment.
MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1.
MicroRNA-590-3P suppresses cell survival and triggers breast cancer cell apoptosis via targeting sirtuin-1 and deacetylation of p53.
MicroRNA?3666 inhibits breast cancer cell proliferation by targeting sirtuin 7.
miR-200a controls hepatic stellate cell activation and fibrosis via SIRT1/Notch1 signal pathway.
miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells.
miR-22 suppresses tumorigenesis and improves radiosensitivity of breast cancer cells by targeting Sirt1.
miR-301 regulates the SIRT1/SOX2 pathway via CPEB1 in the breast cancer progression.
MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1.
MnSOD acetylation and dys-regulation, due to loss of SIRT3 activity, promotes a Luminal B-like breast carcinogenic permissive phenotype.
Molecular characterization, alternative splicing and expression analysis of bovine DBC1.
Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma.
Negative regulation of the deacetylase SIRT1 by DBC1.
New Gene Profiling in Determination of Breast Cancer Recurrence and Prognosis in Iranian Women.
Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization.
Nicotinamide uncouples hormone-dependent chromatin remodeling from transcription complex assembly.
Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies.
O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway.
Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer.
Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma.
Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1? destabilization.
PGC-1? activates SIRT3 to modulate cell proliferation and glycolytic metabolism in breast cancer.
pH sensitive liposomes assisted specific and improved breast cancer therapy using co-delivery of SIRT1 shRNA and Docetaxel.
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts.
Recent progress in carcinogenesis, progression and therapy of breast cancer: the 20th Hiroshima Cancer Seminar--the 4th Three Universities' Consortium International Symposium, October 2010: 31 October 2010, International Conference Center Hiroshima.
Regulation of SIRT1 activity by genotoxic stress.
Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial-mesenchymal transition and modulating SIRT1/?-catenin signaling pathway in breast cancer.
Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism.
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1.
SIRT1 and Estrogen Signaling Cooperation for Breast Cancer Onset and Progression.
SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.
SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer.
SIRT1 in Secretory Organ Cancer.
SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer.
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.
SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor ? in breast cancer.
SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer.
SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression.
SIRT1 promotes formation of breast cancer through modulating Akt activity.
SIRT1 promotes proliferation, migration, and invasion of breast cancer cell line MCF-7 by upregulating DNA polymerase delta1 (POLD1).
SIRT1 Regulates Lysosome Function and Exosome Secretion.
SIRT1 represses estrogen-signaling, ligand-independent ER?-mediated transcription, and cell proliferation in estrogen-responsive breast cells.
SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein.
SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis.
SIRT1-dependent epigenetic regulation of H3 and H4 histone acetylation in human breast cancer.
SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents.
SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation.
SIRT2: tumour suppressor or tumour promoter in operable breast cancer?
Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells.
Sirt3 is a tumor suppressor in lung adenocarcinoma cells.
SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1? Destabilization.
SIRT3 Silencing Sensitizes Breast Cancer Cells to Cytotoxic Treatments Through an Increment in ROS Production.
SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin.
Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia.
Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells.
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice.
Sirtuin 3 interacts with Lon protease and regulates its acetylation status.
SOD1, an unexpected novel target for cancer therapy.
SRC Promotes Tamoxifen Resistance in Breast Cancer via Up-Regulating SIRT1.
SRT1720 induces lysosomal-dependent cell death of breast cancer cells.
SRT1720, a potential sensitizer for radiotherapy and cytotoxicity effects of NVB-BEZ235 in metastatic breast cancer cells.
SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.
Structure-based identification of novel sirtuin inhibitors against triple negative breast cancer: An in silico and in vitro study.
Targeted expression of miR-34a using the T-VISA system suppresses breast cancer cell growth and invasion.
The beneficial role of SIRT1 activator on chemo- and radiosensitization of breast cancer cells in response to IL-6.
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop.
The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target.
The Contrary Effects of Sirt1 on MCF7 Cells Depend on CD36 Expression Level.
The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.
The effect of adipocyte-macrophage cross-talk in obesity-related breast cancer.
The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response.
The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers.
The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer.
The SIRT 3 expression profile is associated with pathological and clinical outcomes in human breast cancer patients.
The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer.
The study of sirtuins in breast cancer patients before and after radiotherapy
Upregulated tumor sirtuin 2 expression correlates with reduced TNM stage and better overall survival in surgical breast cancer patients.
[Mechanism of apoptosis induced by SIRT1 deacetylase inhibitors in human breast cancer MCF-7 drug-resistant cells]
Bronchopulmonary Dysplasia
Attenuated SUMOylation of sirtuin 1 in premature neonates with bronchopulmonary dysplasia.
Budesonide and Poractant Alfa prevent bronchopulmonary dysplasia via triggering SIRT1 signaling pathway.
Sirtuin1 in tracheal aspirate leukocytes: possible role in the development of bronchopulmonary dysplasia in premature infants.
[Decreased SIRT1 expression is related to bronchopulmonary dysplasia in premature infants after oxygen exposure].
Bulbo-Spinal Atrophy, X-Linked
Sirtuin deacetylases in neurodegenerative diseases of aging.
Burkitt Lymphoma
Triptolide induces mitochondria-mediated apoptosis of Burkitt's lymphoma cell via deacetylation of GSK-3? by increased SIRT3 expression.
Candidiasis
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Carcinogenesis
3-Iodothyronamine and 3,5,3'-triiodo-L-thyronine reduce SIRT1 protein expression in the HepG2 cell line.
?-Cryptoxanthin Restores Nicotine-Reduced Lung SIRT1 to Normal Levels and Inhibits Nicotine-Promoted Lung Tumorigenesis and Emphysema in A/J Mice.
A Dual Role for Sirtuin 1 in Tumorigenesis.
A New Regulatory Mechanism Between P53 And YAP Crosstalk By SIRT1 Mediated Deacetylation To Regulate Cell Cycle And Apoptosis In A549 Cell Lines.
A novel role of SIRT1 in gammaherpesvirus latency and replication.
A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets.
A variant in SIRT2 gene 3'-UTR is associated with susceptibility to colorectal cancer.
Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene.
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.
Assessment of SIRT2 Inhibitors in Mouse Models of Cancer.
Balance between SIRT1 and DBC1 expression is lost in breast cancer.
Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer.
Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR-181a to modulate SIRT1 expression.
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage.
CK2?/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients.
Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1.
Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1.
Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients.
Constitutive Activation of NAD-Dependent Sirtuin 3 Plays an Important Role in Tumorigenesis of Chromium(VI)-Transformed Cells.
Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet.
Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis.
DBC1 is a negative regulator of SIRT1.
De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment.
Deacetylation of ?-catenin by SIRT1 regulates self-renewal and oncogenesis of liver cancer stem cells.
Deacetylation of cortactin by SIRT1 promotes cell migration.
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.
Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells.
Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance.
Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects.
Diverse roles of SIRT1 in cancer biology and lipid metabolism.
DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing-a possible predictive biomarker for malignant transformation.
Docosahexaenoic acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon epithelial cells.
Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer.
Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells.
Dual role of SIRT1 in UVB-induced skin tumorigenesis.
Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer.
E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation.
Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target.
Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer.
Enhancement of NAD+-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells.
Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.
ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis.
Expression and prognostic significance of SIRT1 in ovarian epithelial tumours.
Expression of DBC1 is associated with nuclear grade and HER2 expression in breast cancer.
Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin.
Expression of SIRT1 gene in human lung cancer lines enhances their sensitivity to the anticancer effects of cisplatin.
Forkhead Transcription Factor FOXO1 Inhibits Angiogenesis in Gastric Cancer in Relation to SIRT1.
FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain.
Gene expression mapping of histone deacetylases and co-factors, and correlation with survival time and 1H-HRMAS metabolomic profile in human gliomas.
Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma.
Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2.
HBx mediated Increase of SIRT1 Contributes to HBV-related Hepatocellular Carcinoma Tumorigenesis.
Hepatotoxic Effects of Hexafluoropropylene Oxide Trimer Acid (HFPO-TA), A Novel Perfluorooctanoic Acid (PFOA) Alternative, on Mice.
High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients.
hnRNP A1 antagonizes cellular senescence and senescence-associated secretory phenotype via regulation of SIRT1 mRNA stability.
Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation.
Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.
Infection Reveals a Modification of SIRT2 Critical for Chromatin Association.
Inhibition of SIRT1 Limits Self-Renewal and Oncogenesis by Inducing Senescence of Liver Cancer Stem Cells.
Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway.
Insulin/IGF-1R, SIRT1, and FOXOs Pathways-An Intriguing Interaction Platform for Bone and Osteosarcoma.
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.
Investigation of sirtuin 1 polymorphisms in relation to the risk of colorectal cancer by molecular subtype.
Janus-faced role of SIRT1 in tumorigenesis.
Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis.
Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma.
Low Rap1-interacting factor 1 and sirtuin 6 expression predict poor outcome in radiotherapy-treated Hodgkin lymphoma patients.
Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma.
Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers.
Metabolic regulation by SIRT3: implications for tumorigenesis.
Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells.
MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1.
MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma.
MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1.
miR-124-3p combined with miR-506-3p delay hepatic carcinogenesis via modulating sirtuin 1.
miR-22 suppresses tumorigenesis and improves radiosensitivity of breast cancer cells by targeting Sirt1.
miR-543 promotes gastric cancer cell proliferation by targeting SIRT1.
Mitochondrial sirtuins genetic variations and gastric cancer risk: Evidence from retrospective observational study.
Modulating SIRT1 activity variously affects thymic lymphoma development in mice.
Modulation of tumorigenesis by dietary intervention is not mediated by SIRT1 catalytic activity.
Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer.
Multifaceted Modulation of SIRT1 in Cancer and Inflammation.
NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response.
Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells.
Nicotinamide Phosphoribosyltransferase in Malignancy: A Review.
Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways.
Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines.
p30 DBC is a potential regulator of tumorigenesis.
PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells.
Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma.
Publisher Correction: Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.
Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
Reduced expression of SIRT2 in serous ovarian carcinoma promotes cell proliferation through disinhibition of CDK4 expression.
Regulation of Apoptosis and Radiation Sensitization in Lung Cancer Cells via the Sirt1/NF-?B/Smac Pathway.
Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer.
Regulation of MnSOD Enzymatic Activity by Sirt3 Connects the Mitochondrial Acetylome Signaling Networks to Aging and Carcinogenesis.
Regulation of SIRT2 levels for human non-small cell lung cancer therapy.
Rejuvenating sirtuins: the rise of a new family of cancer drug targets.
Research progress on SIRT1 and sepsis.
Resveratrol improves smooth muscle carcinogenesis in the progression of chronic prostatitis via the downregulation of c-kit/SCF by activating Sirt1.
Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius guentheri.
Role of SIRT1 in homologous recombination.
Role of SIRT3 in the regulation of redox balance during oral carcinogenesis.
Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming.
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.
Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020.
Silent information regulator, Sirtuin 1, and age-related diseases.
SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.
Sirt1 and cell migration.
SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation.
SIRT1 and gynecological malignancies (Review).
SIRT1 and p53, effect on cancer, senescence and beyond.
SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.
SIRT1 and the clock gene machinery in colorectal cancer.
SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling.
SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis.
Sirt1 deacetylates c-Myc and promotes c-Myc/Max association.
SIRT1 downregulated FGB expression to inhibit RCC tumorigenesis by destabilizing STAT3.
SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC.
SIRT1 in B[a]P-induced lung tumorigenesis.
Sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers.
SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells.
SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells.
SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo.
SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress.
Sirt1 is a tumor promoter in lung adenocarcinoma.
Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells.
SIRT1 is significantly elevated in mouse and human prostate cancer.
SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation.
SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis.
SIRT1 promotes metastasis of human osteosarcoma cells.
SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability.
SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines.
SIRT1 promotes proliferation, migration, and invasion of breast cancer cell line MCF-7 by upregulating DNA polymerase delta1 (POLD1).
SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells.
SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency.
SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis.
SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling.
Sirt1 protects from K-Ras-driven lung carcinogenesis.
SIRT1 regulates N6 -methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2-dependent FTO SUMOylation.
SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma.
SIRT1 regulates UV-induced DNA repair through deacetylating XPA.
SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells.
SIRT1, a promising regulator of bone homeostasis.
SIRT1, is it a tumor promoter or tumor suppressor?
SIRT1-mediated downregulation of p27Kip1 is essential for overcoming contact inhibition of Kaposi's sarcoma-associated herpesvirus transformed cells.
SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol.
SIRT1: new avenues of discovery for disorders of oxidative stress.
SIRT1: Regulator of p53 Deacetylation.
SIRT1: roles in aging and cancer.
SIRT1: tumor promoter or tumor suppressor?
SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages.
SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status.
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis.
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.
SIRT2 Regulates LPS-Induced Renal Tubular CXCL2 and CCL2 Expression.
Sirt2 Regulates Radiation-Induced Injury.
Sirt2 suppresses glioma cell growth through targeting NF-?B-miR-21 axis.
SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress.
SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients.
SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis.
SIRT3 elicited an anti-Warburg effect through HIF1?/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis.
SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis.
SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis.
SirT3 suppresses hypoxia inducible factor 1? and tumor growth by inhibiting mitochondrial ROS production.
Sirt3, Mitochondrial ROS, Ageing, and Carcinogenesis.
SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.
SIRT7 Is a Prognostic Biomarker Associated With Immune Infiltration in Luminal Breast Cancer.
SIRT7 Is an RNA-Activated Protein Lysine Deacylase.
SIRT7 Regulates Lipopolysaccharide-Induced Inflammatory Injury by Suppressing the NF-?B Signaling Pathway.
Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways.
Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study.
Sirtuin 1 in immune regulation and autoimmunity.
Sirtuin 1 in malignant transformation: Friend or foe?
Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases.
Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.
Sirtuin 1 knockdown inhibits glioma cell proliferation and potentiates temozolomide toxicity via facilitation of reactive oxygen species generation.
Sirtuin 1 promotes autophagy and proliferation of endometrial cancer cells by reducing acetylation level of LC3.
Sirtuin 2 in Endometrial Cancer: A Potential Regulator for Cell Proliferation, Apoptosis and RAS/ERK Pathway.
Sirtuin 2 mutations in human cancers impair its function in genome maintenance.
Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2.
Sirtuin 3: A Janus face in cancer (Review).
Sirtuin activators and inhibitors.
Sirtuin-1 Regulates Acinar-to-Ductal Metaplasia and Supports Cancer Cell Viability in Pancreatic Cancer.
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.
Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer.
Sirtuin1 expression predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer.
Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer.
Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease.
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription.
Sorting out functions of sirtuins in cancer.
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis.
Targeting Sirtuin 1 signaling pathway by ginsenosides.
The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?
The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy.
The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer.
The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas.
The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response.
The possible role of Sirtuins and microRNAs in hepatocellular carcinoma therapy.
The Proteomic Profile of Deleted in Breast Cancer 1 (DBC1) Interactions Points to a Multifaceted Regulation of Gene Expression.
The Regulatory Effect of SIRT1 on Extracellular Microenvironment Remodeling.
The role of SIRT1 in tumorigenesis.
The role of SIRT2 in cancer: A novel therapeutic target.
The Roles of SIRT1 in Cancer.
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
Trending topics of SIRT1 in tumorigenicity.
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.
Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.
Uncoupling genotoxic stress responses from circadian control increases susceptibility to mammary carcinogenesis.
USP31 acetylation at Lys1264 is essential for its activity and cervical cancer cell growth.
Vimentin acetylation is involved in SIRT5-mediated hepatocellular carcinoma migration.
[Mechanism of regulating deacetylase SIRT1 expression and activity.].
[Retracted] FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain.
Carcinoma
A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53.
Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer.
Acetylation status of P53 and the expression of DBC1, SIRT1, and androgen receptor are associated with survival in clear cell renal cell carcinoma patients.
ADC correlation with Sirtuin1 to assess early chemoradiotherapy response of locally advanced esophageal carcinoma patients.
AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells.
Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma.
Associations of sirtuins with clinicopathological parameters and prognosis in non-small cell lung cancer.
Autophagy inhibition enhanced 5?FU?induced cell death in human gastric carcinoma BGC?823 cells.
Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.
CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells.
Clinicopathological and predictive significance of SIRT1 and peroxisome proliferator-activated receptor gamma in esophageal squamous cell carcinoma: The correlation with EGFR and Survivin.
Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1.
Cytoplasmic SIRT1 inhibits cell migration and invasion by impeding epithelial-mesenchymal transition in ovarian carcinoma.
Determination of SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, and RAGE rs1800625 Single Gene Polymorphisms in Patients with Laryngeal Squamous Cell Carcinoma.
Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance.
Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver.
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients.
DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing-a possible predictive biomarker for malignant transformation.
Down-regulation of SIRT3 promotes ovarian carcinoma metastasis.
Dual role of SIRT1 in UVB-induced skin tumorigenesis.
Effects of downregulation of SIRT3 expression on proliferation and apoptosis in esophageal squamous cell carcinoma EC9706 cells and its molecular mechanisms.
Effects of limiting energy availability via diet and physical activity on mammalian target of rapamycin-related signaling in rat mammary carcinomas.
Expression and clinical significance of Sirt1 in colorectal cancer.
Expression and prognostic significance of SIRT1 in ovarian epithelial tumours.
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.
Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin.
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas.
Expression of SIRT1 and survivin correlates with poor prognosis in esophageal squamous cell carcinoma.
Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.
Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.
Function of the SIRT1 protein deacetylase in cancer.
Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau.
Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-?B, and SIRT1 Signaling Pathway.
Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin.
Identification of novel SIRT3 inhibitor scaffolds by virtual screening.
Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer.
Inhibition of SIRT1 combined with gemcitabine therapy for pancreatic carcinoma.
Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma.
Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation.
Low SIRT3 expression contributes to tumor progression, development and poor prognosis in human pancreatic carcinoma.
MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma.
MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma.
MiR-199a-5p represses the stemness of cutaneous squamous cell carcinoma stem cells by targeting Sirt1 and CD44ICD cleavage signaling.
MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1.
Mitochondrial Sirt3 supports cell proliferation by regulating glutamine-dependent oxidation in renal cell carcinoma.
Mitochondrial Sirtuins in Skin and Skin Cancers.
Morphoproteomics and Biomedical Analytics Identify the c-Myc, EZH2, Sirt1 and CXCR4 Pathways as Potential Blocks to Differentiation Leading to Proliferation and Metastatic Potential in Sinonasal Undifferentiated Carcinoma (SNUC) and Provide Therapeutic Options: A Case Study.
Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells.
Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas.
Obesity accelerates murine gastric cancer growth by modulating the Sirt1/YAP pathway.
Overexpression of SIRT1 in urothelial carcinoma of the urinary bladder is associated with local recurrence and poor survival.
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma.
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
Reduced expression of SIRT2 in serous ovarian carcinoma promotes cell proliferation through disinhibition of CDK4 expression.
Role of prosurvival molecules in the action of lidamycin toward human tumor cells.
Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis.
Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma.
Silent information regulator 2 promotes clear cell renal cell carcinoma progression through deacetylation and small ubiquitin-related modifier 1 modification of glucose 6-phosphate dehydrogenase.
SIRT1 acts as a potential tumor suppressor in oral squamous cell carcinoma.
SIRT1 and AMPK mediate hypoxia-induced resistance of non-small cell lung cancers to cisplatin and doxorubicin.
SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients.
SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma.
SIRT1 in Secretory Organ Cancer.
SIRT1 is a useful biomarker for high-grade dysplasia and carcinoma in Barrett's esophagus.
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer.
SIRT1 knockdown up-regulates p53 and p21/Cip1 expression in renal adenocarcinoma cells but not in normal renal-derived cells in a deacetylase-independent manner.
SIRT1 overexpression in cervical squamous intraepithelial lesions and invasive squamous cell carcinoma.
SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma.
SIRT1 prevents hyperuricemia via the PGC-1?/PPAR?-ABCG2 pathway.
Sirt1 protects from K-Ras-driven lung carcinogenesis.
SIRT1 regulates endothelial Notch signaling in lung cancer.
SIRT1 Regulates the Chemoresistance and Invasiveness of Ovarian Carcinoma Cells.
SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway.
SIRT3 is a novel prognostic biomarker for esophageal squamous cell carcinoma.
SIRT3 is correlated with the malignancy of non-small cell lung cancer.
SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis.
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma.
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Sirtuin 7 promotes colorectal carcinoma proliferation and invasion through the inhibition of E-cadherin.
Sirtuin-1 Controls Poly (I:C)-Dependent Matrix Metalloproteinase 9 Activation in Primary Human Nasal Epithelial Cells.
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Synergistic Effect of Dietary Betaines on SIRT1-Mediated Apoptosis in Human Oral Squamous Cell Carcinoma Cal 27.
Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis.
The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesis.
The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas.
The prognostic role of Sirt1 expression in solid malignancies: a meta-analysis.
The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer.
Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer.
Carcinoma, Basal Cell
Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin.
Mitochondrial Sirtuins in Skin and Skin Cancers.
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Carcinoma, Ductal
Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype.
Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer.
SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression.
Carcinoma, Hepatocellular
3-Iodothyronamine and 3,5,3'-triiodo-L-thyronine reduce SIRT1 protein expression in the HepG2 cell line.
?-hydroxybutyrate protects hepatocytes against endoplasmic reticulum stress in a sirtuin 1-independent manner.
An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases.
An insulin-inducible transcription factor, SHARP-1, represses transcription of the SIRT1 longevity gene.
Antiproliferative activity of (R)-4'-methylklavuzon on hepatocellular carcinoma cells and EpCAM+/CD133+ cancer stem cells via SIRT1 and Exportin-1 (CRM1) inhibition.
Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo.
Bioinformatics Prediction and Experimental Validation of MicroRNAs Involved in Cross-Kingdom Interaction.
Correction: Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth.
DBC1 does not function as a negative regulator of SIRT1 in liver cancer.
Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells.
Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver.
Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection.
Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA-3666.
Downregulation of SIRT2 Inhibits Invasion of Hepatocellular Carcinoma by Inhibiting Energy Metabolism.
Downregulation of sirtuin 3 by palmitic acid increases the oxidative stress, impairment of mitochondrial function, and apoptosis in liver cells.
Effect of nutrient deprivation on the expression and the epigenetic signature of sirtuin genes.
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
Engagement with tNOX (ENOX2) to Inhibit SIRT1 and Activate p53-Dependent and -Independent Apoptotic Pathways by Novel 4,11-Diaminoanthra[2,3-b]furan-5,10-diones in Hepatocellular Carcinoma Cells.
Erratum: microRNA-34a overexpression inhibits cell migration and invasion via regulating SIRT1 in hepatocellular carcinoma.
Expression and role of SIRT1 in hepatocellular carcinoma.
Fusaric acid induces mitochondrial stress in human hepatocellular carcinoma (HepG2) cells.
HBx mediated Increase of SIRT1 Contributes to HBV-related Hepatocellular Carcinoma Tumorigenesis.
Hepatitis B virus X (HBX) protein upregulates ?-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase.
Hepatocellular Expression of SIRT1 and Its Effect on Hepatocellular Carcinoma Progression: A Future Therapeutic Perspective.
HSP90 and SIRT3 expression in hepatocellular carcinoma and their effect on invasive capability of human hepatocellular carcinoma cells.
Increased SIRT3 Expression and Antioxidant Defense under Hyperglycemic Conditions in HepG2 Cells.
Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1? protein under hypoxic conditions.
Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription.
Involvement of mammalian sirtuin 1 in the action of ethanol in the liver.
Long noncoding RNA PP7080 promotes hepatocellular carcinoma development by sponging mir-601 and targeting SIRT1.
Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma.
MicroRNA-133b inhibits hepatocellular carcinoma cell progression by targeting Sirt1.
MicroRNA-138 inhibits cell proliferation in hepatocellular carcinoma by targeting Sirt1.
MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma.
microRNA-34a overexpression inhibits cell migration and invasion via regulating SIRT1 in hepatocellular carcinoma.
MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1.
microRNA-526b servers as a prognostic factor and exhibits tumor suppressive property by targeting Sirtuin 7 in hepatocellular carcinoma.
miR-204-5p targeting SIRT1 regulates hepatocellular carcinoma progression.
MiR-29a suppresses cell proliferation by targeting SIRT1 in hepatocellular carcinoma.
miR-494 induces EndMT and promotes the development of HCC (Hepatocellular Carcinoma) by targeting SIRT3/TGF-?/SMAD signaling pathway.
Modulation of antioxidant enzymes, SIRT1 and NF-?B by resveratrol and nicotinamide in alcohol-aflatoxin B1-induced hepatocellular carcinoma.
Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells.
Molecular docking and mechanisms of fusaric acid induced mitochondrial sirtuin aberrations in glycolytically and oxidatively poised human hepatocellular carcinoma (HepG2) cells.
Negative regulation of Sirtuin 1 by AMP-activated protein kinase promotes metformin-induced senescence in hepatocellular carcinoma xenografts.
Novel CDK9 inhibitor oroxylin A promotes wild-type P53 stability and prevents hepatocellular carcinoma progression by disrupting both MDM2 and SIRT1 signaling.
Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma.
Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma.
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Prognostic role of SIRT1 in hepatocellular carcinoma.
Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes.
Resveratrol inhibits proliferation and migration through SIRT1 mediated post?translational modification of PI3K/AKT signaling in hepatocellular carcinoma cells.
SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.
SirT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells.
SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling.
Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis.
Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice.
SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1?-mediated mitochondrial biogenesis.
SIRT1 in the Development and Treatment of Hepatocellular Carcinoma.
SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma.
SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-?B pathway.
SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation.
SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis.
SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling.
SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma.
SirT1 regulates radiosensitivity of hepatoma cells differently under normoxic and hypoxic conditions.
SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma.
SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis.
SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition via akt/GSK-3?/?-catenin signaling (revised version).
SIRT3 expression in hepatocellular carcinoma and its impact on proliferation and invasion of hepatoma cells.
SIRT3 functions as a tumor suppressor in hepatocellular carcinoma.
Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation.
Sirt3 is a tumor suppressor in lung adenocarcinoma cells.
Sirt3 promotes hepatocellular carcinoma cells sensitivity to regorafenib through the acceleration of mitochondrial dysfunction.
SIRT4 Depletion Promotes HCC Tumorigenesis through Regulating AMPK?/mTOR Axis.
SIRT6 Is a Target of Regulation by UBE3A That Contributes to Liver Tumorigenesis in an ANXA2-Dependent Manner.
Sirtuin 1 and 2 inhibitors enhance the inhibitory effect of sorafenib in hepatocellular carcinoma cells.
Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.
Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis via the AKT/GSK-3?/?-Catenin Signaling Pathway.
Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway.
Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3?/BCL2-associated X protein-dependent apoptotic pathway.
Sirtuin-1/Mitochondrial Ribosomal Protein S5 Axis Enhances the Metabolic Flexibility of Liver Cancer Stem Cells.
Sirtuin2 enhances the tumoricidal function of liver natural killer cells in a mouse hepatocellular carcinoma model.
Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Is Reversed by SIRT1.
Suppression of SIRT1 activity in noncancerous tissues of HCC: possible association with non-B non-C hepatitis pathogenesis.
The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?
The effect of alcohol on Sirt1 expression and function in animal and human models of hepatocellular carcinoma (HCC).
The expression of SIRT3 in primary hepatocellular carcinoma and the mechanism of its tumor suppressing effects.
The long non-coding RNA MALAT1 promotes the migration and invasion of hepatocellular carcinoma by sponging miR-204 and releasing SIRT1.
The ménage à trois of autophagy, lipid droplets and liver disease.
The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers.
The tumor suppressor protein menin inhibits NF-?B-mediated transactivation through recruitment of Sirt1 in hepatocellular carcinoma.
Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma.
[Growth inhibition of human hepatocellular carcinoma by miRNA-204 via down-regulation of Bcl-2 and Sirt1 expression].
[Role of SIRT3 in regulating proliferation of hepatocellular carcinoma cells in vitro].
{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3.
Carcinoma, Lewis Lung
SIRT1 regulates endothelial Notch signaling in lung cancer.
Carcinoma, Non-Small-Cell Lung
A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer.
Association of SIRT1 and HMGA1 expression in non-small cell lung cancer.
Corrigendum to "SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth" [Biochem. Biophys. Res. Commun. 483 (2017) 880-884].
Diagnostic investigation of BIRC6 and SIRT1 protein expression level as potential prognostic biomarkers in patients with non-small cell lung cancer.
Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer.
Emerging role of SIRT2 in non-small cell lung cancer.
Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.
Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.
Hsa-miR-217 Inhibits the Proliferation, Migration, and Invasion in Non-small Cell Lung Cancer Cells Via Targeting SIRT1 and P53/KAI1 Signaling
Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer.
Long Noncoding RNA SNHG10 Sponges miR-543 to Upregulate Tumor Suppressive SIRT1 in Nonsmall Cell Lung Cancer.
Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells.
MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1.
Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer.
miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1.
RBM38 induces SIRT1 expression during hypoxia in non-small cell lung cancer cells by suppressing MIR34A expression.
Regulation of SIRT2 levels for human non-small cell lung cancer therapy.
SIRT1 and AMPK mediate hypoxia-induced resistance of non-small cell lung cancers to cisplatin and doxorubicin.
SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC.
SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27.
SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration.
SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-?B signaling.
Sirt1 protects from K-Ras-driven lung carcinogenesis.
SIRT2 inhibits non-small cell lung cancer cell growth through impairing Skp2-mediated p27 degradation.
SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A.
SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.
SIRT3 is correlated with the malignancy of non-small cell lung cancer.
Sirt3 Promoted DNA Damage Repair and Radioresistance Through ATM-Chk2 in Non-small Cell Lung Cancer Cells.
SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2.
Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer.
SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth.
The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?
The expression and mechanism of Sirt1 and AMPK in nonsmall cell lung cancer.
X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
[SIRT1 Influences the Sensitivity of A549 Non-small Cell Lung Cancer Cell Line to ?Cisplatin via Modulating the Noxa Expression].
Carcinoma, Ovarian Epithelial
Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells.
microRNA-494 is a potential prognostic marker and inhibits cellular proliferation, migration and invasion by targeting SIRT1 in epithelial ovarian cancer.
Over-expression of Sirt1 contributes to chemoresistance and indicates poor prognosis in serous epithelial ovarian cancer (EOC).
Carcinoma, Papillary
Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma.
Carcinoma, Renal Cell
Acetylation status of P53 and the expression of DBC1, SIRT1, and androgen receptor are associated with survival in clear cell renal cell carcinoma patients.
Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance.
Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma.
Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation.
MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma.
MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1.
Mitochondrial Sirt3 supports cell proliferation by regulating glutamine-dependent oxidation in renal cell carcinoma.
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma.
Silent information regulator 2 promotes clear cell renal cell carcinoma progression through deacetylation and small ubiquitin-related modifier 1 modification of glucose 6-phosphate dehydrogenase.
SIRT1 knockdown up-regulates p53 and p21/Cip1 expression in renal adenocarcinoma cells but not in normal renal-derived cells in a deacetylase-independent manner.
SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis.
Carcinoma, Squamous Cell
Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma.
Associations of sirtuins with clinicopathological parameters and prognosis in non-small cell lung cancer.
Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1.
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients.
Dual role of SIRT1 in UVB-induced skin tumorigenesis.
Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.
Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.
Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau.
Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer.
MiR-199a-5p represses the stemness of cutaneous squamous cell carcinoma stem cells by targeting Sirt1 and CD44ICD cleavage signaling.
Mitochondrial Sirtuins in Skin and Skin Cancers.
SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients.
SIRT1 overexpression in cervical squamous intraepithelial lesions and invasive squamous cell carcinoma.
SIRT3 is correlated with the malignancy of non-small cell lung cancer.
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Synergistic Effect of Dietary Betaines on SIRT1-Mediated Apoptosis in Human Oral Squamous Cell Carcinoma Cal 27.
The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas.
Cardio-Renal Syndrome
SIRT1 gene polymorphisms are associated with nondiabetic type 1 cardiorenal syndrome.
Cardiomegaly
1.25 Dihydroxyvitamin D3 Attenuates Hypertrophy Markers in Cardiomyoblast H9c2 Cells: Evaluation of Sirtuin3 mRNA and Protein Level.
A machine learning-driven study indicates emodin improves cardiac hypertrophy by modulation of mitochondrial SIRT3 signaling.
Activation of SIRT1 by Resveratrol Alleviates Pressure Overload-Induced Cardiac Hypertrophy via Suppression of TGF-?1 Signaling.
Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the {alpha}-myosin heavy chain expression.
Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1.
ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation.
CSN6 aggravates Ang II-induced cardiomyocyte hypertrophy via inhibiting SIRT2.
Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease.
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.
Endothelial Sirtuin 3 Dictates Glucose Transport to Cardiomyocyte and Sensitizes Pressure Overload-Induced Heart Failure.
Exogenous Hydrogen Sulfide Supplement Attenuates Isoproterenol-Induced Myocardial Hypertrophy in a Sirtuin 3-Dependent Manner.
Fibroblast growth factor 21 protects the heart from angiotensin II-induced cardiac hypertrophy and dysfunction via SIRT1.
Friedreich's Ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase.
Ginkgolide B Protects Cardiomyocytes from Angiotensin II-Induced Hypertrophy via Regulation of Autophagy through SIRT1-FoxO1.
High content screening identifies licoisoflavone A as a bioactive compound of Tongmaiyangxin Pills to restrain cardiomyocyte hypertrophy via activating Sirt3.
Hispidulin Attenuates Cardiac Hypertrophy by Improving Mitochondrial Dysfunction.
Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha.
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3.
LCZ696 Ameliorates Oxidative Stress and Pressure Overload-Induced Pathological Cardiac Remodeling by Regulating the Sirt3/MnSOD Pathway.
Lowering Body Weight in Obese Mice With Diastolic Heart Failure Improves Cardiac Insulin Sensitivity and Function: Implications for the Obesity Paradox.
MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction.
miR-145-5p targets paxillin to attenuate angiotensin II-induced pathological cardiac hypertrophy via downregulation of Rac 1, pJNK, p-c-Jun, NFATc3, ANP and by Sirt-1 upregulation.
Mitochondrial SIRT3 and heart disease.
NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy.
PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2.
PPAR?-Sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway.
Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy.
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy.
Resveratrol ameliorates cardiac oxidative stress in diabetes through deacetylation of NFkB-p65 and histone 3.
Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein.
Roles of SIRT3 in heart failure: from bench to bedside.
Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients.
Sirt1 acts in association with PPAR{alpha} to protect the heart from hypertrophy, metabolic dysregulation, and inflammation.
SIRT1 functions as an important regulator of estrogen-mediated cardiomyocyte protection in angiotensin II-induced heart hypertrophy.
Sirt1 hyperexpression in SHR heart related to left ventricular hypertrophy.
Sirt1 regulates aging and resistance to oxidative stress in the heart.
SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy.
SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis.
Sirt3 attenuates doxorubicin-induced cardiac hypertrophy and mitochondrial dysfunction via suppression of Bnip3.
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.
SIRT3 in Cardiac Physiology and Disease.
SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications.
SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity.
SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation.
SIRT3: A New Regulator of Cardiovascular Diseases.
SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy.
Sirtuin 1 represses PKC-? activity through regulating interplay of acetylation and phosphorylation in cardiac hypertrophy.
Sirtuin 3 Activation by Honokiol Decreases Unilateral Ureteral Obstruction-Induced Renal Inflammation and Fibrosis via Regulation of Mitochondrial Dynamics and the Renal NF-?BTGF-?1/Smad Signaling Pathway.
Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system.
Sirtuin1 Role in the Melatonin Protective Effects Against Obesity-Related Heart Injury.
Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1.
The association between left ventricular mass index and serum sirtuin 3 level in patients with hypertension.
The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy.
The effect of oxygen in Sirt3-mediated myocardial protection: a proof-of-concept study in cultured cardiomyoblasts.
The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy.
The protective effects of 17-? estradiol and SIRT1 against cardiac hypertrophy: a review.
The role of SIRT2 in vascular-related and heart-related diseases: A review.
The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging.
The role of sirtuins in cardiac disease.
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
Upregulation of SIRT1 deacetylase in phenylephrine-treated cardiomyoblasts.
Cardiomyopathies
?-Lapachone Ameliorates Lipotoxic Cardiomyopathy in Acyl CoA Synthase Transgenic Mice.
ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Autophagy-dependent and -independent modulation of oxidative and organellar stress in the diabetic heart by glucose-lowering drugs.
Correction to: ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart.
Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus.
Friedreich's Ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase.
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis.
Inhibiting miR-22 Alleviates Cardiac Dysfunction by Regulating Sirt1 in Septic Cardiomyopathy.
Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1? by PRMT1 and SIRT1.
MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction.
Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.
Perindopril Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1? in a Rat Model of Isoproterenol-Induced Cardiomyopathy.
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside.
Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein.
Role of Deranged Energy Deprivation Signaling in the Pathogenesis of Cardiac and Renal Disease in States of Perceived Nutrient Overabundance.
Silent information regulator, Sirtuin 1, and age-related diseases.
SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy.
SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats.
SIRT1 Mediates Septic Cardiomyopathy in a Murine Model of Polymicrobial Sepsis.
Sirt1 regulates aging and resistance to oxidative stress in the heart.
SIRT1-PGC1?-NF?B Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease.
SIRT1: a promising therapeutic target in type 2 diabetes mellitus.
Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in Mice.
Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction.
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.
The effects of resveratrol and SIRT1 activation on dystrophic cardiomyopathy.
Cardiomyopathy, Dilated
Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice.
Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart.
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis.
Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure.
TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin Toxicity.
Cardiotoxicity
Activation of miR-34a-5p/Sirt1/p66shc pathway contributes to doxorubicin-induced cardiotoxicity.
Adiponectin agonist ADP355 ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and oxidative stress.
Berberine-induced Cardioprotection and Sirt3 Modulation in Doxorubicin-treated H9c2 Cardiomyoblasts.
Calycosin ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1-NOD-like receptor protein 3 pathway.
Cilostazol preconditioning alleviates cyclophosphamide-induced cardiotoxicity in male rats: Mechanistic insights into SIRT1 signaling pathway.
Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1.
Dosing depending on SIRT3 activity attenuates doxorubicin-induced cardiotoxicity via elevated tolerance against mitochondrial dysfunction and oxidative stress.
Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity.
Exosomal LncRNA-NEAT1 derived from MIF-treated mesenchymal stem cells protected against doxorubicin-induced cardiac senescence through sponging miR-221-3p.
Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice.
Melatonin improves cardiac and mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin activity?
MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2.
MicroRNA-22 inhibition prevents doxorubicin-induced cardiotoxicity via upregulating SIRT1.
Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin.
Molecular mechanisms of doxorubicin-induced cardiotoxicity: novel roles of sirtuin 1-mediated signaling pathways.
Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity.
PGC1? activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades.
Protection against Doxorubicin-Related Cardiotoxicity by Jaceosidin Involves the Sirt1 Signaling Pathway.
Protective Effects of Oroxylin A against Doxorubicin-Induced Cardiotoxicity via the Activation of Sirt1 in Mice.
Resveratrol inhibits doxorubicin-induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes.
Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway.
Resveratrol prevents doxorubicin-induced cardiotoxicity in H9c2 cells through the inhibition of endoplasmic reticulum stress and the activation of the Sirt1 pathway.
Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis.
Roflumilast Attenuates Doxorubicin-Induced Cardiotoxicity by Targeting Inflammation and Cellular Senescence in Cardiomyocytes Mediated by SIRT1.
Sesamin ameliorates doxorubicin-induced cardiotoxicity: involvement of Sirt1 and Mn-SOD pathway.
SIRT1 protects cardiac cells against apoptosis induced by zearalenone or its metabolites ?- and ?-zearalenol through an autophagy-dependent pathway.
SIRT1 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the Oxidative Stress and p38MAPK Pathways.
Sirt3 attenuates doxorubicin-induced cardiac hypertrophy and mitochondrial dysfunction via suppression of Bnip3.
Sirt3 promotes sensitivity to sunitinib-induced cardiotoxicity via inhibition of GTSP1/JNK/autophagy pathway in vivo and in vitro.
Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in Mice.
Sirtuins as molecular targets, mediators, and protective agents in metal-induced toxicity.
Cardiovascular Diseases
Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia.
Activation of PPAR alpha by fenofibrate inhibits apoptosis in vascular adventitial fibroblasts partly through SIRT1-mediated deacetylation of FoxO1.
Activation of SIRT1 by Resveratrol Alleviates Pressure Overload-Induced Cardiac Hypertrophy via Suppression of TGF-?1 Signaling.
ACTIVATION OF SIRT1 BY RESVERATROL INDUCES KLF2 EXPRESSION CONFERRING AN ENDOTHELIAL VASOPROTECTIVE PHENOTYPE.
Activators of Sirtuin-1 and their Involvement in Cardioprotection.
Adverse childhood events and cardiovascular diseases: the potential role of Sirt1.
Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated mice.
Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy.
Assessing the performance of three resveratrol in binding with SIRT1 by molecular dynamics simulation and MM/GBSA methods: the weakest binding of resveratrol 3 to SIRT1 triggers a possibility of dissociation from its binding site.
Association of common polymorphisms in the VEGFA and SIRT1 genes with type 2 diabetes-related traits in Mexicans.
Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6.
Cardiovascular determinants of life span.
CD38: A Potential Therapeutic Target in Cardiovascular Disease.
Chronic Psychological Stress Accelerates Vascular Senescence and Impairs Ischemia-Induced Neovascularization: The Role of Dipeptidyl Peptidase-4/Glucagon-Like Peptide-1-Adiponectin Axis.
CKII-SIRT1-SM22? loop evokes a self-limited inflammatory response in vascular smooth muscle cells.
Crosstalk between mitochondrial hyperacetylation and oxidative stress in vascular dysfunction and hypertension.
Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis.
Distribution of the longevity gene product, SIRT1, in developing mouse organs.
Effect of Nasal CPAP on SIRT1 and Endothelial Function in Obstructive Sleep Apnea Syndrome.
Effect of oral appliance on circulating leukocyte telomere length and SIRT1 in obstructive sleep apnea.
Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: The role of sirtuin 1 gene variants in human coronary atherosclerosis.
Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease.
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.
Emerging roles of SIRT1 in vascular endothelial homeostasis.
Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle cells.
Genetic and Functional Sequence Variants of the SIRT3 Gene Promoter in Myocardial Infarction.
Genomics of aging: The role of sirtuin and metabolic health.
High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions.
Homocysteine up-regulates endothelin type A receptor in vascular smooth muscle cells through Sirt1/ERK1/2 signaling pathway.
Improvement of Cardiac Function in Rats With Myocardial Infarction by Low-Intensity to Moderate-Intensity Endurance Exercise Is Associated With Normalization of Klotho and SIRT1.
MicroRNA Regulation of SIRT1.
Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress.
NAD+ and cardiovascular diseases.
Omarigliptin Prevents TNF-?-Induced Cellular Senescence in Rat Aorta Vascular Smooth Muscle Cells.
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.
Post-translational Modification Crosstalk and Hotspots in Sirtuin Interactors Implicated in Cardiovascular Diseases.
Protective effect of SIRT6 on cholesterol crystal-induced endothelial dysfunction via regulating ACE2 expression.
Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS.
Renal protective effect of sirtuin 1.
Resveratrol inhibits parathyroid hormone-induced apoptosis in human aortic smooth muscle cells by upregulating sirtuin 1.
Resveratrol Prevents Right Ventricle Remodeling and Dysfunction in Monocrotaline-Induced Pulmonary Arterial Hypertension with a Limited Improvement in the Lung Vasculature.
Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism.
Role of sirtuins in kidney disease.
Serum containing Buyang Huanwu decoction prevents age-associated migration and invasion of human vascular smooth muscle cells by up regulating SIRT1 expression.
Seven sirtuins for seven deadly diseases of aging.
Silent information regulator 2 homolog 1 counters cerebral hypoperfusion injury by deacetylating endothelial nitric oxide synthase.
Silent information regulator, Sirtuin 1, and age-related diseases.
SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats.
SIRT1 and Gender Differences in Atherosclerotic Cardiovascular Disease.
SIRT1 and Kidney Function.
SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection.
SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.
SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease.
Sirt1 during childhood is associated with microvascular function later in life.
SIRT1 gene polymorphisms affect the protein expression in cardiovascular diseases.
SIRT1 gene variants are related to risk of childhood obesity.
SIRT1 in metabolic syndrome: Where to target matters.
Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress.
SIRT1: new avenues of discovery for disorders of oxidative stress.
SIRT1: recent lessons from mouse models.
SIRT3 as a potential therapeutic target for heart failure.
SIRT3 attenuates AngII-induced cardiac fibrosis by inhibiting myofibroblasts transdifferentiation via STAT3-NFATc2 pathway.
SIRT3 Deficiency Sensitizes Angiotensin-II-Induced Renal Fibrosis.
SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain.
SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications.
SIRT3 regulates progression and development of diseases of aging.
SIRT3: A New Regulator of Cardiovascular Diseases.
Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells.
Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease.
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice.
Sirtuin activators: Designing molecules to extend life span.
Sirtuins and Insulin Resistance.
Sirtuins and renal diseases: relationship with aging and diabetic nephropathy.
Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1.
Sirtuins: a possible clinical implication in cardio- and cerebro- vascular systems.
Stem cell-derived extracellular vesicles mitigate ageing-associated arterial stiffness and hypertension.
Targeting cardiovascular disease with novel SIRT1 pathways.
The effect of the SIRT1 2827 A>G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease.
The relationship of SIRT3 with cellular metabolism and cardiovascular diseases.
The role of SIRT2 in vascular-related and heart-related diseases: A review.
The Role of Sirtuin-1 in the Vasculature: Focus on Aortic Aneurysm.
The role of sirtuins in cardiac disease.
The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and ?Klotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis.
Translating cell survival and cell longevity into treatment strategies with SIRT1.
Tumor Necrosis Factor-alpha (TNF-?) Enhances miR-155-Mediated Endothelial Senescence by Targeting Sirtuin1 (SIRT1).
Carotid Artery Diseases
Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort.
Carotid Artery Thrombosis
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
Carotid Stenosis
Silent information regulator 2 homolog 1 counters cerebral hypoperfusion injury by deacetylating endothelial nitric oxide synthase.
SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow.
Cartilage Diseases
Clock Gene Bmal1 Modulates Human Cartilage Gene Expression by Crosstalk With Sirt1.
Cataract
Acetylated 8-oxoguanine DNA glycosylase 1 and its relationship with p300 and SIRT1 in lens epithelium cells from age-related cataract.
Activation of Sirtuin1 by lyceum barbarum polysaccharides in protection against diabetic cataract.
Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans.
Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice.
Expression of miR-34a in cataract rats and its related mechanism.
Expression of SIRT1 and P53 in Rat Lens Epithelial cells in Experimentally Induced DM.
MicroRNA-34a promoting apoptosis of human lens epithelial cells through down-regulation of B-cell lymphoma-2 and silent information regulator.
miR-211 promotes lens epithelial cells apoptosis by targeting silent mating-type information regulation 2 homolog 1 in age-related cataracts.
miR-23b-3p regulates apoptosis and autophagy via suppressing SIRT1 in lens epithelial cells.
Potential Therapeutic Agents, Polymethoxylated Flavones Isolated from Kaempferia parviflora for Cataract Prevention through Inhibition of Matrix Metalloproteinase-9 in Lens Epithelial Cells.
Relationship between SIRT1 gene expression level and disease in age-related cataract cases
Role of Blueberry Anthocyanin Extract in the Expression of SIRT1 and NF-?B in Rat Lens Epithelial Cells in Experimentally Induced DM.
Role of Sirtuin 1 in the pathogenesis of ocular disease (Review).
Silent information regulator T1 in aqueous humor of patients with cataract.
SIRT1 Protects Human Lens Epithelial Cells Against Oxidative Stress by Inhibiting p53-Dependent Apoptosis.
The role of SIRT1 in ocular aging.
Central Nervous System Diseases
A novel pathway regulates memory and plasticity via SIRT1 and miR-134.
Role of SIRT1 in autoimmune demyelination and neurodegeneration.
Cerebellar Ataxia
Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7.
Cerebral Hemorrhage
Krüppel-Like Factor 6 Silencing Prevents Oxidative Stress and Neurological Dysfunction Following Intracerebral Hemorrhage via Sirtuin 5/Nrf2/HO-1 Axis.
SIRT1/PGC-1? Signaling Promotes Mitochondrial Functional Recovery and Reduces Apoptosis after Intracerebral Hemorrhage in Rats.
Sirt3 Ameliorates Oxidative Stress and Mitochondrial Dysfunction After Intracerebral Hemorrhage in Diabetic Rats.
Cerebral Infarction
Neuroprotective Effect of Astragaloside IV on Cerebral Ischemia/Reperfusion Injury Rats Through Sirt1/Mapt Pathway.
XingNaoJing injection ameliorates cerebral ischaemia/reperfusion injury via SIRT1-mediated inflammatory response inhibition.
[SIRT1].
Cerebrovascular Disorders
SIRT3 protects cells from hypoxia via PGC-1?- and MnSOD-dependent pathways.
Targeting cardiovascular disease with novel SIRT1 pathways.
The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets.
Cervical Intraepithelial Neoplasia
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Chagas Disease
Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease.
Honokiol attenuates oxidative stress-dependent heart dysfunction in chronic Chagas disease by targeting AMPK / NFE2L2 / SIRT3 signaling pathway.
Origin of Monocytes/Macrophages Contributing to Chronic Inflammation in Chagas Disease: SIRT1 Inhibition of FAK-NF?B-Dependent Proliferation and Proinflammatory Activation of Macrophages.
Sirtuin Control of Mitochondrial Dysfunction, Oxidative Stress, and Inflammation in Chagas Disease Models.
Chemical and Drug Induced Liver Injury
The Beneficial Roles of SIRT1 in Drug-Induced Liver Injury.
Cholangiocarcinoma
Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver.
Histone Deacetylase SIRT1 promotes loss of primary cilia in Cholangiocarcinoma.
SIRT3 elicited an anti-Warburg effect through HIF1?/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis.
Cholangitis
Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-?B signaling pathway.
Cholestasis
18?-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway.
Baicalin Protects Against 17?-Ethinylestradiol-Induced Cholestasis via the Sirtuin 1/Hepatic Nuclear Receptor-1?/Farnesoid X Receptor Pathway.
Fine-tuning of SIRT1 expression is essential to protect the liver from cholestatic liver disease.
Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPAR?.
Metformin impairs systemic bile acid homeostasis through regulating SIRT1 protein levels.
MITOCHONDRIAL BIOGENESIS FAILS IN SECONDARY BILIARY CIRRHOSIS IN RATS LEADING TO MITOCHONDRIAL DNA DEPLETION AND DELETIONS.
Nerve growth factor upregulates sirtuin 1 expression in cholestasis: a potential therapeutic target.
Protective effects of SRT1720 via the HNF1?/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury.
SIRT1/PGC-1? signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids.
Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid fed mouse model of cholestasis.
SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model.
[Effect of geniposidic acid on hepato-enteric circulation in cholestasis rats through Sirt1-FXR signaling pathway].
Cholestasis, Extrahepatic
SIRT1/PGC-1? signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids.
Cholestasis, Intrahepatic
Advances in the role of silence information regulator family in pathological pregnancy.
Chondrosarcoma
Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity.
The expression of SIRT1 regulates the metastaticplasticity of chondrosarcoma cells by inducing epithelial-mesenchymal transition.
Choroidal Neovascularization
Expression of sirt1 in choroidal neovascular membranes.
Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2?.
Potential role of sirtuin 1 in Müller glial cells in mice choroidal neovascularization.
SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization.
Cockayne Syndrome
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Linking DNA damage, NAD(+)/SIRT1, and aging.
Colitis
Activation of sirtuin 1 by catalpol-induced down-regulation of microRNA-132 attenuates endoplasmic reticulum stress in colitis.
Anti-inflammatory and -apoptotic effects of a long-term herbal extract treatment on DSS-induced colitis in mice fed with high AGEs-fat diet.
Bergenin, Acting as an Agonist of PPAR?, Ameliorates Experimental Colitis in Mice through Improving Expression of SIRT1, and Therefore Inhibiting NF-?B-Mediated Macrophage Activation.
Cilostazol protects against acetic acid-induced colitis in rats: Possible role for cAMP/SIRT1 pathway.
Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut.
Dual role of sirtuin 1 in inflammatory bowel disease.
Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice.
Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota.
Intestinal SIRT1 Deficiency-Related Intestinal Inflammation and Dysbiosis Aggravate TNF?-Mediated Renal Dysfunction in Cirrhotic Ascitic Mice.
Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/ROR?/NF-?B signaling pathways.
Methyl-deficient diet promotes colitis and SIRT1-mediated endoplasmic reticulum stress.
Reciprocal Regulation Between Smad7 and Sirt1 in the Gut.
Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis.
Rhapontin ameliorates colonic epithelial dysfunction in experimental colitis through SIRT1 signaling.
SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.
Sirtuin-1 in immunotherapy: A Janus-headed target.
Systematic understanding of the mechanism and effects of Arctigenin attenuates inflammation in dextran sulfate sodium-induced acute colitis through suppression of NLRP3 inflammasome by SIRT1.
Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3(+) T-regulatory cells.
Colitis, Ulcerative
Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis.
Effect of Selenium Supplementation on Expression of SIRT1 and PGC-1? Genes in Ulcerative Colitis Patients: a Double Blind Randomized Clinical Trial.
Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes.
Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota.
Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis.
Colonic Neoplasms
A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity.
A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53.
AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells.
Amurensin G enhances the susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity of cancer stem-like cells of HCT-15 cells.
CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance.
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.
Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1.
Cytotoxicity of metformin against HT29 colon cancer cells contributes to mitochondrial Sirt3 upregulation.
Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for ?-catenin or MITF in colon cancer and melanoma cells.
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1.
Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D.
Expression and prognostic significance of SIRT1 in ovarian epithelial tumours.
Ginsenoside Rp1, A Ginsenoside Derivative, Augments Anti-Cancer Effects of Actinomycin D via Downregulation of an AKT-SIRT1 Pathway.
HDACs and HDAC inhibitors in colon cancer.
Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine.
IL-1? induces expression of proinflammatory cytokines and migration of human colon cancer cells through upregulation of SIRT1.
Inhibition of Human Sirtuins by in Situ Generation of an Acetylated Lysine-ADP-Ribose Conjugate.
Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation.
Long noncoding RNA FOXD3-AS1 promotes colon adenocarcinoma progression and functions as a competing endogenous RNA to regulate SIRT1 by sponging miR-135a-5p.
MicroRNA Regulation of SIRT1.
miR-34a repression of SIRT1 regulates apoptosis.
Mitochondrial NOS1 suppresses apoptosis in colon cancer cells through increasing SIRT3 activity.
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
RAR? acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells.
Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy.
SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of ?-catenin.
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer.
Sirt3 binds to and deacetylates mitochondrial pyruvate carrier 1 to enhance its activity.
Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study.
Sirtuin 3 silencing impairs mitochondrial biogenesis and metabolism in colon cancer cells.
Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer.
Sirtuin 7-mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity.
The clinicopathological significance of SIRT1 expression in colon cancer: An immunohistochemical study and meta-analysis.
The role of miR-141/ Sirt1 in colon cancer.
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients.
The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells.
Colorectal Neoplasms
A variant in SIRT2 gene 3'-UTR is associated with susceptibility to colorectal cancer.
Anticancer activities of a benzimidazole compound through sirtuin inhibition in colorectal cancer.
Antioxidant enzymes change in different non-metastatic stages in tumoral and peritumoral tissues of colorectal cancer.
Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells.
Butyrate inhibits the proliferation and induces the apoptosis of colorectal cancer HCT116 cells via the deactivation of mTOR/S6K1 signaling mediated partly by SIRT1 downregulation.
BZD9L1 sirtuin inhibitor as a potential adjuvant for sensitization of colorectal cancer cells to 5-fluorouracil.
BZD9L1 sirtuin inhibitor: Identification of key molecular targets and their biological functions in HCT 116 colorectal cancer cells.
Catalpol?mediated microRNA?34a suppresses autophagy and malignancy by regulating SIRT1 in colorectal cancer.
Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell.
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.
Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis.
Colorectal Cancer Apoptosis Induced by Dietary ?-Valerobetaine Involves PINK1/Parkin Dependent-Mitophagy and SIRT3.
Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1.
Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling.
Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells.
Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells.
ETHE1 overexpression promotes SIRT1 and PGC1? mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer.
Expression and clinical significance of Sirt1 in colorectal cancer.
Frameshift mutation of SIRT1 gene in gastric and colorectal carcinomas with microsatellite instability.
High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients.
Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway.
Intratumoral heterogeneity for inactivating frameshift mutation of CUX1 and SIRT1 genes in gastric and colorectal cancers.
Investigation of sirtuin 1 polymorphisms in relation to the risk of colorectal cancer by molecular subtype.
Knockout of SIRT4 decreases chemosensitivity to 5-FU in colorectal cancer cells.
Long non-coding RNA NEAT1 promotes colorectal cancer progression by competitively binding miR-34a with SIRT1 and enhancing the Wnt/?-catenin signaling pathway.
Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer.
MiR-29b reverses oxaliplatin-resistance in colorectal cancer by targeting SIRT1.
Mitochondrial Effects of Teucrium Polium and Prosopis Farcta Extracts in Colorectal Cancer Cells
Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.
Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells.
Nuclear expression of histone deacetylases and their histone modifications predicts clinical outcome in colorectal cancer.
Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer.
Regulation of SIRT2 by Wnt/?-catenin signaling pathway in colorectal cancer cells.
Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1.
SIRT1 and the clock gene machinery in colorectal cancer.
SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer.
SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
SIRT1 in Colorectal Cancer: A Friend or Foe?
SIRT1 in Secretory Organ Cancer.
Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells.
SIRT1 promotes epithelial-mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression.
SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p.
SIRT1-Mediated Expression of CD24 and Epigenetic Suppression of Novel Tumor Suppressor miR-1185-1 Increases Colorectal Cancer Stemness.
SIRT2 mediated antitumor effects of shikonin on metastatic colorectal cancer.
SIRT2, a direct target of miR-212-5p, suppresses the proliferation and metastasis of colorectal cancer cells.
Sirt3 regulates the level of mitochondrial DNA repair activity through deacetylation of NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 in colorectal cancer.
Sirt3-mediated mitochondrial fission regulates the colorectal cancer stress response by modulating the Akt/PTEN signalling pathway.
SIRT3-Mediated SOD2 and PGC-1? Contribute to Chemoresistance in Colorectal Cancer Cells.
SIRT4 is the molecular switch mediating cellular proliferation in colorectal cancer through GLS mediated activation of AKT/GSK3?/CyclinD1 pathway.
Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study.
Sirtuin 7 promotes colorectal carcinoma proliferation and invasion through the inhibition of E-cadherin.
Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review.
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop.
The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target.
The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?
The clinicopathological significance of SIRT1 expression in colon cancer: An immunohistochemical study and meta-analysis.
The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer.
The pluripotency network in colorectal cancer pathogenesis and prognosis: an update.
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy.
Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.
Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer.
Congenital Abnormalities
Folate and fetal programming: a play in epigenomics?
[Advances in the studies of teratospermia-related genes].
Corneal Injuries
Sirt3 regulates mitophagy level to promote diabetic corneal epithelial wound healing.
Coronary Artery Disease
A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease.
Beneficial effects of omega-3 and vitamin E coadministration on gene expression of SIRT1 and PGC1? and serum antioxidant enzymes in patients with coronary artery disease.
Circulating levels of sirtuin 4, a potential marker of oxidative metabolism, related to coronary artery disease in obese patients suffering from NAFLD, with normal or slightly increased liver enzymes.
Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity.
Corrigendum to "Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes".
Downregulation of Sirt1 is correlated to upregulation of p53 and increased apoptosis in epicardial adipose tissue of patients with coronary artery disease.
Effects of crocin and saffron aqueous extract on gene expression of SIRT1, AMPK, LOX1, NF-?B, and MCP-1 in patients with coronary artery disease: A randomized placebo-controlled clinical trial.
Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: The role of sirtuin 1 gene variants in human coronary atherosclerosis.
In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions.
Low serum level of sirtuin 1 predicts coronary atherosclerosis plaques during computed tomography angiography among an asymptomatic cohort.
MicroRNA 199a Is Downregulated in Patients After Coronary Artery Bypass Graft Surgery and Is Associated with Increased Levels of Sirtuin 1 (SIRT 1) Protein and Major Adverse Cardiovascular Events at 3-Year Follow-Up.
MicroRNA-34a regulates the longevity-associated protein, SIRT1, in coronary artery disease: Effect of statins on SIRT1 and microRNA-34a expression.
Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease.
Peripheral blood monocyte Sirt1 expression is reduced in patients with coronary artery disease.
Reverse expression pattern of sirtuin-1 and histone deacetylase-9 in coronary artery disease.
SIRT1 gene polymorphisms associated with decreased risk of atherosclerotic coronary artery disease.
SIRT1 gene variants are related to risk of childhood obesity.
SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease.
SIRT3-mediated cardiac remodeling/repair following myocardial infarction.
Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease.
The relationship between coronary artery disease and SIRT1 protein.
Ticagrelor Increases SIRT1 and HES1 mRNA Levels in Peripheral Blood Cells from Patients with Stable Coronary Artery Disease and Chronic Obstructive Pulmonary Disease.
Coronary Disease
MiR-339 is a potential biomarker of coronary heart disease to aggravate oxidative stress through Nrf2/FOXO3 targeting Sirt2.
Shorter Leukocyte Telomere Lengths in Healthy Relatives of Patients with Coronary Heart Disease.
Targeting cardiovascular disease with novel SIRT1 pathways.
Coronary Thrombosis
Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.
Coronavirus Infections
A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication.
COVID-19
COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity.
The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patients.
[Coronavirus disease (COVID-19) and sirtuins].
Cysts
Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease.
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
SIRT1 and Kidney Function.
Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease.
Cytomegalovirus Infections
The antiviral sirtuin 3 bridges protein acetylation to mitochondrial integrity and metabolism during human cytomegalovirus infection.
Deafness
SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study.
Dementia
Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model.
Evidence for a neuroprotective microRNA pathway in amnestic mild cognitive impairment.
Phytosterols and Dementia.
Seven sirtuins for seven deadly diseases of aging.
SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease.
SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease.
SIRT1: The Value of Functional Outcome, Stroke-Related Dementia, Anxiety, and Depression in Patients with Acute Ischemic Stroke.
Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease.
Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia.
[Sir2 gene]
Dementia, Vascular
[Effect of triptolide on cognitive dysfunction in vascular dementia rats through SIRT1/NF-?B signaling pathway].
Demyelinating Diseases
Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets.
Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Role of SIRT1 in autoimmune demyelination and neurodegeneration.
SIRT1 Activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease.
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
Dengue
Melatonin Inhibits Dengue Virus Infection via the Sirtuin 1-Mediated Interferon Pathway.
Tenovin-1 inhibited dengue virus replication through SIRT2.
Depression, Postpartum
Ameliorative effect of SIRT1 in postpartum depression mediated by upregulation of the glucocorticoid receptor.
Dermatitis
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Inhibiting Protein Kinase Activity of Pyruvate Kinase M2 by SIRT2 Deacetylase Attenuates Psoriasis.
Dermatitis, Atopic
A combination of Olea europaea leaf extract and Spirodela polyrhiza extract alleviates atopic dermatitis by modulating immune balance and skin barrier function in a 1-chloro-2,4-dinitrobenzene-induced murine model.
Siraitia grosvenorii Residual Extract Attenuates Atopic Dermatitis by Regulating Immune Dysfunction and Skin Barrier Abnormality.
The Expression of Epidermal Stem Cell Marker and SIRT1 in Atopic Dermatitis: A Discussion of Regenerative Potential.
Dermatitis, Phototoxic
The photocytotoxicity effect of cationic sulfonated corrole towards lung cancer cells: in vitro and in vivo study.
Desmoplastic Small Round Cell Tumor
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Diabetes Complications
Diabetic complications within the context of aging: Nicotinamide adenine dinucleotide redox, insulin C-peptide, sirtuin 1-liver kinase B1-adenosine monophosphate-activated protein kinase positive feedback and forkhead box O3.
Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus.
In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions.
Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes.
Reappraisal of metallothionein: Clinical implications for patients with diabetes mellitus.
SIRT1 as a therapeutic target in diabetic complications.
SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism.
Sirtuin 1 as the mechanism of action of agents used in the diabetes mellitus pharmacotherapy.
The emerging role of the epigenetic enzyme Sirtuin-1 and high mobility group Box 1 in patients with diabetic foot ulceration.
Diabetes Mellitus
A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease.
Assessment of Sirtuin 3 and Sirtuin 4 Level in Patients with Diabetes Mellitus and Periodontitis: A Clinical Study.
Association of Genetic Variants of SIRT1 With Type 2 Diabetes Mellitus.
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial.
Biochanin A improves insulin sensitivity and controls hyperglycemia in type 2 diabetes.
Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus.
Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet.
Circulating SIRT1 Increases After Intragastric Balloon Fat Loss in Obese Patients.
Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis.
Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake.
Effects of Resveratrol in Patients With Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure.
Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus.
Ellagic acid protects against diabetic cardiomyopathy in rats by stimulating cardiac silent information regulator 1 signaling.
Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus.
Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice.
Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis.
Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes.
Functional genetic variants within the SIRT2 gene promoter in type 2 diabetes mellitus.
Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway.
In vivo RNA interference models of inducible and reversible Sirt1 knockdown in kidney cells.
Increased malondialdehyde vs. reduced sirtuin 1 in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes.
Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity.
Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes.
MicroRNA-93-5p participates in type 2 diabetic retinopathy through targeting Sirt1.
P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1.
Phosphorylation regulates SIRT1 function.
Proposed Tandem Effect of Physical Activity and Sirtuin 1 and 3 Activation in Regulating Glucose Homeostasis.
Quercetin protects islet ?-cells from oxidation-induced apoptosis via Sirt3 in T2DM.
Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1.
Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights.
Role of Blueberry Anthocyanin Extract in the Expression of SIRT1 and NF-?B in Rat Lens Epithelial Cells in Experimentally Induced DM.
Roux-en-Y Gastric Bypass Improves Hepatic Glucose Metabolism Involving Upregulation of Sirt1 in Type 2 Diabetes Mellitus.
Rs12778366 single nucleotide polymorphism of Sirtuin 1 (SIRT1) and response to resveratrol supplementation in patients with type 2 diabetes mellitus.
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats.
SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis.
SIRT1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons.
SIRT1 and insulin resistance.
SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats.
SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models.
SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.
SIRT1: a promising therapeutic target in type 2 diabetes mellitus.
Sirtuin 1 as the mechanism of action of agents used in the diabetes mellitus pharmacotherapy.
Sirtuin 1 rs7069102 polymorphism is associated with diabetic nephropathy in patients with type 2 diabetes mellitus.
Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease.
Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism.
Sirtuins and Insulin Resistance.
The Association between SIRT1 Genetic Variation and Type 2 Diabetes Mellitus Is Influenced by Dietary Intake in Elderly Chinese.
The effect of hesperidin and quercetin on oxidative stress, NF-?B and SIRT1 levels in a STZ-induced experimental diabetes model.
The Emerging Role of Sirtuin 1 in Cellular Metabolism, Diabetes Mellitus, Diabetic Kidney Disease and Hypertension.
Transcriptional Coactivator p300 and Silent Information Regulator 1 (SIRT1) Gene Polymorphism Associated with Diabetic Kidney Disease in a Chinese Cohort.
Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population.
Translating cell survival and cell longevity into treatment strategies with SIRT1.
[Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver.]
[Hepatic SIRT1 and UCP2 expressions in rats with type 2 diabetes mellitus and nonalcoholic fatty liver].
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Diabetes Mellitus, Experimental
Experimental diabetes mellitus exacerbates ischemia/reperfusion-induced myocardial injury by promoting mitochondrial fission: Role of down-regulation of myocardial Sirt1 and subsequent Akt/Drp1 interaction.
Diabetes Mellitus, Type 1
Can Functionally Mature Islet ?-Cells Be Derived from Pluripotent Stem Cells? - A Step Towards Ready-To-Use ?-Cells in Type 1 Diabetes.
Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes.
Dietary advanced glycated end-products and medicines influence the expression of SIRT1 and DDOST in peripheral mononuclear cells from long-term type 1 diabetes patients.
Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes.
Novel SIRT1 Mutation Linked to Autoimmune Diabetes in Humans.
Papers of note in Science Immunology2 (9).
Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes.
Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights.
Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy.
SIRT1 activation attenuates ? cell hyperplasia, hyperglucagonaemia and hyperglycaemia in STZ-diabetic mice.
Sirt1 attenuates diabetic keratopathy by regulating the endoplasmic reticulum stress pathway.
Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease.
The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism.
Diabetes Mellitus, Type 2
A Label-free Sirtuin 1 Assay based on Droplet-Electrospray Ionization Mass Spectrometry.
A Phase II, Randomized, Placebo-Controlled, Double-Blind, Multi-Dose Study of SRT2104, a SIRT1 Activator, in Subjects With Type 2 Diabetes.
A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers.
AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease.
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice.
Association between low SIRT1 expression in visceral and subcutaneous adipose tissues and metabolic abnormalities in women with obesity and type 2 diabetes.
Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes.
Association between the SIRT1 mRNA Expression and Acute Coronary Syndrome.
Association of Genetic Variants of SIRT1 With Type 2 Diabetes Mellitus.
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Autophagy-dependent and -independent modulation of oxidative and organellar stress in the diabetic heart by glucose-lowering drugs.
Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial.
Biochanin A improves insulin sensitivity and controls hyperglycemia in type 2 diabetes.
Brain SIRT1 Mediates Metabolic Homeostasis and Neuroprotection.
Can targeting SIRT-1 to treat type 2 diabetes be a good strategy? A review.
Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus.
Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet.
Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis.
Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia.
Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: a model of type 2 diabetes.
Differential Effects of Resveratrol and SRT1720 on Lifespan of Adult Caenorhabditis elegans.
Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake.
Differential expressions of SIRT1, SIRT3, and SIRT4 in peripheral blood mononuclear cells from patients with type 2 diabetic retinopathy.
Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats.
Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial.
Effects of Resveratrol in Patients With Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure.
Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus.
Elevated microRNA-34a in obesity reduces NAD(+) levels and SIRT1 activity by directly targeting NAMPT.
Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6.
Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice.
Expression Profile of Diabetes-Related Genes Associated with Leukocyte Sirtuin 1 Overexpression in Gestational Diabetes.
Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis.
Formononetin Treatment in Type 2 Diabetic Rats Reduces Insulin Resistance and Hyperglycemia.
Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes.
Functional genetic variants within the SIRT2 gene promoter in type 2 diabetes mellitus.
Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease.
Genetic analysis of the SIRT1 gene promoter in ventricular septal defects.
Genomics of aging: The role of sirtuin and metabolic health.
Haplotypes of the Mutated SIRT2 Promoter Contributing to Transcription Factor Binding and Type 2 Diabetes Susceptibility.
Hexosamines stimulate apoptosis by altering Sirt1 action and levelsin rodent pancreatic {beta}-cells.
In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions.
In silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database.
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.
Increased malondialdehyde vs. reduced sirtuin 1 in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes.
Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity.
Influences of Breakfast on Clock Gene Expression and Postprandial Glycemia in Healthy Individuals and Individuals With Diabetes: A Randomized Clinical Trial.
Interferon gamma (IFN-?) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription.
Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes.
Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes.
MicroRNA-93-5p participates in type 2 diabetic retinopathy through targeting Sirt1.
MiR-138-5p affects insulin resistance to regulate type 2 diabetes progression through inducing autophagy in HepG2 cells by regulating SIRT1.
Mitochondria, the NLRP3 Inflammasome, and Sirtuins in Type 2 Diabetes: New Therapeutic Targets.
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Overexpressed eNOS upregulates SIRT1 expression and protects mouse pancreatic ? cells from apoptosis.
Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes.
PDE5 Inhibition Ameliorates Visceral Adiposity Targeting the miR-22/SIRT1 Pathway: Evidence From the CECSID Trial.
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.
Phosphorylation regulates SIRT1 function.
Pomegranate Juice Increases Sirtuin1 Protein in Peripheral Blood Mononuclear Cell from Patients with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trial.
Poor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signalling via platelet-activating factor receptor activation.
Pro-inflammatory Cytokine Interleukin 1? Disrupts ? cell Circadian Clock Function and Regulation of Insulin Secretion.
Proposed Tandem Effect of Physical Activity and Sirtuin 1 and 3 Activation in Regulating Glucose Homeostasis.
Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes.
Quercetin protects islet ?-cells from oxidation-induced apoptosis via Sirt3 in T2DM.
Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1.
Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1.
Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism.
Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-Inhibitors.
Roles and Tissue Source of Adiponectin Involved in Lifestyle Modifications.
Roux-en-Y Gastric Bypass Improves Hepatic Glucose Metabolism Involving Upregulation of Sirt1 in Type 2 Diabetes Mellitus.
Rs12778366 single nucleotide polymorphism of Sirtuin 1 (SIRT1) and response to resveratrol supplementation in patients with type 2 diabetes mellitus.
Serum sirtuin 1 protein as a potential biomarker for type 2 diabetes: Increased expression of sirtuin 1 and the correlation with microRNAs.
Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes.
SIRT1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons.
SIRT1 and insulin resistance.
SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats.
SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention--the TULIP Study.
SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin.
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.
SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential.
SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians.
SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex.
SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models.
SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.
SIRT1: a promising therapeutic target in type 2 diabetes mellitus.
SIRT2 negatively regulates insulin resistance in C2C12 skeletal muscle cells.
Sirt3 regulates adipogenesis and adipokine secretion via its enzymatic activity.
SirT3 regulates diabetogenic effects caused by arsenic: An implication for mitochondrial complex II modification.
Sirtuin 1 as the mechanism of action of agents used in the diabetes mellitus pharmacotherapy.
Sirtuin 1 rs7069102 polymorphism is associated with diabetic nephropathy in patients with type 2 diabetes mellitus.
Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients.
Sirtuin activators: Designing molecules to extend life span.
Sirtuin biology and relevance to diabetes treatment.
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.
Sirtuin1-p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat.
Sirtuins and Insulin Resistance.
Sirtuins in Vascular Diseases: Emerging Roles and Therapeutic Potential.
Sirtuins--novel therapeutic targets to treat age-associated diseases.
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.
Targeting sirtuins for the treatment of diabetes.
The Association between SIRT1 Genetic Variation and Type 2 Diabetes Mellitus Is Influenced by Dietary Intake in Elderly Chinese.
The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1? signalling pathway.
The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism.
The interactive effect of SIRT1 promoter region polymorphism on type 2 diabetes susceptibility in the North Indian population.
The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes.
The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.
The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity.
The role of sirtuin proteins in obesity.
The Sirtuin family: therapeutic targets to treat diseases of aging.
The sirtuins: Markers of metabolic health.
The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes.
Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes.
TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.
Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding.
Transcriptional Coactivator p300 and Silent Information Regulator 1 (SIRT1) Gene Polymorphism Associated with Diabetic Kidney Disease in a Chinese Cohort.
Trifolium pratense (Red Clover) Improve SIRT1 Expression and Glycogen Content in High Fat Diet-Streptozotocin Induced Type 2 Diabetes in Rats.
Type 2 diabetes-associated polymorphisms correlate with SIRT1 and TGF-?1 gene expression.
Understanding Genetic Heterogeneity in Type 2 Diabetes by Delineating Physiological Phenotypes: SIRT1 and its Gene Network in Impaired Insulin Secretion.
Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial.
[Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver.]
[Hepatic SIRT1 and UCP2 expressions in rats with type 2 diabetes mellitus and nonalcoholic fatty liver].
Diabetes, Gestational
Advances in the role of silence information regulator family in pathological pregnancy.
Expression Profile of Diabetes-Related Genes Associated with Leukocyte Sirtuin 1 Overexpression in Gestational Diabetes.
Skeletal Muscle MnSOD, Mitochondrial Complex II, and SIRT3 Enzyme Activities Are Decreased in Maternal Obesity During Human Pregnancy and Gestational Diabetes Mellitus.
Diabetic Angiopathies
Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway.
SIRT1 Antagonizes Oxidative Stress in Diabetic Vascular Complication.
SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.
Diabetic Cardiomyopathies
(-)-Epigallocatechin-3-gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions.
Advanced glycation end-products impair Na?/K?-ATPase activity in diabetic cardiomyopathy: role of the adenosine monophosphate-activated protein kinase/sirtuin 1 pathway.
An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy.
Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3.
Bakuchiol Alleviates Hyperglycemia-Induced Diabetic Cardiomyopathy by Reducing Myocardial Oxidative Stress via Activating the SIRT1/Nrf2 Signaling Pathway.
Blockage of ROS and MAPKs-mediated inflammation via restoring SIRT1 by a new compound LF10 prevents type 1 diabetic cardiomyopathy.
Catalase alleviates cardiomyocyte dysfunction in diabetes: role of Akt, Forkhead transcriptional factor and silent information regulator 2.
LncRNA HOTAIR functions as a competing endogenous RNA to upregulate SIRT1 by sponging miR-34a in diabetic cardiomyopathy.
Mst1 inhibits Sirt3 expression and contributes to diabetic cardiomyopathy through inhibiting Parkin-dependent mitophagy.
Polydatin ameliorates diabetic cardiomyopathy via Sirt3 activation.
Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy.
Salidroside protects cardiac function in mice with diabetic cardiomyopathy via activation of mitochondrial biogenesis and SIRT3.
SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats.
SIRT1 Activation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice.
SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism.
SIRT2 regulates microtubule stabilization in diabetic cardiomyopathy.
Sirt3 is essential for apelin-induced angiogenesis in post-myocardial infarction of diabetes.
SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation.
Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism.
Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation.
Taohuajing reduces oxidative stress and inflammation in diabetic cardiomyopathy through the sirtuin 1/nucleotide-binding oligomerization domain-like receptor protein 3 pathway.
Tetrahydrocurcumin Ameliorates Diabetic Cardiomyopathy by Attenuating High Glucose-Induced Oxidative Stress and Fibrosis via Activating the SIRT1 Pathway.
The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy.
The Role of Heme Oxygenase 1 in the Protective Effect of Caloric Restriction against Diabetic Cardiomyopathy.
The role of SIRT1 in diabetic cardiomyopathy.
The role of SIRT2 in vascular-related and heart-related diseases: A review.
Diabetic Foot
Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity.
The emerging role of the epigenetic enzyme Sirtuin-1 and high mobility group Box 1 in patients with diabetic foot ulceration.
Diabetic Nephropathies
3,5-Diiodo-l-thyronine ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats.
AGEs-RAGE system down-regulates Sirt1 through the ubiquitin-proteasome pathway to promote FN and TGF-?1 expression in male rat glomerular mesangial cells.
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy.
Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes.
Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy.
Cdk5-Mediated Phosphorylation of Sirt1 Contributes to Podocyte Mitochondrial Dysfunction in Diabetic Nephropathy.
Cissus quadrangularis extract attenuates diabetic nephropathy by altering SIRT1/DNMT1 axis.
Correlation Between Polymorphisms of the SIRT1 Gene microRNA Target Sites and Diabetic Nephropathy.
Correlations between SIRT1 gene polymorphisms and diabetic kidney disease.
Diabetic nephropathy: Sirt1 attenuates diabetic albuminuria.
Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: a model of type 2 diabetes.
Endogenous Nampt upregulation is associated with diabetic nephropathy inflammatory-fibrosis through the NF-?B p65 and Sirt1 pathway; NMN alleviates diabetic nephropathy inflammatory-fibrosis by inhibiting endogenous Nampt.
Epigenetic regulation through SIRT1 in podocytes.
Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice.
Hydrogen sulfide modulates SIRT1 and suppresses oxidative stress in diabetic nephropathy.
Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury.
Inhibition of miRNA-155 Alleviates High Glucose-Induced Podocyte Inflammation by Targeting SIRT1 in Diabetic Mice.
Inhibition of miRNA?135a?5p ameliorates TGF??1?induced human renal fibrosis by targeting SIRT1 in diabetic nephropathy.
Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating SIRT1 expression.
Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes.
miR-133b and miR-199b knockdown attenuate TGF-?1-induced epithelial to mesenchymal transition and renal fibrosis by targeting SIRT1 in diabetic nephropathy.
Nephroprotective action of sirtuin 1 (SIRT1).
Novel tubular-glomerular interplay in diabetic kidney disease mediated by sirtuin 1, nicotinamide mononucleotide, and nicotinamide adenine dinucleotide Oshima Award Address 2017.
Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-?1 in rat glomerular messangial cells.
Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-?B and STAT3.
Renal protective effect of sirtuin 1.
Renal protective effects of resveratrol.
Role of ketogenic starvation sensors in mediating the renal protective effects of SGLT2 inhibitors in type 2 diabetes.
Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells.
Salidroside stimulates the Sirt1/PGC-1? axis and ameliorates diabetic nephropathy in mice.
Selenium nanoparticles involve HSP-70 and SIRT1 in preventing the progression of type 1 diabetic nephropathy.
SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis.
Sirt1 inhibits renal tubular cell epithelial-mesenchymal transition through YY1 deacetylation in diabetic nephropathy.
SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease.
Sirt1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat.
SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy.
SIRT1: Mechanism and Protective in Diabetic Nephropathy.
SIRT3 Facilitates Amniotic Fluid Stem Cells to Repair Diabetic Nephropathy Through Protecting Mitochondrial Homeostasis by Modulation of Mitophagy.
Sirt3 overexpression alleviates hyperglycemia-induced vascular inflammation through regulating redox balance, cell survival, and AMPK-mediated mitochondrial homeostasis.
Sirtuin 1 rs7069102 polymorphism is associated with diabetic nephropathy in patients with type 2 diabetes mellitus.
Sirtuin and metabolic kidney disease.
Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-?1 pathway.
The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-?1 expressions in rat glomerular mesangial cells.
The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats.
The Emerging Role of Sirtuin 1 in Cellular Metabolism, Diabetes Mellitus, Diabetic Kidney Disease and Hypertension.
The Role of SIRT1 in Diabetic Kidney Disease.
[The renal protective effect and mechanism of liraglutide in diabetic mice induced by high-fat diet].
[The role of SIRT1 in the treatment of diabetic nephropathy].
Diabetic Neuropathies
Biomarkers in diabetic neuropathy.
Formononetin Ameliorates Diabetic Neuropathy by Increasing Expression of SIRT1 and NGF.
Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy.
mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy.
Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy.
SIRT1 Activation by Polydatin Alleviates Oxidative Damage and Elevates Mitochondrial Biogenesis in Experimental Diabetic Neuropathy.
Diabetic Retinopathy
Arbutin inhibits inflammation and apoptosis by enhancing autophagy via SIRT1.
CircRNA cPWWP2A: an emerging player in diabetes mellitus.
Coumestrol mitigates retinal cell inflammation, apoptosis, and oxidative stress in a rat model of diabetic retinopathy via activation of SIRT1.
Cross-Talk between Sirtuin 1 and the Proinflammatory Mediator High-Mobility Group Box-1 in the Regulation of Blood-Retinal Barrier Breakdown in Diabetic Retinopathy.
Deacetylation of MnSOD by PARP-regulated SIRT3 protects retinal capillary endothelial cells from hyperglycemia-induced damage.
Differential expressions of SIRT1, SIRT3, and SIRT4 in peripheral blood mononuclear cells from patients with type 2 diabetic retinopathy.
Effects of microRNA?217 on high glucose?induced inflammation and apoptosis of human retinal pigment epithelial cells (ARPE?19) and its underlying mechanism.
Feno?brate suppresses cellular metabolic memory of high glucose in diabetic retinopathy via a sirtuin 1-dependent signalling pathway.
LncRNA XIST restrains the activation of Müller cells and inflammation in diabetic retinopathy via stabilizing SIRT1.
Melatonin attenuates oxidative stress and inflammation of Müller cells in diabetic retinopathy via activating the Sirt1 pathway.
MicroRNA-29b-3p Promotes Human Retinal Microvascular Endothelial Cell Apoptosis via Blocking SIRT1 in Diabetic Retinopathy.
MicroRNA-34a promotes apoptosis of retinal vascular endothelial cells by targeting SIRT1 in rats with diabetic retinopathy.
MicroRNA-93-5p participates in type 2 diabetic retinopathy through targeting Sirt1.
miR-195 regulates SIRT1-mediated changes in diabetic retinopathy.
MiR-204 inhibits inflammation and cell apoptosis in retinopathy rats with diabetic retinopathy by regulating Bcl-2 and SIRT1 expressions.
Molecular Mechanism of Transcriptional Regulation of Matrix Metalloproteinase-9 in Diabetic Retinopathy.
Overexpression of histone deacetylase SIRT1 exerts an anti-angiogenic role in diabetic retinopathy via miR-20a elevation and YAP/HIF1?/VEGFA depletion.
PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners.
Protective effects of SIRT1 in patients with proliferative diabetic retinopathy via the inhibition of IL-17 expression.
Role of Sirtuin 1 in the pathogenesis of ocular disease (Review).
Serum microRNA-211 as a biomarker for diabetic retinopathy via modulating Sirtuin 1.
Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy.
Sirt1: A Guardian of the Development of Diabetic Retinopathy.
The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor.
The role of SIRT1 in diabetic retinopathy.
The role of sirt1 in the retinal ganglion cells cultured by high glucose.
Diphtheria
Intracellular Mono-ADP-Ribosylation in Signaling and Disease.
DNA Repair-Deficiency Disorders
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Dry Eye Syndromes
Expression of SIRT1 and oxidative stress in diabetic dry eye.
PPAR?: the dominant regulator among PPARs in dry eye lacrimal gland and diabetic lacrimal gland.
Dyslipidemias
A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers.
Carob pod insoluble fiber exerts anti-atherosclerotic effects in rabbits through sirtuin-1 and peroxisome proliferator-activated receptor-? coactivator-1?.
Inhibition of miR-29 has a significant lipid-lowering benefit through suppression of lipogenic programs in liver.
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.
Supplementation with an insoluble fiber obtained from carob pod (Ceratonia siliqua L.) rich in polyphenols prevents dyslipidemia in rabbits through SIRT1/PGC-1? pathway.
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
[Rhein promotes the expression of SIRT1 in kidney tissues of type 2 diabetic rat].
Encephalitis
Overexpression of SIRT1 Induced by Resveratrol and Inhibitor of miR-204 Suppresses Activation and Proliferation of Microglia.
The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation.
Encephalomyelitis
Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation.
Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity.
Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets.
Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Role of the epigenetic factor Sirt7 in neuroinflammation and neurogenesis.
Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients.
SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review.
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
Encephalomyelitis, Autoimmune, Experimental
Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation.
Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity.
Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets.
Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients.
SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review.
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
Sirtuin-1 in immunotherapy: A Janus-headed target.
End Stage Liver Disease
SIRT1 activation by resveratrol reverses atrophy of apical dendrites of hippocampal CA1 pyramidal neurons and neurobehavioral impairments in moderate grade hepatic encephalopathy rats.
Endocrine System Diseases
Resveratrol reduces the progression of titanium particle-induced osteolysis via the Wnt/?-catenin signaling pathway in vivo and in vitro.
Endodermal Sinus Tumor
Morphoproteomics Identifies the EZH2 and SIRT1 Pathways as Potential Blocks to Differentiation in Yolk Sac Tumor of the Ovary and Provides Therapeutic Options: a Case Study.
Endometrial Hyperplasia
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Autophagy in the physiological endometrium and cancer.
Endometrial Neoplasms
Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium.
Autophagy in the physiological endometrium and cancer.
Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression.
SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis.
Sirtuin 1 promotes autophagy and proliferation of endometrial cancer cells by reducing acetylation level of LC3.
Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target.
Sirtuin 2 in Endometrial Cancer: A Potential Regulator for Cell Proliferation, Apoptosis and RAS/ERK Pathway.
Sirtuin 2 promotes cell stemness and MEK/ERK signaling pathway while reduces chemosensitivity in endometrial cancer.
Endometriosis
A potential role of Sirtuin3 and its target enzyme activities in patients with ovarian endometrioma.
Differential Expression of KRAS and SIRT1 in Ovarian Cancers with and Without Endometriosis.
Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women.
Inhibitory effect of resveratrol on the growth and angiogenesis of human endometrial tissue in an In Vitro three-dimensional model of endometriosis.
Is There a Balance in Oxidative-Antioxidant Status in Blood Serum of Patients with Advanced Endometriosis?
KRAS Activation and over-expression of SIRT1/BCL6 Contributes to the Pathogenesis of Endometriosis and Progesterone Resistance.
miR-9-5p promotes the invasion and migration of endometrial stromal cells in endometriosis patients through the SIRT1/NF-?B pathway.
MiRNA 34-a regulate SIRT-1 and Foxo-1 expression in endometriosis.
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
Resveratrol suppresses inflammatory responses in endometrial stromal cells derived from endometriosis: A possible role of the sirtuin 1 pathway.
Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility.
Endotoxemia
Constant light exposure aggravates POMC-mediated muscle wasting associated with hypothalamic alteration of circadian clock and SIRT1 in endotoxemia rats.
Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia.
Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia.
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis.
Interferon ? protects against lethal endotoxic and septic shock through SIRT1 upregulation.
Moderate SIRT1 overexpression protects against brown adipose tissue inflammation.
Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury.
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Enterocolitis
Lipopolysaccharide upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1).
Enterocolitis, Necrotizing
Melatonin-induced lncRNA LINC01512 prevents Treg/Th17 imbalance by promoting SIRT1 expression in necrotizing enterocolitis.
miR?34a increases inflammation and oxidative stress levels in patients with necrotizing enterocolitis by downregulating SIRT1 expression.
SIRT1 relieves Necrotizing Enterocolitis through inactivation of Hypoxia-inducible factor (HIF)-1a.
Epilepsy
Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy.
Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy.
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy.
miR-135a-5p inhibitor protects glial cells against apoptosis via targeting SIRT1 in epilepsy.
miR?128 is upregulated in epilepsy and promotes apoptosis through the SIRT1 cascade.
Progress on mitochondrial silence information regulator family in epilepsy.
Suppression of microRNA-141 suppressed p53 to protect against neural apoptosis in epilepsy by SIRT1 expression.
Targeting of microRNA-199a-5p protects against pilocarpine-induced status epilepticus and seizure damage via SIRT1-p53 cascade.
The Role of Sirt1 in Epileptogenesis.
Epiretinal Membrane
Cross-Talk between Sirtuin 1 and the Proinflammatory Mediator High-Mobility Group Box-1 in the Regulation of Blood-Retinal Barrier Breakdown in Diabetic Retinopathy.
Protective effects of SIRT1 in patients with proliferative diabetic retinopathy via the inhibition of IL-17 expression.
Erectile Dysfunction
MicroRNA-200a is up-regulated in aged rats with erectile dysfunction and could attenuate endothelial function via SIRT1 inhibition.
SIRT1 as a therapeutic target in diabetic complications.
[Aging-related change of erectile function and the expression of SIRT1].
[Deacetylase SIRT1 and vascular endothelial function].
Esophageal Neoplasms
Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin.
Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma.
Rapamycin suppresses the PI3K/AKT/mTOR signaling pathway by targeting SIRT1 in esophageal cancer.
SIRT1 expression regulates the transformation of resistant esophageal cancer cells via the epithelial-mesenchymal transition.
Sirtuin-3 (SIRT3) expression is associated with overall survival in esophageal cancer.
Esophageal Squamous Cell Carcinoma
ADC correlation with Sirtuin1 to assess early chemoradiotherapy response of locally advanced esophageal carcinoma patients.
Clinicopathological and predictive significance of SIRT1 and peroxisome proliferator-activated receptor gamma in esophageal squamous cell carcinoma: The correlation with EGFR and Survivin.
Effects of downregulation of SIRT3 expression on proliferation and apoptosis in esophageal squamous cell carcinoma EC9706 cells and its molecular mechanisms.
Expression of SIRT1 and survivin correlates with poor prognosis in esophageal squamous cell carcinoma.
Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin.
Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma.
SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma.
SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma.
SIRT3 is a novel prognostic biomarker for esophageal squamous cell carcinoma.
Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma.
Essential Hypertension
Letter by Zhou et al Regarding Article, "Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress".
Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress.
Response by Dikalova and Dikalov to Letter Regarding Article, "Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress".
Role of Klotho in the Development of Essential Hypertension.
Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension.
Eye Diseases
Potential suppression of the high glucose and insulin-induced retinal neovascularization by Sirtuin 3 in the human retinal endothelial cells.
Prediction of potential drugs and targets based on meibomian gland dysfunction module classification to guide individualized treatment.
Role of Sirtuin 1 in the pathogenesis of ocular disease (Review).
SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice.
Fanconi Anemia
The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice.
Fasciitis
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Fatty Liver
A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators.
Activation of the aryl hydrocarbon receptor sensitizes mice to non-alcoholic steatohepatitis by deactivating the mitochondrial sirtuin deacetylase Sirt3.
Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway.
Betaine feeding prevents the blood alcohol cycle in rats fed alcohol continuously for 1month using the rat intragastric tube feeding model.
Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa.
Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway.
Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet.
Circulating SIRT1 Increases After Intragastric Balloon Fat Loss in Obese Patients.
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced hepatic steatosis in mice.
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice.
Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients.
Effect of Daisaikoto on Expressions of SIRT1 and NF-kappaB of Diabetic Fatty Liver Rats Induced by High-Fat Diet and Streptozotocin.
Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice.
Emerging roles of SIRT1 in fatty liver diseases.
Epigallocatechin-3-Gallate-Rich Green Tea Extract Ameliorates Fatty Liver and Weight Gain in Mice Fed a High Fat Diet by Activating the Sirtuin 1 and AMP Activating Protein Kinase Pathway.
Exendin-4 Improves Steatohepatitis by Increasing Sirt1 Expression in High-Fat Diet-Induced Obese C57BL/6J Mice.
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation.
Foie gras and liver regeneration: a fat dilemma.
Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose Diet.
Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism.
Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial.
Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation.
Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease.
Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling.
Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/- Mice: A Role of Lipid Mobilization and Inflammation.
Lipids: Celastrol protects against fatty liver through SIRT1.
Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition.
Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism.
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Metformin Alleviates Steatohepatitis in Diet-Induced Obese Mice in a SIRT1-Dependent Way.
Metformin Regulating miR-34a Pathway to Inhibit Egr1 in Rat Mesangial Cells Cultured with High Glucose.
MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3.
miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease.
miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload.
Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression.
Molecular, Cellular, and Physiological Characterization of Sirtuin 7 (SIRT7).
Obesity and aging diminish SIRT1-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3.
Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver.
Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients.
PPAR? Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury.
Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease.
Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease.
Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat.
Renalase Attenuates Mouse Fatty Liver Ischemia/Reperfusion Injury through Mitigating Oxidative Stress and Mitochondrial Damage via Activating SIRT1.
Retinoic acid ameliorates high-fat diet-induced liver steatosis through sirt1.
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis.
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism.
SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPAR?/FoxO1 signaling pathway.
SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding.
SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF??B pathway in mouse kupffer cells.
SIRT1: recent lessons from mouse models.
SIRT3 as a Regulator of Non-alcoholic Fatty Liver Disease.
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome.
SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1?-LIPIN 1 pathway and increasing CD36 through Nrf2.
Sirtuin 1 is involved in oleic acid-induced calf hepatocyte steatosis via alterations in lipid metabolism-related proteins.
Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4?.
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice.
Sirtuin 3 improves fatty acid metabolism in response to high nonesterified fatty acids in calf hepatocytes by modulating gene expression.
Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates non-alcoholic fatty liver disease.
Sirtuins and Insulin Resistance.
Stem cell transplantation upregulates Sirt1 and antioxidant expression, ameliorating fatty liver in type 2 diabetic mice.
Targeting Sirt1 in a rat model of high-fat diet-induced non-alcoholic fatty liver disease: Comparison of Gegen Qinlian decoction and resveratrol.
The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial.
The ménage à trois of autophagy, lipid droplets and liver disease.
Tomatidine ameliorates obesity-induced nonalcoholic fatty liver disease in mice.
Treatment with SRT1720, a SIRT1 Activator, Ameliorates Fatty Liver with Reduced Expression of Lipogenic Enzymes in MSG Mice.
Fatty Liver, Alcoholic
2-Methoxyestradiol protects against ischemia/reperfusion injury in alcoholic fatty liver by enhancing sirtuin 1-mediated autophagy.
Association of SIRT1 gene polymorphism and its expression for the risk of alcoholic fatty liver disease in the Han population.
Combined intake of blueberry juice and probiotics ameliorate mitochondrial dysfunction by activating SIRT1 in alcoholic fatty liver disease.
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
Involvement of mammalian sirtuin 1 in the action of ethanol in the liver.
Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice.
MiR-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1.
Resveratrol alleviates alcoholic fatty liver in mice.
Sirtuin 1 signaling and alcoholic fatty liver disease.
The combination of blueberry juice and probiotics reduces apoptosis of alcoholic fatty liver of mice by affecting SIRT1 pathway.
Fetal Diseases
High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects.
Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy.
Fetal Growth Retardation
Advances in the role of silence information regulator family in pathological pregnancy.
Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction.
Fibromatosis, Aggressive
The role of miRNA-133b and its target gene SIRT1 in FAP-derived desmoid tumor.
Fibrosarcoma
Activation of SIRT1 protects pancreatic ?-cells against palmitate-induced dysfunction.
miR-520c and miR-373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF-?B factor in human fibrosarcoma cells.
Resveratrol with antioxidant activity inhibits matrix metalloproteinase via modulation of SIRT1 in human fibrosarcoma cells.
Flavivirus Infections
Tenovin-1 inhibited dengue virus replication through SIRT2.
Fragile X Syndrome
Can Sir(2) regulate cancer?
SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome.
Sirtuin activators and inhibitors.
Friedreich Ataxia
Friedreich's Ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase.
Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.
Frontotemporal Dementia
Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia.
Gallbladder Neoplasms
SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition.
Gallstones
Hepatic Deletion of SIRT1 Decreases Hepatocyte Nuclear Factor 1?/Farnesoid X Receptor Signaling and Induces Formation of Cholesterol Gallstones in Mice.
Ganglion Cysts
Activating Sirt1 by resveratrol suppresses Nav1.7 expression in DRG through miR-182 and alleviates neuropathic pain in rats.
Gastritis
Helicobacter pylori infection increases sirt2 gene expression in gastric epithelial cells of gastritis patients.
Gastrointestinal Diseases
2, 3, 5, 4'-Tetrahydroxystilbene-2-O-beta-D-glucoside improves gastrointestinal motility disorders in STZ-induced diabetic mice.
Gastrointestinal Neoplasms
Meta-analysis of SIRT1 expression as a prognostic marker for overall survival in gastrointestinal cancer.
Gastrointestinal Stromal Tumors
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Genetic Diseases, Inborn
Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension.
Giant Cell Arteritis
An Insight into Giant Cell Arteritis Pathogenesis: Evidence for Oxidative Stress and SIRT1 Downregulation.
Glaucoma
Evaluation of silent information regulator T (SIRT) 1 and Forkhead Box O (FOXO) transcription factor 1 and 3a genes in glaucoma.
Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans.
Role of Sirtuin 1 in the pathogenesis of ocular disease (Review).
SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice.
Sirtuins Expression and Their Role in Retinal Diseases.
The role of SIRT1 in ocular aging.
[SIRT1 promote GTM cell DSBs repair and resist cellular senescence].
Glaucoma, Open-Angle
The relationship between HDAC6, CXCR3, and SIRT1 genes expression levels with progression of primary open-angle glaucoma.
Glioblastoma
A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma.
CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance.
Cyproheptadine causes apoptosis and decreases inflammation by disrupting thiol/disulfide balance and enhancing the levels of SIRT1 in C6 glioblastoma cells.
FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain.
Induction of Nuclear Enlargement and Senescence by Sirtuin Inhibitors in Glioblastoma Cells.
Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNF?)-induced apoptosis through SIRT1 inhibition.
Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1.
miR-22 inhibits the proliferation, motility, and invasion of human glioblastoma cells by directly targeting SIRT1.
Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells.
SIRT2-mediated inactivation of p73 is required for glioblastoma tumorigenicity.
[Mechanism of temozolomide-induced anti-tumor effects on glioblastoma cells in vitro is via ROS-dependent SIRT1 signaling pathway].
[Retracted] FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain.
[SIRT2, a multi-talented deacetylase].
Glioma
Betulinic acid derivative B10 inhibits glioma cell proliferation through suppression of SIRT1, acetylation of FOXO3a and upregulation of Bim/PUMA.
Cinnamon polyphenols attenuate the hydrogen peroxide-induced down regulation of S100? secretion by regulating sirtuin 1 in C6 rat glioma cells.
Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR-181a to modulate SIRT1 expression.
Circ_0005075 stimulates the proliferation and metastasis of glioma via downregulating SIRT1.
CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression.
Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines.
Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines.
Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression.
Exendin-4 inhibits glioma cell migration, invasion and epithelial-to-mesenchymal transition through GLP-1R/sirt3 pathway.
FoxM1 regulates Sirt1 expression in glioma cells.
Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype.
Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNF?)-induced apoptosis through SIRT1 inhibition.
Knockdown of circ0082374 inhibits cell viability, migration, invasion and glycolysis in glioma cells by miR-326/SIRT1.
Knockdown of long non-coding RNA ANRIL inhibits proliferation, migration, and invasion but promotes apoptosis of human glioma cells by upregulation of miR-34a.
Long noncoding RNA-GAS5 attenuates progression of glioma by eliminating microRNA-10b and Sirtuin 1 in U251 and A172 cells.
Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1.
Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH).
MicroRNA and target protein patterns reveal physiopathological features of glioma subtypes.
MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1.
MicroRNA-320 Enhances Radiosensitivity of Glioma Through Down-Regulation of Sirtuin Type 1 by Directly Targeting Forkhead Box Protein M1.
MicroRNA-34a: a novel tumor suppressor in p53-mutant glioma cell line U251.
miR-133b inhibits glioma cell proliferation and invasion by targeting Sirt1.
miR?34a derived from mesenchymal stem cells stimulates senescence in glioma cells by inducing DNA damage.
miRNA regulation of Sirtuin-1 expression in human astrocytoma.
Noninvasive quantification of SIRT1 expression-activity and pharmacologic inhibition in a rat model of intracerebral glioma using 2-[18F]BzAHA PET/CT/MRI.
Prognostic significance of sirtuin 2 protein nuclear localization in glioma: an immunohistochemical study.
Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene.
Sinomenine Induces G1-Phase Cell Cycle Arrest and Apoptosis in Malignant Glioma Cells Via Downregulation of Sirtuin 1 and Induction of p53 Acetylation.
SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of "cancer cells with neural stemness" in a p53-dependent manner.
SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines.
SIRT2 activity is required for the survival of C6 glioma cells.
SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest.
Sirt2 suppresses glioma cell growth through targeting NF-?B-miR-21 axis.
SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress.
Sirt3 enhances glioma cell viability by stabilizing Ku70-BAX interaction.
Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia.
Sirtuin 1 knockdown inhibits glioma cell proliferation and potentiates temozolomide toxicity via facilitation of reactive oxygen species generation.
Sirtuin 7 promotes glioma proliferation and invasion through activation of the ERK/STAT3 signaling pathway.
Sirtuin activation targets IDH-mutant tumors.
Sirtuin1 activator SRT2183 suppresses glioma cell growth involving activation of endoplasmic reticulum stress pathway.
The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation.
Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas.
Glomerulonephritis
Resveratrol possesses protective effects in a pristane-induced lupus mouse model.
Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway.
Glomerulonephritis, IGA
IgA Nephropathy Benefits from Compound K Treatment by Inhibiting NF-?B/NLRP3 Inflammasome and Enhancing Autophagy and SIRT1.
Glomus Tumor
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Glucose Intolerance
Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.
High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression.
Increased Sirt1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice.
Intra-arterial Targeted Islet-specific Expression of Sirt1 Protects ? Cells From Streptozotocin-induced Apoptosis in Mice.
Muscle-specific sirtuin 3 overexpression does not attenuate the pathological effects of high-fat/high-sucrose feeding but does enhance cardiac SERCA2a activity.
Obesity and aging diminish SIRT1-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3.
Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver.
Parental SIRT1 Overexpression Attenuate Metabolic Disorders Due to Maternal High-Fat Feeding.
Short-term effects induced by nicotinamide in ovariectomized females.
Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.
SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and ?-cell formation.
SIRT1 in Astrocytes Regulates Glucose Metabolism and Reproductive Function.
SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding.
Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein.
Up-regulation of the Sirtuin 1 (Sirt1) and peroxisome proliferator-activated receptor ? coactivator-1? (PGC-1?) genes in white adipose tissue of Id1 protein-deficient mice: implications in the protection against diet and age-induced glucose intolerance.
Glucose Metabolism Disorders
Inhibition of silent information regulator 1 induces glucose metabolism disorders of hepatocytes and enhances hepatitis C virus replication.
Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway.
Glycogen Storage Disease
Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia.
Sirtuin signaling controls mitochondrial function in glycogen storage disease type Ia.
Glycosuria
SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes.
Gout
Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients.
Sirt1 ameliorates monosodium urate crystal-induced inflammation by altering macrophage polarization via the PI3K/Akt/STAT6 pathway.
Graft vs Host Disease
[SIRT1 deficiency in CD4+T cells induces acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation].
Granulosa Cell Tumor
Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors.
Graves Disease
Decreased SIRT1 expression in the peripheral blood of patients with Graves' disease.
Hashimoto Disease
Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease.
Head and Neck Neoplasms
A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.
MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers.
SIRT2 modulates VEGFD-associated lymphangiogenesis by deacetylating EPAS1 in human head and neck cancer.
Hearing Loss
Environmental enrichment modulates silent information regulator 1 (SIRT1) activity to attenuate central presbycusis in a rat model of normal aging.
Localization of sirtuins (SIRT1-7) in the aged mouse inner ear.
Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation.
Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis.
Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing loss.
Protective Effects of N1-Methylnicotinamide Against High-Fat Diet- and Age-Induced Hearing Loss via Moderate Overexpression of Sirtuin 1 Protein.
Roles of Bak and Sirt3 in Paraquat-Induced Cochlear Hair Cell Damage.
Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice.
SIRT1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss.
SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy.
SIRT3 deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status.
SIRT3 in calorie restriction: can you hear me now?
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1? axis in mice.
The Protective Effect of Egb 761 Against 3-Nitropropionic Acid-Induced Hearing Loss: The Role of Sirtuin 1.
Thymoquinone ameliorates age-related hearing loss in C57BL/6J mice by modulating Sirt1 activity and Bak1 expression.
Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice.
Hearing Loss, Noise-Induced
Activation of SIRT3 by the NAD? precursor nicotinamide riboside protects from noise-induced hearing loss.
The SIRT2 inhibitor AK-7 decreases cochlear cell apoptosis and attenuates noise-induced hearing loss.
Hearing Loss, Sensorineural
The Protective Effect of Egb 761 Against 3-Nitropropionic Acid-Induced Hearing Loss: The Role of Sirtuin 1.
Heart Arrest
Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels.
Heart Diseases
1,25(OH)2 D3 improves cardiac dysfunction, hypertrophy and fibrosis through PARP1/SIRT1/mTOR related mechanisms in Type 1 diabetes.
A sirtuin link between metabolism and heart disease.
Acetylation of Mitochondrial Proteins in the Heart: The Role of SIRT3.
Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease.
Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet.
Exogenous Hydrogen Sul?de Postconditioning Protects Isolated Rat Hearts From Ischemia/Reperfusion Injury Through Sirt1/PGC-1? Signaling Pathway.
Mitochondrial SIRT3 and heart disease.
Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target.
Molecular mechanisms of doxorubicin-induced cardiotoxicity: novel roles of sirtuin 1-mediated signaling pathways.
Protection of the heart against ischemia/reperfusion by silent information regulator 1.
Receptor-Interacting Protein 140 represses Sirtuin 3 to facilitate hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction in cardiomyocytes.
SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection.
SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.
SIRT3: A New Regulator of Cardiovascular Diseases.
Sirtuin 1 Activation Reduces Transforming Growth Factor-?1-Induced Fibrogenesis and Affords Organ Protection in a Model of Progressive, Experimental Kidney and Associated Cardiac Disease.
Sirtuin3 protects aged human mesenchymal stem cells against oxidative stress and enhances efficacy of cell therapy for ischaemic heart diseases.
The Comparative Study on Expression of SIRT1 Signal Transduction by Xuefuzhuyu Capsule.
The Roles of SIRT1 in Cancer.
Heart Failure
Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3.
Application of a real-ambient fine particulate matter exposure system on different animal models.
Caffeic acid ethanolamide prevents cardiac dysfunction through sirtuin dependent cardiac bioenergetics preservation.
Cardiac Rehabilitation Increases SIRT1 Activity and ?-Hydroxybutyrate Levels and Decreases Oxidative Stress in Patients with HF with Preserved Ejection Fraction.
Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice.
Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice.
Correction to: Role of SIRT1 in Modulating Acetylation of the Sarco- Endoplasmic Reticulum Ca2+-ATPase in Heart Failure.
Downregulation of Sirt1 as aging change in advanced heart failure.
Elevated plasma Sirtuin2 level predicts heart failure after acute myocardial infarction.
Emerging beneficial roles of sirtuins in heart failure.
Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease.
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.
Endothelial Sirtuin 3 Dictates Glucose Transport to Cardiomyocyte and Sensitizes Pressure Overload-Induced Heart Failure.
High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss.
Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure.
Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53.
Kallistatin alleviates heart failure in rats by inhibiting myocardial inflammation and apoptosis via regulating sirt1.
Mangiferin prevents myocardial infarction-induced apoptosis and heart failure in mice by activating the Sirt1/FoxO3a pathway.
Metformin improves cardiac function in mice with heart failure after myocardial infarction by regulating mitochondrial energy metabolism.
MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction.
MicroRNA?138?5p drives the progression of heart failure via inhibiting sirtuin 1 signaling.
Mitochondrial Hyperacetylation in the Failing Hearts of Obese Patients Mediated Partly by a Reduction in SIRT3: The Involvement of the Mitochondrial Permeability Transition Pore.
Mitochondrial proteins in heart failure: The role of deacetylation by SIRT3.
Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease: Pathophysiological implications and therapeutic potential.
Non-histone lysine acetylated proteins in heart failure.
Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure.
Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity.
Protective mechanism of SIRT1 on Hcy-induced atrial fibrosis mediated by TRPC3.
Reduced SIRT1 expression correlates with enhanced oxidative stress in compensated and decompensated heart failure.
Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy.
Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure.
Resveratrol-enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice.
Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress.
Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure.
Roles of SIRT3 in heart failure: from bench to bedside.
Silent information regulator, Sirtuin 1, and age-related diseases.
Sirt1 Activity in PBMCs as a Biomarker of Different Heart Failure Phenotypes.
Sirt1 improves heart failure through modulating the NF-?B p65/microRNA-155/BNDF signaling cascade.
SIRT3 as a potential therapeutic target for heart failure.
Sirt3 attenuates doxorubicin-induced cardiac hypertrophy and mitochondrial dysfunction via suppression of Bnip3.
Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer.
SIRT3 in Cardiac Physiology and Disease.
SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications.
SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation.
SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION.
Sirtuin1 Regulates the Stem Cell Therapeutic Effects on Regenerative Capability for Treating Severe Heart Failure in a Juvenile Animal Model.
The role of SIRT2 in vascular-related and heart-related diseases: A review.
Heart Neoplasms
Expression of SIRT1 in Gastric Cardiac Cancer and Its Clinicopathologic Significance.
Heart Septal Defects, Ventricular
Genetic analysis of the SIRT1 gene promoter in ventricular septal defects.
Heart Valve Diseases
[Association between single nucleotide polymorphism in promoter region of SIRT1 gene and senile degenerative heart valvular disease].
Hemangiosarcoma
SIRT1 Expression Is Associated With Cell Proliferation in Angiosarcoma.
Hematologic Neoplasms
AML1-ETO promotes SIRT1 expression to enhance leukemogenesis of t(8;21) acute myeloid leukemia.
Autophagy maintains ubiquitination-proteasomal degradation of Sirt3 to limit oxidative stress in K562 leukemia cells.
Role of SIRT1 in hematologic malignancies.
SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia.
SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression.
SIRTUIN 1: regulating the regulator.
Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy.
Hepatic Encephalopathy
SIRT1 activation by resveratrol reverses atrophy of apical dendrites of hippocampal CA1 pyramidal neurons and neurobehavioral impairments in moderate grade hepatic encephalopathy rats.
Sirtuin-3 activation by honokiol restores mitochondrial dysfunction in the hippocampus of the hepatic encephalopathy rat model of ammonia neurotoxicity.
Hepatitis
Aryl hydrocarbon receptor (AHR) functions: Balancing opposing processes including inflammatory reactions.
Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway.
Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice.
SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy.
Suppression of SIRT1 activity in noncancerous tissues of HCC: possible association with non-B non-C hepatitis pathogenesis.
The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo.
Hepatitis A
The sirtuin inhibitor sirtinol inhibits hepatitis A virus (HAV) replication by inhibiting HAV internal ribosomal entry site activity.
Hepatitis B
AGK2, A SIRT2 Inhibitor, Inhibits Hepatitis B Virus Replication In Vitro And In Vivo.
An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases.
Hepatitis B virus X (HBX) protein upregulates ?-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase.
Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription.
MicroRNA-141 Targets Sirt1 and Inhibits Autophagy to Reduce HBV Replication.
Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma.
SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma.
SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis.
SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3-9 homolog 1 and SET domain containing 1A histone methyltransferases.
Sirtuin 1 regulates hepatitis B virus transcription and replication by targeting transcription factor AP-1.
Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis via the AKT/GSK-3?/?-Catenin Signaling Pathway.
The metabolic sensors FXR?, PGC-1?, and SIRT1 cooperatively regulate hepatitis B virus transcription.
The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo.
Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma.
Hepatitis, Alcoholic
The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3.
Hepatoblastoma
Single-walled carbon nanohorn aggregates promotes mitochondrial dysfunction-induced apoptosis in hepatoblastoma cells by targeting SIRT3.
Herpes Zoster
A novel role of SIRT2 in regulating gap junction communications via connexin-43 in bovine cumulus-oocyte complexes.
Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice.
Resveratrol Improves the Mitochondrial Function and Fertilization Outcome of Bovine Oocytes.
SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.
Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis.
HIV Infections
Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation.
Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide.
HIV-Associated Lipodystrophy Syndrome
Investigation of SIRT1 gene variants in HIV-associated lipodystrophy and metabolic syndrome.
Hodgkin Disease
Expression of Sirt1 and FoxP3 in classical Hodgkin lymphoma and tumor infiltrating lymphocytes: Implications for immune dysregulation, prognosis and potential therapeutic targeting.
Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation.
Huntington Disease
A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase.
A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.
Amelioration of Huntington's disease phenotypes by Beta-Lapachone is associated with increases in Sirt1 expression, CREB phosphorylation and PGC-1? deacetylation.
An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease.
Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway.
Cerebellar Predominant Increase in mRNA Expression Levels of Sirt1 and Sirt3 Isoforms in a Transgenic Mouse Model of Huntington's Disease.
Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington's Disease Models.
Correction: SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice.
Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo.
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.
Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1.
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Finding a sirtuin truth in Huntington's disease.
Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration.
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.
Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics.
Modulation of sirtuins: new targets for antiageing.
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.
Neuronal protection by sirtuins in Alzheimer's disease.
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets.
Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner.
Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease.
Resveratrol--a boon for treating Alzheimer's disease?
Safety, pharmacokinetics, pharmacogenomics and QT concentration-effect modelling of the SirT1 inhibitor selisistat in healthy volunteers.
SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice.
SIRT1 and neuronal diseases.
SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases.
SIRT1 and SIRT2: emerging targets in neurodegeneration.
Sirt1 in cerebral ischemia.
SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease.
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway.
SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo.
SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke.
SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia.
SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells.
SIRT2 regulates insulin sensitivity in insulin resistant neuronal cells.
SIRT3 and mitochondrial metabolism in neurodegenerative diseases.
Sirtuin 1 activator SRT2104 protects Huntington's disease mice.
Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease.
Sirtuin deacetylases in neurodegenerative diseases of aging.
The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models.
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
trans-(-)-?-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease.
Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective.
Hyperalgesia
Antioxidant modulation of sirtuin 3 during acute inflammatory pain: The ROS control.
Down-regulation of microRNA-34c-5p alleviates neuropathic pain via the SIRT1/STAT3 signaling pathway in rat models of chronic constriction injury of sciatic nerve.
Intrathecal Injection of Resveratrol Attenuates Burn Injury Pain by Activating Spinal Sirtuin 1.
Involvement of spinal SIRT1 in development of chronic constriction injury induced neuropathic pain in rats.
Overexpression of SIRT2 Alleviates Neuropathic Pain and Neuroinflammation Through Deacetylation of Transcription Factor Nuclear Factor-Kappa B.
Reduction of Silent Information Regulator 1 Activates Interleukin-33/ST2 Signaling and Contributes to Neuropathic Pain Induced by Spared Nerve Injury in Rats.
Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib.
SIRT1 Activation Attenuates Bone Cancer Pain by Inhibiting mGluR1/5.
SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats.
Sirt2 in the Spinal Cord Regulates Chronic Neuropathic Pain Through Nrf2-Mediated Oxidative Stress Pathway in Rats.
Upregulation of silent information regulator 1 alleviates mitochondrial dysfunction in the trigeminal nucleus caudalis in a rat model of chronic migraine.
Hyperandrogenism
Decreased brain and muscle ARNT-like protein 1 expression mediated the contribution of hyperandrogenism to insulin resistance in polycystic ovary syndrome.
Hypercholesterolemia
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.
Hyperglycemia
Baicalin regulates SirT1/STAT3 pathway and restrains excessive hepatic glucose production.
Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes.
Differential Telomere Shortening in Blood versus Arteries in an Animal Model of Type 2 Diabetes.
Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes.
Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice.
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.
Formononetin Ameliorates Diabetic Neuropathy by Increasing Expression of SIRT1 and NGF.
Formononetin Treatment in Type 2 Diabetic Rats Reduces Insulin Resistance and Hyperglycemia.
Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation.
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.
High glucose concentration suppresses a SIRT2 regulated pathway that enhances neurite outgrowth in cultured adult sensory neurons.
High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway.
Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance.
P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1.
Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6.
Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication-Potential Implication of Sirtuins.
Protective Role of SIRT1 in Diabetic Vascular Dysfunction.
Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1.
Resveratrol ameliorates hyperglycemia-induced renal tubular oxidative stress damage via modulating the SIRT1/FOXO3a pathway.
Resveratrol improves sperm DNA quality and reproductive capacity in type 1 diabetes.
Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.
SIRT1 activation inhibits hyperglycemia-induced apoptosis by reducing oxidative stress and mitochondrial dysfunction in human endothelial cells.
SIRT1 activation promotes angiogenesis in diabetic wounds by protecting endothelial cells against oxidative stress.
SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis.
SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and ?-cell formation.
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.
Sirt3 Ameliorates Oxidative Stress and Mitochondrial Dysfunction After Intracerebral Hemorrhage in Diabetic Rats.
Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin.
Sodium meta-arsenite ameliorates hyperglycemia in obese diabetic db/db mice by inhibition of hepatic gluconeogenesis.
Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia.
The Relationship between Diabetes Mellitus Type II and Intervertebral Disc Degeneration in Diabetic Rodent Models: A Systematic and Comprehensive Review.
The role of SIRT1 in diabetic cardiomyopathy.
Up-regulation of GLP-1R improved the dysfunction of late EPCs under hyperglycemia by regulating SIRT1 expression.
Hyperhomocysteinemia
Picroside II attenuates hyperhomocysteinemia-induced endothelial injury by reducing inflammation, oxidative stress and cell apoptosis.
Hyperinsulinism
Adipose depot-specific upregulation of Ucp1 or mitochondrial oxidative complex proteins are early consequences of genetic insulin reduction in mice.
Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity.
Low dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia.
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity.
Hyperlipidemias
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice.
Antihyperlipidemic and Hepatoprotective Properties of Vitamin B6 Supplementation in Rats with High-Fat Diet-Induced Hyperlipidemia.
Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway.
Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice.
Low serum level of sirtuin 1 predicts coronary atherosclerosis plaques during computed tomography angiography among an asymptomatic cohort.
Negative Regulation of SIRT1 by IRF9 Involved in Hyperlipidemia Acute Pancreatitis Associated with Kidney Injury.
Novel PPAR pan agonist, ZBH ameliorates hyperlipidemia and insulin resistance in high fat diet induced hyperlipidemic hamster.
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase.
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome.
Sirt3 Deficiency Increased the Vulnerability of Pancreatic Beta Cells to Oxidative Stress-Induced Dysfunction.
Hyperphosphatemia
Sirtuin-1 and Its Relevance in Vascular Calcification.
[Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Regulatory Mechanism of Mammalian Sirtuin SIRT1 in Vascular calcification: impact of vascular smooth muscle cell senescence].
Hypersensitivity
Protective effect of miR-138-5p inhibition modified human mesenchymal stem cell on ovalbumin-induced allergic rhinitis and asthma syndrome.
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity.
Sirt1 negatively regulates Fc?RI-mediated mast cell activation through AMPK- and PTP1B-dependent processes.
SIRT3 alleviates neuropathic pain by deacetylating FoxO3a in the spinal dorsal horn of diabetic model rats.
Sirtuin 1 promotes Th2 responses and airway allergy by repressing peroxisome proliferator-activated receptor-? activity in dendritic cells.
Hypertension
15-HETE protects pulmonary artery smooth muscle cells against apoptosis via SIRT1 regulation during hypoxia.
?-Linolenic acid but not linolenic acid protects against hypertension: critical role of SIRT3 and autophagic flux.
A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease.
Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity.
Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?
Angiotensin II-induced overexpression of sirtuin 1 contributes to enhanced expression of Gi? proteins and hyperproliferation of vascular smooth muscle cells.
Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure.
Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood.
Crosstalk between mitochondrial hyperacetylation and oxidative stress in vascular dysfunction and hypertension.
Decreased Urinary Levels of SIRT1 as Non-Invasive Biomarker of Early Renal Damage in Hypertension.
Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1.
Effect of Aldosterone on Senescence and Proliferation Inhibition of Endothelial Progenitor Cells Induced by Sirtuin 1 (SIRT1) in Pulmonary Arterial Hypertension.
Effect of Sucrose Ingestion at the End of a Critical Window that Increases Hypertension Susceptibility on Peripheral Mechanisms Regulating Blood Pressure in Rats. Role of Sirtuins 1 and 3.
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.
Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1.
Fibroblast growth factor 21 protects the heart from angiotensin II-induced cardiac hypertrophy and dysfunction via SIRT1.
FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway.
Food restriction improves glucose and lipid metabolism through Sirt1 expression: a study using a new rat model with obesity and severe hypertension.
Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort.
Hypertension and Mitochondrial Oxidative Stress Revisited: Sirtuin 3, the Improved "Antioxidant".
Inhibition of Mitochondrial Oxidative Damage Improves Reendothelialization Capacity of Endothelial Progenitor Cells via SIRT3 (Sirtuin 3)-Enhanced SOD2 (Superoxide Dismutase 2) Deacetylation in Hypertension.
Letter by Zhou et al Regarding Article, "Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress".
Maternal Melatonin Therapy Attenuated Maternal High-Fructose Combined with Post-Weaning High-Salt Diets-Induced Hypertension in Adult Male Rat Offspring.
Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies.
MicroRNA-140-5p aggravates hypertension and oxidative stress of atherosclerosis via targeting Nrf2 and Sirt2.
Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress.
Mitochondrial Isolevuglandins Contribute to Vascular Oxidative Stress and Mitochondria-Targeted Scavenger of Isolevuglandins Reduces Mitochondrial Dysfunction and Hypertension.
NAMPT/SIRT1 Attenuate Ang II-Induced Vascular Remodeling and Vulnerability to Hypertension by Inhibiting the ROS/MAPK Pathway.
Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice.
Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension.
Response by Dikalova and Dikalov to Letter Regarding Article, "Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress".
Resveratrol Prevents Right Ventricle Dysfunction, Calcium Mishandling, and Energetic Failure via SIRT3 Stimulation in Pulmonary Arterial Hypertension.
Resveratrol prevents the combined maternal plus postweaning high-fat-diets-induced hypertension in male offspring.
SIRT1, heme oxygenase-1 and NO-mediated vasodilation in a human model of endogenous angiotensin II type 1 receptor antagonism: implications for hypertension.
Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension.
Sirt3 promotes sensitivity to sunitinib-induced cardiotoxicity via inhibition of GTSP1/JNK/autophagy pathway in vivo and in vitro.
Sirtuin 1 as a potential therapeutic target in pulmonary artery hypertension.
Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation: role in pulmonary arterial hypertension.
Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.
SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION.
Targeting histone acetylation in pulmonary hypertension and right ventricular hypertrophy.
The association between left ventricular mass index and serum sirtuin 3 level in patients with hypertension.
The effect of SIRT1 gene polymorphisms on ambulatory blood pressure of hypertensive patients in the Kazakh population.
The Emerging Role of Sirtuin 1 in Cellular Metabolism, Diabetes Mellitus, Diabetic Kidney Disease and Hypertension.
The influence of ethnicity in the association of WC, WHR, hypertension and PGC-1? (Gly482Ser), UCP2 -866 G/A and SIRT1 -1400 T/C polymorphisms with T2D in the population of Punjab.
The TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling.
Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension.
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Hypertension, Portal
Endothelin-1 in portal hypertension: The intricate role of hepatic stellate cells.
MiR-9a-5p regulates proliferation and migration of hepatic stellate cells under pressure through inhibition of Sirt1.
Hypertension, Pulmonary
Sirt3 Deficiency Does not Augment Hypoxia-Induced Pulmonary Hypertension.
Hyperthyroidism
Thyroid hormone regulation of Sirtuin 1 expression and implications to integrated responses in fasted mice.
Hypertrophy, Left Ventricular
Left ventricular hypertrophy is associated with increased sirtuin level in newly diagnosed hypertensive patients.
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside.
Sirt1 hyperexpression in SHR heart related to left ventricular hypertrophy.
Sirt3 Deficiency Does not Augment Hypoxia-Induced Pulmonary Hypertension.
Hypoglycemia
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.
Hypothyroidism
Fetal Hypothyroidism Impairs Aortic Vasorelaxation Responses in Adulthood: Involvement of Hydrogen Sulfide and Nitric Oxide Cross talk.
The effect of methimazole-induced postnatal hypothyroidism on the retinal maturation and on the Sirtuin 2 level.
Idiopathic Pulmonary Fibrosis
Sirt1 antisense long non-coding RNA attenuates pulmonary fibrosis through sirt1-mediated epithelial-mesenchymal transition.
SIRT3 Overexpression Ameliorates Asbestos-Induced Pulmonary Fibrosis, mt-DNA Damage, and Lung Fibrogenic Monocyte Recruitment.
Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-?1/Smad2 and nuclear factor-?B signaling pathways in human fetal lung fibroblasts.
Targeting anti-aging protein sirtuin (Sirt) in the diagnosis of idiopathic pulmonary fibrosis.
Infarction, Middle Cerebral Artery
Calorie restriction attenuates cerebral ischemic injury via increasing SIRT1 synthesis in the rat.
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Ischemia Injury induces mPTP opening by reducing Sirt3.
Maresin 1 attenuates the inflammatory response and mitochondrial damage in mice with cerebral ischemia/reperfusion in a SIRT1-dependent manner.
N-Palmitoylethanolamide-Oxazoline Protects against Middle Cerebral Artery Occlusion Injury in Diabetic Rats by Regulating the SIRT1 Pathway.
Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance.
Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-?B and Nrf2/Keap-1 Signaling.
Neuroprotective epi-drugs quench the inflammatory response and microglial/macrophage activation in a mouse model of permanent brain ischemia.
Post-Stroke Microglia Induce Sirtuin2 Expression to Suppress the Anti-inflammatory Function of Infiltrating Regulatory T Cells.
QKI 6 ameliorates CIRI through promoting synthesis of triglyceride in neuron and inhibiting neuronal apoptosis associated with SIRT1-PPAR?-PGC-1? axis.
Sirt1-ROS-TRAF6 Signaling-Induced Pyroptosis Contributes to Early Injury in Ischemic Mice.
SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke.
Sirt3 deficiency impairs neurovascular recovery in ischemic stroke.
Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke.
Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1?/VEGF Signaling and Blood-Brain Barrier Integrity.
Infections
2,3,7,8-Tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of SIRT3 and cytoskeletal reorganization.
A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection.
A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication.
Aberrant Decrease of the Endogenous SIRT3 and Increases of Acetylated Proteins in Scrapie Infected Cell Line SMB-S15 and in the Brains of Experimental Mice.
AGK2, A SIRT2 Inhibitor, Inhibits Hepatitis B Virus Replication In Vitro And In Vivo.
Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis.
Celecoxib sensitizes Staphylococcus aureus to antibiotics in macrophages by modulating SIRT1.
Clinical significance of sirtuin 1 level in sepsis: correlation with disease risk, severity, and mortality risk.
Crosstalk of PD-1 signaling with the SIRT1/FOXO-1 axis during the progression of visceral leishmaniasis.
Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i.
Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia.
EV71 infection induces cell apoptosis through ROS generation and SIRT1 activation.
Helicobacter pylori infection increases sirt2 gene expression in gastric epithelial cells of gastritis patients.
Helicobacter pylori inhibits autophagic flux and promotes its intracellular survival and colonization by down-regulating SIRT1.
Hexosamines stimulate apoptosis by altering Sirt1 action and levelsin rodent pancreatic {beta}-cells.
Histone deficiency and accelerated replication stress in T cell aging.
Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis.
Host sirtuin 2 as an immunotherapeutic target against tuberculosis.
Human sirtuin 2 localization, transient interactions, and impact on the proteome point to its role in intracellular trafficking.
Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy.
Infection Reveals a Modification of SIRT2 Critical for Chromatin Association.
Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology.
Involvement of FOXO transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type II-induced apoptosis.
Involvement of SIRT1 in amelioration of schistosomiasis-induced hepatic fibrosis by genistein.
Legionella pneumophila Infection Rewires the Acanthamoeba castellanii Transcriptome, Highlighting a Class of Sirtuin Genes.
Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis.
Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis.
MicroRNA-217 promotes angiogenesis of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and FOXO3A.
microRNA-34a aggravates coxsackievirus B3-induced apoptosis of cardiomyocytes through the SIRT1-p53 pathway.
microRNA-579 upregulation mediates death of human macrophages with mycobacterium tuberculosis infection.
MiR-199a-5p promotes migration and tube formation of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and eNOS.
Modulation of the AMPK/Sirt1 axis during neuronal infection by herpes simplex virus type 1.
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.
Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control.
MYO1F regulates antifungal immunity by regulating acetylation of microtubules.
Nutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection.
Papers of note in Science Immunology2 (9).
PHARMACOLOGICAL SIRT1 ACTIVATION IMPROVES MORTALITY AND MARKEDLY ALTERS TRANSCRIPTIONAL PROFILES THAT ACCOMPANY EXPERIMENTAL SEPSIS.
Plant defence suppression is mediated by a fungal sirtuin during rice infection by Magnaporthe oryzae.
Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma.
Role of Sirt1 in innate immune mechanisms against Mycobacterium tuberculosis via the inhibition of TAK1 activation.
Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy.
Scrapie Infection in Experimental Rodents and SMB-S15 Cells Decreased the Brain Endogenous Levels and Activities of Sirt1.
Shrimp SIRT1 activates of the WSSV IE1 promoter independently of the NF-?B binding site.
Sirt1 Activation Markedly Alters Transcription Profiles and Improves Outcome in Experimental Sepsis.
Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax.
Sirt1 Gene Expression and Gastric Epithelial Cells Tumor Stage in Patients with Helicobacter pylori Infection
SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?
SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis.
SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-?B signaling.
SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux.
SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages.
SIRT2: Controversy and multiple roles in disease and physiology.
SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions.
SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3-9 homolog 1 and SET domain containing 1A histone methyltransferases.
Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus-Induced Immune Responses.
Sirtuin 1 regulates hepatitis B virus transcription and replication by targeting transcription factor AP-1.
Sirtuin 1 regulates mitochondrial function and immune homeostasis in respiratory syncytial virus infected dendritic cells.
Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain.
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis via the AKT/GSK-3?/?-Catenin Signaling Pathway.
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death.
Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis.
Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses.
Sirtuin inhibits M. tuberculosis -induced apoptosis in macrophage through glycogen synthase kinase-3?.
Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice.
Sirtuins in the phylum Basidiomycota: A role in virulence in Cryptococcus neoformans.
Suppressive effects of sirtinol on human cytomegalovirus (hCMV) infection and hCMV-induced activation of molecular mechanisms of senescence and production of reactive oxygen species.
The antiviral sirtuin 3 bridges protein acetylation to mitochondrial integrity and metabolism during human cytomegalovirus infection.
The clinical significance of the SIRT2 expression level in the early stage of sepsis patients.
The contribution of Toll-like receptor 2 to the innate recognition of a Leishmania infantum silent information regulator 2 protein.
The dominant model analysis of Sirt3 genetic variants is associated with susceptibility to tuberculosis in a Chinese Han population.
The Pleiotropic Function of Human Sirtuins as Modulators of Metabolic Pathways and Viral Infections.
The sirtuin inhibitor sirtinol inhibits hepatitis A virus (HAV) replication by inhibiting HAV internal ribosomal entry site activity.
Warm, Sweetened Milk at the Twilight of Immunity - Alzheimer's Disease - Inflammaging, Insulin Resistance, M. paratuberculosis and Immunosenescence.
[Coronavirus disease (COVID-19) and sirtuins].
{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM) inhibited human hepatocellular carcinoma growth through upregulation of Sirtuin-3 (SIRT3).
Infertility
3 SIRT1-A POSSIBLE MARKER FOR REPRODUCTIVE AGING OF IN VIVO-DERIVED BOVINE OOCYTES?
Absence of Sirtuin 1 impairs the testicular development in cattleyak by inactivating SF-1.
Melatonin regulates the cross-talk between autophagy and apoptosis by SIRT3 in testicular Leydig cells.
Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility.
Infertility, Male
MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death.
Seminal SIRT1 expression in infertile oligoasthenoteratozoospermic men with varicocoele.
The histone deacetylase SIRT1 controls male fertility in mice through regulation of hypothalamic-pituitary gonadotropin signaling.
Inflammatory Bowel Diseases
Activation of sirtuin 1 by catalpol-induced down-regulation of microRNA-132 attenuates endoplasmic reticulum stress in colitis.
Dual role of sirtuin 1 in inflammatory bowel disease.
SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.
Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3(+) T-regulatory cells.
The Protection Effect of Resveratrol Against Radiation-Induced Inflammatory Bowel Disease via NLRP-3 Inflammasome Repression in Mice.
Influenza, Human
Enhanced Viral Replication by Cellular Replicative Senescence.
Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway.
Insulin Resistance
(Healthy) ageing: focus on iodothyronines.
A defect in the activity of Delta6 and Delta5 desaturases may be a factor predisposing to the development of insulin resistance syndrome.
A novel SIRT1 activator E6155 improves insulin sensitivity in type 2 diabetic KKA
A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators.
AAV-mediated Sirt1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance.
Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes (L-serine activates SIRT1 in C2C12 myotubes).
Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi.
Activation of the AMPK/Sirt1 pathway by a leucine-metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism and increases life span in Caenorhabditis elegans.
Acupuncture Targeting SIRT1 in the Hypothalamic Arcuate Nucleus Can Improve Obesity in High-Fat-Diet-Induced Rats with Insulin Resistance via an Anorectic Effect.
Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue.
Adipocyte SIRT1 knockout promotes PPAR? activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity.
Adipose Tissue SIRT1 Regulates Insulin Sensitizing and Anti-Inflammatory Effects of Berberine.
Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity.
Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Type 2 Diabetes Show Reduced "Stemness" through an Altered Secretome Profile, Impaired Anti-Oxidative Protection, and Mitochondrial Dynamics Deterioration.
Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release.
Adrenergic signaling and oxidative stress: a role for sirtuins?
Age-Associated Weight Gain, Leptin, and SIRT1: A Possible Role for Hypothalamic SIRT1 in the Prevention of Weight Gain and Aging through Modulation of Leptin Sensitivity.
Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway.
Alzheimer's Disease and Diabetes: Insulin Signaling as the Bridge Linking Two Pathologies.
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol.
An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance.
Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?
Application of resveratrol in diabetes: rationale, strategies and challenges.
Association of Genetic Variants of SIRT1 With Type 2 Diabetes Mellitus.
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis.
Bone Marrow Mesenchymal Stem Cells-Derived Exosomal MiR-29b-3p Regulates Aging-Associated Insulin Resistance.
Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats.
CLOCK and BMAL1 regulate muscle insulin sensitivity via SIRT1 in male mice.
CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity via SIRT1.
Connecting the dots: molecular and epigenetic mechanisms in type 2 diabetes.
Consumption of a Mango Fruit Powder Protects Mice from High-Fat Induced Insulin Resistance and Hepatic Fat Accumulation.
Correction to: Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes.
Decreased brain and muscle ARNT-like protein 1 expression mediated the contribution of hyperandrogenism to insulin resistance in polycystic ovary syndrome.
DEL-1 ameliorates high-fat diet-induced insulin resistance in mouse skeletal muscle through SIRT1/SERCA2-mediated ER stress suppression.
Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia.
Depletion of Sirt3 leads to the impairment of adipogenic differentiation and insulin resistance via interfering mitochondrial function of adipose-derived human mesenchymal stem cells.
Diet-induced obesity and insulin resistance are associated with brown fat degeneration in SIRT1-deficient mice.
Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators.
Distinctive Roles of Sirtuins on Diabetes, Protective or Detrimental?
Docosahexaenoic acid attenuates adipose tissue angiogenesis and insulin resistance in high fat diet-fed middle-aged mice via a sirt1-dependent mechanism.
Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1.
Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity.
Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms.
Effects of metformin and Exenatide on insulin resistance and AMPK?-SIRT1 molecular pathway in PCOS rats.
Effects of myeloid sirtuin 1 deficiency on hypothalamic neurogranin in mice fed a high-fat diet.
Effects of resveratrol on the amelioration of insulin resistance in KKA(y) mice.
Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice.
ELECTROACUPUNCTURE IMPROVES INSULIN SENSITIVITY IN HIGH-FAT DIET-INDUCED INSULIN RESISTANT RATS BY ACTIVATING SIRT1 AND GLUT4 IN QUADRICEPS FEMORIS.
Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism.
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.
Fatty acid type-specific regulation of SIRT1 does not affect insulin sensitivity in human skeletal muscle.
Formononetin Treatment in Type 2 Diabetic Rats Reduces Insulin Resistance and Hyperglycemia.
FoxO1 mediates an autofeedback loop regulating SIRT1 expression.
Functional genetic variants within the SIRT2 gene promoter in type 2 diabetes mellitus.
Gastric Bypass Surgery Improves the Skeletal Muscle Ceramide/S1P Ratio and Upregulates the AMPK/ SIRT1/ PGC-1? Pathway in Zucker Diabetic Fatty Rats.
GLP?1 improves palmitate?induced insulin resistance in human skeletal muscle via SIRT1 activity.
Haplotypes of the Mutated SIRT2 Promoter Contributing to Transcription Factor Binding and Type 2 Diabetes Susceptibility.
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver.
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.
Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions.
High dose of dietary resveratrol enhances insulin sensitivity in healthy rats but does not lead to metabolite concentrations effective for SIRT1 expression.
High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression.
Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction.
HOTAIR participates in hepatic insulin resistance via regulating SIRT1.
Increased Sirt1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice.
Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide.
Influence of resveratrol on endoplasmic reticulum stress and expression of adipokines in adipose tissues/adipocytes induced by high-calorie diet or palmitic acid.
iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-?B and p53.
Insulin signaling and life span.
Involvement of nitric oxide synthase/nitric oxide pathway in the regulation of SIRT1-AMPK crosstalk in podocytes: Impact on glucose uptake.
Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy.
Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice.
Leucine Supplementation Increases SIRT1 Expression and Prevents Mitochondrial Dysfunction and Metabolic Disorders in High Fat Diet-induced Obese Mice.
Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.
Low dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia.
Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1.
Macrophage {alpha}1-AMP-activated protein kinase ({alpha}1AMPK) antagonizes fatty acid-induced inflammation through SIRT1.
Metabolic and energetic benefits of microRNA-22 inhibition.
Metformin ameliorates insulin resistance in L6 rat skeletal muscle cells through upregulation of SIRT3.
Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial.
Metformin in contrast to berberine reversed arsenic-induced oxidative stress in mitochondria from rat pancreas probably via Sirt3-dependent pathway.
Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK.
MiR-138-5p affects insulin resistance to regulate type 2 diabetes progression through inducing autophagy in HepG2 cells by regulating SIRT1.
miR-221 negatively regulates inflammation and insulin sensitivity in white adipose tissue by repression of sirtuin-1 (SIRT1).
MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1).
Moderate SIRT1 overexpression protects against brown adipose tissue inflammation.
Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span.
Modulation of SIRT1-Foxo1 Signaling axis by Resveratrol: Implications in Skeletal Muscle Aging and Insulin Resistance.
Modulation of the Inflammatory Status of Macrophages and Their Paracrine Effect on the Sensitivity of Adipocytes to Insulin with Sirtuin and PPAR? Receptor Activators.
Molecular docking and mechanisms of fusaric acid induced mitochondrial sirtuin aberrations in glycolytically and oxidatively poised human hepatocellular carcinoma (HepG2) cells.
Myeloid SIRT1 regulates macrophage infiltration and insulin sensitivity in mice fed a high-fat diet.
Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets.
Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice.
N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation.
Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues.
New Amphiphilic Squalene Derivative Improves Metabolism of Adipocytes Differentiated From Diabetic Adipose-Derived Stem Cells and Prevents Excessive Lipogenesis.
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.
Novel PPAR pan agonist, ZBH ameliorates hyperlipidemia and insulin resistance in high fat diet induced hyperlipidemic hamster.
Nutritional biomarkers: Current view and future perspectives.
Obesity Is Associated With Low NAD(+)/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins.
Opposite Effects of Metabolic Syndrome and Calorie Restriction on Thrombotic Disease: Head and Tail of Same Coin-Resveratrol's Role.
Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1.
Oral AGE restriction ameliorates insulin resistance in obese individuals with the metabolic syndrome: a randomised controlled trial.
Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans.
Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance.
Peripheral and central regulation of insulin by the intestine and microbiome.
Peroxisome Proliferator-Activated Receptor -?/?, -? Agonists and Resveratrol Modulate Hypoxia Induced Changes in Nuclear Receptor Activators of Muscle Oxidative Metabolism.
PGRN exerts inflammatory effects via SIRT1-NF-?B in adipose insulin resistance.
Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6.
Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1.
Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication-Potential Implication of Sirtuins.
Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation.
Probiotic assisted weight management as a main factor for glycemic control in patients with type 2 diabetes: a randomized controlled trial.
Protectin DX ameliorates palmitate-induced hepatic insulin resistance through AMPK/SIRT1-mediated modulation of fetuin-A and SeP expression.
Protection Against Insulin Resistance by Apolipoprotein M/Sphingosine 1-Phosphate.
Publisher Correction: Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice.
Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression.
Regulation of SIRT1 in vascular smooth muscle cells from streptozotocin-diabetic rats.
Relationship between insulin sensitivity and gene expression in human skeletal muscle.
Resistin mitigates stemness and metabolic profile of human adipose-derived mesenchymal stem cells via insulin resistance.
Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1.
Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.
Resveratrol and life extension.
Resveratrol attenuates excessive ethanol exposure induced insulin resistance in rats via improving NAD(+) /NADH ratio.
Resveratrol attenuates intermittent hypoxia-induced insulin resistance in rats: involvement of Sirtuin 1 and the phosphatidylinositol-4,5-bisphosphate 3-kinase/AKT pathway.
Resveratrol Improves Adipose Insulin Signaling and Reduces the Inflammatory Response in Adipose Tissue of Rhesus Monkeys on High-Fat, High-Sugar Diet.
Resveratrol improves high-fat diet induced insulin resistance by rebalancing subsarcolemmal mitochondrial oxidation and antioxidantion.
Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of AMP-activated protein kinase and sirtuin 1 activities.
Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK.
Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary.
Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner.
Resveratrol vs. calorie restriction: Data from rodents to humans.
Resveratrol-activated SIRT1 in liver and pancreatic ?-cells: a Janus head looking to the same direction of metabolic homeostasis.
Resveratrol: a relevant pharmacological approach for the treatment of metabolic syndrome?
Roles and Tissue Source of Adiponectin Involved in Lifestyle Modifications.
Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice.
Serum sirtuin 1 levels in patients with polycystic ovary syndrome.
Short-Term Treatment With Rapamycin and Dietary Restriction Have Overlapping and Distinctive Effects in Young Mice.
Silencing insulin resistance through SIRT1.
Silent information regulator, Sirtuin 1, and age-related diseases.
Silymarin ameliorates the disordered glucose metabolism of mice with diet-induced obesity by activating the hepatic SIRT1 pathway.
Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.
SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats.
SIRT1 Activation by Natural Phytochemicals: An Overview.
Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice.
SIRT1 and insulin resistance.
Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function.
SIRT1 attenuates high glucose-induced insulin resistance via reducing mitochondrial dysfunction in skeletal muscle cells.
SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150.
SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance.
SIRT1 deacetylates mitochondrial trifunctional enzyme ? subunit to inhibit ubiquitylation and decrease insulin resistance.
Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction.
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.
SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting.
SirT1 gain of function increases energy efficiency and prevents diabetes in mice.
SIRT1 gene variants are related to risk of childhood obesity.
SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention--the TULIP Study.
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.
SIRT1 in Astrocytes Regulates Glucose Metabolism and Reproductive Function.
SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential.
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity.
SIRT1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats.
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.
SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity.
SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding.
SIRT1 overexpression in skeletal muscle in vivo induces increased insulin sensitivity and enhanced complex I but not complex II-V functions in individual subsarcolemmal and intermyofibrillar mitochondria.
SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models.
SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.
SIRT1 Regulation in Ageing and Obesity.
SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol.
SIRT1-AMPK crosstalk is involved in high glucose-dependent impairment of insulin responsiveness in primary rat podocytes.
SIRT1: a promising therapeutic target in type 2 diabetes mellitus.
SIRT2 knockout exacerbates insulin resistance in high fat-fed mice.
SIRT2 negatively regulates insulin resistance in C2C12 skeletal muscle cells.
SIRT2 regulates insulin sensitivity in insulin resistant neuronal cells.
SIRT3 as a Regulator of Non-alcoholic Fatty Liver Disease.
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome.
SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity.
SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat-Fed Mice.
Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4?.
Sirtuin biology and relevance to diabetes treatment.
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.
Sirtuins and Insulin Resistance.
Sirtuins as possible drug targets in type 2 diabetes.
Sirtuins: novel targets for metabolic disease in drug development.
Sirtuins: novel targets for metabolic disease.
Skeletal Muscle Gene Expression Profile in Response to Caloric Restriction and Aging: A Role for SirT1.
Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice.
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia.
Supplementation with Red Wine Extract Increases Insulin Sensitivity and Peripheral Blood Mononuclear Sirt1 Expression in Nondiabetic Humans.
Suppression of SIRT1 in Diabetic Conditions Induces Osteogenic Differentiation of Human Vascular Smooth Muscle Cells via RUNX2 Signalling.
Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice.
Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity?
Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis.
The Brain: A New Organ for the Metabolic Actions of SIRT1.
The effect of adipocyte-macrophage cross-talk in obesity-related breast cancer.
The effect of aerobic, resistance, and combined training on PPAR-?, SIRT1 gene expression, and insulin resistance in high-fat diet-induced NAFLD male rats.
The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial.
The effects of Sea buckthorn seed protein on glucose metabolism in streptozotocin-induced diabetic ICR mice.
The effects of trans-resveratrol on insulin resistance, inflammation, and microbiota in men with the metabolic syndrome: A pilot randomized, placebo-controlled clinical trial.
The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1.
The Gender Association of the SIRT1 rs7895833 Polymorphism with Pediatric Obesity: A 3-Year Panel Study.
The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing.
The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.
The probable role of insulin resistance and SIRT1 proteins in the Alzheimer's disease.
The role of sirtuin proteins in obesity.
Therapeutic potential of activators and inhibitors of sirtuins.
Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway.
TRB3 stimulates SIRT1 degradation and induces insulin resistance by lipotoxicity via COP1.
Treatment with SRT1720, a SIRT1 Activator, Ameliorates Fatty Liver with Reduced Expression of Lipogenic Enzymes in MSG Mice.
Trifolium pratense (Red Clover) Improve SIRT1 Expression and Glycogen Content in High Fat Diet-Streptozotocin Induced Type 2 Diabetes in Rats.
Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: A pilot study.
Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial.
Vitamin K2 Alleviates Insulin Resistance in Skeletal Muscle by Improving Mitochondrial Function Via SIRT1 Signaling.
Zinc, copper, sirtuin 1 concentration, and glucose metabolism parameters in the blood of women with polycystic ovary syndrome.
[Expression of Sirtuin 1 in visceral adipose tissue in Tibetan mini-pigs with obesity and insulin resistance induced by high fat/cholesterol diet].
[Progress of Research on Mechanism of Acupuncture for Diabetes Mellitus].
[Rhein promotes the expression of SIRT1 in kidney tissues of type 2 diabetic rat].
[Rosuvastatin improves insulin sensitivity in overweight rats induced by high fat diet. Role of SIRT1 in adipose tissue.]
[The role of SIRT1 in the pathogenesis of insulin resistance in skeletal muscle].
Insulinoma
High glucose-induced PRDX3 acetylation contributes to glucotoxicity in pancreatic ?-cells: Prevention by Teneligliptin.
Intellectual Disability
Biochemical insight into pseudouridine synthase 7 (PUS7) as a novel interactor of sirtuin, SIRT1.
Can Sir(2) regulate cancer?
Neurodegeneration-associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells.
SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome.
Sirtuin activators and inhibitors.
Intervertebral Disc Degeneration
Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration.
Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis.
MiR-138-5p promotes TNF-?-induced apoptosis in human intervertebral disc degeneration by targeting SIRT1 through PTEN/PI3K/Akt signaling.
Mitophagy in degenerative joint diseases.
Resveratrol could reverse the expression of SIRT1 and MMP-1 in vitro.
Role of Sirt1 Plays in Nucleus Pulposus Cells and Intervertebral Disc Degeneration.
SIRT1 Inhibits the Catabolic Effect of IL-1? Through TLR2/SIRT1/NF-?B Pathway in Human Degenerative Nucleus Pulposus Cells.
SIRT1 plays a Protective role in Intervertebral Disc Degeneration in a Puncture-Induced Rodent model.
Sirt1 suppresses MCP-1 production during the intervertebral disc degeneration by inactivating AP-1 subunits c-Fos/c-Jun.
SIRT3 mitigates intervertebral disc degeneration by delaying oxidative stress-induced senescence of nucleus pulposus cells.
SIRT3 retards intervertebral disc degeneration by anti-oxidative stress by activating the SIRT3/FOXO3/SOD2 signaling pathway.
Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration.
Small molecule natural compound agonist of SIRT3 as a therapeutic target for the treatment of intervertebral disc degeneration.
The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis.
Intervertebral Disc Displacement
Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis.
Iron Deficiencies
Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2.
Iron Overload
miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload.
PPAR? agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and ?-catenin signaling.
SIRT3 Deficiency Sensitizes Angiotensin-II-Induced Renal Fibrosis.
Ischemic Stroke
A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia.
Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome.
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Emerging Roles of Sirtuins in Ischemic Stroke.
Ischemia Injury induces mPTP opening by reducing Sirt3.
Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice.
Localization and Expression of Sirtuins 1, 2, 6 and Plasticity-Related Proteins in the Recovery Period after a Photothrombotic Stroke in Mice.
Long non?coding RNA H19 inhibition ameliorates oxygen?glucose deprivation?induced cell apoptosis and inflammatory cytokine expression by regulating the microRNA?29b/SIRT1/PGC?1? axis.
Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats.
Muscle-specific sirtuin1 gain-of-function ameliorates skeletal muscle atrophy in a pre-clinical mouse model of cerebral ischemic stroke.
Neuroprotective Effects of Ginkgolide B Against Ischemic Stroke: A Review of Current Literature.
Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-?B and Nrf2/Keap-1 Signaling.
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons.
Overexpression of sirtuin 2 and its association with prognosis in acute ischemic stroke patients.
PPAR-? promotes p38 MAP kinase-mediated endothelial cell permeability through activating Sirt3.
Prognostic value of Sirtuin1 in acute ischemic stroke and its correlation with functional outcomes.
Silent information regulator 1 protects the brain against cerebral ischemic damage.
SIRT1: The Value of Functional Outcome, Stroke-Related Dementia, Anxiety, and Depression in Patients with Acute Ischemic Stroke.
SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke.
Sirt3 deficiency impairs neurovascular recovery in ischemic stroke.
Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke.
Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1?/VEGF Signaling and Blood-Brain Barrier Integrity.
Sirtuin 3 mediates neuroprotection of ketones against ischemic stroke.
Sirtuin 3 promotes microglia migration by upregulating CX3CR1.
Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system.
The Anti-apoptosis Effect of Single Electroacupuncture Treatment via Suppressing Neuronal Autophagy in the Acute Stage of Ischemic Stroke Without Infarct Alleviation.
The NAD-dependent deacetylase SIRT2 is required for programmed necrosis.
The Role of Sirt1 in Ischemic Stroke: Pathogenesis and Therapeutic Strategies.
Keratosis, Actinic
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Ketosis
Ketosis may promote brain macroautophagy by activating Sirt1 and hypoxia-inducible factor-1.
Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-Inhibitors.
Sirtuin 3 inhibits nuclear factor-?B signaling activated by a fatty acid challenge in bovine mammary epithelial cells.
Kidney Calculi
Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population.
Re: SIRT3 Inhibited the Formation of Calcium Oxalate-Induced Kidney Stones through Regulating NRF2/HO-1 Signaling Pathway.
Sirt1 inhibits kidney stones formation by attenuating calcium oxalate-induced cell injury.
SIRT3 inhibited the formation of calcium oxalate-induced kidney stones through regulating NRF2/HO-1 signaling pathway.
Sirt3 suppresses calcium oxalate-induced renal tubular epithelial cell injury via modification of FoxO3a-mediated autophagy.
Sirtuin 3 suppresses the formation of renal calcium oxalate crystals through promoting M2 polarization of macrophages.
Kidney Diseases
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy.
Anti-Fibrotic Effect of Losartan, an Angiotensin II Receptor Blocker, Is Mediated through Inhibition of ER Stress via Up-Regulation of SIRT1, Followed by Induction of HO-1 and Thioredoxin.
Correlation Between Polymorphisms of the SIRT1 Gene microRNA Target Sites and Diabetic Nephropathy.
Genistein Ameliorates Ischemia/Reperfusion-Induced Renal Injury in a SIRT1-Dependent Manner.
Ghrelin-mediated pathway in Apolipoprotein-E deficient mice: a survival system.
Impaired SIRT1 activity leads to diminution in glomerular endowment without accelerating age-associated GFR decline.
Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury.
Liraglutide protects against high-fat diet-induced kidney injury by ameliorating apoptosis.
Reduction in podocyte SIRT1 accelerates kidney injury in aging mice.
Renal protective effect of sirtuin 1.
Role of SIRT1 in HIV-associated kidney disease.
Role of sirtuins in kidney disease.
SIRT1 and Kidney Function.
SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation.
SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease.
SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells.
Sirtuin 1: A Target for Kidney diseases.
Sirtuin and metabolic kidney disease.
Sirtuin1 (SIRT1) Regulates Tumor Necrosis Factor-alpha (TNF-?-Induced) Aquaporin-2 (AQP2) Expression in Renal Medullary Collecting Duct Cells Through Inhibiting the NF-?B Pathway.
Sirtuins and their relevance to the kidney.
Sirtuins in Renal Health and Disease.
The Sirt1 activator, SRT1720, attenuates renal fibrosis by inhibiting CTGF and oxidative stress.
Up-Regulation of SIRT1 Reduces Endoplasmic Reticulum Stress and Renal Fibrosis.
Kidney Failure, Chronic
Critical role of mitochondrial dysfunction and impaired mitophagy in diabetic nephropathy.
Kidney Neoplasms
SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis.
Learning Disabilities
Folate and fetal programming: a play in epigenomics?
Legionnaires' Disease
Legionella pneumophila Infection Rewires the Acanthamoeba castellanii Transcriptome, Highlighting a Class of Sirtuin Genes.
Leiomyoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Leiomyosarcoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Leishmaniasis
Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis.
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.
Novel Synthetic Approaches for Bisnaphthalimidopropyl (BNIP) Derivatives as Potential Anti-Parasitic Agents for the Treatment of Leishmaniasis.
Sir2-Related Protein 1 from Leishmania amazonensis is a glycosylated NAD+-dependent deacetylase.
Lentivirus Infections
Effect of shikonin on multidrug resistance in HepG2: The role of SIRT1.
Potential suppression of the high glucose and insulin-induced retinal neovascularization by Sirtuin 3 in the human retinal endothelial cells.
SIRT1 Deletion Impairs Retinal Endothelial Cell Migration Through Downregulation of VEGF-A/VEGFR-2 and MMP14.
SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway.
Leukemia
A correlation analysis of miRNA?34a and its predicted target genes in leukemia.
A minicircuitry comprised of microRNA-9 and SIRT1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia.
Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib.
Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia.
Albendazole-Induced SIRT3 Upregulation Protects Human Leukemia K562 Cells from the Cytotoxicity of MCL1 Suppression.
Autophagy maintains ubiquitination-proteasomal degradation of Sirt3 to limit oxidative stress in K562 leukemia cells.
CD150(-) Side Population Defines Leukemia Stem Cells in a BALB/c Mouse Model of CML and Is Depleted by Genetic Loss of SIRT1.
Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling.
Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia.
Correction: Inhibition of the NAD-Dependent Protein Deacetylase SIRT2 Induces Granulocytic Differentiation in Human Leukemia Cells.
Deregulation of mitochondrial sirtuins and OGG1-2a acts as a prognostic and diagnostic biomarker in leukemia.
Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia.
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.
Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-Cell Chronic Lymphocytic Leukemia (CLL).
Ginsenoside Rg1 Inhibits Cell Proliferation and Induces Markers of Cell Senescence in CD34+CD38- Leukemia Stem Cells Derived from KG1? Acute Myeloid Leukemia Cells by Activating the Sirtuin 1 (SIRT1)/Tuberous Sclerosis Complex 2 (TSC2) Signaling Pathway.
High expression of the longevity gene product SIRT1, and apoptosis induction by sirtinol in adult T-cell leukemia cells.
Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells.
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
Inhibition of the NAD-Dependent Protein Deacetylase SIRT2 Induces Granulocytic Differentiation in Human Leukemia Cells.
Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation.
Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition.
Role of SIRT1 in hematologic malignancies.
Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells.
Roles of SIRT1 in leukemogenesis.
SIRT1 counteracted the activation of STAT3 and NF-?B to repress the gastric cancer growth.
Sirt1 deacetylates c-Myc and promotes c-Myc/Max association.
SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells.
SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia.
SIRT1 regulates metabolism and leukemogenic potential in CML stem cells.
Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways.
Synergistic Interactions between HDAC and Sirtuin Inhibitors in Human Leukemia Cells.
The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress.
The emerging and diverse roles of sirtuins in cancer: a clinical perspective.
The impact of Mir-9 regulation in normal and malignant hematopoiesis.
The role of Sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells.
[Construction of SIRT1 Promoter Expression Vector and Its Activity Analysis as well as Influence of AML1-ETO on Transcriptional Regulation of SIRT1 Gene].
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
[New strategy of adult T-cell leukemia treatment targeted for anti-tumor immunity and a longevity gene-encoded protein].
Leukemia, Erythroblastic, Acute
Exosomal miR-486 regulates hypoxia-induced erythroid differentiation of erythroleukemia cells through targeting Sirt1.
Leukemia, Lymphocytic, Chronic, B-Cell
Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.
Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-Cell Chronic Lymphocytic Leukemia (CLL).
HDAC isoenzyme expression is deregulated in chronic lymphocytic leukemia B-cells and has a complex prognostic significance.
Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies.
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia.
Divalproex sodium enhances the anti-leukemic effects of imatinib in chronic myeloid leukemia cells partly through SIRT1.
Emerging Drug Target In Pancreatic Cancer: Placing Sirtuin 1 on the Canvas.
EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1.
Nicotinamide increases the sensitivity of chronic myeloid leukemia cells to doxorubicin via the inhibition of SIRT1.
Role of SIRT1 in hematologic malignancies.
Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells.
Roles of SIRT1 in leukemogenesis.
Sensitization of chemo-resistant human chronic myeloid leukemia stem-like cells to Hsp90 inhibitor by SIRT1 inhibition.
SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells.
SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia.
Sirtuin 1 inhibits lipopolysaccharide-induced inflammation in chronic myelogenous leukemia k562 cells through interacting with the Toll-like receptor 4-nuclear factor ? B-reactive oxygen species signaling axis.
Sirtuins in hematological aging and malignancy.
Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 (CDKN1A) Expression in a p53-Independent Manner.
Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population.
Leukemia, Myeloid
SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells.
The role of Sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells.
Leukemia, Myeloid, Acute
A minicircuitry comprised of microRNA-9 and SIRT1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia.
AML1-ETO promotes SIRT1 expression to enhance leukemogenesis of t(8;21) acute myeloid leukemia.
Ginsenoside Rg1 Inhibits Cell Proliferation and Induces Markers of Cell Senescence in CD34+CD38- Leukemia Stem Cells Derived from KG1? Acute Myeloid Leukemia Cells by Activating the Sirtuin 1 (SIRT1)/Tuberous Sclerosis Complex 2 (TSC2) Signaling Pathway.
Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines.
Role of SIRT1 in hematologic malignancies.
Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells.
SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells.
SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia.
SIRT2 is an unfavorable prognostic biomarker in patients with acute myeloid leukemia.
SIRT2 mediates multidrug resistance in acute myelogenous leukemia cells via ERK1/2 signaling pathway.
Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways.
The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer.
The role of Sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells.
Leukemia, Promyelocytic, Acute
Inhibition of the NAD-Dependent Protein Deacetylase SIRT2 Induces Granulocytic Differentiation in Human Leukemia Cells.
Leukemia, T-Cell
SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription.
Leukemia-Lymphoma, Adult T-Cell
Deciphering microRNA-mRNA regulatory network in adult T-cell leukemia/lymphoma; the battle between oncogenes and anti-oncogenes.
High expression of the longevity gene product SIRT1, and apoptosis induction by sirtinol in adult T-cell leukemia cells.
KU70 Inhibition Impairs Both Non-Homologous End Joining and Homologous Recombination DNA Damage Repair Through SHP-1 Induced Dephosphorylation of SIRT1 in Adult T-Cell Leukemia-Lymphoma Cells.
SIRT1 downregulation enhances chemosensitivity and survival of adult T-cell leukemia-lymphoma cells by reducing DNA double-strand repair.
Lipid Metabolism Disorders
Quercetin Improves Glucose and Lipid Metabolism of Diabetic Rats: Involvement of Akt Signaling and SIRT1.
Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats.
Silent information regulator 1 inhibition induces lipid metabolism disorders of hepatocytes and enhances hepatitis C virus replication.
Lipodystrophy
Investigation of SIRT1 gene variants in HIV-associated lipodystrophy and metabolic syndrome.
Lipoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Liposarcoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Listeriosis
Infection Reveals a Modification of SIRT2 Critical for Chromatin Association.
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Liver Cirrhosis
?-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis.
Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs.
Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression.
Ampelopsin attenuates carbon tetrachloride-induced mouse liver fibrosis and hepatic stellate cell activation associated with the SIRT1/TGF-?1/Smad3 and autophagy pathway.
Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis.
Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling.
Corrigendum: Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis.
Downregulated long non-coding RNA LINC01093 in liver fibrosis promotes hepatocyte apoptosis via increasing ubiquitination of SIRT1.
Downregulation of p16 decreases biliary damage and liver fibrosis in the Mdr2-/- mouse model of primary sclerosing cholangitis.
Genome Edited Sirt1-Overexpressing Human Mesenchymal Stem Cells Exhibit Therapeutic Effects in Treating Collagen-Induced Arthritis.
GRHL2 induces liver fibrosis and intestinal mucosal barrier dysfunction in non-alcoholic fatty liver disease via microRNA-200 and the MAPK pathway.
Hepatic stellate cell-specific deletion of SIRT1 exacerbates liver fibrosis in mice.
MiR-9a-5p regulates proliferation and migration of hepatic stellate cells under pressure through inhibition of Sirt1.
Nicotinamide riboside protects against liver fibrosis induced by CCl4 via regulating the acetylation of Smads signaling pathway.
Noninvasive 40-Hz Light Flicker Rescues Circadian Behavior and Abnormal Lipid Metabolism Induced by Acute Ethanol Exposure via Improving SIRT1 and the Circadian Clock in the Liver-Brain Axis.
PKC? Mediates NF-?B Inflammatory Response and Downregulates SIRT1 Expression in Liver Fibrosis.
Protective effects of selenium-glutathione-enriched probiotics on CCl4-induced liver fibrosis.
Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion.
SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice.
Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence.
SOD3 deficiency induces liver fibrosis by promoting hepatic stellate cell activation and epithelial-mesenchymal transition.
Targeting Sirtuin1 to treat aging-related tissue fibrosis: From prevention to therapy.
Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy.
Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis.
TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence.
Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner.
Liver Cirrhosis, Biliary
Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-?B signaling pathway.
Liver Diseases
A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators.
A Redox-resistant Sirtuin-1 Mutant Protects against Hepatic Metabolic and Oxidant Stress.
AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease.
Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization.
Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs.
Altered microRNA-9 Expression Level is Directly Correlated with Pathogenesis of Nonalcoholic Fatty Liver Disease by Targeting Onecut2 and SIRT1.
Association of SIRT1 gene polymorphism and its expression for the risk of alcoholic fatty liver disease in the Han population.
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway.
Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats.
Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway.
Combined intake of blueberry juice and probiotics ameliorate mitochondrial dysfunction by activating SIRT1 in alcoholic fatty liver disease.
Cudratricusxanthone A attenuates sepsis-induced liver injury via SIRT1 signaling.
Cysteine cathepsins control hepatic NF-?B-dependent inflammation via sirtuin-1 regulation.
Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced hepatic steatosis in mice.
DHA Protects Against Hepatic Steatosis by Activating Sirt1 in a High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mouse Model.
Dihydromyricetin Ameliorates Nonalcoholic Fatty Liver Disease by Improving Mitochondrial Respiratory Capacity and Redox Homeostasis Through Modulation of SIRT3 Signaling.
Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients.
Emerging roles of SIRT1 in fatty liver diseases.
EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats.
Fine-tuning of SIRT1 expression is essential to protect the liver from cholestatic liver disease.
Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK.
Hepatoprotection of Berberine Against Hydrogen Peroxide-induced Apoptosis by Upregulation of Sirtuin 1.
Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease.
Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis.
Involvement of mammalian sirtuin 1 in the action of ethanol in the liver.
Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition.
Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism.
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Metabolic benefits from Sirt1 and Sirt1 activators.
MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3.
miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease.
MiR-181b regulates steatosis in nonalcoholic fatty liver disease via targeting SIRT1.
MiR-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1.
miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload.
Molecular, Cellular, and Physiological Characterization of Sirtuin 7 (SIRT7).
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients.
Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease.
Protective effect of autologous transplantation of resveratrol preconditioned adipose-derived stem cells in the treatment of diabetic liver dysfunction in rat model.
Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway.
Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease.
Relevance of SIRT1-NF-?B Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease.
Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes.
Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice.
Silybin Restored CYP3A Expression through the Sirtuin 2/Nuclear Factor ?-B Pathway in Mouse Nonalcoholic Fatty Liver Disease.
SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease.
Sirt1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrol.
SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPAR?/FoxO1 signaling pathway.
SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding.
SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF??B pathway in mouse kupffer cells.
SIRT3 as a Regulator of Non-alcoholic Fatty Liver Disease.
SIRT3 Deficiency Promotes High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Correlation with Impaired Intestinal Permeability through Gut Microbial Dysbiosis.
SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity.
SIRT3 regulates ?-SMA production through the succinate dehydrogenase-GPR91 pathway in hepatic stellate cells.
Sirtuin 1 modulation in rat model of acetaminophen-induced hepatotoxicity.
Sirtuin 1 signaling and alcoholic fatty liver disease.
Sirtuin 3 improves fatty acid metabolism in response to high nonesterified fatty acids in calf hepatocytes by modulating gene expression.
Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates non-alcoholic fatty liver disease.
Sirtuins and Insulin Resistance.
Targeting Sirt1 in a rat model of high-fat diet-induced non-alcoholic fatty liver disease: Comparison of Gegen Qinlian decoction and resveratrol.
The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats.
The ménage à trois of autophagy, lipid droplets and liver disease.
The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation.
Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy.
Upregulation of Sirt1 in carbon-tetrachloride-induced acute liver injury.
[Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver.]
[Effects of calorie restriction on SIRT1 expression in liver of nonalcoholic fatty liver disease: experiment with rats]
Liver Diseases, Alcoholic
Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression.
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
Dietary schizophyllan reduces mitochondrial damage by activating SIRT3 in mice.
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
Hepatic SIRT3 Upregulation in Response to Chronic Alcohol Consumption Contributes to Alcoholic Liver Disease in Mice.
Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Noninvasive 40-Hz Light Flicker Rescues Circadian Behavior and Abnormal Lipid Metabolism Induced by Acute Ethanol Exposure via Improving SIRT1 and the Circadian Clock in the Liver-Brain Axis.
Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion.
Liver Failure, Acute
Protective role of AGK2 on thioacetamide-induced acute liver failure in mice.
Liver Neoplasms
Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis.
AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells.
DBC1 does not function as a negative regulator of SIRT1 in liver cancer.
Deacetylation of ?-catenin by SIRT1 regulates self-renewal and oncogenesis of liver cancer stem cells.
Exploring the newer oxadiazoles as real inhibitors of human SIRT2 in hepatocellular cancer cells.
Facilitation of liver cancer SMCC7721 cell aging by sirtuin 4 via inhibiting JAK2/STAT3 signal pathway.
HSP90 and SIRT3 expression in hepatocellular carcinoma and their effect on invasive capability of human hepatocellular carcinoma cells.
Inhibition of SIRT1 Limits Self-Renewal and Oncogenesis by Inducing Senescence of Liver Cancer Stem Cells.
MEK1 signaling promotes self-renewal and tumorigenicity of liver cancer stem cells via maintaining SIRT1 protein stabilization.
Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells.
MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma.
MicroRNA-29c restores cisplatin sensitivity in liver cancer through direct inhibition of sirtuin 1 expression.
MicroRNA?486?5p functions as a tumor suppressor of proliferation and cancer stem?like cell properties by targeting Sirt1 in liver cancer.
miR-124-3p combined with miR-506-3p delay hepatic carcinogenesis via modulating sirtuin 1.
miR-425 regulates lipophagy via SIRT1 to promote sorafenib resistance in liver cancer.
Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells.
SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.
SIRT1 in the Development and Treatment of Hepatocellular Carcinoma.
SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling.
Sirt1 suppresses Wnt/?Catenin signaling in liver cancer cells by targeting ?Catenin in a PKA?-dependent manner.
Sirt3 promotes hepatocellular carcinoma cells sensitivity to regorafenib through the acceleration of mitochondrial dysfunction.
Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway.
Suppression of SIRT1 activity in noncancerous tissues of HCC: possible association with non-B non-C hepatitis pathogenesis.
The photodynamic activity and toxicity evaluation of 5,10,15-tris(ethoxylcarbonyl)corrole phosphorus(V) in vivo and in vitro.
Transcriptional and translational regulation of C/EBP?-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1? proteins at the early and late stages of liver cancer.
Lung Diseases
Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD.
BET Inhibition Upregulates SIRT1 and Alleviates Inflammatory Responses.
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.
Redox Regulation Of Sirt1 In Inflammation And Cellular Senescence.
SIRT1 as a therapeutic target in inflammaging of the pulmonary disease.
[Sirtuin1 and lung disease].
Lung Injury
Activation of SIRT1 ameliorates LPS-induced lung injury in mice via decreasing endothelial tight junction permeability.
Arbutin attenuates LPS-induced lung injury via Sirt1/ Nrf2/ NF-?Bp65 pathway.
Effect of miR-132 on lung injury in sepsis rats via regulating Sirt1 expression.
Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation.
Identification of Multiple Anti-inflammatory Pathways Triggered by Resveratrol Leading to Amelioration of Staphylococcal Enterotoxin B-Induced Lung Inflammation.
Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide.
Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis.
Melatonin Attenuates Sepsis-Induced Acute Lung Injury Through Improvement of Epithelial Sodium Channel-Mediated Alveolar Fluid Clearance Via Activation of SIRT1/SGK1/Nedd4-2 Signaling Pathway.
MicroRNA-217 modulates inflammation, oxidative stress, and lung injury in septic mice via SIRT1.
Niacin Pretreatment Attenuates Ischemia and Reperfusion of Pancreas-induced Acute Pancreatitis and Remote Lung Injury Through Suppressing Oxidative Stress and Inflammation and Activation of SIRT1.
p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis.
Polydatin alleviated radiation-induced lung injury through activation of Sirt3 and inhibition of epithelial-mesenchymal transition.
Propofol reduces renal ischemia/reperfusion-induced acute lung injury by stimulating sirtuin 1 and inhibiting pyroptosis.
Redox imbalance and mitochondrial abnormalities in the diabetic lung.
Resolvin D1 Promotes SIRT1 Expression to Counteract the Activation of STAT3 and NF-?B in Mice with Septic-Associated Lung Injury.
Resveratrol attenuates spinal cord injury-induced inflammatory damage in rat lungs.
Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways.
Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p-Akt pathway in methamphetamine-induced chronic lung injury.
Silent information regulator type-1 mediates amelioration of inflammatory response and oxidative stress in lipopolysaccharide-induced acute respiratory distress syndrome.
SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro.
SIRT1 mediates a primed response to immune challenge after traumatic lung injury.
SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury.
Sirtuin 1 Activator SRT1720 Protects Against Lung Injury via Reduction of Type II Alveolar Epithelial Cells Apoptosis in Emphysema.
Tanshinone IIA protects against lipopolysaccharide-induced lung injury through targeting Sirt1.
The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-?B acetylation.
The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia.
[Resveratrol inhibits hyperxia-induced cell apoptosis through up-regulating SIRT1 expression in HPAECs].
Lung Neoplasms
?-Cryptoxanthin Restores Nicotine-Reduced Lung SIRT1 to Normal Levels and Inhibits Nicotine-Promoted Lung Tumorigenesis and Emphysema in A/J Mice.
A new series of benzoxazole-based SIRT1 modulators for targeted therapy of non-small-cell lung cancer.
A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer.
A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis.
Adjudin synergizes with paclitaxel and inhibits cell growth and metastasis by regulating the sirtuin 3-Forkhead box O3a axis in human small-cell lung cancer.
An RNA-binding-protein, NONO governs energy metabolism by regulating NAMPT in lung cancer.
Association of SIRT1 and HMGA1 expression in non-small cell lung cancer.
Celecoxib and sulindac inhibit TGF-?1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1.
Corrigendum to "SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth" [Biochem. Biophys. Res. Commun. 483 (2017) 880-884].
Cytokines from the tumor microenvironment modulate sirtinol cytotoxicity in A549 lung carcinoma cells.
Cytoplasm-localized SIRT1 downregulation attenuates apoptosis and cell cycle arrest in cisplatin-resistant lung cancer A549 cells.
DBC1 does not function as a negative regulator of SIRT1 in liver cancer.
Diagnostic investigation of BIRC6 and SIRT1 protein expression level as potential prognostic biomarkers in patients with non-small cell lung cancer.
Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer.
Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells.
E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation.
Effect of SIRT1 activators and inhibitors on CD44+/CD133+?enriched non?small cell lung cancer cells.
Emerging role of SIRT2 in non-small cell lung cancer.
Enhanced nucleotide excision repair capacity in lung cancer cells by preconditioning with DNA-damaging agents.
Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.
Expression of SIRT1 gene in human lung cancer lines enhances their sensitivity to the anticancer effects of cisplatin.
Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.
Extract of Bryophyllum laetivirens reverses etoposide resistance in human lung A549 cancer cells by downregulation of NF-?B.
Future treatments for chronic obstructive pulmonary disease and its comorbidities.
Ginsenoside Rp1, A Ginsenoside Derivative, Augments Anti-Cancer Effects of Actinomycin D via Downregulation of an AKT-SIRT1 Pathway.
Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells.
Hsa-miR-217 Inhibits the Proliferation, Migration, and Invasion in Non-small Cell Lung Cancer Cells Via Targeting SIRT1 and P53/KAI1 Signaling
Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer.
K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation.
Long Noncoding RNA SNHG10 Sponges miR-543 to Upregulate Tumor Suppressive SIRT1 in Nonsmall Cell Lung Cancer.
Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells.
MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1.
Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer.
miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1.
miR-30a suppresses lung cancer progression by targeting SIRT1.
miR-448 promotes progression of non-small-cell lung cancer via targeting SIRT1.
miR?150 promotes the proliferation and migration of non?small cell lung cancer cells by regulating the SIRT2/JMJD2A signaling pathway.
miRNAs deregulation in serum of mice is associated with lung cancer related pathway deregulation induced by PM2.5.
Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1.
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
RBM38 induces SIRT1 expression during hypoxia in non-small cell lung cancer cells by suppressing MIR34A expression.
Regulation of Apoptosis and Radiation Sensitization in Lung Cancer Cells via the Sirt1/NF-?B/Smac Pathway.
Regulation of SIRT2 levels for human non-small cell lung cancer therapy.
Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK.
Silent information regulator 1 suppresses epithelial-to-mesenchymal transition in lung cancer cells via its regulation of mitochondria status.
SIRT1 and AMPK mediate hypoxia-induced resistance of non-small cell lung cancers to cisplatin and doxorubicin.
SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer.
SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC.
SIRT1 gene polymorphisms and risk of lung cancer.
SIRT1 in B[a]P-induced lung tumorigenesis.
SIRT1 in Secretory Organ Cancer.
SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27.
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.
SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration.
SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-?B signaling.
SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue.
SIRT1 regulates endothelial Notch signaling in lung cancer.
Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells.
SIRT2 inhibits non-small cell lung cancer cell growth through impairing Skp2-mediated p27 degradation.
SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A.
SIRT3 acts as a novel biomarker for the diagnosis of lung cancer: A retrospective study.
SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.
SIRT3 increases cisplatin sensitivity of small-cell lung cancer through apoptosis.
SIRT3 is correlated with the malignancy of non-small cell lung cancer.
Sirt3 Promoted DNA Damage Repair and Radioresistance Through ATM-Chk2 in Non-small Cell Lung Cancer Cells.
SIRT3 promotion reduces resistance to cisplatin in lung cancer by modulating the FOXO3/CDT1 axis.
SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2.
Sirtuin 3 induces apoptosis and necroptosis by regulating mutant p53 expression in small?cell lung cancer.
Sirtuin 7 promotes non?small cell lung cancer progression by facilitating G1/S phase and epithelial?mesenchymal transition and activating AKT and ERK1/2 signaling.
Sirtuin SIRT6 suppresses cell proliferation through inhibition of Twist1 expression in non-small cell lung cancer.
SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth.
Suppression of Sirt1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis.
The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/?-catenin-Foxo3a axis.
The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?
The expression and mechanism of Sirt1 and AMPK in nonsmall cell lung cancer.
The Expression and Related Clinical Significance of SIRT3 in Non-Small-Cell Lung Cancer.
X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
[SIRT1 Influences the Sensitivity of A549 Non-small Cell Lung Cancer Cell Line to ?Cisplatin via Modulating the Noxa Expression].
Lupus Erythematosus, Systemic
SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus.
Ultraviolet B inhibition of DNMT1 activity via AhR activation dependent SIRT1 suppression in CD4+ T cells from systemic lupus erythematosus patients.
Lupus Nephritis
Accelerated, severe lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF-?B/NLRP3 inflammasome and sirtuin 1/autophagy axis.
Renal protective effect of sirtuin 1.
The Therapeutic Effects of the Chinese Herbal Medicine, Lang Chuang Fang Granule, on Lupus-Prone MRL/lpr Mice.
Urinary levels of sirtuin-1 associated with disease activity in lupus nephritis.
Lymphatic Metastasis
Clinicopathological and prognostic role of SIRT1 in breast cancer patients: a meta-analysis.
Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis.
Effect of the SIRT3-AMPK/PPAR pathway on invasion and migration of cervical cancer cells.
Expression and clinical significance of Sirt1 in colorectal cancer.
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.
Expression of miR-204 in pediatric retinoblastoma and its effects on proliferation and apoptosis of cancer cells.
Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer.
Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.
Expression of SIRT1 and survivin correlates with poor prognosis in esophageal squamous cell carcinoma.
Expression of SIRT1 in Gastric Cardiac Cancer and Its Clinicopathologic Significance.
Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer.
Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy.
MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells.
Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer.
Over-expression of Sirt1 contributes to chemoresistance and indicates poor prognosis in serous epithelial ovarian cancer (EOC).
SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer.
SIRT1 promotes formation of breast cancer through modulating Akt activity.
SIRT2 expression exhibits potential to serve as a biomarker for disease surveillance and prognosis in the management of cervical cancer patients.
SIRT2, a direct target of miR-212-5p, suppresses the proliferation and metastasis of colorectal cancer cells.
Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma.
Sirtuin2 correlates with lymph node metastasis, increased FIGO stage, worse overall survival, and reduced chemosensitivity to cisplatin and paclitaxel in endometrial cancer.
Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis.
The Expression and Related Clinical Significance of SIRT3 in Non-Small-Cell Lung Cancer.
The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers.
The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients.
[Expression Level of SIRT2 in Cervical Cancer Tissue and Its Clinical Significance].
Lymphoma
Advances in spirocyclic hybrids: chemistry and medicinal actions.
Expression of miR-34a and miR-15b during the progression of cervical cancer in a murine model expressing the HPV16 E7 oncoprotein.
Expression of the significance of silent information regulator type-1 in Angioimmunoblastic T-cell lymphoma is greater association with tumorigenesis and has strong implications for adverse prognosis.
Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies.
Methylation changes of SIRT1, KLF4, DAPK1 and SPG20 in B-lymphocytes derived from follicular and diffuse large B-cell lymphoma.
Mir-141-3p Regulates Apoptosis and Mitochondrial Membrane Potential via Targeting Sirtuin1 in a 1-Methyl-4-Phenylpyridinium in vitro Model of Parkinson's Disease.
Modulating SIRT1 activity variously affects thymic lymphoma development in mice.
Resveratrol alleviates sepsis?induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF?? and myocardial apoptosis via activation of Sirt1.
SIRT1 and AMPK pathways are essential for the proliferation and survival of primary effusion lymphoma cells.
SIRT1 counteracted the activation of STAT3 and NF-?B to repress the gastric cancer growth.
SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma.
SIRT1 rs3758391 polymorphism and risk of diffuse large B cell lymphoma in a Chinese population.
SIRT3 in Neural Stem Cells Attenuates Microglia Activation-Induced Oxidative Stress Injury Through Mitochondrial Pathway.
Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma.
The emerging and diverse roles of sirtuins in cancer: a clinical perspective.
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Lymphoma, B-Cell
Aging-Related Functional and Structural Changes in Renal Tissues: Lesson from a Camel Model.
Alcohol-mediated miR-34a modulates hepatocyte growth and apoptosis.
Alogliptin: a novel approach against cyclophosphamide-induced hepatic injury via modulating SIRT1/FoxO1 pathway.
B-cell Lymphomas Exhibit a Non-Oncogene Addiction to SIRT3.
Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats.
Consecutive stimulation of HBsAg promotes the viability of the human B lymphoblastoid cell line IM-9 through regulating the SIRT1-NF-?B pathway.
Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies.
Effect of charcoal:dextran stripped fetal bovine serum on in vitro development of bovine embryos.
Expression of miR-204 in pediatric retinoblastoma and its effects on proliferation and apoptosis of cancer cells.
Expression of miR-34a and miR-15b during the progression of cervical cancer in a murine model expressing the HPV16 E7 oncoprotein.
Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer.
Fibronectin protected bovine preantral follicles from the deleterious effects of kisspeptin.
Melatonin Counteracts at a Transcriptional Level the Inflammatory and Apoptotic Response Secondary to Ischemic Brain Injury Induced by Middle Cerebral Artery Blockade in Aging Rats.
Methylation changes of SIRT1, KLF4, DAPK1 and SPG20 in B-lymphocytes derived from follicular and diffuse large B-cell lymphoma.
Mir-141-3p Regulates Apoptosis and Mitochondrial Membrane Potential via Targeting Sirtuin1 in a 1-Methyl-4-Phenylpyridinium in vitro Model of Parkinson's Disease.
MiR-204 inhibits inflammation and cell apoptosis in retinopathy rats with diabetic retinopathy by regulating Bcl-2 and SIRT1 expressions.
Protective effects of ginsenoside Rc against acute cold exposure-induced myocardial injury in rats.
Protective effects of icariin-mediated SIRT1/FOXO3 signaling pathway on intestinal ischemia/reperfusion-induced acute lung injury.
Puerarin in inducing apoptosis of bladder cancer cells through inhibiting SIRT1/p53 pathway.
Resveratrol alleviates sepsis?induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF?? and myocardial apoptosis via activation of Sirt1.
SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma.
Sirt1 gene confers Adriamycin resistance in DLBCL via activating the PCG-1? mitochondrial metabolic pathway.
SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain.
SIRT1 rs3758391 polymorphism and risk of diffuse large B cell lymphoma in a Chinese population.
SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma.
Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 activation.
Xanomeline Protects Cortical Cells From Oxygen-Glucose Deprivation via Inhibiting Oxidative Stress and Apoptosis.
Lymphoma, Large B-Cell, Diffuse
Methylation changes of SIRT1, KLF4, DAPK1 and SPG20 in B-lymphocytes derived from follicular and diffuse large B-cell lymphoma.
SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma.
Sirt1 gene confers Adriamycin resistance in DLBCL via activating the PCG-1? mitochondrial metabolic pathway.
SIRT1 rs3758391 polymorphism and risk of diffuse large B cell lymphoma in a Chinese population.
SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma.
Lymphoma, Mantle-Cell
Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies.
Lymphoma, Primary Effusion
SIRT1 and AMPK pathways are essential for the proliferation and survival of primary effusion lymphoma cells.
Lymphoma, T-Cell
A C21-steroidal derivative suppresses T-cell lymphoma in mice by inhibiting SIRT3 via SAP18-SIN3.
Expression of the significance of silent information regulator type-1 in Angioimmunoblastic T-cell lymphoma is greater association with tumorigenesis and has strong implications for adverse prognosis.
The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration.
Lymphoma, T-Cell, Cutaneous
SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis.
Lymphoma, T-Cell, Peripheral
Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-?B pathways and expressions of IGF-1R, Sirt1, COX-2, and FASN in peripheral T-cell lymphomas: pathogenetic implications and therapeutic options.
Machado-Joseph Disease
Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.
Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo.
Macular Degeneration
Delivery of Oct4 and SirT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium.
Expression of sirt1 in choroidal neovascular membranes.
Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2?.
Role of Sirtuin 1 in the pathogenesis of ocular disease (Review).
Single Nucleotide Polymorphisms of the Sirtuin 1 (SIRT1) Gene are Associated With age-Related Macular Degeneration in Chinese Han Individuals: A Case-Control Pilot Study.
SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization.
SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, LIPC rs10468017, rs493258 and LPL rs12678919 genotypes and haplotype evaluation in patients with age-related macular degeneration.
Sirtuins Expression and Their Role in Retinal Diseases.
The role of SIRT1 in ocular aging.
Malaria
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.
Next issue (November 2007): Singapore Biotech Crossroads.
Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity.
Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum.
Malaria, Cerebral
Biochemical characterization of Plasmodium falciparum Sir2, a NAD(+)-dependent deacetylase.
Malnutrition
Better Nutritional Status Is Positively Associated with mRNA Expression of SIRT1 in Community-Dwelling Older Adults in the Toledo Study for Healthy Aging.
Catch-Up Growth: Basic Mechanisms.
Determinants of GH resistance in malnutrition.
Reduced metabolic capacity in fast and slow skeletal muscle via oxidative stress and the energy-sensing of AMPK/SIRT1 in malnutrition.
SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression.
Variants in the SIRT1 gene may affect diabetes risk in interaction with prenatal exposure to famine.
Malocclusion
Disruption of Igfbp1 fails to rescue the phenotype of Sirt1-/- mice.
Marfan Syndrome
Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension.
Massive Hepatic Necrosis
Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-?B.
The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice.
Medulloblastoma
Expression patterns and potential roles of SIRT1 in human medulloblastoma cells in vivo and in vitro.
MiR-34a deficiency accelerates medulloblastoma formation in vivo.
Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells.
p53 Regulates LIF expression in human medulloblastoma cells.
Melanoma
4'-Bromo-resveratrol, a dual Sirtuin-1 and Sirtuin-3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming.
A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity.
AC-93253 triggers the downregulation of melanoma progression markers and the inhibition of melanoma cell proliferation.
Activation of the SIRT1 pathway and modulation of the cell cycle were involved in silymarin's protection against UV-induced A375-S2 cell apoptosis.
Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for ?-catenin or MITF in colon cancer and melanoma cells.
Expression of proteins involved in epigenetic regulation in human cutaneous melanoma and peritumoral skin.
Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy.
Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma.
MicroRNA-148b Inhibits the Malignant Biological Behavior of Melanoma by Reducing Sirtuin 7 Expression Levels.
MicroRNA-9 inhibits the proliferation and migration of malignant melanoma cells via targeting sirituin 1.
Mitochondrial Sirtuins in Skin and Skin Cancers.
Nicotinamide inhibits melanoma in vitro and in vivo.
Novel downstream molecular targets of SIRT1 in melanoma: a quantitative proteomics approach.
Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma.
RNA interference-mediated knockdown of SIRT1 and/or SIRT2 in melanoma: Identification of downstream targets by large-scale proteomics analysis.
Roles of SIRT1 and phosphoinositide 3-OH kinase/protein kinase C pathways in evodiamine-induced human melanoma A375-S2 cell death.
SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation.
SIRT1 induces epithelial-mesenchymal transition by promoting autophagic degradation of E-cadherin in melanoma cells.
SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells.
SIRT1 Regulates Lamellipodium Extension and Migration of Melanoma Cells.
SIRT1 regulates Mxd1 during malignant melanoma progression.
SIRT2 Contributes to the Resistance of Melanoma Cells to the Multikinase Inhibitor Dasatinib.
SIRT2 Expression Is Higher in Uveal Melanoma than In Ocular Melanocytes.
SIRT2 promotes murine melanoma progression through natural killer cell inhibition.
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma.
Sirtuin deacetylases: a new target for melanoma management.
Targeting SIRT2 Sensitizes Melanoma Cells to Cisplatin via an EGFR-Dependent Mechanism.
The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer.
Tumour Expression of Histone Deacetylases in Uveal Melanoma.
Memory Disorders
Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression.
Early-Life Exposure to Lead Induces Cognitive Impairment in Elder Mice Targeting SIRT1 Phosphorylation and Oxidative Alterations.
Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction.
Kaempferol protects against cadmium chloride-induced hippocampal damage and memory deficits by activation of silent information regulator 1 and inhibition of poly (ADP-Ribose) polymerase-1.
Ketones improves Apolipoprotein E4-related memory deficiency via sirtuin 3.
Obesity caused by a high-fat diet regulates the Sirt1/PGC-1?/FNDC5/BDNF pathway to exacerbate isoflurane-induced postoperative cognitive dysfunction in older mice.
Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1.
SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1?.
Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection.
Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation.
Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease.
Woohwangcheongsimwon Prevents High-Fat Diet-Induced Memory Deficits and Induces SIRT1 in Mice.
Mesothelioma
CDKN2A Determines Mesothelioma Cell Fate to EZH2 Inhibition.
PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1.
Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1.
SIRT1 at the crossroads of AKT1 and ER? in malignant pleural mesothelioma cells.
Sirtuin Family Members Selectively Regulate Autophagy in Osteosarcoma and Mesothelioma Cells in Response to Cellular Stress.
Mesothelioma, Malignant
Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1.
SIRT1 at the crossroads of AKT1 and ER? in malignant pleural mesothelioma cells.
Metabolic Diseases
(Healthy) ageing: focus on iodothyronines.
A molecular mechanism for direct sirtuin activation by resveratrol.
A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition.
A review of Sirt1 and Sirt1 modulators in cardiovascular and metabolic diseases.
Antagonistic crosstalk between SIRT1, PARP-1, and -2 in the regulation of chronic inflammation associated with aging and metabolic diseases.
Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes.
Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases.
Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet.
Continuous multiparametric monitoring of cell metabolism in response to transient overexpression of the sirtuin deacetylase SIRT3.
Controlling SIRT1 expression by microRNAs in health and metabolic disease.
Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia.
Differential Effects of Resveratrol and SRT1720 on Lifespan of Adult Caenorhabditis elegans.
Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies.
Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide.
E. coli endotoxin modulates the expression of Sirtuin proteins in PBMC in humans.
Effect of nutrient deprivation on the expression and the epigenetic signature of sirtuin genes.
Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease.
Extranuclear Sirtuins and Metabolic Stress.
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states.
Ginsenoside Rg2 ameliorates high-fat diet-induced metabolic disease through SIRT1.
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.
How much successful are the medicinal chemists in modulation of SIRT1: A critical review.
Hypothalamic Sirt1 regulates food intake in a rodent model system.
Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis.
Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation.
Inhibitors of NAD+ dependent histone deacetylases (sirtuins).
Knockdown of
Lipopolysaccharides-Induced Inflammatory Response in White Blood Cells Is Associated with Alterations in Senescence Mediators: Modulation by Metformin.
Mammalian Sirt1: insights on its biological functions.
Mass spectrometric studies on the in vitro generated metabolites of SIRT1 activating drugs for doping control purposes.
MicroRNA Regulation of SIRT1.
Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target.
Overexpressed eNOS upregulates SIRT1 expression and protects mouse pancreatic ? cells from apoptosis.
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation.
PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners.
Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cells.
Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells.
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.
Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights.
Silent information regulator, Sirtuin 1, and age-related diseases.
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease.
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity.
SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents.
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase.
SIRT1: new avenues of discovery for disorders of oxidative stress.
SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity.
SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation.
SIRT4 overexpression protects against diabetic nephropathy by inhibiting podocyte apoptosis.
Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis.
Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism.
Sirtuin 1 in lipid metabolism and obesity.
SIRTUIN 1: regulating the regulator.
Sirtuin 3: A major control point for obesity-related metabolic diseases?
Sirtuin modulators: targets for metabolic diseases and beyond.
Sirtuin-targeting drugs: Mechanisms of action and potential therapeutic applications.
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.
Sirtuins as endogenous regulators of lung fibrosis: A current perspective.
Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise.
Suppression of native defense mechanisms, SIRT1 and PPAR?, by dietary glycoxidants precedes disease in adult humans; relevance to lifestyle-engendered chronic diseases.
Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5.
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.
The role of mitochondrial sirtuins in health and disease.
The sirtuins: Markers of metabolic health.
Metabolic Syndrome
A patent review of sirtuin activators: an update.
A Redox-resistant Sirtuin-1 Mutant Protects against Hepatic Metabolic and Oxidant Stress.
AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells.
Association Between SIRT1, Cytokines, and Metabolic Syndrome in Schizophrenia Patients With Olanzapine or Clozapine Monotherapy.
At the Crossroads of Longevity and Metabolism: The Metabolic Syndrome and Life-Span Determinant Pathways.
Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation.
Chronic High Fat Diet Intake Impairs Hepatic Metabolic Parameters in Ovariectomized Sirt3 KO Mice.
Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development.
Development of a dietary-induced metabolic syndrome model using miniature pigs involvement of AMPK and SIRT1.
Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms.
Effects of natural mineral-rich water consumption on the expression of sirtuin 1 and angiogenic factors in the erectile tissue of rats with fructose-induced metabolic syndrome.
Food restriction improves glucose and lipid metabolism through Sirt1 expression: a study using a new rat model with obesity and severe hypertension.
High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions.
Increased malondialdehyde vs. reduced sirtuin 1 in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes.
Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
Investigation of SIRT1 gene variants in HIV-associated lipodystrophy and metabolic syndrome.
Ketogenesis and SIRT1 as a tool in managing obesity.
Metabolomic connections between schizophrenia, antipsychotic drugs and metabolic syndrome: A variety of players.
Mitochondrial Hyperacetylation in the Failing Hearts of Obese Patients Mediated Partly by a Reduction in SIRT3: The Involvement of the Mitochondrial Permeability Transition Pore.
Mitochondrial SIRT3: a new potential therapeutic target for metabolic syndrome.
Mitochondrial Sirtuin 3 and Renal Diseases.
Molecular Mechanisms of Latent Inflammation in Metabolic Syndrome. Possible Role of Sirtuins and Peroxisome Proliferator-Activated Receptor Type ?.
Myeloid-specific deletion of SIRT1 increases hepatic steatosis and hypothalamic inflammation in mice fed a high-fat diet.
Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice.
Natural mineral-rich water ingestion improves hepatic and fat glucocorticoid-signaling and increases sirtuin 1 in an animal model of metabolic syndrome.
Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation.
Opposite Effects of Metabolic Syndrome and Calorie Restriction on Thrombotic Disease: Head and Tail of Same Coin-Resveratrol's Role.
Phosphorylation regulates SIRT1 function.
Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients.
Resveratrol: a relevant pharmacological approach for the treatment of metabolic syndrome?
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
Short-term fructose ingestion affects the brain independently from establishment of metabolic syndrome.
SIRT1 and insulin resistance.
SIRT1 in metabolic syndrome: Where to target matters.
SIRT1 Regulation in Ageing and Obesity.
Sirt1-PPARS Cross-Talk in Complex Metabolic Diseases and Inherited Disorders of the One Carbon Metabolism.
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome.
SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain.
SIRT3 Regulates Mitochondrial Protein Acetylation and Intermediary Metabolism.
SIRT3 regulates progression and development of diseases of aging.
SIRT3 Weighs Heavily in the Metabolic Balance: A New Role for SIRT3 in Metabolic Syndrome.
SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging.
SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction.
Sirtuin 1 stabilization by HuR represses TNF-? and glucose induced E-Selectin release and endothelial cell adhesiveness in vitro. Relevance to human metabolic syndrome.
Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.
Sirtuin activators: Designing molecules to extend life span.
Sirtuin biology and relevance to diabetes treatment.
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.
Sirtuins as regulators of mammalian aging.
Sirtuins in Renal Health and Disease.
Tang-Nai-Kang alleviates pre-diabetes and metabolic disorders and induces a gene expression switch toward fatty acid oxidation in SHR.Cg-Leprcp/NDmcr rats.
The metabolic footprint during adipocyte commitment highlights ceramide modulation as an adequate approach for obesity treatment.
The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome.
Vascular Smooth Muscle Sirtuin-1 Protects Against Diet-Induced Aortic Stiffness.
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
[Research progression of deacetylase (SIRT1)]
Metabolism, Inborn Errors
Sirtuin activation as a therapeutic approach against inborn errors of metabolism.
methylenetetrahydrofolate dehydrogenase (nad+) deficiency
Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1.
Migraine Disorders
miR-34a-5p up-regulates the IL-1?/COX2/PGE2 inflammation pathway and induces the release of CGRP via inhibition of SIRT1 in rat trigeminal ganglion neurons.
Upregulation of silent information regulator 1 alleviates mitochondrial dysfunction in the trigeminal nucleus caudalis in a rat model of chronic migraine.
[Effects of electroacupuncture on miR-34a-5p/SIRT1 signaling in the trigeminal ganglion of rats with migraine].
Mitochondrial Diseases
Curcumin Upregulates Antioxidant Defense, Lon Protease, and Heat-Shock Protein 70 Under Hyperglycemic Conditions in Human Hepatoma Cells.
Extranuclear localization of SIRT1 and PGC-1?: an insight into possible roles in diseases associated with mitochondrial dysfunction.
Fra-1 Inhibits Cell Growth and the Warburg Effect in Cervical Cancer Cells via STAT1 Regulation of the p53 Signaling Pathway.
NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease.
Regulation of mitochondrial F(o)F(1)ATPase activity by Sirt3-catalyzed deacetylation and its deficiency in human cells harboring 4977bp deletion of mitochondrial DNA.
Roles of sirtuins in the regulation of antioxidant defense and bioenergetic function of mitochondria under oxidative stress.
Mitral Valve Insufficiency
Regulation of left atrial fibrosis induced by mitral regurgitation by SIRT1.
Motor Neuron Disease
SIRT1 in neurodevelopment and brain senescence.
Mouth Neoplasms
Differential prooxidative effects of the green tea polyphenol, (-)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling.
DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing-a possible predictive biomarker for malignant transformation.
Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-?B, and SIRT1 Signaling Pathway.
Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis.
Sirtuin 1 and oral cancer.
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.
The ambiguous role of sirtuins in head and neck squamous cell carcinoma.
Movement Disorders
Mitochondrial Respiration in Intact Peripheral Blood Mononuclear Cells and Sirtuin 3 Activity in Patients with Movement Disorders.
MPTP Poisoning
Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced parkinsonism.
mrna m6a methyltransferase deficiency
METTL3 Induces AAA Development and Progression by Modulating N6-Methyladenosine-Dependent Primary miR34a Processing.
Mucositis
Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation-induced oral mucositis in mice.
Multiple Myeloma
Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1.
Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS.
Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells.
Proteasome inhibitor induced SIRT1 deacetylates GLI2 to enhance hedgehog signaling activity and drug resistance in multiple myeloma.
SIRT2 and SIRT3 expression correlates with redox imbalance and advanced clinical stage in patients with multiple myeloma.
Sirtuin 2 knockdown inhibits cell proliferation and RAS/ERK signaling, and promotes cell apoptosis and cell cycle arrest in multiple myeloma.
Targeting SIRT1 to inhibit the proliferation of multiple myeloma cells.
The time-dependent autophagy protects against apoptosis with possible involvement of Sirt1 protein in multiple myeloma under nutrient depletion.
Multiple Sclerosis
Association of miRNA and mRNA Levels of the Clinical Onset of Multiple Sclerosis Patients.
Dysregulation of SIRT-1 Signaling in Multiple Sclerosis and Neuroimmune Disorders: A Systematic Review on SIRTUIN Activators as Potential Immunomodulators and Influences on other Dysfunctions.
Ellagic acid improves muscle dysfunction in cuprizone-induced demyelinated mice via mitochondrial Sirt3 regulation.
Evidence for possible role of melatonin in reducing oxidative stress in multiple sclerosis through its effect on SIRT1 and antioxidant enzymes.
Histone Deacetylase SIRT1 Mediates C5b-9-Induced Cell Cycle in Oligodendrocytes.
Phosphorylated SIRT1 as a biomarker of relapse and response to treatment with glatiramer acetate in multiple sclerosis.
Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.
Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients.
SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review.
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
SIRT1 as a potential biomarker of response to treatment with glatiramer acetate in multiple sclerosis.
SIRT1 deacetylates ROR?t and enhances Th17 cell generation.
SIRT1 is decreased during relapses in patients with multiple sclerosis.
Multiple Sclerosis, Relapsing-Remitting
Phosphorylated SIRT1 as a biomarker of relapse and response to treatment with glatiramer acetate in multiple sclerosis.
SIRT1 is decreased during relapses in patients with multiple sclerosis.
Multiple System Atrophy
Role of TPPP/p25 on ?-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy.
Muscular Atrophy
Carboxyamidotriazole alleviates muscle atrophy in tumor-bearing mice by inhibiting NF-?B and activating SIRT1.
Differential expression of HDAC and HAT genes in atrophying skeletal muscle.
HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation.
Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65.
Isoflavones Derived from Soy Beans Prevent MuRF1-Mediated Muscle Atrophy in C2C12 Myotubes through SIRT1 Activation.
Muscle-specific sirtuin1 gain-of-function ameliorates skeletal muscle atrophy in a pre-clinical mouse model of cerebral ischemic stroke.
Myricanol rescues dexamethasone-induced muscle dysfunction via a sirtuin 1-dependent mechanism.
NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy.
Preventing muscle wasting by osteoporosis drug alendronate in vitro and in myopathy models via sirtuin-3 down-regulation.
Role of SIRT2 in regulating the dexamethasone-activated autophagy pathway in skeletal muscle atrophy.
SIRT1 by blocking the activities of FoxO1 and 3 inhibits muscle atrophy and promotes muscle growth.
Sirtuin 3 deficiency accelerates Angiotensin II-induced skeletal muscle atrophy.
Sirtuin deacetylases in neurodegenerative diseases of aging.
Tart Cherry (Fruit of Prunus cerasus) Concentrated Powder (TCcp) Ameliorates Glucocorticoid-Induced Muscular Atrophy in Mice.
The Treatment of Rhodiola Mimics Exercise to Resist High-Fat Diet-Induced Muscle Dysfunction via Sirtuin1-Dependent Mechanisms.
Muscular Diseases
Role of SIRT2 in regulating the dexamethasone-activated autophagy pathway in skeletal muscle atrophy.
The novel relationship between Sirt3 and autophagy in myocardial ischemia-reperfusion.
Muscular Disorders, Atrophic
PGC-1?-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging.
Muscular Dystrophies
Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.
Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy.
Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy.
SIRT1: A Novel Target for the Treatment of Muscular Dystrophies.
Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1.
Muscular Dystrophy, Duchenne
A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy.
Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy.
Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice.
Muscular Dystrophy, Oculopharyngeal
Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.
Mycobacterium Infections, Nontuberculous
Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis.
Mycoses
MYO1F regulates antifungal immunity by regulating acetylation of microtubules.
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Myelodysplastic Syndromes
A SIRT1 Agonist May Be Beneficial in Myelodysplastic Syndrome.
Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
Role of SIRT1 in hematologic malignancies.
SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function.
Myocardial Infarction
A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease.
A TagSNP in SIRT1 Gene Confers Susceptibility to Myocardial Infarction in a Chinese Han Population.
Cardiomyocyte-Specific JunD Overexpression Increases Infarct Size following Ischemia/Reperfusion Cardiac Injury by Downregulating Sirt3.
Cardioprotective effect of a moderate and prolonged exercise training involves sirtuin pathway.
Effect of statins on sirtuin 1 and endothelial nitric oxide synthase expression in young patients with a history of premature myocardial infarction.
Euterpe Oleracea Mart. (Açaí) Reduces Oxidative Stress and Improves Energetic Metabolism in Myocardial Ischemia-Reperfusion Injury in Rats.
Exogenous Hydrogen Sul?de Postconditioning Protects Isolated Rat Hearts From Ischemia/Reperfusion Injury Through Sirt1/PGC-1? Signaling Pathway.
Flavonoid Extract from Propolis Inhibits Cardiac Fibrosis Triggered by Myocardial Infarction through Upregulation of SIRT1.
Functional genetic variants within the SIRT2 gene promoter in acute myocardial infarction.
Genetic analysis of the SIRT1 gene promoter in myocardial infarction.
Genetic and Functional Sequence Variants of the SIRT3 Gene Promoter in Myocardial Infarction.
Hydrogen sulfide restores sevoflurane postconditioning mediated cardioprotection in diabetic rats: Role of SIRT1/Nrf2 signaling-modulated mitochondrial dysfunction and oxidative stress.
Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress.
Improvement of Cardiac Function in Rats With Myocardial Infarction by Low-Intensity to Moderate-Intensity Endurance Exercise Is Associated With Normalization of Klotho and SIRT1.
Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.
Metformin improves cardiac function in mice with heart failure after myocardial infarction by regulating mitochondrial energy metabolism.
miR-124-3p targeted SIRT1 to regulate cell apoptosis, inflammatory response, and oxidative stress in acute myocardial infarction in rats via modulation of the FGF21/CREB/PGC1? pathway.
MiR-34a promotes myocardial infarction in rats by inhibiting the activity of SIRT1.
Myocardial Injection of Apelin-Overexpressing Bone Marrow Cells Improves Cardiac Repair via Upregulation of Sirt3 after Myocardial Infarction.
PLGA-PNIPAM Microspheres Loaded with the Gastrointestinal Nutrient NaB Ameliorate Cardiac Dysfunction by Activating Sirt3 in Acute Myocardial Infarction.
Polydatin protects cardiomyocytes against myocardial infarction injury by activating Sirt3.
Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility.
Preserved recovery of cardiac function following ischemia-reperfusion in mice lacking SIRT3.
Pretreatment with Tilianin improves mitochondrial energy metabolism and oxidative stress in rats with myocardial ischemia/reperfusion injury via AMPK/SIRT1/PGC-1 alpha signaling pathway.
Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-?B, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation.
Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure.
Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients.
Sirt1 Antisense Long Noncoding RNA Promotes Cardiomyocyte Proliferation by Enhancing the Stability of Sirt1.
SIRT1 confers protection against ischemia/reperfusion injury in cardiomyocytes via regulation of uncoupling protein 2 expression.
SIRT1 is Required for Exercise-Induced Beneficial Effects on Myocardial Ischemia/Reperfusion Injury.
SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study.
SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications.
SIRT3 Transfection of Aged Human Bone Marrow-Derived Mesenchymal Stem Cells Improves Cell Therapy-Mediated Myocardial Repair.
SIRT3-mediated cardiac remodeling/repair following myocardial infarction.
Sirtuin1-p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat.
Sirtuin3 protects aged human mesenchymal stem cells against oxidative stress and enhances efficacy of cell therapy for ischaemic heart diseases.
The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.
The miRNA199a/SIRT1/P300/Yy1/sST2 signaling axis regulates adverse cardiac remodeling following MI.
The NAD-dependent deacetylase SIRT2 is required for programmed necrosis.
The novel relationship between Sirt3 and autophagy in myocardial ischemia-reperfusion.
Theacrine attenuates myocardial fibrosis after myocardial infarction via the SIRT3/?-catenin/PPAR? pathway in estrogen-deficient mice.
Using ultrasound three-dimensional speckle tracking technology to explore the role of SIRT1 in ventricular remodeling after myocardial infarction.
[Cardioprotective Effect and Its Mechanism of Total Saponins of Panacis Majoris Rhizoma in Myocardial Infarction Rats].
[Effects of aerobic interval training on myocardial oxidative stress and inflammation in rats with myocardial infarction and its mechanism].
[SIRT1].
Myocardial Ischemia
Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia.
Cardiomyocyte Specific Deletion of Sirt1 Gene Sensitizes Myocardium to Ischemia and Reperfusion Injury.
Critical role of SIRT1 upregulation on the protective effect of lncRNA ANRIL against hypoxia/reoxygenation injury in H9c2 cardiomyocytes.
Losartan protects the heart against ischemia reperfusion injury: sirtuin3 involvement.
Rno-microRNA-30c-5p promotes myocardial ischemia reperfusion injury in rats through activating NF-?B pathway and targeting SIRT1.
SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury.
SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease.
Sirtinol abrogates late phase of cardiac ischemia preconditioning in rats.
SUV39H1 mediated SIRT1 trans-repression contributes to cardiac ischemia-reperfusion injury.
Ubiquitin-like protein FAT10 suppresses SIRT1-mediated autophagy to protect against ischemic myocardial injury.
Myocardial Reperfusion Injury
Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D.
Interferon regulatory factor 9 is an essential mediator of heart dysfunction and cell death following myocardial ischemia/reperfusion injury.
Myocarditis
miR?217 and miR?543 downregulation mitigates inflammatory response and myocardial injury in children with viral myocarditis by regulating the SIRT1/AMPK/NF??B signaling pathway.
Myositis
Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers.
nadh:ubiquinone reductase (h+-translocating) deficiency
Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation.
Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure.
Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K.
Resveratrol attenuates oxidative stress in mitochondrial Complex I deficiency: Involvement of SIRT3.
Nasal Polyps
Glycyrrhetinic acid suppressed hmgb1 release by up-regulation of Sirt6 in nasal inflammation.
Sirtuin-1 Controls Poly (I:C)-Dependent Matrix Metalloproteinase 9 Activation in Primary Human Nasal Epithelial Cells.
Nasopharyngeal Carcinoma
[Research of SIRT1 on promoting the proliferation, migration and lipid metabolism of nasopharyngeal carcinoma].
Neoplasm Metastasis
A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer.
A novel Ubc9 -dependent pathway regulates SIRT1- ER-? Axis and BRCA1-associated TNBC lung metastasis.
A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis.
Adjudin synergizes with paclitaxel and inhibits cell growth and metastasis by regulating the sirtuin 3-Forkhead box O3a axis in human small-cell lung cancer.
Associations of sirtuins with clinicopathological parameters and prognosis in non-small cell lung cancer.
Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer.
Circ_0005075 stimulates the proliferation and metastasis of glioma via downregulating SIRT1.
Clinicopathological and prognostic role of SIRT1 in breast cancer patients: a meta-analysis.
Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1.
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.
Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis.
Combination of SIRT1 and Src overexpression suggests poor prognosis in luminal breast cancer.
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.
Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance.
Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype.
Down Regulation of SIRT2 Reduced ASS Induced NSCLC Apoptosis Through the Release of Autophagy Components via Exosomes.
Down-regulation of SIRT3 promotes ovarian carcinoma metastasis.
Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling.
Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1.
Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes.
Effect of the SIRT3-AMPK/PPAR pathway on invasion and migration of cervical cancer cells.
Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines.
Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target.
Emerging role of sirtuins in breast cancer metastasis and multidrug resistance: Implication for novel therapeutic strategies targeting sirtuins.
Expression and clinical significance of Sirt1 in colorectal cancer.
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.
Expression of Leptin and Sirtuin-1 is associated with poor prognosis in patients with osteosarcoma.
Expression of miR-204 in pediatric retinoblastoma and its effects on proliferation and apoptosis of cancer cells.
Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer.
Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.
Expression of SIRT1 and survivin correlates with poor prognosis in esophageal squamous cell carcinoma.
Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer.
Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy.
FK866 inhibits the epithelial-mesenchymal transition of hepatocarcinoma MHCC97-H cells.
HBx mediated Increase of SIRT1 Contributes to HBV-related Hepatocellular Carcinoma Tumorigenesis.
Hepatocellular Expression of SIRT1 and Its Effect on Hepatocellular Carcinoma Progression: A Future Therapeutic Perspective.
How much successful are the medicinal chemists in modulation of SIRT1: A critical review.
Hsa-miR-217 Inhibits the Proliferation, Migration, and Invasion in Non-small Cell Lung Cancer Cells Via Targeting SIRT1 and P53/KAI1 Signaling
Hsa_circ_0006571 promotes spinal metastasis through sponging microRNA-138 to regulate sirtuin 1 expression in lung adenocarcinoma.
Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3.
Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway.
Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies.
MicroRNA-1225-5p inhibits the development and progression of thyroid cancer via targeting sirtuin 3.
MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma.
MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1.
miR-133b inhibits glioma cell proliferation and invasion by targeting Sirt1.
miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1.
MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells.
MiR-29a function as tumor suppressor in cervical cancer by targeting SIRT1 and predict patient prognosis.
MiR-770 promotes oral squamous cell carcinoma migration and invasion by regulating the Sirt7/Smad4 pathway.
Mitohormesis Primes Tumor Invasion and Metastasis.
Morphoproteomics and Biomedical Analytics Identify the c-Myc, EZH2, Sirt1 and CXCR4 Pathways as Potential Blocks to Differentiation Leading to Proliferation and Metastatic Potential in Sinonasal Undifferentiated Carcinoma (SNUC) and Provide Therapeutic Options: A Case Study.
Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells.
O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway.
Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer.
Over-expression of Sirt1 contributes to chemoresistance and indicates poor prognosis in serous epithelial ovarian cancer (EOC).
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma.
PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells.
Recent progress in carcinogenesis, progression and therapy of breast cancer: the 20th Hiroshima Cancer Seminar--the 4th Three Universities' Consortium International Symposium, October 2010: 31 October 2010, International Conference Center Hiroshima.
Resistin induces breast cancer cells epithelial to mesenchymal transition (EMT) and stemness through both adenylyl cyclase-associated protein 1 (CAP1)-dependent and CAP1-independent mechanisms.
Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis.
Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma.
Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR(mt) to promote metastasis.
Silent information regulator 1 suppresses epithelial-to-mesenchymal transition in lung cancer cells via its regulation of mitochondria status.
Silent information regulator, Sirtuin 1, and age-related diseases.
SIRT1 and gynecological malignancies (Review).
SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis.
SIRT1 deacetylates KLF4 to activate Claudin-5 transcription in ovarian cancer cells.
SIRT1 expression regulates the transformation of resistant esophageal cancer cells via the epithelial-mesenchymal transition.
SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1?-mediated mitochondrial biogenesis.
SIRT1 in the Development and Treatment of Hepatocellular Carcinoma.
SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis.
SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer.
SIRT1 inhibits gastric cancer proliferation and metastasis via STAT3/MMP-13 signaling.
SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-?B pathway.
Sirt1 is a tumor promoter in lung adenocarcinoma.
SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor ? in breast cancer.
SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration.
Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells.
SIRT1 promotes epithelial-mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression.
SIRT1 promotes formation of breast cancer through modulating Akt activity.
SIRT1 promotes metastasis of human osteosarcoma cells.
SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells.
SIRT1 Regulates Lamellipodium Extension and Migration of Melanoma Cells.
SIRT1 regulates N6 -methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2-dependent FTO SUMOylation.
SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells.
SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p.
SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis.
SIRT1 suppresses the migration and invasion of gastric cancer by regulating ARHGAP5 expression.
SIRT2 expression exhibits potential to serve as a biomarker for disease surveillance and prognosis in the management of cervical cancer patients.
SIRT2 mediated antitumor effects of shikonin on metastatic colorectal cancer.
SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition via akt/GSK-3?/?-catenin signaling (revised version).
SIRT2, a direct target of miR-212-5p, suppresses the proliferation and metastasis of colorectal cancer cells.
SIRT3 acts as a novel biomarker for the diagnosis of lung cancer: A retrospective study.
SIRT3 inhibits prostate cancer metastasis through regulation of FOXO3A by suppressing Wnt/?-catenin pathway.
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases.
Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma.
Sirtuin2 correlates with lymph node metastasis, increased FIGO stage, worse overall survival, and reduced chemosensitivity to cisplatin and paclitaxel in endometrial cancer.
Sirtuin6 (SIRT6) Promotes the EMT of Hepatocellular Carcinoma by Stimulating Autophagic Degradation of E-Cadherin.
SRT1720 induces lysosomal-dependent cell death of breast cancer cells.
SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.
Sulforaphane-cisplatin combination inhibits the stemness and metastatic potential of TNBCs via down regulation of sirtuins-mediated EMT signaling axis.
Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma.
Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis.
Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis.
The Expression and Related Clinical Significance of SIRT3 in Non-Small-Cell Lung Cancer.
The expression of SIRT1 regulates the metastaticplasticity of chondrosarcoma cells by inducing epithelial-mesenchymal transition.
The possible role of Sirtuins and microRNAs in hepatocellular carcinoma therapy.
The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers.
The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response.
The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients.
The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration.
Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone.
Trending topics of SIRT1 in tumorigenicity.
Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy.
Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.
Upregulation of long non-coding RNA OGFRP1 facilitates endometrial cancer by regulating miR-124-3p/SIRT1 axis and by activating PI3K/AKT/GSK-3? pathway.
[Expression Level of SIRT2 in Cervical Cancer Tissue and Its Clinical Significance].
[SIRT1 participates in epithelial-mesenchymal transition of EC-9706 and Eca-109 cells in vitro by regulating Snail expression].
Neoplasms
1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes.
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells.
75-kd sirtuin 1 blocks tumor necrosis factor ?-mediated apoptosis in human osteoarthritic chondrocytes.
?-Cryptoxanthin Restores Nicotine-Reduced Lung SIRT1 to Normal Levels and Inhibits Nicotine-Promoted Lung Tumorigenesis and Emphysema in A/J Mice.
?2-AR activation promotes cleavage and nuclear translocation of Her2 and metastatic potential of cancer cells.
A biotin switch-based proteomics approach identifies 14-3-3? as a target of Sirt1 in the metabolic regulation of caspase-2.
A c-Myc-SIRT1 feedback loop regulates cell growth and transformation.
A C21-steroidal derivative suppresses T-cell lymphoma in mice by inhibiting SIRT3 via SAP18-SIN3.
A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes.
A Dual Role for Sirtuin 1 in Tumorigenesis.
A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors.
A knockout Combo: eradicating AML Stem Cells with TKI plus SIRT1 inhibition.
A Label-free Sirtuin 1 Assay based on Droplet-Electrospray Ionization Mass Spectrometry.
A multicancer-like syndrome in a dog characterized by p53 and cell cycle-checkpoint kinase 2 (CHK2) mutations and Sirtuin gene (SIRT1) down-regulation.
A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose exposed HepG2 cells.
A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53.
A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma.
A Novel Substrate Radiotracer for Molecular Imaging of SIRT2 Expression and Activity with Positron Emission Tomography.
A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition.
A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators.
A Provocative Molecular Link between Mammographic Density and BRCA1-loss associated TNBC.
A scaffold replacement approach towards new sirtuin 2 inhibitors.
A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity.
A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53.
A Small-Molecule SIRT2 Inhibitor That Promotes K-Ras4a Lysine Fatty-Acylation.
A tumor suppressor SIRTainty.
A variant in SIRT2 gene 3'-UTR is associated with susceptibility to colorectal cancer.
Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells.
Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer.
ABT737 enhances ovarian cancer cells sensitivity to cisplatin through regulation of mitochondrial fission via Sirt3 activation.
Accelerating cancer evolution: a dark side of SIRT1 in genome maintenance.
Activators of Sirtuin-1 and their Involvement in Cardioprotection.
Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity.
ADC correlation with Sirtuin1 to assess early chemoradiotherapy response of locally advanced esophageal carcinoma patients.
Adipose tissue gene expression profiles in ob/ob mice treated with leptin.
Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7.
Advances in characterization of SIRT3 deacetylation targets in mitochondrial function.
Aging and cancer: are sirtuins the link?
AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells.
Alterations in expression levels of genes in p53-related pathways determined using RNA-Seq analysis in patients with breast cancer following CIK therapy.
Altered Expression of CD44, SIRT1, CXCR4, miR-21, miR-34a, and miR-451 Genes in MKN-45 Cell Line After Docetaxel Treatment.
Altered sirtuin expression is associated with node-positive breast cancer.
Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.
AML1-ETO promotes SIRT1 expression to enhance leukemogenesis of t(8;21) acute myeloid leukemia.
Amurensin G enhances the susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity of cancer stem-like cells of HCT-15 cells.
Amurensin G, a novel SIRT1 inhibitor, sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis.
Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene.
Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signaling.
Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?
Anticancer agents targeted to sirtuins.
Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC.
Antioxidant enzymes change in different non-metastatic stages in tumoral and peritumoral tissues of colorectal cancer.
Antiproliferative activity of (R)-4'-methylklavuzon on hepatocellular carcinoma cells and EpCAM+/CD133+ cancer stem cells via SIRT1 and Exportin-1 (CRM1) inhibition.
Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo.
Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation.
Aqueous Extract of Whitmania Pigra Whitman Alleviates Thrombus Burden via Sirtuin 1/NF-?B Pathway.
AROS has a context-dependent effect on SIRT1.
AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma.
Arsenic exposure disrupts epigenetic regulation of SIRT1 in human keratinocytes.
Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-X(L) and survivin.
aSIRTing Control over Cancer Stem Cells.
Assessment of SIRT2 Inhibitors in Mouse Models of Cancer.
Association between SIRT1 Gene Polymorphisms and Breast Cancer in Egyptians.
Association Between SIRT1, Cytokines, and Metabolic Syndrome in Schizophrenia Patients With Olanzapine or Clozapine Monotherapy.
Association of SIRT1 and HMGA1 expression in non-small cell lung cancer.
Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma.
Associations of sirtuins with clinicopathological variables and prognosis in human ovarian cancer.
Autophagy in the physiological endometrium and cancer.
Autophagy maintains ubiquitination-proteasomal degradation of Sirt3 to limit oxidative stress in K562 leukemia cells.
Axonal Protection by Nicotinamide Riboside via SIRT1-Autophagy Pathway in TNF-Induced Optic Nerve Degeneration.
B-cell Lymphomas Exhibit a Non-Oncogene Addiction to SIRT3.
Baicalin, a Chinese Herbal Medicine, Inhibits the Proliferation and Migration of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells, A549 and H1299, by Activating the SIRT1/AMPK Signaling Pathway.
Balance between SIRT1 and DBC1 expression is lost in breast cancer.
Benzodeazaoxaflavins as Sirtuin Inhibitors with Antiproliferative Properties in Cancer Stem Cells.
BOS Is Associated With Decreased SIRT1 in Peripheral Blood Proinflammatory T, NK, and NKT-like Lymphocytes.
Bouchardatine suppresses rectal cancer in mice by disrupting its metabolic pathways via activating the SIRT1-PGC-1?-UCP2 axis.
BRCA1 inhibits AR-mediated proliferation of breast cancer cells through the activation of SIRT1.
Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer.
Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation.
c-MYC and SIRT1 locked in a vicious cycle.
Calorie restriction upregulated sirtuin 1 by attenuating its ubiquitin degradation in cancer cells.
Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.
Camptothecin activates SIRT1 to promote lipid catabolism through AMPK/FoxO1/ATGL pathway in C2C12 myogenic cells.
Can Sir(2) regulate cancer?
Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent inhibition of sirtuin 1.
Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival.
Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.
Catalpol?mediated microRNA?34a suppresses autophagy and malignancy by regulating SIRT1 in colorectal cancer.
CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells.
CCAR1 and CCAR2 as gene chameleons with antagonistic duality: Preclinical, human translational, and mechanistic basis.
CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance.
Cell-surface G-protein-coupled receptors for tumor-associated metabolites: A direct link to mitochondrial dysfunction in cancer.
Cellular regulation of SIRT1.
Characterization of FOXO Acetylation.
CHFR negatively regulates SIRT1 activity upon oxidative stress.
Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells.
Cilostazol Mediated Nurr1 and Autophagy Enhancement: Neuroprotective Activity in Rat Rotenone PD Model.
Circ-sirt1 inhibits growth and invasion of gastric cancer by sponging miR-132-3p/miR-212-3p and upregulating sirt1 expression.
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage.
CKII-SIRT1-SM22? loop evokes a self-limited inflammatory response in vascular smooth muscle cells.
Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma.
Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer.
Clinicopathological and molecular analysis of SIRT7 in hepatocellular carcinoma.
Clinicopathological and predictive significance of SIRT1 and peroxisome proliferator-activated receptor gamma in esophageal squamous cell carcinoma: The correlation with EGFR and Survivin.
Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1.
Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.
Combination of SIRT1 and Src overexpression suggests poor prognosis in luminal breast cancer.
Combination of sirtuin 3 and hyperoxia diminishes tumorigenic properties of MDA-MB-231 cells.
Comparative deacetylase activity of wild type and mutants of SIRT1.
Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats.
Complex roles of Sirtuin 1 in cancer and aging.
Comprehensive silencing of target-sharing microRNAs is a mechanism for SIRT1 overexpression in cancer.
Construction of SIRT1 gene shRNA lentivirus vector and its effect on the proliferation of breast cancer cells.
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.
Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet.
Continuous multiparametric monitoring of cell metabolism in response to transient overexpression of the sirtuin deacetylase SIRT3.
Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1.
Correction for Shah et al., "A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of Cancer-Related Genes".
Correction: Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth.
Cortactin is associated with tumour progression and poor prognosis in prostate cancer and SIRT2 other than HADC6 may work as facilitator in situ.
CPEB1 mediates hepatocellular carcinoma cancer stemness and chemoresistance.
Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis.
CSAG2 is a cancer-specific activator of SIRT1.
Current advances in the synthesis and antitumoral activity of SIRT1-2 inhibitors by modulation of p53 and pro-apoptotic proteins.
Cyanidin 3-O-?-Glucoside Ameliorates Ethanol-Induced Acute Liver Injury by Attenuating Oxidative Stress and Apoptosis: The Role of SIRT1/FOXO1 Signaling.
Cytoplasmic SIRT1 inhibits cell migration and invasion by impeding epithelial-mesenchymal transition in ovarian carcinoma.
Cytotoxicity of metformin against HT29 colon cancer cells contributes to mitochondrial Sirt3 upregulation.
d-Limonene protects PC12 cells against corticosterone-induced neurotoxicity by activating the AMPK pathway.
DBC1 does not function as a negative regulator of SIRT1 in liver cancer.
DBC1 Functions as a Tumor Suppressor by Regulating p53 Stability.
DBC1 is a negative regulator of SIRT1.
De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment.
Deacetylation by SIRT1 Reprograms Inflammation and Cancer.
Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response.
Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation.
Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT2 down-regulates its enzymatic activity.
Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1.
Deacetylation-activated construction of single quantum dot-based nanosensor for sirtuin 1 assay.
Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia.
Decreased Expression of MiR-138-5p by LncRNA H19 in Cervical Cancer Promotes Tumor Proliferation.
Decreased expression of SIRT6 promotes tumor cell growth correlates closely with poor prognosis of ovarian cancer.
Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer.
Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1.
Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut.
Deleted in Breast Cancer 1 (DBC1) is a dynamically regulated protein.
Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.
Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5.
Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors.
Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice.
Diagnostic investigation of BIRC6 and SIRT1 protein expression level as potential prognostic biomarkers in patients with non-small cell lung cancer.
Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer.
Diet-induced obesity promotes murine gastric cancer growth through a nampt/sirt1/c-myc positive feedback loop.
Dietary energy balance modulates ovarian cancer progression and metastasis.
Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis.
Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia.
Differential expression of selected histone modifier genes in human solid cancers.
Differential expression of the sirtuin family in renal cell carcinoma: Aspects of carcinogenesis and prognostic significance.
Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas.
Differential roles of Sirt1 in HIF-1? and HIF-2? mediated hypoxic responses.
Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver.
Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors.
Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors.
Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1.
Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor.
Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis.
Discovery of Potent Natural-Product-Derived SIRT2 Inhibitors Using Structure-Based Exploration of SIRT2 Pharmacophoric Space Coupled With QSAR Analyses.
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.
Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies.
Discovery of SIRT3 Inhibitors Using SAMDI Mass Spectrometry.
Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation.
Distinct effects of SIRT1 in cancer and stromal cells on tumor promotion.
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients.
Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype.
Diverse roles of SIRT1 in cancer biology and lipid metabolism.
Docosahexaenoic acid-enriched phospholipids and eicosapentaenoic acid-enriched phospholipids inhibit tumor necrosis factor-alpha-induced lipolysis in 3T3-L1 adipocytes by activating sirtuin 1 pathways.
Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island.
Down Regulation of miR-34a and miR-143 May Indirectly Inhibit p53 in Oral Squamous Cell Carcinoma: a Pilot Study.
Down-regulation of SIRT3 promotes ovarian carcinoma metastasis.
Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection.
Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling.
Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells.
Downregulation of SIRT2 Inhibits Invasion of Hepatocellular Carcinoma by Inhibiting Energy Metabolism.
Drug repurposing for ligand-induced rearrangement of Sirt2 active site-based inhibitors via molecular modeling and quantum mechanics calculations.
Dual role of SIRT1 in UVB-induced skin tumorigenesis.
Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer.
Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.
Dysregulation of Key Proteins Associated with Sperm Motility and Fertility Potential in Cancer Patients.
Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes.
Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness.
E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells.
E. coli endotoxin modulates the expression of Sirtuin proteins in PBMC in humans.
E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation.
Effect of resveratrol derivative BTM-0512 on high glucose-induced dysfunction of endothelial cells: role of SIRT1.
Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells.
Effect of the SIRT3-AMPK/PPAR pathway on invasion and migration of cervical cancer cells.
Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS.
Effects of inhalational anaesthetics in experimental allergic asthma.
Effects of nasal CPAP on exhaled SIRT1 and tumor necrosis factor-? in patients with obstructive sleep apnea.
Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines.
Emerging Drug Target In Pancreatic Cancer: Placing Sirtuin 1 on the Canvas.
Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target.
Emerging role of SIRT2 in non-small cell lung cancer.
Emerging role of sirtuins in breast cancer metastasis and multidrug resistance: Implication for novel therapeutic strategies targeting sirtuins.
Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer.
Emerging Roles of SIRT1 in Cancer Drug Resistance.
Emerging roles of telomeric chromatin alterations in cancer.
Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1.
Endothelin-1 in portal hypertension: The intricate role of hepatic stellate cells.
Energy sensing pathways: Bridging type 2 diabetes and colorectal cancer?
Energy-Based Pharmacophore and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling Combined with Virtual Screening To Identify Novel Small-Molecule Inhibitors of Silent Mating-Type Information Regulation 2 Homologue 1 (SIRT1).
Enhanced activation of NAD(P)H: quinone oxidoreductase 1 attenuates spontaneous hypertension by improvement of endothelial nitric oxide synthase coupling via tumor suppressor kinase liver kinase B1/adenosine 5'-monophosphate-activated protein kinase-mediated guanosine 5'-triphosphate cyclohydrolase 1 preservation.
Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression.
Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.
Enzymatic and Biological Characterization of Novel Sirtuin Modulators against Cancer.
Epac1 and Glycyrrhizin Both Inhibit HMGB1 Levels to Reduce Diabetes-Induced Neuronal and Vascular Damage in the Mouse Retina.
Epigenetic mechanisms in anti-cancer actions of bioactive food components - the implications in cancer prevention.
Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis.
Ethanol Exposure Attenuates Immune Response in Sepsis via Sirtuin 2 Expression.
Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: Their evaluation as inhibitors of SIRT1.
Evaluation of The Relationship among The Levels of SIRT1 and SIRT3 with Oxidative Stress and DNA Fragmentation in Asthenoteratozoospermic Men.
EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1.
Exendin-4 exhibits a tumour suppressor effect in SKOVR-3 and OVACR-3 ovarian cancer cells lines by the activation of SIRT1 and inhibition of NF-?B.
Exploitation of DHODH and p53 activation as therapeutic targets - a case study in polypharmacology.
Expression and clinical significance of Sirt1 in colorectal cancer.
Expression and prognostic significance of SIRT1 in ovarian epithelial tumours.
Expression and role of SIRT1 in hepatocellular carcinoma.
Expression and sequence of canine SIRT2 and p53 genes in canine mammary tumour cells - effects on downstream targets Wip1 and p21/Cip1.
Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma.
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.
Expression of DBC1 is associated with nuclear grade and HER2 expression in breast cancer.
Expression of immune checkpoints and T cell exhaustion markers in early and advanced stages of colorectal cancer.
Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer.
Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.
Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma.
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas.
Expression of Sirt1 and FoxP3 in classical Hodgkin lymphoma and tumor infiltrating lymphocytes: Implications for immune dysregulation, prognosis and potential therapeutic targeting.
Expression of SIRT1 and survivin correlates with poor prognosis in esophageal squamous cell carcinoma.
Expression of SIRT1 gene in human lung cancer lines enhances their sensitivity to the anticancer effects of cisplatin.
Expression of SIRT1 in Gastric Cardiac Cancer and Its Clinicopathologic Significance.
Expression of SIRT1 in Ocular Surface Squamous Neoplasia.
Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer.
Expression of SIRT1, SIRT3 and SIRT6 Genes for Predicting Survival in Triple-Negative and Hormone Receptor-Positive Subtypes of Breast Cancer.
Expression of SIRT2 and SIRT6 in retinoblastoma.
Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.
Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-? in psoriatic patients.
Expression of the significance of silent information regulator type-1 in Angioimmunoblastic T-cell lymphoma is greater association with tumorigenesis and has strong implications for adverse prognosis.
Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice.
Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy.
Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.
Feeding restriction alleviates high carbohydrate diet-induced oxidative stress and inflammation of Megalobrama amblycephala by activating the AMPK-SIRT1 pathway.
FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2).
Fission Yeast Sirtuin Hst4 Functions in Preserving Genomic Integrity by Regulating Replisome Component Mcl1.
FK866 inhibits the epithelial-mesenchymal transition of hepatocarcinoma MHCC97-H cells.
From anti-aging drugs to cancer therapy: is there a potential for sirtuin activators in gliomas?
Function of miR-212 as a tumor suppressor in thyroid cancer by targeting SIRT1.
Function of the SIRT1 protein deacetylase in cancer.
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.
Functional benefit and molecular mechanism of vitamin C against perfluorooctanesulfonate-associated leukemia.
Further characterization of HDAC and SIRT gene expression patterns in pancreatic cancer and their relation to disease outcome.
Gene expression mapping of histone deacetylases and co-factors, and correlation with survival time and 1H-HRMAS metabolomic profile in human gliomas.
Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease.
Genetic analysis of the SIRT1 gene promoter in ventricular septal defects.
Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma.
Genetic variation in healthy oldest-old.
Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau.
Genomic organization and localization of the NAD-dependent histone deacetylase gene sirtuin 3 (Sirt3) in the mouse.
Genomics of aging: The role of sirtuin and metabolic health.
Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation.
Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype.
Global effect of inauhzin on human p53-responsive transcriptome.
Global transcriptome analysis of formalin-fixed prostate cancer specimens identifies biomarkers of disease recurrence.
Glycyrrhetinic acid suppressed hmgb1 release by up-regulation of Sirt6 in nasal inflammation.
Glycyrrhizin protects IGFBP-3 knockout mice from retinal damage.
Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial.
Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2.
Haploinsufficiency of SIRT1 Enhances Glutamine Metabolism and Promotes Cancer Development.
HDAC is indispensable for IFN-?-induced B7-H1 expression in gastric cancer.
HDAC4 mediates IFN-? induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells.
HDAC6 and SIRT2 Regulate the Acetylation State and Oncogenic Activity of Mutant K-RAS.
Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions.
Hepatocellular Expression of SIRT1 and Its Effect on Hepatocellular Carcinoma Progression: A Future Therapeutic Perspective.
HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs).
High expression of Sirt7 served as a predictor of adverse outcome in breast cancer.
High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions.
High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients.
High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients.
High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma.
High-Intensity Training and Saffron: Effects on Breast Cancer-related Gene Expression.
High-throughput screening of Sirtuin family of genes in breast cancer.
Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin.
Histone Deacetylase SIRT1 promotes loss of primary cilia in Cholangiocarcinoma.
Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice.
Horizontal transfer of miR-23a from hypoxic tumor cell colonies can induce angiogenesis.
How does SIRT1 affect metabolism, senescence and cancer?
Human Sir2 and the 'silencing' of p53 activity.
Human sirtuin 2 localization, transient interactions, and impact on the proteome point to its role in intracellular trafficking.
HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA.
Hypermethylated in cancer 1 (HIC1) mediates high glucose induced ROS accumulation in renal tubular epithelial cells by epigenetically repressing SIRT1 transcription.
Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma.
Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression.
Identification of a novel polyprenylated acylphloroglucinol?derived SIRT1 inhibitor with cancer?specific anti-proliferative and invasion-suppressing activities.
Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.
Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity.
Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity.
Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2.
Identification of dysregulated microRNAs in canine malignant melanoma.
Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways.
Identification of Sirtuin 3, a mitochondrial protein deacetylase, as a new contributor to tamoxifen resistance in breast cancer cells.
IL-1? induces expression of proinflammatory cytokines and migration of human colon cancer cells through upregulation of SIRT1.
Impact of Sirtuin Enzymes on the Altered Metabolic Phenotype of Malignantly Transformed Cells.
Impact of vitamin D metabolism on clinical epigenetics.
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.
Improved Expression of Sirt1 on Thymic Epithelial Cells of SAMP10 after Intra Bone Marrow-Bone Marrow Transplantation.
Improving SIRT1 by trehalose supplementation reduces oxidative stress, inflammation, and histopathological scores in the kidney of aged rats.
In silico Design of Novel Sirtuin 1 Enzyme Activators for Treatment of Age-related Diseases and Life Span.
Increase of Hspa1a and Hspa1b genes in the resting B cells of Sirt1 knockout mice.
Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity.
Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNF?)-induced apoptosis through SIRT1 inhibition.
Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3.
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.
Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells.
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage.
Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs.
Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1? protein under hypoxic conditions.
Inhibition of SIRT1 Limits Self-Renewal and Oncogenesis by Inducing Senescence of Liver Cancer Stem Cells.
Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation.
Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells.
Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway.
Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies.
Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling.
Inhibitors of NAD+ dependent histone deacetylases (sirtuins).
Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins).
Inhibitory effect of baicalin on collagen-induced arthritis in rats through the nuclear factor-?B pathway.
Insight into the Mechanism of Intramolecular Inhibition of the Catalytic Activity of Sirtuin 2 (SIRT2).
Insulin/IGF-1R, SIRT1, and FOXOs Pathways-An Intriguing Interaction Platform for Bone and Osteosarcoma.
Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma.
Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress.
Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology.
Interferon ? protects against lethal endotoxic and septic shock through SIRT1 upregulation.
Interferon gamma (IFN-?) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription.
Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53.
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.
Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer.
Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming.
Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells.
Intersections between mitochondrial sirtuin signaling and tumor cell metabolism.
Investigation of sirtuin 1 polymorphisms in relation to the risk of colorectal cancer by molecular subtype.
JAK1-mediated Sirt1 phosphorylation functions as a negative feedback of the JAK1-STAT3 pathway.
Janus-faced role of SIRT1 in tumorigenesis.
Jaridon 6, a new diterpene from Rabdosia rubescens (Hemsl.) Hara, can display anti-gastric cancer resistance by inhibiting SIRT1 and inducing autophagy.
JNK activation-mediated nuclear SIRT1 protein suppression contributes to silica nanoparticle-induced pulmonary damage via p53 acetylation and cytoplasmic localisation.
JNK2-dependent regulation of SIRT1 protein stability.
K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation.
Kaempferol Protects Against Hydrogen Peroxide-Induced Retinal Pigment Epithelium Cell Inflammation and Apoptosis by Activation of SIRT1 and Inhibition of PARP1.
KDM4D Predicts Recurrence in Exocrine Pancreatic Cells of Resection Margins from Patients with Pancreatic Adenocarcinoma.
Knockdown of
Knockdown of SIRT1 inhibits proliferation and promotes apoptosis of paclitaxel-resistant human cervical cancer cells.
Knockout of SIRT4 decreases chemosensitivity to 5-FU in colorectal cancer cells.
Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation.
Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a.
Lentivirus-mediated siRNA targeting VEGF inhibits gastric cancer growth in vivo.
Licochalcone A attenuates abdominal aortic aneurysm induced by angiotensin II via regulating the miR-181b/SIRT1/HO-1 signaling.
Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products.
Limited role of Sirt1 in cancer protection by dietary restriction.
Lipopolysaccharide-induced depression is associated with estrogen receptor-?/SIRT1/NF-?B signaling pathway in old female mice.
Lipopolysaccharides-Induced Inflammatory Response in White Blood Cells Is Associated with Alterations in Senescence Mediators: Modulation by Metformin.
Long non-coding RNA H19 confers 5-Fu resistance in colorectal cancer by promoting SIRT1-mediated autophagy.
Long Noncoding RNA SNHG10 Sponges miR-543 to Upregulate Tumor Suppressive SIRT1 in Nonsmall Cell Lung Cancer.
Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma.
Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria.
Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice.
Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies.
Loss of SIRT4 promotes the self-renewal of Breast Cancer Stem Cells.
Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.
Low SIRT3 expression contributes to tumor progression, development and poor prognosis in human pancreatic carcinoma.
Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma.
Lysine Acetylome Study of Human Hepatocellular Carcinoma Tissues for Biomarkers and Therapeutic Targets Discovery.
Macromolecular crowding effect is critical for maintaining SIRT1's nuclear localization in cancer cells.
Mammalian SIRT1 represses forkhead transcription factors.
Mammalian Sirt1: insights on its biological functions.
Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin.
MAPK pathway and SIRT1 are involved in the down-regulation of secreted osteopontin expression by genistein in metastatic cancer cells.
Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators.
Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction.
Mechanistic understanding of ?-cryptoxanthin and lycopene in cancer prevention in animal models.
Melatonin and sirtuins: A "not-so unexpected" relationship.
Melatonin and the pathologies of weakened or dysregulated circadian oscillators.
Melatonin Counteracts at a Transcriptional Level the Inflammatory and Apoptotic Response Secondary to Ischemic Brain Injury Induced by Middle Cerebral Artery Blockade in Aging Rats.
Melatonin improves cardiac and mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin activity?
Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway.
Melatonin rescues the mice brain against cisplatin-induced neurodegeneration, an insight into antioxidant and anti-inflammatory effects.
Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model.
Mesenchymal stem cells overexpressing Sirt1 inhibit prostate cancer growth by recruiting natural killer cells and macrophages.
Metal-binding effects of sirtuin inhibitor sirtinol.
Metformin activates AMPK/SIRT1/NF-?B pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis.
Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells.
Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1?/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents.
Micellar Delivery of miR-34a Modulator Rubone and Paclitaxel in Resistant Prostate Cancer.
MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma.
MicroRNA Regulation of SIRT1.
MicroRNA-1225-5p inhibits the development and progression of thyroid cancer via targeting sirtuin 3.
MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1.
MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma.
MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma.
MicroRNA-34a induces a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells with a wild-type p53 gene background.
MicroRNA-34a regulates proliferation and apoptosis of gastric cancer cells by targeting silent information regulator 1.
MicroRNA-34a: a novel tumor suppressor in p53-mutant glioma cell line U251.
microRNA-526b servers as a prognostic factor and exhibits tumor suppressive property by targeting Sirtuin 7 in hepatocellular carcinoma.
MicroRNA?486?5p functions as a tumor suppressor of proliferation and cancer stem?like cell properties by targeting Sirt1 in liver cancer.
microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials.
miR-124-3p combined with miR-506-3p delay hepatic carcinogenesis via modulating sirtuin 1.
miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss.
miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1.
Mir-141-3p Regulates Apoptosis and Mitochondrial Membrane Potential via Targeting Sirtuin1 in a 1-Methyl-4-Phenylpyridinium in vitro Model of Parkinson's Disease.
miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells.
miR-204-5p targeting SIRT1 regulates hepatocellular carcinoma progression.
MiR-217 Inhibits Proliferation, Migration, and Invasion by Targeting SIRT1 in Osteosarcoma.
MiR-29a function as tumor suppressor in cervical cancer by targeting SIRT1 and predict patient prognosis.
miR-34a induces immunosuppression in colorectal carcinoma through modulating a SIRT1/NF-?B/B7-H3/TNF-? axis.
MiR-34a reverses radiation resistance on ECA-109 cells by inhibiting PI3K/AKT/mTOR signal pathway through downregulating the expression of SIRT1.
miR?128 is upregulated in epilepsy and promotes apoptosis through the SIRT1 cascade.
Mitochondrial Effects of Teucrium Polium and Prosopis Farcta Extracts in Colorectal Cancer Cells
Mitochondrial Sirt3 supports cell proliferation by regulating glutamine-dependent oxidation in renal cell carcinoma.
Mitochondrial Sirtuin 3 and Renal Diseases.
Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target.
Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation.
Mitophagy in degenerative joint diseases.
MnSOD acetylation and dys-regulation, due to loss of SIRT3 activity, promotes a Luminal B-like breast carcinogenic permissive phenotype.
Modulating SIRT1 activity variously affects thymic lymphoma development in mice.
Modulation of Sirt1 and FoxO1 on Hypothalamic Leptin-Mediated Sympathetic Activation and Inflammation in Diet-Induced Obese Rats.
Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells.
Modulation of tumorigenesis by dietary intervention is not mediated by SIRT1 catalytic activity.
Molecular docking and mechanisms of fusaric acid induced mitochondrial sirtuin aberrations in glycolytically and oxidatively poised human hepatocellular carcinoma (HepG2) cells.
Molecular imaging HDACs class IIa expression-activity and pharmacologic inhibition in intracerebral glioma models in rats using PET/CT/(MRI) with [18F]TFAHA.
Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review.
Molecular modeling study for conformational changes of Sirtuin 2 due to substrate and inhibitor binding.
Molecular Pathways: Emerging Roles of Mammalian Sirtuin SIRT7 in Cancer.
Morphoproteomics and Biomedical Analytics Identify the c-Myc, EZH2, Sirt1 and CXCR4 Pathways as Potential Blocks to Differentiation Leading to Proliferation and Metastatic Potential in Sinonasal Undifferentiated Carcinoma (SNUC) and Provide Therapeutic Options: A Case Study.
Morphoproteomics Identifies the EZH2 and SIRT1 Pathways as Potential Blocks to Differentiation in Yolk Sac Tumor of the Ovary and Provides Therapeutic Options: a Case Study.
Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer.
mTOR signaling promotes foam cell formation and inhibits foam cell egress through suppressing the SIRT1 signaling pathway.
Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma.
Multifaceted Modulation of SIRT1 in Cancer and Inflammation.
Multifunctional transcription factor TFII-I is an activator of BRCA1 function.
Mutant p53 induces SIRT3/MnSOD axis to moderate ROS production in melanoma cells.
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.
Myeloid-specific SIRT1 deletion exacerbates airway inflammatory response in a mouse model of allergic asthma.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
NAMPT inhibition synergizes with NQO1-targeting agents in inducing apoptotic cell death in non-small cell lung cancer cells.
Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells.
Natural products with anti-aging potential: Affected targets and molecular mechanisms.
Natural Sirtuin Modulators in Drug Discovery: A Review (2010 -2020).
Negative control of p53 by Sir2alpha promotes cell survival under stress.
Negative regulation of the deacetylase SIRT1 by DBC1.
Neuroprotective Effects of Ginsenosides against Cerebral Ischemia.
Neuroprotective properties of resveratrol in different neurodegenerative disorders.
New clinical findings on the longevity gene in disease, health, & longevity: Sirtuin 1 often decreases with advanced age & serious diseases in most parts of the human body, while relatively high & constant Sirtuin 1 regardless of age was first found in the hippocampus of supercentenarians.
New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng.
Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas.
Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways.
Nicotinamide-induced silencing of SIRT1 by miR-22-3p increases periodontal ligament stem cell proliferation and differentiation.
Nicotinamide-mediated inhibition of SIRT1 deacetylase is associated with the viability of cancer cells exposed to antitumor agents and apoptosis.
Nicotinic-nAChR signaling mediates drug resistance in lung cancer.
Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis.
Noninvasive quantification of SIRT1 expression-activity and pharmacologic inhibition in a rat model of intracerebral glioma using 2-[18F]BzAHA PET/CT/MRI.
Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies.
Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.
Novel role of the SIRT4-OPA1 axis in mitochondrial quality control.
Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines.
O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway.
Obesity accelerates murine gastric cancer growth by modulating the Sirt1/YAP pathway.
Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells.
Oncogene Ras/Phosphatidylinositol 3-kinase (PI3K) signaling targets histone H3 acetylation at lysine K56.
Oncogenic potential of BEX4 is conferred by Polo-like kinase 1-mediated phosphorylation.
Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer.
Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma.
Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide.
Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1? destabilization.
Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes.
Over-expression of nicotinamide phosphoribosyltransferase in ovarian cancers.
Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo.
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma.
Overexpression of sirtuin 2 and its association with prognosis in acute ischemic stroke patients.
Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma.
Overlapping tumor-specific expression of p53, p16INK4a, and sirtuin 1 in Bowen's disease: A case report.
Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
p53 inhibits the upregulation of sirtuin 1 expression induced by c-Myc.
PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation.
Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats.
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.
PGC-1? activates SIRT3 to modulate cell proliferation and glycolytic metabolism in breast cancer.
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells.
Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.
Pharmacological Targets and the Biological Mechanisms of Formononetin for Alzheimer's Disease: A Network Analysis.
Pharmacophore modeling and virtual screening studies to identify novel selective SIRT2 inhibitors.
Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson's Disease.
PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells.
PPAR? agonist fenofibrate attenuates TNF-?-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway.
PPAR?: the dominant regulator among PPARs in dry eye lacrimal gland and diabetic lacrimal gland.
Probing the mechanism of SIRT1 activation by a 1,4-dihydropyridine.
Profiles of autophagy-related genes in esophageal adenocarcinoma.
Prognostic and clinical value of Sirt1 expression in gastric cancer: A systematic meta-analysis.
Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma.
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.
Prognostic Impact of DNA Repair Protein Expression in Non-Small Cell Lung Cancers Treated with Platinum-Based Chemotherapy and Subsequent Curative Lung Resection.
Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity-breast cancer connection.
Protected from the inside: endogenous histone deacetylase inhibitors and the road to cancer.
Protection of resveratrol on acute kidney injury in septic rats.
Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-?B, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation.
Protective effects of icariin-mediated SIRT1/FOXO3 signaling pathway on intestinal ischemia/reperfusion-induced acute lung injury.
Protective Effects of N1-Methylnicotinamide Against High-Fat Diet- and Age-Induced Hearing Loss via Moderate Overexpression of Sirtuin 1 Protein.
Proteomic analyses of Sirt1-mediated cisplatin resistance in OSCC cell line.
Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors.
Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene.
Putative tumor suppression function of SIRT6 in endometrial cancer.
QSAR studies on the human sirtuin 2 inhibition by non-covalent 7,5,2-anilinobenzamide derivatives.
Quercetin 3,5,7,3',4'-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1.
Rapamycin suppresses the PI3K/AKT/mTOR signaling pathway by targeting SIRT1 in esophageal cancer.
RASSF1A Regulates Spindle Organization by Modulating Tubulin Acetylation via SIRT2 and HDAC6 in Mouse Oocytes.
Reactivation of p53 by Novel MDM2 Inhibitors: Implications for Pancreatic Cancer Therapy.
Rebamipide reduces amyloid-? 1-42 (A?42) production and ameliorates A?43-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells.
Recent Progress on the Discovery of Sirt2 Inhibitors for the Treatment of Various Cancers.
Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1.
Reduced expression of SIRT2 in serous ovarian carcinoma promotes cell proliferation through disinhibition of CDK4 expression.
Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat.
Reduced Plasma Kallistatin Is Associated With the Severity of Coronary Artery Disease, and Kallistatin Treatment Attenuates Atherosclerotic Plaque Formation in Mice.
Regulation of Apoptosis and Radiation Sensitization in Lung Cancer Cells via the Sirt1/NF-?B/Smac Pathway.
Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress.
Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C.
Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer.
Regulation of SIRT2 levels for human non-small cell lung cancer therapy.
Rejuvenating sirtuins: the rise of a new family of cancer drug targets.
RelB acts as a molecular switch driving chronic inflammation in glioblastoma multiforme.
Renal protective effect of sirtuin 1.
Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1.
Repression of SIRT1 promotes the differentiation of mouse induced pluripotent stem cells into neural stem cells.
Resistin induces breast cancer cells epithelial to mesenchymal transition (EMT) and stemness through both adenylyl cyclase-associated protein 1 (CAP1)-dependent and CAP1-independent mechanisms.
Resveratrol (trans-3,5,4'-trihydroxystilbene) suppresses EL4 tumor growth by induction of apoptosis involving reciprocal regulation of SIRT1 and NF-?B.
Resveratrol and Resveratrol-Aspirin Hybrid Compounds as Potent Intestinal Anti-Inflammatory and Anti-Tumor Drugs.
Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius guentheri.
Resveratrol inhibits high-glucose-induced inflammatory "metabolic memory" in human retinal vascular endothelial cells through SIRT1-dependent signaling.
Resveratrol inhibits proliferation and promotes apoptosis of osteosarcoma cells.
Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation.
Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis.
Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism.
Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation.
Reversible modulation of SIRT1 activity in a mouse strain.
Rhein lysinate decreases the generation of ?-amyloid in the brain tissues of Alzheimer's disease model mice by inhibiting inflammatory response and oxidative stress.
Rikkunshito attenuates induction of epithelial-mesenchymal switch via activation of Sirtuin1 in ovarian cancer cells.
RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3' Nuclease-resistant Mini-hairpin Structure.
Role of mitochondrial dysfunction in cancer progression.
Role of prosurvival molecules in the action of lidamycin toward human tumor cells.
Role of SIRT1 in hematologic malignancies.
Role of SIRT1/AMPK signaling in the proliferation, migration and invasion of renal cell carcinoma cells.
Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma.
Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?
Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming.
ROS-Induced SIRT2 Upregulation Contributes to Cisplatin Sensitivity in Ovarian Cancer.
Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1.
Salermide upregulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells.
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.
Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells.
Selective Cytotoxicity of Kaempferia parviflora Extracts in Human Cell Lines.
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020.
Selenium?enriched exopolysaccharides produced by Enterobacter cloacae Z0206 alleviate adipose inflammation in diabetic KKAy mice through the AMPK/SirT1 pathway.
Senescent Stromal Cells Promote Cancer Resistance through SIRT1 Loss-Potentiated Overproduction of Small Extracellular Vesicles.
Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1.
Serum levels of SIRT3 and other inflammatory factors are associated with clinical outcomes and prognosis in severe community-acquired pneumonia in adults: A prospective study.
Seven sirtuins for seven deadly diseases of aging.
SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation.
Silent information regulator 1 suppresses epithelial-to-mesenchymal transition in lung cancer cells via its regulation of mitochondria status.
Silent information regulator 2 promotes clear cell renal cell carcinoma progression through deacetylation and small ubiquitin-related modifier 1 modification of glucose 6-phosphate dehydrogenase.
Silent information regulator, Sirtuin 1, and age-related diseases.
Simultaneous Inhibition of SIRT2 Deacetylase and Defatty-Acylase Activities via a PROTAC Strategy.
SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-?B/STAT3 complex to its promoter in malignant lymphoid cells.
SIRT1 acts as a potential tumor suppressor in oral squamous cell carcinoma.
SIRT1 alleviates isoniazid-induced hepatocyte injury by reducing histone acetylation in the IL-6 promoter region.
SIRT1 and AMPK mediate hypoxia-induced resistance of non-small cell lung cancers to cisplatin and doxorubicin.
SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3? activity in neuroblastoma cells.
SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.
Sirt1 and cell migration.
SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation.
SIRT1 and gynecological malignancies (Review).
SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells.
SIRT1 and microRNAs: The role in breast, lung and prostate cancers.
SIRT1 and p53, effect on cancer, senescence and beyond.
SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth.
SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection.
SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.
Sirt1 antisense transcript is down-regulated in human tumors.
SIRT1 attenuates murine allergic rhinitis by downregulated HMGB 1/TLR4 pathway.
SirT1 brings stemness closer to cancer and aging.
SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
SirT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells.
SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism.
SIRT1 contributes to neuroendocrine differentiation of prostate cancer.
SIRT1 controls cell proliferation by regulating contact inhibition.
SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms.
SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis.
SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation.
SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells.
SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer.
Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis.
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.
SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing.
SIRT1 downregulated FGB expression to inhibit RCC tumorigenesis by destabilizing STAT3.
SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells.
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.
SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury via targeting p53/microRNA-22.
SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer.
SIRT1 Expression Is Associated With Cell Proliferation in Angiosarcoma.
SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients.
SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma.
SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma.
SIRT1 expression is associated with poor prognosis of lung adenocarcinoma.
SIRT1 expression regulates the transformation of resistant esophageal cancer cells via the epithelial-mesenchymal transition.
SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1?-mediated mitochondrial biogenesis.
Sirt1 Gene Expression and Gastric Epithelial Cells Tumor Stage in Patients with Helicobacter pylori Infection
SIRT1 Gene SNP rs932658 is Associated with Medication-Related Osteonecrosis of the Jaw.
SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.
SIRT1 in Secretory Organ Cancer.
SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27.
SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells.
SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis.
SIRT1 induces resistance to apoptosis in human granulosa cells by activating the ERK pathway and inhibiting NF-?B signaling with anti-inflammatory functions.
SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer.
SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage.
SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells.
SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo.
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.
SIRT1 Inhibitory Diterpenoids from the Vietnamese Medicinal Plant Croton tonkinensis.
SIRT1 inhibits chemoresistance and cancer stemness of gastric cancer by initiating an AMPK/FOXO3 positive feedback loop.
SIRT1 inhibits gastric cancer proliferation and metastasis via STAT3/MMP-13 signaling.
Sirt1 inhibits gouty arthritis via activating PPAR?.
SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-?B pathway.
SIRT1 inhibits TNF-?-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1.
SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress.
Sirt1 is a tumor promoter in lung adenocarcinoma.
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer.
SIRT1 is downregulated in gastric cancer and leads to G1-phase arrest via NF-?B/Cyclin D1 signaling.
SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor ? in breast cancer.
SIRT1 is involved in adrenocortical cancer growth and motility.
SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer.
SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of "cancer cells with neural stemness" in a p53-dependent manner.
Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells.
SIRT1 is significantly elevated in mouse and human prostate cancer.
SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1?-dependent glycolysis.
SIRT1 modulates cell cycle progression by regulating CHK2 acetylation-phosphorylation.
SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis.
SIRT1 overexpression decreases cisplatin-induced acetylation of NF-?B p65 subunit and cytotoxicity in renal proximal tubule cells.
SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance.
SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma.
SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-?B signaling.
SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue.
SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation.
SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression.
SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia.
SIRT1 promotes DNA repair activity and deacetylation of Ku70.
SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis.
SIRT1 promotes epithelial-mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression.
SIRT1 promotes formation of breast cancer through modulating Akt activity.
SIRT1 promotes GLUT1 expression and bladder cancer progression via regulation of glucose uptake.
SIRT1 promotes metastasis of human osteosarcoma cells.
SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells.
SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells.
SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency.
SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis.
SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling.
Sirt1 protects from K-Ras-driven lung carcinogenesis.
SIRT1 protein levels in cancer: tuning SIRT1 to the needs of a cancer cell.
SIRT1 regulates CD40 expression induced by TNF-? via NF-?B pathway in endothelial cells.
SIRT1 Regulates Lysosome Function and Exosome Secretion.
Sirt1 regulates microtubule dynamics through negative regulation of Plk1 in mitosis.
SIRT1 regulates N6 -methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2-dependent FTO SUMOylation.
SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma.
SIRT1 Regulates the Chemoresistance and Invasiveness of Ovarian Carcinoma Cells.
SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression.
SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma.
SIRT1 Regulation in Ageing and Obesity.
SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells.
SIRT1 signaling as potential modulator of skeletal muscle diseases.
SIRT1 stabilizes PML promoting its sumoylation.
SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein.
SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p.
SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis.
SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53.
SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF??B pathway in mouse kupffer cells.
Sirt1's systemic protective roles and its promise as a target in antiaging medicine.
SIRT1, is it a tumor promoter or tumor suppressor?
SIRT1, metabolism and cancer.
SIRT1-dependent regulation of chromatin and transcription: Linking NAD(+) metabolism and signaling to the control of cellular functions.
SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with A?: An Early but Transient Response Rescued by Melatonin.
SIRT1-Mediated Expression of CD24 and Epigenetic Suppression of Novel Tumor Suppressor miR-1185-1 Increases Colorectal Cancer Stemness.
SIRT1-mediated transcriptional regulation of SOX2 is important for self-renewal of liver cancer stem cells.
SIRT1-NOX4 signaling axis regulates cancer cachexia.
SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol.
SIRT1-ZEB1-positive feedback promotes epithelial-mesenchymal transition process and metastasis of osteosarcoma.
SIRT1/PGC1?-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer.
SIRT1: a potential tumour biomarker and therapeutic target.
SIRT1: cellular senescence, cancer and organismal aging?
SIRT1: recent lessons from mouse models.
SIRT1: Regulator of p53 Deacetylation.
SIRT1: roles in aging and cancer.
SIRT1: tumor promoter or tumor suppressor?
SIRT2 as a new player in epigenetic programming of keratinocyte differentiation and a candidate tumor suppressor.
SIRT2 as a Therapeutic Target for Age-Related Disorders.
Sirt2 deacetylase is a novel AKT binding partner critical for AKT activation by insulin.
SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents.
SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status.
SIRT2 directs the replication stress response through CDK9 deacetylation.
SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis.
SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest.
SIRT2 expression exhibits potential to serve as a biomarker for disease surveillance and prognosis in the management of cervical cancer patients.
SIRT2 Expression Is Higher in Uveal Melanoma than In Ocular Melanocytes.
Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells.
SIRT2 inhibits non-small cell lung cancer cell growth through impairing Skp2-mediated p27 degradation.
SIRT2 Interacts with ?-Catenin to Inhibit Wnt Signaling Output in Response to Radiation-Induced Stress.
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis.
SIRT2 is an unfavorable prognostic biomarker in patients with acute myeloid leukemia.
SIRT2 knockdown increases basal autophagy and prevents post-slippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors.
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.
SIRT2 mediated antitumor effects of shikonin on metastatic colorectal cancer.
SIRT2 modulates VEGFD-associated lymphangiogenesis by deacetylating EPAS1 in human head and neck cancer.
SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition via akt/GSK-3?/?-catenin signaling (revised version).
SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation.
SIRT2 promotes murine melanoma progression through natural killer cell inhibition.
SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair.
SIRT2 reduces actin polymerization and cell migration through deacetylation and degradation of HSP90.
SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation.
Sirt2 Regulates Radiation-Induced Injury.
SIRT2 regulates tumour hypoxia response by promoting HIF-1? hydroxylation.
SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A.
SIRT2, a direct target of miR-212-5p, suppresses the proliferation and metastasis of colorectal cancer cells.
SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth.
SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology.
SIRT2: Controversy and multiple roles in disease and physiology.
SIRT2: tumour suppressor or tumour promoter in operable breast cancer?
SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients.
SIRT3 acts as a novel biomarker for the diagnosis of lung cancer: A retrospective study.
SIRT3 and cancer: tumor promoter or suppressor?
SirT3 and p53 Deacetylation in Aging and Cancer.
SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis.
Sirt3 attenuates doxorubicin-induced cardiac hypertrophy and mitochondrial dysfunction via suppression of Bnip3.
SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIF.
SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.
SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.
SIRT3 deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status.
Sirt3 enhances glioma cell viability by stabilizing Ku70-BAX interaction.
SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells.
Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells.
SIRT3 functions as a tumor suppressor in hepatocellular carcinoma.
SIRT3 inhibits cell proliferation in human gastric cancer through down-regulation of Notch-1.
SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition.
Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation.
SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway.
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress.
SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis.
Sirt3 is a tumor suppressor in lung adenocarcinoma cells.
SIRT3 is correlated with the malignancy of non-small cell lung cancer.
SIRT3 is Pro-Apoptotic and Participates in Distinct Basal Apoptotic Pathways.
SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1? Destabilization.
SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis.
Sirt3 promotes hepatocellular carcinoma cells sensitivity to regorafenib through the acceleration of mitochondrial dysfunction.
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
SIRT3 promotion reduces resistance to cisplatin in lung cancer by modulating the FOXO3/CDT1 axis.
SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism.
SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2.
SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.
SIRT3 regulates progression and development of diseases of aging.
Sirt3 regulates the level of mitochondrial DNA repair activity through deacetylation of NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 in colorectal cancer.
SirT3 regulates the mitochondrial unfolded protein response.
SirT3 suppresses hypoxia inducible factor 1? and tumor growth by inhibiting mitochondrial ROS production.
SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging.
Sirt3, Mitochondrial ROS, Ageing, and Carcinogenesis.
SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth.
Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia.
SIRT3: Oncogene and Tumor Suppressor in Cancer.
SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma.
SIRT6 inhibits growth of gastric cancer by inhibiting JAK2/STAT3 pathway.
SIRT6 inhibits proliferation and invasion in osteosarcoma cells by targeting N-cadherin.
SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.
SIRT6 regulates the proliferation and apoptosis of hepatocellular carcinoma via the ERK1/2 signaling pathway.
Sirt7 Deficiency Attenuates Neointimal Formation Following Vascular Injury by Modulating Vascular Smooth Muscle Cell Proliferation.
SIRT7 depletion inhibits cell proliferation, migration, and increases drug sensitivity by activating p38MAPK in breast cancer cells.
SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors.
SIRTUIN (SIRT) 1 AND STEROID HORMONE RECEPTOR ACTIVITY IN CANCER.
Sirtuin 1 (SIRT1) Deacetylase Activity and NAD?/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death.
Sirtuin 1 (Sirt1) Overexpression in BaF3 Cells Contributes to Cell Proliferation Promotion, Apoptosis Resistance and Pro-Inflammatory Cytokine Production.
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Sirtuin 1 (SIRT1): the misunderstood HDAC.
Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-?B signaling pathway.
Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways.
Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis.
Sirtuin 1 and oral cancer.
Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors.
Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging-A Systematic Review.
Sirtuin 1 in malignant transformation: Friend or foe?
Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases.
Sirtuin 1 inhibits TNF-?-mediated osteoclastogenesis of bone marrow-derived macrophages through both ROS generation and TRPV1 activation.
Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha.
Sirtuin 1 promotes autophagy and proliferation of endometrial cancer cells by reducing acetylation level of LC3.
Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target.
Sirtuin 1 reduces hyaluronan synthase 2 expression by inhibiting nuclear translocation of NF-?B and expression of the long-noncoding RNA HAS2-AS1.
Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells.
Sirtuin 1: A Dilemma in Transplantation.
SIRTUIN 1: regulating the regulator.
Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma.
Sirtuin 2 mutations in human cancers impair its function in genome maintenance.
Sirtuin 2 promotes cell stemness and MEK/ERK signaling pathway while reduces chemosensitivity in endometrial cancer.
Sirtuin 2-mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses.
Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway.
Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis.
Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3?/BCL2-associated X protein-dependent apoptotic pathway.
Sirtuin 3 silencing impairs mitochondrial biogenesis and metabolism in colon cancer cells.
Sirtuin 3: A Janus face in cancer (Review).
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.
Sirtuin 7 plays an oncogenic role in human osteosarcoma via downregulating CDC4 expression.
Sirtuin 7 promotes non?small cell lung cancer progression by facilitating G1/S phase and epithelial?mesenchymal transition and activating AKT and ERK1/2 signaling.
Sirtuin 7-mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity.
Sirtuin activation targets IDH-mutant tumors.
Sirtuin activators and inhibitors.
Sirtuin deacetylases in neurodegenerative diseases of aging.
Sirtuin deacetylases: a new target for melanoma management.
Sirtuin Family Members Selectively Regulate Autophagy in Osteosarcoma and Mesothelioma Cells in Response to Cellular Stress.
Sirtuin inhibitors as anticancer agents.
Sirtuin inhibitors: An overview from medicinal chemistry perspective.
Sirtuin mechanism and inhibition: explored with N(?)-acetyl-lysine analogs.
Sirtuin-1 Activation Controls Tumor Growth by Impeding Th17 Differentiation via STAT3 Deacetylation.
Sirtuin-1 Regulates Acinar-to-Ductal Metaplasia and Supports Cancer Cell Viability in Pancreatic Cancer.
Sirtuin-1/Mitochondrial Ribosomal Protein S5 Axis Enhances the Metabolic Flexibility of Liver Cancer Stem Cells.
Sirtuin-3 (SIRT3) and the Hallmarks of Cancer.
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.
Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer.
Sirtuin-targeting drugs: Mechanisms of action and potential therapeutic applications.
Sirtuin1 (SIRT1) Regulates Tumor Necrosis Factor-alpha (TNF-?-Induced) Aquaporin-2 (AQP2) Expression in Renal Medullary Collecting Duct Cells Through Inhibiting the NF-?B Pathway.
Sirtuin1 and Chronic Myeloid Leukemia: a Comprehensive Glance at Drug Resistance.
Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer.
Sirtuin1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions.
Sirtuin2 correlates with lymph node metastasis, increased FIGO stage, worse overall survival, and reduced chemosensitivity to cisplatin and paclitaxel in endometrial cancer.
Sirtuin6 (SIRT6) Promotes the EMT of Hepatocellular Carcinoma by Stimulating Autophagic Degradation of E-Cadherin.
Sirtuins and disease: the road ahead.
Sirtuins and p53.
Sirtuins as Novel Targets for Alzheimer's Disease and Other Neurodegenerative Disorders: Experimental and Genetic Evidence.
Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence.
Sirtuins in hematological aging and malignancy.
Sirtuins in Renal Health and Disease.
Sirtuins' modulation of autophagy.
Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer.
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
Small-molecule chromatin-modifying agents: therapeutic applications.
SOD1, an unexpected novel target for cancer therapy.
SOD2 to SOD1 switch in breast cancer.
Sorting out functions of sirtuins in cancer.
SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth.
SRT1720 induces lysosomal-dependent cell death of breast cancer cells.
SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis.
SRT1720, a potential sensitizer for radiotherapy and cytotoxicity effects of NVB-BEZ235 in metastatic breast cancer cells.
SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.
Stabilization of P/CAF, as a ubiquitin ligase toward MDM2, suppresses mitotic cell death through p53-p21 activation in HCT116?cells with SIRT2 suppression.
Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™).
Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor.
Stress Inducibility of SIRT1 and Its Role in Cytoprotection and Cancer.
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change.
Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode.
Structure-Based Development of an Affinity Probe for Sirtuin?2.
Structure-based drug design of small molecule SIRT1 modulators to treat cancer and metabolic disorders.
Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors.
SUMOylation is essential for Sirt2 tumor-suppressor function in neuroblastoma.
Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma.
Surtuin 1 as a potential prognostic biomarker in very elderly patients with colorectal cancer.
Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis.
Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1.
Synthesis and Assay of SIRT1-Activating Compounds.
Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1.
Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5.
Targeting aberrant cancer metabolism - The role of sirtuins.
Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis.
Targeting histone deacetylase SIRT1 selectively eradicates EGFR TKI-resistant cancer stem cells via regulation of mitochondrial oxidative phosphorylation in lung adenocarcinoma.
Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review.
Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes.
Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 (CDKN1A) Expression in a p53-Independent Manner.
Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway.
The 2.5 Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.
The ambiguous role of sirtuins in head and neck squamous cell carcinoma.
The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/?-catenin-Foxo3a axis.
The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases.
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop.
The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin.
The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?
The Contrary Effects of Sirt1 on MCF7 Cells Depend on CD36 Expression Level.
The controversial role of Sirtuins in tumorigenesis - SIRT7 joins the debate.
The Critical Role of SIRT1 in Parkinson's Disease: Mechanism and Therapeutic Considerations.
The critical role of the class III histone deacetylase SIRT1 in cancer.
The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesis.
The dual role of sirtuins in cancer.
The effect of adipocyte-macrophage cross-talk in obesity-related breast cancer.
The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial.
The emerging and diverse roles of sirtuins in cancer: a clinical perspective.
The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer.
The Expression and Related Clinical Significance of SIRT3 in Non-Small-Cell Lung Cancer.
The expression levels of the sirtuins in patients with BCC.
The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas.
The expression of SIRT1 regulates the metastaticplasticity of chondrosarcoma cells by inducing epithelial-mesenchymal transition.
The expression of SIRT3 in primary hepatocellular carcinoma and the mechanism of its tumor suppressing effects.
The Function of PPAR?/AMPK/SIRT-1 Pathway in Inflammatory Response of Human Articular Chondrocytes Stimulated by Advanced Glycation End Products.
The Fungal Metabolite Eurochevalierine, a Sequiterpene Alkaloid, Displays Anti-Cancer Properties through Selective Sirtuin 1/2 Inhibition.
The histone deacetylase inhibitor cambinol prevents acidic pH
The histone deacetylase SIRT2 stabilizes Myc oncoproteins.
The Histone Variant MacroH2A1 Impacts Circadian Gene Expression and Cell Phenotype in an In Vitro Model of Hepatocellular Carcinoma.
The HMGB1-RAGE/TLR-TNF-? signaling pathway may contribute to kidney injury induced by hypoxia.
The human sirtuin family: Evolutionary divergences and functions.
The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response.
The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers.
The prognostic role of Sirt1 expression in solid malignancies: a meta-analysis.
The protein-protein interaction network of the human Sirtuin family.
The relationship of SIRT3 with cellular metabolism and cardiovascular diseases.
The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress.
The role of miRNA-133b and its target gene SIRT1 in FAP-derived desmoid tumor.
The role of mitochondrial sirtuins in health and disease.
The role of SIRT1 in cancer: the saga continues.
The role of SIRT1 in tumorigenesis.
The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer.
The role of SIRT2 in cancer: A novel therapeutic target.
The Roles of SIRT1 in Cancer.
The Roles of Sirtuin Family Proteins in Cancer Progression.
The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells.
The signaling pathways implicated in impairment of hepatic autophagy in glycogen storage disease type Ia.
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
The SIRT1/HIF2? axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.
The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer.
The SIRT2/cMYC Pathway Inhibits Peroxidation-Related Apoptosis In Cholangiocarcinoma Through Metabolic Reprogramming.
The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line.
The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients.
The sirtuin family in cancer.
The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells.
The sirtuins in the pathogenesis of cancer.
The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration.
The study of sirtuins in breast cancer patients before and after radiotherapy
The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53.
The tumor suppressor protein menin inhibits NF-?B-mediated transactivation through recruitment of Sirt1 in hepatocellular carcinoma.
The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation.
The ups and downs of SIRT1.
Therapeutic potential of activators and inhibitors of sirtuins.
Therapeutic strategies against cancer stem cells in human colorectal cancer.
Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing.
Thymoquinone ameliorates obesity-induced metabolic dysfunction, improves reproductive efficiency exhibiting a dose-organ relationship.
TNF-? and LPS activate angiogenesis via VEGF and SIRT1 signalling in human dental pulp cells.
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population.
Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone.
Translating cell survival and cell longevity into treatment strategies with SIRT1.
Trending topics of SIRT1 in tumorigenicity.
TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage.
Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma.
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.
Tumor-suppressive function of SIRT4 in neuroblastoma through mitochondrial damage.
Tumour Expression of Histone Deacetylases in Uveal Melanoma.
Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS.
TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence.
Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex.
Ubiquitin-Specific Protease 22/Silent Information Regulator 1 Axis Plays a Pivotal Role in the Prognosis and 5-Fluorouracil Resistance in Hepatocellular Carcinoma.
Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.
UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer.
Ultrasound?targeted microbubble destruction?mediated overexpression of Sirtuin 3 inhibits the progression of ovarian cancer.
Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors.
Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer.
Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells.
Upregulated tumor sirtuin 2 expression correlates with reduced TNM stage and better overall survival in surgical breast cancer patients.
Upregulation of long non-coding RNA OGFRP1 facilitates endometrial cancer by regulating miR-124-3p/SIRT1 axis and by activating PI3K/AKT/GSK-3? pathway.
Upregulation of mitochondrial NAD(+) levels impairs the clonogenicity of SSEA1(+) glioblastoma tumor-initiating cells.
Upregulation of SIRT1 gene in gastric adenocarcinoma.
Use of the Monte Carlo Method for OECD Principles-Guided QSAR Modeling of SIRT1 Inhibitors.
VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1?/HO-1 pathway.
Vinpocetine ameliorates L-arginine induced acute pancreatitis via Sirt1/Nrf2/TNF pathway and inhibition of oxidative stress, inflammation, and apoptosis.
Werner Helicase Control of Human Papillomavirus 16 E1-E2 DNA Replication Is Regulated by SIRT1 Deacetylation.
X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability.
ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition.
Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer.
[Chromosome arm 17p13.3: could hic1 be the one ?]
[Combating tumor cells through SIRT3 activation and exercise].
[Coronavirus disease (COVID-19) and sirtuins].
[Dexmedetomidine alleviates postoperative cognitive dysfunction in aged rats probably via silent information regulator 1 pathway].
[Effect of electroacupuncture on SIRT1/NF-?B signaling pathway in adipose tissue of obese rats].
[Effects of activating silent information regulator 1 on early kidney damage in rats with severe burn].
[Effects of aerobic interval training on myocardial oxidative stress and inflammation in rats with myocardial infarction and its mechanism].
[Feasibility of integrating tumor therapy with therapeutic effect evaluation using siRNA-loaded microbubbles].
[Mechanisms of electroacupuncture for improving Alzheimer's disease from reducing ? amyloid protein level].
[Research of SIRT1 on promoting the proliferation, migration and lipid metabolism of nasopharyngeal carcinoma].
[Research progression of deacetylase (SIRT1)]
[Retracted] Function of miR?212 as a tumor suppressor in thyroid cancer by targeting SIRT1.
[SIRT1 Influences the Sensitivity of A549 Non-small Cell Lung Cancer Cell Line to ?Cisplatin via Modulating the Noxa Expression].
[Sirtuins and their role in metabolism regulation].
[Sirtuins--modulation of their activity as a novel therapeutic target].
Nephritis
SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus.
Nephrocalcinosis
Theaflavin protects against oxalate calcium-induced kidney oxidative stress injury via upregulation of SIRT1.
Nephrolithiasis
Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population.
Sirt1 inhibits kidney stones formation by attenuating calcium oxalate-induced cell injury.
Sirt3 suppresses calcium oxalate-induced renal tubular epithelial cell injury via modification of FoxO3a-mediated autophagy.
Nephrosclerosis
Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence.
Nervous System Diseases
A novel pathway regulates memory and plasticity via SIRT1 and miR-134.
Could Sirtuin Activities Modify ALS Onset and Progression?
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Impact of curcumin on sirtuins: A review.
Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance.
Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2.
Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells.
Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson's disease.
Resveratrol Promotes Recovery of Hearing following Intense Noise Exposure by Enhancing Cochlear SIRT1 Activity.
SIRT1 activation by minocycline on regulation of microglial polarization homeostasis.
SIRT1/PGC-1? signaling activation by mangiferin attenuates cerebral hypoxia/reoxygenation injury in neuroblastoma cells.
SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke.
SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia.
SIRT2 plays a key role in both cell cycle regulation and cell survival of BV2 microglia.
Sirtuin 2 (SIRT2): Confusing Roles in the Pathophysiology of Neurological Disorders.
Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation.
The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS.
Neural Tube Defects
High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects.
Sirtuin inhibitor Ex-527 causes neural tube defects, ventral edema formations, and gastrointestinal malformations in Xenopus laevis embryos.
Neuralgia
Activating Sirt1 by resveratrol suppresses Nav1.7 expression in DRG through miR-182 and alleviates neuropathic pain in rats.
Combination of Botulinum Toxin and minocycline Ameliorates Neuropathic Pain Through Antioxidant Stress and Anti-Inflammation via Promoting SIRT1 Pathway.
Down-regulation of microRNA-34c-5p alleviates neuropathic pain via the SIRT1/STAT3 signaling pathway in rat models of chronic constriction injury of sciatic nerve.
Downregulated SIRT1 in the CeA is involved in chronic pain-depression comorbidity.
Icariin, a flavonoid with anti-cancer effects, alleviated paclitaxel-induced neuropathic pain in a SIRT1-dependent manner.
Intrathecal Injection of SIRT1-modified Human Mesenchymal Stem Cells Alleviates Neuropathic Pain in Rat.
Intrathecal SRT1720, a SIRT1 agonist, exerts anti-hyperalgesic and anti-inflammatory effects on chronic constriction injury-induced neuropathic pain in rats.
Involvement of spinal SIRT1 in development of chronic constriction injury induced neuropathic pain in rats.
MicroRNA-448 modulates the progression of neuropathic pain by targeting sirtuin 1.
miR-124a and miR-155 enhance differentiation of regulatory T cells in patients with neuropathic pain.
Natural Antioxidant Control of Neuropathic Pain-Exploring the Role of Mitochondrial SIRT3 Pathway.
Overexpression of SIRT2 Alleviates Neuropathic Pain and Neuroinflammation Through Deacetylation of Transcription Factor Nuclear Factor-Kappa B.
Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib.
Resveratrol facilitates pain attenuation in a rat model of neuropathic pain through the activation of spinal sirt1.
Role of SIRT1 in Neuropathic Pain from the Viewpoint of Neuroimmunity.
SIRT1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons.
SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats.
SIRT1 Decreases Emotional Pain Vulnerability with Associated CaMKII? Deacetylation in Central Amygdala.
SIRT1 Mediates Neuropathic Pain Induced by Sciatic Nerve Chronic Constrictive Injury in the VTA-NAc Pathway.
Sirt2 in the Spinal Cord Regulates Chronic Neuropathic Pain Through Nrf2-Mediated Oxidative Stress Pathway in Rats.
SIRT3 alleviates neuropathic pain by deacetylating FoxO3a in the spinal dorsal horn of diabetic model rats.
Spinal miR-34a regulates inflammatory pain by targeting SIRT1 in complete Freund's adjuvant mice.
Spinal SIRT1 activation attenuates neuropathic pain in mice.
Synergistic interaction between total glucosides and total flavonoids on chronic constriction injury induced neuropathic pain in rats.
Neurilemmoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Neuroblastoma
A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1.
Effect of atorvastatin on A?1-42 -induced alteration of SESN2, SIRT1, LC3II and TPP1 protein expressions in neuronal cell cultures.
Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents.
Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells.
Insulin induces neurite outgrowth via SIRT1 in SH-SY5Y cells.
Leptin attenuates BACE1 expression and amyloid-? genesis via the activation of SIRT1 signaling pathway.
Nicotinamide N-methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3.
Pharmacological activation of Sirt1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy.
Resveratrol augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1.
Resveratrol Inhibits Proliferation and Promotes Apoptosis of Neuroblastoma Cells: Role of Sirtuin 1.
SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3? activity in neuroblastoma cells.
SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability.
SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a.
SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition.
SUMOylation is essential for Sirt2 tumor-suppressor function in neuroblastoma.
The histone deacetylase SIRT2 stabilizes Myc oncoproteins.
The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide.
Treatment with the neurotoxic A? (25-35) peptide modulates the expression of neuroprotective factors Pin1, Sirtuin 1, and brain-derived neurotrophic factor in SH-SY5Y human neuroblastoma cells.
Neurodegenerative Diseases
A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors.
Aberrant Decrease of the Endogenous SIRT3 and Increases of Acetylated Proteins in Scrapie Infected Cell Line SMB-S15 and in the Brains of Experimental Mice.
After the grape rush: Sirtuins as epigenetic drug targets in neurodegenerative disorders.
Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated mice.
AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells.
Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway.
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy.
Antioxidant Modulation of mTOR and Sirtuin Pathways in Age-Related Neurodegenerative Diseases.
Attenuation of Pb-induced A? generation and autophagic dysfunction via activation of SIRT1: Neuroprotective properties of resveratrol.
Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity.
Brain Activation of SIRT1: Role in Neuropathology.
Brain SIRT1 Mediates Metabolic Homeostasis and Neuroprotection.
Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1.
Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity.
CELLULAR STRESS RESPONSES, THE HORMESIS PARADIGM AND VITAGENES: NOVEL TARGETS FOR THERAPEUTIC INTERVENTION IN NEURODEGENERATIVE DISORDERS.
Cognitive Impairment and Dementia: Gaining Insight through Circadian Clock Gene Pathways.
Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington's Disease Models.
Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5.
Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors.
Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor.
Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis.
Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies.
Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.
Drug repurposing for ligand-induced rearrangement of Sirt2 active site-based inhibitors via molecular modeling and quantum mechanics calculations.
Effects of age and gender on Sirt 1 mRNA expressions in the hypothalamus of the mouse.
Effects of Resveratrol and trans-3,5,4'-Trimethoxystilbene on Glutamate-Induced Cytotoxicity, Heme Oxygenase-1, and Sirtuin 1 in HT22 Neuronal Cells.
Effects of Sirtuin 1 on microglia in spinal cord injury: involvement of Wnt/?-catenin signaling pathway.
Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
Eriodictyol alleviates lipopolysaccharide-triggered oxidative stress and synaptic dysfunctions in BV-2 microglial cells and mouse brain.
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.
Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease.
Genetic analysis of the SIRT1 gene promoter in ventricular septal defects.
Grape seed procyanidins suppress the apoptosis and senescence of chondrocytes and ameliorates osteoarthritis via the DPP4-Sirt1 pathway.
Hydroxysafflor Yellow A Exerts Anti-Inflammatory Effects Mediated by SIRT1 in Lipopolysaccharide-Induced Microglia Activation.
Inhibition of the Peroxisome Proliferator-Activated Receptor gamma Coactivator 1-alpha (PGC-1?)/Sirtuin 3 (SIRT3) Pathway Aggravates Oxidative Stress After Experimental Subarachnoid Hemorrhage.
Inhibitors of NAD+ dependent histone deacetylases (sirtuins).
Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases.
Is systemic activation of Sirt1 beneficial for ageing-associated metabolic disorders?
JAZ (Znf346), a SIRT1-interacting protein, protects neurons by stimulating p21 (WAF/CIP1) protein expression.
Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide.
Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure.
Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics.
Modulation of sirtuins: new targets for antiageing.
Molecular modelling studies of sirtuin 2 inhibitors using three-dimensional structure-activity relationship analysis and molecular dynamics simulations.
Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer.
Natural Sirtuin Modulators in Drug Discovery: A Review (2010 -2020).
Neuronal protection by sirtuins in Alzheimer's disease.
Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington's disease and other neurodegenerative disorders.
Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease.
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.
Paths of convergence: sirtuins in aging and neurodegeneration.
Potential role of sirtuin as a therapeutic target for neurodegenerative diseases.
Probing the mechanism of SIRT1 activation by a 1,4-dihydropyridine.
Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway.
Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-?B pathway contributed to the suppression of microglial activation-induced PC12 cell apoptosis.
Renal protective effect of sirtuin 1.
Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection.
Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases.
Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner.
Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice.
Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer's disease.
Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease.
Resveratrol:New Avenues For A Natural Compound In Neuroprotection.
Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.
Role of Sirt1 During the Ageing Process: Relevance to Protection of Synapses in the Brain.
Role of SIRT1 in autoimmune demyelination and neurodegeneration.
Silent information regulator, Sirtuin 1, and age-related diseases.
SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells.
SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease.
SIRT1 and neuronal diseases.
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases.
SIRT1 and SIRT2: emerging targets in neurodegeneration.
SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
SIRT1 in neurodevelopment and brain senescence.
SIRT1 Inhibitory Diterpenoids from the Vietnamese Medicinal Plant Croton tonkinensis.
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway.
SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA.
Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling.
SIRT1 promotes neuronal fortification in neurodegenerative diseases through attenuation of pathological hallmarks and enhancement of cellular lifespan.
SIRT1 regulates O-GlcNAcylation of tau through OGT.
SIRT1 Regulation in Ageing and Obesity.
SIRT1 regulation modulates stroke outcome.
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
SIRT1: new avenues of discovery for disorders of oxidative stress.
Sirt1’s beneficial roles in neurodegenerative diseases - a chaperonin containing TCP-1 (CCT) connection?
SIRT2 as a Therapeutic Target for Age-Related Disorders.
SIRT2 in age-related neurodegenerative disorders.
SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-?B p65 acetylation and activation.
SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition.
SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation.
SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology.
SIRT2: Controversy and multiple roles in disease and physiology.
SIRT3 activator Honokiol attenuates ?-Amyloid by modulating amyloidogenic pathway.
SIRT3 and mitochondrial metabolism in neurodegenerative diseases.
SIRT3 regulates progression and development of diseases of aging.
SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases.
Sirtuin 1 activator SRT2104 protects Huntington's disease mice.
Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection.
SIRTUIN 1: regulating the regulator.
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation.
Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease.
Sirtuin activators and inhibitors.
Sirtuin activators: Designing molecules to extend life span.
Sirtuin deacetylases in neurodegenerative diseases of aging.
Sirtuin inhibitors.
Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration.
Sirtuin3 in Neurological Disorders.
Sirtuins and renal diseases: relationship with aging and diabetic nephropathy.
Sirtuins as Novel Targets for Alzheimer's Disease and Other Neurodegenerative Disorders: Experimental and Genetic Evidence.
Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence.
Sirtuins as Possible Targets in Neurodegenerative Diseases.
Sirtuins in Neuroendocrine Regulation and Neurological Diseases.
Sirtuins inhibitors: The approach to affinity and selectivity.
Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change.
Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors.
Synthesis and Evaluation of Substituted Chroman-4-one and Chromone Derivatives as Sirtuin 2-Selective Inhibitors.
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
The neurobiology of sirtuins and their role in neurodegeneration.
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration.
The role of mitochondrial sirtuins in health and disease.
The role of PARP1 in neurodegenerative diseases and aging.
The Role SIRT2 in Programmed Necrosis: Implications for Stroke and Neurodegenerative Disorders.
The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS.
The Sirtuin family: therapeutic targets to treat diseases of aging.
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
The systemic role of SIRT1 in exercise mediated adaptation.
The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders.
Therapeutic potential of activators and inhibitors of sirtuins.
Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease.
Therapeutic role of sirtuins in neurodegenerative disease.
Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing.
Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways.
trans-(-)-?-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease.
Translating cell survival and cell longevity into treatment strategies with SIRT1.
Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors.
[Research progression of deacetylase (SIRT1)]
[SIRT1/PGC-1: a neuroprotective axis?]
[SIRT1].
Neurofibrosarcoma
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Neuroinflammatory Diseases
17?-Estradiol via SIRT1/Acetyl-p53/NF-kB Signaling Pathway Rescued Postnatal Rat Brain Against Acute Ethanol Intoxication.
5-Heptadecylresorcinol, a Biomarker for Whole Grain Rye Consumption, Ameliorates Cognitive Impairments and Neuroinflammation in APP/PS1 Transgenic Mice.
Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside.
Activation of silent information regulator 1 exerts a neuroprotective effect after intracerebral hemorrhage by deacetylating NF-?B/p65.
AGK2 Alleviates Lipopolysaccharide Induced Neuroinflammation through Regulation of Mitogen-Activated Protein Kinase Phosphatase-1.
All Trans Retinoic Acid Attenuates Markers of Neuroinflammation in Rat Brain by Modulation of SIRT1 and NF?B.
AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia.
An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury.
Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome.
Berberine ameliorates lipopolysaccharide-induced learning and memory deficit in the rat: insights into underlying molecular mechanisms.
Berberine enhances survival and axonal regeneration of motoneurons following spinal root avulsion and re-implantation in rats.
Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.
Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 Levels Improving Cognition in Aged Rats.
Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia.
Dexmedetomidine Ameliorates Hippocampus Injury and Cognitive Dysfunction Induced by Hepatic Ischemia/Reperfusion by Activating SIRT3-Mediated Mitophagy and Inhibiting Activation of the NLRP3 Inflammasome in Young Rats.
Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model.
Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer's Disease.
Effects of Sirtuin 1 on microglia in spinal cord injury: involvement of Wnt/?-catenin signaling pathway.
Emerging Roles of Sirtuins in Ischemic Stroke.
Eriodictyol alleviates lipopolysaccharide-triggered oxidative stress and synaptic dysfunctions in BV-2 microglial cells and mouse brain.
Eriodictyol Attenuates LPS-Induced Neuroinflammation, Amyloidogenesis, and Cognitive Impairments via the Inhibition of NF-?B in Male C57BL/6J Mice and BV2 Microglial Cells.
Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation.
Increasing Nrf2 Activity as a Treatment Approach in Neuropsychiatry.
Laquinimod inhibits MMP+?induced NLRP3 inflammasome activation in human neuronal cells.
Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model.
Microglia activation induces oxidative injury and decreases SIRT3 expression in dopaminergic neuronal cells.
Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices.
MicroRNA-448 modulates the progression of neuropathic pain by targeting sirtuin 1.
Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets.
NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1? pathway.
Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-?B and Nrf2/Keap-1 Signaling.
Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease.
Overexpression of SIRT2 Alleviates Neuropathic Pain and Neuroinflammation Through Deacetylation of Transcription Factor Nuclear Factor-Kappa B.
Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson's Disease.
Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway.
Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration.
Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice.
Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery.
Resveratrol Targeting of Carcinogen-Induced Brain Endothelial Cell Inflammation Biomarkers MMP-9 and COX-2 is Sirt1-Independent.
Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.
Role of the epigenetic factor Sirt7 in neuroinflammation and neurogenesis.
Saffron extract attenuates neuroinflammation in rmTBI mouse model by suppressing NLRP3 inflammasome activation via SIRT1.
Schisandrin ameliorates cognitive deficits, endoplasmic reticulum stress and neuroinflammation in streptozotocin (STZ)-induced Alzheimer's disease rats.
SIRT1 and SIRT2 modulators reduce LPS-induced inflammation in HAPI microglial cells and protect SH-SY5Y neuronal cells in vitro.
SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-?B p65 acetylation and activation.
SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice.
SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain.
Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke.
Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats.
Sirtuin 1 alleviates neuroinflammation-induced apoptosis after traumatic brain injury.
Sirtuin 1 and Alzheimer's disease: An up-to-date review.
Sirtuin 3 attenuates neuroinflammation-induced apoptosis in BV-2 microglia.
Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation.
Targeting sirtuin activity with nicotinamide riboside reduces neuroinflammation in a GWI mouse model.
The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases.
The Critical Role of SIRT1 in Parkinson's Disease: Mechanism and Therapeutic Considerations.
The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation.
The role of PARP1 in neurodegenerative diseases and aging.
The role of SIRT1 in neuroinflammation and cognitive dysfunction in aged rats after anesthesia and surgery.
Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population.
Treadmill exercise mitigates neuroinflammation and increases BDNF via activation of SIRT1 signaling in a mouse model of T2DM.
Yes-associated protein reduces neuroinflammation through upregulation of Sirt3 and inhibition of JNK signaling pathway.
Nevus
Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy.
Nevus, Pigmented
Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma.
nicotinamide phosphoribosyltransferase deficiency
Nicotinamide phosphoribosyltransferase (Nampt) may serve as the marker for osteoblast differentiation of bone marrow-derived mesenchymal stem cells.
Nijmegen Breakage Syndrome
AsSIRTing the DNA damage response.
Impairment of sirtuin 1-mediated DNA repair is involved in bisphenol A-induced aggravation of macrophage inflammation and atherosclerosis.
Role of SIRT1 in homologous recombination.
SIRT1 regulates the function of the Nijmegen breakage syndrome protein.
Non-alcoholic Fatty Liver Disease
A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice.
A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.
A Novel Role of SIRT1/ FGF-21 in Taurine Protection Against Cafeteria Diet-Induced Steatohepatitis in Rats.
A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators.
AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease.
Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization.
Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats.
Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH.
Altered microRNA-9 Expression Level is Directly Correlated with Pathogenesis of Nonalcoholic Fatty Liver Disease by Targeting Onecut2 and SIRT1.
Association of SIRT1 gene polymorphism and its expression for the risk of alcoholic fatty liver disease in the Han population.
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3.
Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway.
Cadmium chloride induces non-alcoholic fatty liver disease in rats by stimulating miR-34a/SIRT1/FXR/p53 axis.
Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats.
Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway.
Cardiovascular disease is associated with high-fat-diet-induced liver damage and up-regulation of the hepatic expression of hypoxia-inducible factor 1? in a rat model.
Circulating levels of sirtuin 4, a potential marker of oxidative metabolism, related to coronary artery disease in obese patients suffering from NAFLD, with normal or slightly increased liver enzymes.
Corrigendum to "Circulating Levels of Sirtuin 4, a Potential Marker of Oxidative Metabolism, Related to Coronary Artery Disease in Obese Patients Suffering from NAFLD, with Normal or Slightly Increased Liver Enzymes".
Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced hepatic steatosis in mice.
DHA Protects Against Hepatic Steatosis by Activating Sirt1 in a High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mouse Model.
Dietary blueberry and bifidobacteria attenuate nonalcoholic fatty liver disease in rats by affecting SIRT1-mediated signaling pathway.
Differential TM4SF5-mediated SIRT1 modulation and metabolic signaling in nonalcoholic steatohepatitis progression.
Dihydromyricetin Ameliorates Nonalcoholic Fatty Liver Disease by Improving Mitochondrial Respiratory Capacity and Redox Homeostasis Through Modulation of SIRT3 Signaling.
Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients.
Effect of miR-34a in regulating steatosis by targeting PPAR? expression in nonalcoholic fatty liver disease.
Effects of resveratrol, exercises and their combination on Farnesoid X receptor, Liver X receptor and Sirtuin 1 gene expression and apoptosis in the liver of elderly rats with nonalcoholic fatty liver.
Electroacupuncture Attenuates Liver Inflammation in Nonalcoholic Fatty Liver Disease Rats.
Eliciting the mitochondrial unfolded protein response via NAD(+) repletion reverses fatty liver disease.
Elucidation of SIRT-1/PGC-1?-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease.
Emerging roles of SIRT1 in fatty liver diseases.
Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease.
EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats.
Gender effect of hyperuricemia on the development of nonalcoholic fatty liver disease (NAFLD): A clinical analysis and mechanistic study.
Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK.
Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial.
GRHL2 induces liver fibrosis and intestinal mucosal barrier dysfunction in non-alcoholic fatty liver disease via microRNA-200 and the MAPK pathway.
Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing.
Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressor.
Hepatoprotective Effect and Molecular Mechanisms of Hengshun Aromatic Vinegar on Non-Alcoholic Fatty Liver Disease.
Hugan Qingzhi Exerts Anti-Inflammatory Effects in a Rat Model of Nonalcoholic Fatty Liver Disease.
Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease.
Inhibition of microRNA-124a attenuates non-alcoholic fatty liver disease through upregulation of adipose triglyceride lipase and the effect of liraglutide intervention.
Lipidomic Analysis of the Protective Effects of Shenling Baizhu San on Non-Alcoholic Fatty Liver Disease in Rats.
Long noncoding RNA FLRL2 alleviated nonalcoholic fatty liver disease through Arntl-Sirt1 pathway.
Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity.
Major royal jelly proteins prevents NAFLD by improving mitochondrial function and lipid accumulation through activating the AMPK / SIRT3 pathway in vitro.
Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy.
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Metabolic benefits from Sirt1 and Sirt1 activators.
MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3.
miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease.
MiR-181b regulates steatosis in nonalcoholic fatty liver disease via targeting SIRT1.
miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload.
miR-34a/SIRT1/p53 is Suppressed by Ursodeoxycholic Acid in Rat Liver and Activated by Disease Severity in Human Non-alcoholic Fatty Liver Disease.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
NAD+-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin.
Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe-/-mice: role of SIRT1.
Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver.
Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients.
Prevalence, clinical characteristics, risk factors, and indicators for lean Chinese adults with nonalcoholic fatty liver disease.
Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease.
Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease.
Regulation of Mitochondrial Trifunctional Protein Modulates Nonalcoholic Fatty Liver Disease in Mice.
Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion.
Silybin Restored CYP3A Expression through the Sirtuin 2/Nuclear Factor ?-B Pathway in Mouse Nonalcoholic Fatty Liver Disease.
SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease.
SIRT1 Mediates the Effect of GLP-1 Receptor Agonist Exenatide on Ameliorating Hepatic Steatosis.
SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPAR?/FoxO1 signaling pathway.
SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding.
SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis.
SIRT3 as a Regulator of Non-alcoholic Fatty Liver Disease.
SIRT3 Deficiency Promotes High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Correlation with Impaired Intestinal Permeability through Gut Microbial Dysbiosis.
SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity.
SIRT3 regulates ?-SMA production through the succinate dehydrogenase-GPR91 pathway in hepatic stellate cells.
Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4?.
Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity.
Sirtuin 3 improves fatty acid metabolism in response to high nonesterified fatty acids in calf hepatocytes by modulating gene expression.
Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates non-alcoholic fatty liver disease.
Targeting Sirt1 in a rat model of high-fat diet-induced non-alcoholic fatty liver disease: Comparison of Gegen Qinlian decoction and resveratrol.
The effect of aerobic, resistance, and combined training on PPAR-?, SIRT1 gene expression, and insulin resistance in high-fat diet-induced NAFLD male rats.
The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial.
The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats.
The ménage à trois of autophagy, lipid droplets and liver disease.
Theacrine protects against nonalcoholic fatty liver disease by regulating acylcarnitine metabolism.
Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy.
Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice.
Treating hyperuricemia related non-alcoholic fatty liver disease in rats with resveratrol.
Treatment with SRT1720, a SIRT1 Activator, Ameliorates Fatty Liver with Reduced Expression of Lipogenic Enzymes in MSG Mice.
[Association of single nucleotide polymorphism of SIRT1 and APOC3 with nonalcoholic fatty liver disease].
[Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver.]
[Effects of calorie restriction on SIRT1 expression in liver of nonalcoholic fatty liver disease: experiment with rats]
[Hepatic SIRT1 and UCP2 expressions in rats with type 2 diabetes mellitus and nonalcoholic fatty liver].
Obesity
(Healthy) ageing: focus on iodothyronines.
?-Mangostin Regulates Hepatic Steatosis and Obesity through SirT1-AMPK and PPAR? Pathways in High-Fat Diet-Induced Obese Mice.
Acupuncture Targeting SIRT1 in the Hypothalamic Arcuate Nucleus Can Improve Obesity in High-Fat-Diet-Induced Rats with Insulin Resistance via an Anorectic Effect.
Adipocyte SIRT1 knockout promotes PPAR? activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity.
Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity.
Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release.
Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway.
ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity.
Anti-obesity Activity of Ethanol Extract from Bitter Melon in Mice Fed High-Fat Diet.
Anti-obesity effects of Spirulina maxima in high fat diet induced obese rats via the activation of AMPK pathway and SIRT1.
Association between low SIRT1 expression in visceral and subcutaneous adipose tissues and metabolic abnormalities in women with obesity and type 2 diabetes.
Association of SIRT1 gene variation with visceral obesity.
Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity.
Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway.
Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa.
Brain SIRT1 Mediates Metabolic Homeostasis and Neuroprotection.
Brain SIRT1: anatomical distribution and regulation by energy availability.
Breaking the intergenerational cycle of obesity with SIRT1.
Brown Alga Ecklonia cava Polyphenol Extract Ameliorates Hepatic Lipogenesis, Oxidative Stress, and Inflammation by Activation of AMPK and SIRT1 in High-Fat Diet-Induced Obese Mice.
Circulating SIRT1 Increases After Intragastric Balloon Fat Loss in Obese Patients.
Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity.
Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation.
Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline.
Correction to: ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis.
Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis.
Decreased levels and activity of Sirt1 are modulated by increased miR-34a expression in adipose tissue mononuclear cells from subjects with overweight and obesity: A pilot study.
Diet-induced obesity and insulin resistance are associated with brown fat degeneration in SIRT1-deficient mice.
Diet-induced obesity promotes murine gastric cancer growth through a nampt/sirt1/c-myc positive feedback loop.
Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor.
Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice.
Electroacupuncture: A Feasible Sirt1 Promoter Which Modulates Metainflammation in Diet-Induced Obesity Rats.
Elevated microRNA-34a in obesity reduces NAD(+) levels and SIRT1 activity by directly targeting NAMPT.
Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6.
Environment and Gene Association With Obesity and Their Impact on Neurodegenerative and Neurodevelopmental Diseases.
Epithelial sodium channels in endothelial cells mediate diet-induced endothelium stiffness and impaired vascular relaxation in obese female mice.
Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis.
Food restriction improves glucose and lipid metabolism through Sirt1 expression: a study using a new rat model with obesity and severe hypertension.
Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease.
Genetic analysis of the SIRT1 gene promoter in ventricular septal defects.
Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study.
Genomics of aging: The role of sirtuin and metabolic health.
Growth hormone signaling in muscle and adipose tissue of obese human subjects: associations with measures of body composition and interaction with resveratrol treatment.
Gynostemma Pentaphyllum Extract Ameliorates High-Fat Diet-Induced Obesity in C57BL/6N Mice by Upregulating SIRT1.
Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions.
High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions.
High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss.
High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction.
High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression.
Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance.
Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice.
Hypothalamic Sirt1 regulates food intake in a rodent model system.
Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators.
In silico Design of Novel Sirtuin 1 Enzyme Activators for Treatment of Age-related Diseases and Life Span.
Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation.
Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue.
Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index.
Ketogenesis and SIRT1 as a tool in managing obesity.
Lactobacillus sakei Alleviates High-Fat-Diet-Induced Obesity and Anxiety in Mice by Inducing AMPK Activation and SIRT1 Expression and Inhibiting Gut Microbiota-Mediated NF-?B Activation.
Leucine Supplementation Increases SIRT1 Expression and Prevents Mitochondrial Dysfunction and Metabolic Disorders in High Fat Diet-induced Obese Mice.
LncRNA TUG1 reduces inflammation and enhances insulin sensitivity in white adipose tissue by regulating miR-204/SIRT1 axis in obesity mice.
Macrophage {alpha}1-AMP-activated protein kinase ({alpha}1AMPK) antagonizes fatty acid-induced inflammation through SIRT1.
Maize extract rich in ferulic acid and anthocyanins prevents high-fat-induced obesity in mice by modulating SIRT1, AMPK and IL-6 associated metabolic and inflammatory pathways.
Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide.
Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice.
Metabolic actions of hypothalamic SIRT1.
Metabolic benefits from Sirt1 and Sirt1 activators.
Metabolic programming of sirtuin 1 (SIRT1) expression by moderate energy restriction during gestation in rats may be related to obesity susceptibility in later life.
Metabolic Reprogramming by 3-Iodothyronamine (T1AM): A New Perspective to Reverse Obesity through Co-Regulation of Sirtuin 4 and 6 Expression.
MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function.
Minireview: Central Sirt1 Regulates Energy Balance via the Melanocortin System and Alternate Pathways.
MiR-22 modulates the expression of lipogenesis-related genes and promotes hepatic steatosis in vitro.
miR-221 negatively regulates inflammation and insulin sensitivity in white adipose tissue by repression of sirtuin-1 (SIRT1).
MiR-30a-5p accelerates adipogenesis by negatively regulating Sirtuin 1.
MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1).
Mitochondrial Hyperacetylation in the Failing Hearts of Obese Patients Mediated Partly by a Reduction in SIRT3: The Involvement of the Mitochondrial Permeability Transition Pore.
Modulation of Sirt1 and FoxO1 on Hypothalamic Leptin-Mediated Sympathetic Activation and Inflammation in Diet-Induced Obese Rats.
Muscle-specific sirtuin 3 overexpression does not attenuate the pathological effects of high-fat/high-sucrose feeding but does enhance cardiac SERCA2a activity.
Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice.
Neurodegeneration Alters Metabolic Profile and Sirt 1 Signaling in High-Fat-Induced Obese Mice.
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Non-enzymatic N-acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S-acetylated Thiol Intermediate Sensitive to Glyoxalase II.
Obesity and aging diminish SIRT1-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3.
Obesity and kidney disease: potential mechanisms.
Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1.
Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver.
Overexpression of SIRT1 in mouse forebrain impairs lipid/glucose metabolism and motor function.
Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.
Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity.
Pharmacologic or genetic activation of SIRT1 attenuates the fat-induced decrease in beta-cell function in vivo.
Pinitol alleviates systemic inflammatory cytokines in human obesity by a mechanism involving unfolded protein response and sirtuin 1.
Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication-Potential Implication of Sirtuins.
PPAR? and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders.
Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity.
Reduced gene expression of sirtuins and active AMPK levels in children and adolescents with obesity and insulin resistance.
Reduced SIRT1 and SIRT2 expression promotes adipogenesis of human visceral adipose stem cells and associates with accumulation of visceral fat in human obesity.
Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.
Resveratrol-activated SIRT1 in liver and pancreatic ?-cells: a Janus head looking to the same direction of metabolic homeostasis.
Resveratrol: a relevant pharmacological approach for the treatment of metabolic syndrome?
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
Roles of FoxO1 and Sirt1 in the central regulation of food intake.
SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism.
Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency, and diastolic function early in life.
Silymarin ameliorates the disordered glucose metabolism of mice with diet-induced obesity by activating the hepatic SIRT1 pathway.
Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
SIRT1 Activation by Equisetum Arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats.
SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling.
SIRT1 and CLOCK 3111T>C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity.
SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status.
SIRT1 as a Potential Biomarker for Obesity.
SIRT1 CONTRIBUTES TO POLARIZATION OF PERIPHERAL BLOOD MONOCYTES BY INCREASING STAT6 EXPRESSION IN YOUNG PEOPLE WITH OVERWEIGHT AND LOW-RISK OBESITY.
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity.
SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance.
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism.
Sirt1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR/S6K1 pathway in mice.
SIRT1 gene variants are related to risk of childhood obesity.
SIRT1 genetic variation is related to body mass index and risk of obesity.
SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians.
SIRT1 Limits Adipocyte Hyperplasia through c-Myc Inhibition.
SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents.
SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways.
SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex.
SIRT1 Regulation in Ageing and Obesity.
Sirt1 rescues the obesity induced by insulin-resistant constitutively-nuclear FoxO1 in POMC neurons of male mice.
SIRT3 Acts as a Positive Autophagy Regulator to Promote Lipid Mobilization in Adipocytes via Activating AMPK.
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome.
Sirt3 Deficiency Increased the Vulnerability of Pancreatic Beta Cells to Oxidative Stress-Induced Dysfunction.
SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity.
SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain.
Sirt3 is dispensable for oocyte quality and female fertility in lean and obese mice.
Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes.
Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity.
Sirtuin 1 in lipid metabolism and obesity.
Sirtuin 1 is upregulated in young obese Zucker rat cerebral arteries.
SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION.
Sirtuin activators and inhibitors.
Sirtuin activators: Designing molecules to extend life span.
Sirtuin gene expression in human mononuclear cells is modulated by caloric restriction.
Sirtuin-1 is a nutrient-dependent modulator of inflammation.
Sirtuin1 Role in the Melatonin Protective Effects Against Obesity-Related Heart Injury.
Sirtuins and Insulin Resistance.
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.
Sirtuins-mediators of maternal obesity-induced complications in offspring?
Skeletal Muscle MnSOD, Mitochondrial Complex II, and SIRT3 Enzyme Activities Are Decreased in Maternal Obesity During Human Pregnancy and Gestational Diabetes Mellitus.
Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise.
Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia.
Spontaneous caloric restriction associated with increased leptin levels in obesity-resistant alphaMUPA mice.
Stimulation of brown adipose tissue by polyphenols in extra virgin olive oil.
Structure-based drug design of small molecule SIRT1 modulators to treat cancer and metabolic disorders.
The effect of adipocyte-macrophage cross-talk in obesity-related breast cancer.
The Gender Association of the SIRT1 rs7895833 Polymorphism with Pediatric Obesity: A 3-Year Panel Study.
The metabolic footprint during adipocyte commitment highlights ceramide modulation as an adequate approach for obesity treatment.
The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.
The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy.
The role of sirtuin proteins in obesity.
The Roles of SIRT1 in Cancer.
The sirtuins: Markers of metabolic health.
Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding.
Treatment with SRT1720, a SIRT1 Activator, Ameliorates Fatty Liver with Reduced Expression of Lipogenic Enzymes in MSG Mice.
Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review.
Vascular Smooth Muscle Sirtuin-1 Protects Against Diet-Induced Aortic Stiffness.
Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: A pilot study.
Visfatin/Nampt and SIRT1: Roles in Postterm Delivery in Pregnancies Associated With Obesity.
[Effect of electroacupuncture on silent information regulator 1, fork head transcription factor O1 and proopiomelanocortin in the hypothalamus of rats with obesity induced by high-fat diet].
[Effect of SIRT1 deficiency on function of brown adipose tissue in obese mice].
[Electroacupuncture reduces obesity by improving metabolism and up-regulating expression of hypothalamic Sirtuin 1 and proopiomelanocortin in obese rats].
[Expression of Sirtuin 1 in visceral adipose tissue in Tibetan mini-pigs with obesity and insulin resistance induced by high fat/cholesterol diet].
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
[Mechanism of electroacupuncture for regulation of lipid production and improvement in obesity by mediating Wnt/ ?-catenin pathway through activating SIRT1].
Obesity, Abdominal
Association of SIRT1 gene variation with visceral obesity.
SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae.
SIRT1 as a Potential Biomarker for Obesity.
Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: A pilot study.
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Obesity, Maternal
A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.
Dyslipidemia, insulin resistance, and impairment of placental metabolism in the offspring of obese mothers.
Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning.
NAFLD at the interface of the mother-infant dyad.
Parental SIRT1 Overexpression Attenuate Metabolic Disorders Due to Maternal High-Fat Feeding.
SIRT1 Attenuates Kidney Disorders in Male Offspring Due to Maternal High-Fat Diet.
Skeletal Muscle MnSOD, Mitochondrial Complex II, and SIRT3 Enzyme Activities Are Decreased in Maternal Obesity During Human Pregnancy and Gestational Diabetes Mellitus.
Obesity, Morbid
Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity.
Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity.
The FTO gene polymorphism (rs9939609) is associated with metabolic syndrome in morbidly obese subjects from southern Italy.
Ophthalmoplegia, Chronic Progressive External
Mitochondrial respiratory dysfunction-elicited oxidative stress and posttranslational protein modification in mitochondrial diseases.
Regulation of mitochondrial F(o)F(1)ATPase activity by Sirt3-catalyzed deacetylation and its deficiency in human cells harboring 4977bp deletion of mitochondrial DNA.
Optic Atrophy, Autosomal Dominant
Mitochondrial cAMP prevents apoptosis modulating Sirt3 protein level and OPA1 processing in cardiac myoblast cells.
Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation.
Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer.
Sirt3 modulate renal ischemia-reperfusion injury through enhancing mitochondrial fusion and activating the ERK-OPA1 signaling pathway.
SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo.
Optic Nerve Diseases
Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1.
SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells.
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
SIRT1 promotes RGC survival and delays loss of function following optic nerve crush.
Optic Nerve Injuries
Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1.
Sirtuin 1 regulates lipid metabolism associated with optic nerve regeneration.
The involvement of sirtuins during optic nerve injury of rats.
Optic Neuritis
Does CETP rs5882, rs708272, SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, VEGFA rs833068, IL6 rs1800795 polymorphisms play a role in optic neuritis development?
SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells.
SIRT1 activation confers neuroprotection in experimental optic neuritis.
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.
SIRT1 promotes RGC survival and delays loss of function following optic nerve crush.
Sirtuins Expression and Their Role in Retinal Diseases.
The role of SIRT1 in ocular aging.
Oral Ulcer
The Anti-Inflammatory Effect of Zhibaidihuang Decoction on Recurrent Oral Ulcer with Sirt1 as the Key Regulatory Target.
Osteoarthritis
Curcumin Inhibits the PERK-eIF2?-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model.
Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway.
Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice.
DOT1L safeguards cartilage homeostasis and protects against osteoarthritis.
Effects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice.
Epigenetic regulation of chondrocyte hypertrophy and apoptosis through Sirt1/P53/P21 pathway in surgery-induced osteoarthritis.
Ferulic acid suppresses interleukin-1?-induced degeneration of chondrocytes isolated from patients with osteoarthritis through the SIRT1/AMPK/PGC-1? signaling pathway.
Fisetin inhibits IL-1?-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice.
Grape seed procyanidins suppress the apoptosis and senescence of chondrocytes and ameliorates osteoarthritis via the DPP4-Sirt1 pathway.
Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis.
Inhibition of Knee Osteoarthritis Progression in Mice by Administering SRT2014, an Activator of Silent Information Regulator 2 Ortholog 1.
Intra-articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF-2?
Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice.
LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes.
Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/?-catenin activity.
miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis.
Mitophagy in degenerative joint diseases.
Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions.
Protective Effect of SIRT1 Activator on the Knee With Osteoarthritis.
Reduced Sirtuin1 expression at the femoral neck in women who sustained an osteoporotic hip fracture.
Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients.
Resveratrol inhibits interleukin 1?-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-?B activity.
Resveratrol, a sirtuin 1 activator, increases IL-6 production by peripheral blood mononuclear cells of patients with knee osteoarthritis.
Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence.
Sirt1 and osteoarthritis. Comments on the paper by Gabay et al.: "Sirt1-deficient mice exhibit an altered cartilage phenotype", Joint Bone Spine 2013.
SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance.
Sirt1 Promotes a Thermogenic Gene Program in Bone Marrow Adipocytes: From Mice to (Wo)Men.
Sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol-treated osteoarthritis chondrocytes via the Wnt/?-catenin signaling pathways.
SIRT1 regulation of apoptosis of human chondrocytes.
SIRT2 inhibits oxidative stress and inflammatory response in diabetic osteoarthritis.
SIRT3 ameliorates osteoarthritis via regulating chondrocyte autophagy and apoptosis through the PI3K/Akt/mTOR pathway.
Sulforaphane protects against oxidative stress?induced apoptosis via activating SIRT1 in mouse osteoarthritis.
The role of sirtuin 1 and its activator, resveratrol in osteoarthritis.
The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis.
Towards elucidating the role of SirT1 in osteoarthritis.
Underlying mechanism of Sirt1 on apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes.
[Sirtuin type 1 signaling pathway mediates the effect of diosgenin on chondrocyte metabolisms in osteoarthritis].
Osteoarthritis, Knee
Inhibition of Knee Osteoarthritis Progression in Mice by Administering SRT2014, an Activator of Silent Information Regulator 2 Ortholog 1.
Resveratrol, a sirtuin 1 activator, increases IL-6 production by peripheral blood mononuclear cells of patients with knee osteoarthritis.
The expression of SIRT1 in articular cartilage of patients with knee osteoarthritis and its correlation with disease severity.
Osteolysis
Hydrogen sulfide protects against particle-induced inflammatory response and osteolysis via SIRT1 pathway in prosthesis loosening.
Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling.
miR-9-5p promotes wear-particle-induced osteoclastogenesis through activation of the SIRT1/NF-?B pathway.
Particle-induced SIRT1 downregulation promotes osteoclastogenesis and osteolysis through ER stress regulation.
Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3?/?-catenin signalling pathway.
SIRT1 protects osteoblasts against particle-induced inflammatory responses and apoptosis in aseptic prosthesis loosening.
The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-?B deacetylation in aseptic loosening.
Osteonecrosis
miR-122/SIRT1 axis regulates chondrocyte extracellular matrix degradation in osteoarthritis.
SIRT1 Gene SNP rs932658 is Associated with Medication-Related Osteonecrosis of the Jaw.
SIRT1, a promising regulator of bone homeostasis.
Therapeutic effect of SIRT3 on glucocorticoid-induced osteonecrosis of femoral head via intracellular oxidative suppression.
Osteophyte
The NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13 in Chondrocytes in Osteoarthritis.
Osteoporosis
Alcohol Induces Cellular Senescence and Impairs Osteogenic Potential in Bone Marrow-Derived Mesenchymal Stem Cells.
Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders?
Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice.
Effect of resveratrol and mesenchymal stem cell monotherapy and combined treatment in management of osteoporosis in ovariectomized rats: Role of SIRT1/FOXO3a and Wnt/?-catenin pathways.
Ferulic acid, a natural polyphenol, protects against osteoporosis by activating SIRT1 and NF-?B in neonatal rats with glucocorticoid-induced osteoporosis.
MicroRNA-579-3p promotes the progression of osteoporosis by inhibiting osteogenic differentiation of mesenchymal stem cells through regulating Sirt1.
MiR-132 regulates osteogenic differentiation via downregulating Sirtuin1 in a peroxisome proliferator-activated receptor ?/?-dependent manner.
Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency.
Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition.
Protective effects of resveratrol on osteoporosis via activation of the SIRT1-NF-?B signaling pathway in rats.
Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-?B signaling pathway.
Reduced Sirtuin1 expression at the femoral neck in women who sustained an osteoporotic hip fracture.
Resveratrol promotes osteogenesis of human mesenchymal stem cells by up-regulating RUNX2 gene expression via SIRT1/FOXO3A axis.
Role of sirtuins in bone biology: Potential implications for novel therapeutic strategies for osteoporosis.
Seven sirtuins for seven deadly diseases of aging.
Silent information regulator, Sirtuin 1, and age-related diseases.
SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis.
SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2.
Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor.
SIRT1, a promising regulator of bone homeostasis.
SIRT2 deficiency prevents age-related bone loss in rats by inhibiting osteoclastogenesis.
Sirtuin 1 activity in peripheral blood mononuclear cells of patients with osteoporosis.
Sirtuin 1 deficiency decreases bone mass and increases bone marrow adiposity in a mouse model of chronic energy deficiency.
Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice.
Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing ?-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors.
The Role and Mechanism of SIRT1 in Resveratrol-regulated Osteoblast Autophagy in Osteoporosis Rats.
The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells.
The Sirtuin1 activator SRT3025 down-regulates sclerostin and rescues ovariectomy-induced bone loss and biomechanical deterioration in female mice.
Towards elucidating the role of SirT1 in osteoarthritis.
[Sir2 gene]
Osteoporosis, Postmenopausal
17?-Estradiol improves osteoblastic cell function through the Sirt1/NF-?B/MMP-8 pathway.
Deletion of SIRT3 inhibits osteoclastogenesis and alleviates aging or estrogen deficiency-induced bone loss in female mice.
Estrogen promotes lncRNA H19 expression to regulate osteogenic differentiation of BMSCs and reduce osteoporosis via miR-532-3p/SIRT1 axis.
Osteosarcoma
Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1.
Expression of Leptin and Sirtuin-1 is associated with poor prognosis in patients with osteosarcoma.
Insulin/IGF-1R, SIRT1, and FOXOs Pathways-An Intriguing Interaction Platform for Bone and Osteosarcoma.
LncRNA C2dat1 Promotes Cell Proliferation, Migration, and Invasion by Targeting MiR-34a-5p in Osteosarcoma Cells.
MicroRNA-126 inhibits osteosarcoma cells proliferation by targeting Sirt1.
MicroRNA-133b Inhibits Cell Proliferation and Invasion in Osteosarcoma by Targeting Sirt1.
MicroRNA-204 inhibits proliferation, migration, invasion and epithelial-mesenchymal transition in osteosarcoma cells via targeting Sirtuin 1.
MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1.
MiR-217 Inhibits Proliferation, Migration, and Invasion by Targeting SIRT1 in Osteosarcoma.
Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas.
SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells.
Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy.
SIRT1 promotes metastasis of human osteosarcoma cells.
SIRT1-ZEB1-positive feedback promotes epithelial-mesenchymal transition process and metastasis of osteosarcoma.
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Sirtuin 7 plays an oncogenic role in human osteosarcoma via downregulating CDC4 expression.
Sirtuin Family Members Selectively Regulate Autophagy in Osteosarcoma and Mesothelioma Cells in Response to Cellular Stress.
Suppressive effect of microRNA-138 on the proliferation and invasion of osteosarcoma cells via targeting SIRT1.
[Retracted] MicroRNA-204 inhibits proliferation, migration, invasion and epithelial-mesenchymal transition in osteosarcoma cells via targeting Sirtuin 1.
Ototoxicity
Augmentation of NAD(+) by NQO1 attenuates cisplatin-mediated hearing impairment.
Dunnione ameliorates cisplatin ototoxicity through modulation of NAD(+) metabolism.
Modulation of NAD+ biosynthesis activates SIRT1 and resists cisplatin-induced ototoxicity.
Roles of Bak and Sirt3 in Paraquat-Induced Cochlear Hair Cell Damage.
Sirt3 confers protection against acrolein-induced oxidative stress in cochlear nucleus neurons.
Sirtuin 1 and Autophagy Attenuate Cisplatin-Induced Hair Cell Death in the Mouse Cochlea and Zebrafish Lateral Line.
Ovarian Neoplasms
A new SIRT1 inhibitor, MHY2245, induces autophagy and inhibits energy metabolism via PKM2/mTOR pathway in human ovarian cancer cells.
A novel crosstalk between BRCA1 and sirtuin 1 in ovarian cancer.
ABT737 enhances ovarian cancer cells sensitivity to cisplatin through regulation of mitochondrial fission via Sirt3 activation.
Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC.
Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142.
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.
Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells.
Deacetylation of cortactin by SIRT1 promotes cell migration.
Development and validation of SIRT3-related nomogram predictive of overall survival in patients with serous ovarian cancer.
Differential Effects of Estradiol and Bisphenol A on SET8 and SIRT1 Expression in Ovarian Cancer Cells.
Differential Expression of KRAS and SIRT1 in Ovarian Cancers with and Without Endometriosis.
Distinct effects of SIRT1 in cancer and stromal cells on tumor promotion.
Down-regulation of SIRT3 promotes ovarian carcinoma metastasis.
Effect of the BRCA1-SIRT1-EGFR axis on cisplatin sensitivity in ovarian cancer.
Exendin-4 exhibits a tumour suppressor effect in SKOVR-3 and OVACR-3 ovarian cancer cells lines by the activation of SIRT1 and inhibition of NF-?B.
Functional role of SIRT1-induced HMGB1 expression and acetylation in migration, invasion and angiogenesis of ovarian cancer.
Gene expression and prognosis of sirtuin family members in ovarian cancer.
Ginsenoside Rp1, A Ginsenoside Derivative, Augments Anti-Cancer Effects of Actinomycin D via Downregulation of an AKT-SIRT1 Pathway.
Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression.
Identification of DBC1 as a transcriptional repressor for BRCA1.
Knockdown of long non-coding RNA HOTAIR reverses cisplatin resistance of ovarian cancer cells through inhibiting miR-138-5p-regulated EZH2 and SIRT1.
Lysophosphatidic Acid Promotes Epithelial to Mesenchymal Transition in Ovarian Cancer Cells by Repressing SIRT1.
MicroRNA-142-3p inhibits cell proliferation and chemoresistance in ovarian cancer via targeting sirtuin 1.
Mir-29b Regulates Oxidative Stress by Targeting SIRT1 in Ovarian Cancer Cells.
Multifunctional transcription factor TFII-I is an activator of BRCA1 function.
PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells.
PKMYT1 aggravates the progression of ovarian cancer by targeting SIRT3.
Potential relationship between Sirt3 and autophagy in ovarian cancer.
Reduced expression of SIRT2 in serous ovarian carcinoma promotes cell proliferation through disinhibition of CDK4 expression.
ROS-Induced SIRT2 Upregulation Contributes to Cisplatin Sensitivity in Ovarian Cancer.
Selecting key genes associated with ovarian cancer based on differential expression network.
SIRT1 deacetylates KLF4 to activate Claudin-5 transcription in ovarian cancer cells.
SIRT3 aggravates metformin-induced energy stress and apoptosis in ovarian cancer cells.
SIRT3 participates in glucose metabolism interruption and apoptosis induced by BH3 mimetic S1 in ovarian cancer cells.
SIRT4 and SIRT6 Serve as Novel Prognostic Biomarkers With Competitive Functions in Serous Ovarian Cancer.
Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer.
Targeting estrogen receptor beta (ER?) for treatment of ovarian cancer: importance of KDM6B and SIRT1 for ER? expression and functionality.
The plasma peptides of ovarian cancer.
Ultrasound?targeted microbubble destruction?mediated overexpression of Sirtuin 3 inhibits the progression of ovarian cancer.
Overnutrition
Heat Shock Gene Inactivation and Protein Aggregation with Links to Chronic Diseases.
Maternal High-Fat Feeding Increases Placental Lipoprotein Lipase Activity by Reducing SIRT1 Expression in Mice.
Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or ? Cell Metabolism in the Absence of Overnutrition.
SirT1 regulates adipose tissue inflammation.
Sirtuin-1 is a nutrient-dependent modulator of inflammation.
Targeting sirtuins for the treatment of diabetes.
Overweight
Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity.
Aerobic Training Increases Expression Levels of SIRT3 and PGC-1? in Skeletal Muscle of Overweight Adolescents Without Change in Caloric Intake.
Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity.
Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation.
Combined high-intensity interval training and green tea supplementation enhance metabolic and antioxidant status in response to acute exercise in overweight women.
Decreased levels and activity of Sirt1 are modulated by increased miR-34a expression in adipose tissue mononuclear cells from subjects with overweight and obesity: A pilot study.
Diminished levels of regulatory T cell subsets (CD8+Foxp3, CD4+Foxp3 and CD4+CD39+Foxp3) but increased Foxp3 expression in adipose tissue from overweight subjects.
Gene Expression of Sirtuin-1 and Endogenous Secretory Receptor for Advanced Glycation End Products in Healthy and Slightly Overweight Subjects after Caloric Restriction and Resveratrol Administration.
Inflammatory Cytokines and SIRT1 Levels in Subcutaneous Abdominal Fat: Relationship With Cardiac Performance in Overweight Pre-diabetics Patients.
Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease.
Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease.
Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals.
Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A randomized trial.
SIRT1 CONTRIBUTES TO POLARIZATION OF PERIPHERAL BLOOD MONOCYTES BY INCREASING STAT6 EXPRESSION IN YOUNG PEOPLE WITH OVERWEIGHT AND LOW-RISK OBESITY.
Three single nucleotide variants of the SIRT1 gene are associated with overweight in a Chinese population: a case control study.
Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial.
[Rosuvastatin improves insulin sensitivity in overweight rats induced by high fat diet. Role of SIRT1 in adipose tissue.]
Pancreatic Neoplasms
Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells.
Ectopic expression of miR-494 inhibited the proliferation, invasion and chemoresistance of pancreatic cancer by regulating SIRT1 and c-Myc.
Emerging Drug Target In Pancreatic Cancer: Placing Sirtuin 1 on the Canvas.
Further characterization of HDAC and SIRT gene expression patterns in pancreatic cancer and their relation to disease outcome.
Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.
miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1.
Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways.
SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis.
SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo.
SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of ?-catenin.
SIRT1 promotes GLUT1 expression and bladder cancer progression via regulation of glucose uptake.
SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells.
SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells.
SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway.
SIRT1-NOX4 signaling axis regulates cancer cachexia.
SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients.
SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.
Sirtuin 1 facilitates chemoresistance of pancreatic cancer cells by regulating adaptive response to chemotherapy-induced stress.
Sirtuin1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions.
The histone deacetylase SIRT2 stabilizes Myc oncoproteins.
Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer.
Pancreatitis
A novel resveratrol analog upregulates sirtuin 1 and inhibits inflammatory cell infiltration in acute pancreatitis.
Activation of AMPK restored impaired autophagy and inhibited inflammation reaction by up-regulating SIRT1 in acute pancreatitis.
Association of Serum Levels of Silent Information Regulator 1 with Persistent Organ Failure in Acute Pancreatitis.
Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice.
Negative Regulation of SIRT1 by IRF9 Involved in Hyperlipidemia Acute Pancreatitis Associated with Kidney Injury.
Niacin Pretreatment Attenuates Ischemia and Reperfusion of Pancreas-induced Acute Pancreatitis and Remote Lung Injury Through Suppressing Oxidative Stress and Inflammation and Activation of SIRT1.
Resveratrol Suppresses Severe Acute Pancreatitis-Induced Microcirculation Disturbance through Targeting SIRT1-FOXO1 Axis.
Pancytopenia
The Sirt1 activator resveratrol improved hematopoiesis in pancytopenia mice induced by irradiation.
Papilloma
SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol.
Papillomavirus Infections
Regulation of the Human Papillomavirus Life Cycle by DNA Damage Repair Pathways and Epigenetic Factors.
[Expression Level of SIRT2 in Cervical Cancer Tissue and Its Clinical Significance].
Paralysis
Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain.
Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism.
Parasitemia
Origin of Monocytes/Macrophages Contributing to Chronic Inflammation in Chagas Disease: SIRT1 Inhibition of FAK-NF?B-Dependent Proliferation and Proinflammatory Activation of Macrophages.
Parasitic Diseases
Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.
Sirtuin activators and inhibitors.
Parkinson Disease
5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors.
After the grape rush: Sirtuins as epigenetic drug targets in neurodegenerative disorders.
Cdk5 suppression blocks SIRT1 degradation via the ubiquitin-proteasome pathway in Parkinson's disease models.
Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: implications for Parkinson's disease.
Design and in vitro analysis of SIRT2 inhibitor targeting Parkinson's disease.
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Elevated Serum SIRT 2 May Differentiate Parkinson's Disease From Atypical Parkinsonian Syndromes.
Elucidating the Neuroprotective Role of Formulated Camel ?-Lactalbumin-Oleic Acid Complex by Curating the SIRT1 Pathway in Parkinson's Disease Model.
Emerging Role of Sirtuin 2 in Parkinson's Disease.
Erratum to: Treadmill Exercise Attenuates ?-Synuclein Levels by Promoting Mitochondrial Function and Autophagy Possibly via SIRT1 in the Chronic MPTP/P-Induced Mouse Model of Parkinson's Disease.
Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration.
Gene variants and expression changes of SIRT1 and SIRT6 in peripheral blood are associated with Parkinson's disease.
Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease.
Genetic association of sirtuin genes and Parkinson's disease.
Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65.
Inhibition of SIRT2 by Targeting GSK3?-Mediated Phosphorylation Alleviates SIRT2 Toxicity in SH-SY5Y Cells.
Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake.
Linking SIRT2 to Parkinson's disease.
MicroRNA-212-5p Prevents Dopaminergic Neuron Death by Inhibiting SIRT2 in MPTP-Induced Mouse Model of Parkinson's Disease.
MicroRNA-7 inhibits neuronal apoptosis in a cellular Parkinson's disease model by targeting Bax and Sirt2.
miR-486-3p Influences the Neurotoxicity of a-Synuclein by Targeting the SIRT2 Gene and the Polymorphisms at Target Sites Contributing to Parkinson's Disease.
miR-494-3p modulates the progression of in vitro and in vivo Parkinson's disease models by targeting SIRT3.
miR-9-5p modulates the progression of Parkinson's disease by targeting SIRT1.
Mitophagy in degenerative joint diseases.
Molecular modelling studies of sirtuin 2 inhibitors using three-dimensional structure-activity relationship analysis and molecular dynamics simulations.
Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells.
Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway.
Reduced serum SIRT1 levels in patients with Parkinson's disease: a cross-sectional study in China.
Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson's disease.
Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.
Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells.
Rs2015 Polymorphism in miRNA Target Site of Sirtuin2 Gene Is Associated with the Risk of Parkinson's Disease in Chinese Han Population.
Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells.
SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease.
SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases.
SIRT1 and SIRT2: emerging targets in neurodegeneration.
SIRT1 Deacetylates TET2 and Promotes Its Ubiquitination Degradation to Achieve Neuroprotection Against Parkinson's Disease.
Sirt1 in cerebral ischemia.
SIRT1 Protects Dopaminergic Neurons in Parkinson's Disease Models via PGC-1?-Mediated Mitochondrial Biogenesis.
SIRT1: new avenues of discovery for disorders of oxidative stress.
SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke.
SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia.
SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells.
SIRT2 regulates insulin sensitivity in insulin resistant neuronal cells.
SIRT3 and mitochondrial metabolism in neurodegenerative diseases.
Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3?/?-catenin pathway.
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.
Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease.
Sirtuin deacetylases in neurodegenerative diseases of aging.
Sirtuin inhibitors.
Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration.
Small-molecule chromatin-modifying agents: therapeutic applications.
The Critical Role of SIRT1 in Parkinson's Disease: Mechanism and Therapeutic Considerations.
The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models.
The Sirtuin family: therapeutic targets to treat diseases of aging.
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
Theacrine, a purine alkaloid from kucha, protects against Parkinson's disease through SIRT3 activation.
Treadmill Exercise Attenuates ?-Synuclein Levels by Promoting Mitochondrial Function and Autophagy Possibly via SIRT1 in the Chronic MPTP/P-Induced Mouse Model of Parkinson's Disease.
[SIRT1].
[Sirtuins--modulation of their activity as a novel therapeutic target].
Parkinsonian Disorders
Potential therapeutic role of fibroblast growth factor 21 in neurodegeneration: Evidence for ameliorating parkinsonism via silent information regulator 2 homolog 1 and implication for gene therapy.
Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant ?-synuclein rat model of parkinsonism.
Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective.
Pediatric Obesity
SIRT1 gene variants are related to risk of childhood obesity.
The Gender Association of the SIRT1 rs7895833 Polymorphism with Pediatric Obesity: A 3-Year Panel Study.
Periapical Granuloma
A potential role for the silent information regulator 2 homologue 1 (SIRT1) in periapical periodontitis.
Expression of silent information regulator 2 homolog 1 (SIRT1) in periapical granulomas.
Periapical Periodontitis
A potential role for the silent information regulator 2 homologue 1 (SIRT1) in periapical periodontitis.
Expression of silent information regulator 2 homolog 1 (SIRT1) in periapical granulomas.
Periodontal Diseases
Influence of the treatment of periodontal disease in serum concentration of sirtuin 1 and mannose-binding lectin.
Periodontitis
Assessment of Sirtuin 3 and Sirtuin 4 Level in Patients with Diabetes Mellitus and Periodontitis: A Clinical Study.
Nicotinamide-induced silencing of SIRT1 by miR-22-3p increases periodontal ligament stem cell proliferation and differentiation.
Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model.
Sirt1 alleviates LPS induced inflammation of periodontal ligament fibroblasts via downregulation of TLR4.
Peripheral Nerve Injuries
MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration.
Sirt2 in the Spinal Cord Regulates Chronic Neuropathic Pain Through Nrf2-Mediated Oxidative Stress Pathway in Rats.
SIRT2 Inhibition Improves Functional Motor Recovery After Peripheral Nerve Injury.
Peripheral Nervous System Diseases
Role of mitochondria in diabetic peripheral neuropathy: Influencing the NAD+-dependent SIRT1-PGC-1?-TFAM pathway.
SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair.
Sirt2-associated transcriptome modifications in cisplatin-induced neuronal injury.
Peritoneal Fibrosis
Ameliorative role of SIRT1 in peritoneal fibrosis: an in vivo and in vitro study.
Peritonitis
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Peroxisomal Disorders
SIRT1 activation alleviates brain microvascular endothelial dysfunction in peroxisomal disorders.
Persistent Infection
Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control.
Pheochromocytoma
LONP1 induction by SRT1720 attenuates mitochondrial dysfunction against high glucose induced neurotoxicity in PC12 cells.
MiR-199a-5p regulates sirtuin1 and PI3K in the rat hippocampus with intrauterine growth restriction.
SIRT1 downregulation mediated Manganese-induced neuronal apoptosis through activation of FOXO3a-Bim/PUMA axis.
SIRT1 Protects Against Apoptosis by Promoting Autophagy in the Oxygen Glucose Deprivation/Reperfusion-Induced Injury.
Pituitary Neoplasms
Association of FGFR2 rs2981582, SIRT1 rs12778366, STAT3 rs744166 gene polymorphisms with pituitary adenoma.
SIRT1 (rs3740051) role in pituitary adenoma development.
Pleural Effusion
A novel Ubc9 -dependent pathway regulates SIRT1- ER-? Axis and BRCA1-associated TNBC lung metastasis.
Pneumonia
An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury.
Curcumin Attenuates Hemorrhagic Shock and Blood Replenish Resuscitation-induced Impairment of Pulmonary Barrier Function by Increasing SIRT1 and Reducing Malondialdehyde and TNF-? Contents and Neutrophil Infiltration in Lung in a Dose-Dependent Fashion.
Depletion of microRNA-451 in response to allergen exposure accentuates asthmatic inflammation by regulating Sirtuin2.
Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation.
Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4(+) T Cells.
MiR-155 regulates Th9 differentiation in children with methicillin-resistant Staphylococcus aureus pneumonia by targeting SIRT1.
Niacin Pretreatment Attenuates Lung Ischemia and Reperfusion-Induced Pulmonary Barrier Function Impairment by Reducing Oxidative Stress and Activating SIRT1 in an Isolated-Perfused Rat Lung Model.
Resolvin D1 Promotes SIRT1 Expression to Counteract the Activation of STAT3 and NF-?B in Mice with Septic-Associated Lung Injury.
Serum levels of SIRT3 and other inflammatory factors are associated with clinical outcomes and prognosis in severe community-acquired pneumonia in adults: A prospective study.
SIRT1 as a therapeutic target in inflammaging of the pulmonary disease.
SIRT1 protects against cigarette smoke-induced lung oxidative stress via FOXO3-dependent mechanism.
Sirt1 protects against thrombomodulin down-regulation and lung coagulation after particulate matter exposure.
Sirt1 restrains lung inflammasome activation in a murine model of sepsis.
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Pneumonia, Staphylococcal
MiR-155 regulates Th9 differentiation in children with methicillin-resistant Staphylococcus aureus pneumonia by targeting SIRT1.
Polycystic Kidney Diseases
Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease.
Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease.
Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease.
Polycystic Ovary Syndrome
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Energy sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1).
Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide.
Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women.
Role of some MiRNA Affecting Polycystic Ovarian Syndrome and SIRT1 levels.
Serum sirtuin 1 levels in patients with polycystic ovary syndrome.
Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility.
Zinc, copper, sirtuin 1 concentration, and glucose metabolism parameters in the blood of women with polycystic ovary syndrome.
Polycythemia
Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-Inhibitors.
Pre-Eclampsia
Advances in the role of silence information regulator family in pathological pregnancy.
Analysis of SIRT1 Expression in Plasma and in an In Vitro Model of Preeclampsia.
Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction.
SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the cells from death.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Morphoproteomics Identifies SIRT1 and EZH2 Pathways as Commonalities in B-cell Acute Lymphoblastic Leukemia: Pathogenetic Implications and Opportunities for Therapeutic Intervention.
Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1.
SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression.
Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways.
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis.
SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression.
Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-?B Pathways.
Prediabetic State
Increased malondialdehyde vs. reduced sirtuin 1 in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes.
Pregnancy Complications
Advances in the role of silence information regulator family in pathological pregnancy.
Premature Birth
Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6.
Effects of perinatal factors on sirtuin 3, 8-hydroxy-2'- deoxyguanosine, brain-derived neurotrophic factor and serotonin in cord blood and early breast milk: an observational study.
Presbycusis
Age-related decrease in the mitochondrial sirtuin deacetylase Sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging rat model.
Primary Ovarian Insufficiency
Energy sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1).
Ginsenoside Rg1 attenuates premature ovarian failure of D-gal induced POF mice through downregulating p16INK4a and upregulating SIRT1 expression.
[Effect of SIRT1 on delay of D-gal-induced premature ovarian failure in mice with ginsenoside Rg_1].
Prion Diseases
Aberrant Decrease of the Endogenous SIRT3 and Increases of Acetylated Proteins in Scrapie Infected Cell Line SMB-S15 and in the Brains of Experimental Mice.
Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity.
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration.
Progeria
Genetic variation in healthy oldest-old.
Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria.
SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation.
Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice.
Prostatic Hyperplasia
SIRT3 affects mitochondrial metabolic reprogramming via the AMPK-PGC-1? axis in the development of benign prostatic hyperplasia.
Prostatic Intraepithelial Neoplasia
Cortactin is associated with tumour progression and poor prognosis in prostate cancer and SIRT2 other than HADC6 may work as facilitator in situ.
Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation.
Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria.
Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer.
Prostatic Neoplasms
A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells.
Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signaling.
Cortactin is associated with tumour progression and poor prognosis in prostate cancer and SIRT2 other than HADC6 may work as facilitator in situ.
Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis.
Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation.
Down-regulation of mir-221 and mir-222 restrain prostate cancer cell proliferation and migration that is partly mediated by activation of SIRT1.
Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes.
Editorial comment to inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells.
Effect of SIRT1 Gene on Epithelial-Mesenchymal Transition of Human Prostate Cancer PC-3 Cells.
Energy-Based Pharmacophore and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling Combined with Virtual Screening To Identify Novel Small-Molecule Inhibitors of Silent Mating-Type Information Regulation 2 Homologue 1 (SIRT1).
Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer.
Expression Patterns of ER?, ER?, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue.
Global transcriptome analysis of formalin-fixed prostate cancer specimens identifies biomarkers of disease recurrence.
Hormonal control of androgen receptor function through SIRT1.
Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells.
Knockdown of TNF receptor-associated factor 2 (TRAF2) modulates in vitro growth of TRAIL-treated prostate cancer cells.
Leptin contributes to long-term stabilization of HIF-1? in cancer cells subjected to oxygen limiting conditions.
Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1.
Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria.
Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model.
Mesenchymal stem cells overexpressing Sirt1 inhibit prostate cancer growth by recruiting natural killer cells and macrophages.
MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular senescence.
MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1.
MiR-204 enhances mitochondrial apoptosis in doxorubicin-treated prostate cancer cells by targeting SIRT1/p53 pathway.
MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms.
miR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression.
MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition.
NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response.
Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1.
Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes.
Peptide switch is essential for Sirt1 deacetylase activity.
Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration-dependent modulation of multiple nuclear receptor-mediated pathways in androgen-responsive prostate cancer cell LNCaP.
Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer.
RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells.
Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells.
Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?
Selective Cytotoxicity of Kaempferia parviflora Extracts in Human Cell Lines.
SIRT1 and microRNAs: The role in breast, lung and prostate cancers.
SIRT1 contributes to neuroendocrine differentiation of prostate cancer.
SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells.
SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis.
SIRT1 is significantly elevated in mouse and human prostate cancer.
SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis.
SIRT1 represses estrogen-signaling, ligand-independent ER?-mediated transcription, and cell proliferation in estrogen-responsive breast cells.
SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway.
SIRT3 inhibits prostate cancer metastasis through regulation of FOXO3A by suppressing Wnt/?-catenin pathway.
Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor.
Sirtuin 7: a new marker of aggressiveness in prostate cancer.
Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation.
The role of SIRT1 in cancer: the saga continues.
The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response.
The UCA1/miR-204/Sirt1 axis modulates docetaxel sensitivity of prostate cancer cells.
Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone.
[Effect of long-chain non-coding RNA-AC024560.2 on proliferation and invasion of prostate cancer cells by targeted regulation of miR-30a-5p].
[Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients].
Prostatitis
Resveratrol Improved the Progression of Chronic Prostatitis via the Downregulation of c-kit/SCF by Activating Sirt1.
Resveratrol improves smooth muscle carcinogenesis in the progression of chronic prostatitis via the downregulation of c-kit/SCF by activating Sirt1.
protein acetyllysine n-acetyltransferase deficiency
A novel pathway regulates memory and plasticity via SIRT1 and miR-134.
A Possible Reason to Induce Acute Graft-vs.-Host Disease After Hematopoietic Stem Cell Transplantation: Lack of Sirtuin-1 in CD4+ T Cells.
A potential role of Sirtuin3 and its target enzyme activities in patients with ovarian endometrioma.
A Sex-Specific Role of Endothelial Sirtuin 3 on Blood Pressure and Diastolic Dysfunction in Female Mice.
Accelerated senescence of cord blood endothelial progenitor cells in premature neonates is driven by SIRT1 decreased expression.
Aconitine attenuates mitochondrial dysfunction of cardiomyocytes via promoting deacetylation of cyclophilin-D mediated by sirtuin-3.
Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release.
Aerobic Interval Training Regulated SIRT3 Attenuates High-Fat-Diet-Associated Cognitive Dysfunction.
Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene.
Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6.
Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer.
Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy.
Cardiomyocyte Specific Deletion of Sirt1 Gene Sensitizes Myocardium to Ischemia and Reperfusion Injury.
CO ameliorates endothelial senescence induced by 5-fluorouracil through SIRT1 activation.
Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development.
Depletion of Sirt3 leads to the impairment of adipogenic differentiation and insulin resistance via interfering mitochondrial function of adipose-derived human mesenchymal stem cells.
Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart.
Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer's Disease.
Effects of myeloid sirtuin 1 deficiency on hypothalamic neurogranin in mice fed a high-fat diet.
Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys.
Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence.
Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.
Epidermal SIRT1 regulates inflammation, cell migration, and wound healing.
Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure.
Fibrogenic Secretome of Sirtuin 1-Deficient Endothelial Cells: Wnt, Notch and Glycocalyx Rheostat.
Formononetin Activates the Nrf2/ARE Signaling Pathway Via Sirt1 to Improve Diabetic Renal Fibrosis.
Geniposide Protects against Obesity-Related Cardiac Injury through AMPK?- and Sirt1-Dependent Mechanisms.
Ginsenoside Rg2 ameliorates high-fat diet-induced metabolic disease through SIRT1.
Hepatic Deletion of SIRT1 Decreases Hepatocyte Nuclear Factor 1?/Farnesoid X Receptor Signaling and Induces Formation of Cholesterol Gallstones in Mice.
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.
High glucose-induced PRDX3 acetylation contributes to glucotoxicity in pancreatic ?-cells: Prevention by Teneligliptin.
High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients.
High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities.
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis.
Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation.
Inducible Cardiac-Specific Deletion of Sirt1 in Male Mice Reveals Progressive Cardiac Dysfunction and Sensitization of the Heart to Pressure Overload.
Inhibiting Protein Kinase Activity of Pyruvate Kinase M2 by SIRT2 Deacetylase Attenuates Psoriasis.
Inhibition of SIRT2 suppresses hepatic fibrosis.
Inhibition of transcriptional activity of c-JUN by SIRT1.
Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis.
Intestinal SIRT1 Deficiency-Related Intestinal Inflammation and Dysbiosis Aggravate TNF?-Mediated Renal Dysfunction in Cirrhotic Ascitic Mice.
LCZ696 Ameliorates Oxidative Stress and Pressure Overload-Induced Pathological Cardiac Remodeling by Regulating the Sirt3/MnSOD Pathway.
Lipopolysaccharide upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1).
LncRNA HOTAIR functions as a competing endogenous RNA to upregulate SIRT1 by sponging miR-34a in diabetic cardiomyopathy.
Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer.
Maternal Eicosapentaenoic Acid Feeding Decreases Placental Lipid Deposition and Improves the Homeostasis of Oxidative Stress Through a Sirtuin-1 (SIRT1) Independent Manner.
Maternal eicosapentaenoic acid feeding promotes placental angiogenesis through a Sirtuin-1 independent inflammatory pathway.
Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model.
Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway.
MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction.
Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-?-dependent feedback regulation of SOD2.
Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer.
MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1).
Mitochondrial Deacetylase SIRT3 Plays an Important Role in Donor T Cell Responses after Experimental Allogeneic Hematopoietic Transplantation.
Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges.
Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis.
Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues.
Neuroprotective role of retinal SIRT3 against acute photo-stress.
Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans.
Oxymatrine attenuates oxidized low?density lipoprotein?induced HUVEC injury by inhibiting NLRP3 inflammasome?mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway.
Oxypaeoniflorin Prevents Acute Lung Injury Induced by Lipopolysaccharide through the PTEN/AKT Pathway in a Sirt1-Dependent Manner.
Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity.
Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity.
Preserved recovery of cardiac function following ischemia-reperfusion in mice lacking SIRT3.
Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease.
Protective Effects of Oroxylin A against Doxorubicin-Induced Cardiotoxicity via the Activation of Sirt1 in Mice.
Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation.
Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery.
Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice.
Resveratrol possesses protective effects in a pristane-induced lupus mouse model.
Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders.
Sirt1 activation ameliorates renal fibrosis by inhibiting the TGF-?/Smad3 pathway.
SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function.
Sirt1 activation protects the mouse renal medulla from oxidative injury.
Sirt1 counteracts decrease in membrane phospholipid unsaturation and diastolic dysfunction during saturated fatty acid overload.
SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing.
SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells.
Sirt1 deficiency attenuates spermatogenesis and germ cell function.
SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse.
SIRT1 Deficiency Downregulates PTEN/JNK/FOXO1 Pathway to Block ROS-Induced Apoptosis in Mouse Embryonic Stem Cells.
SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1?.
SIRT1 deficiency interferes with membrane resealing after cell membrane injury.
Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice.
Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice.
SIRT1 Deficiency, Specifically in Fibroblasts, Decreases Apoptosis Resistance and Is Associated with Resolution of Lung-Fibrosis.
SIRT1 induces the adipogenic differentiation of mouse embryonic stem cells by regulating RA-induced RAR expression via NCOR1 acetylation.
Sirt1 inhibits HG-induced endothelial injury: Role of Mff-based mitochondrial fission and F?actin homeostasis-mediated cellular migration.
SIRT1 Involved in the Regulation of Alternative Splicing Affects the DNA Damage Response in Neural Stem Cells.
SIRT1 is essential for normal cognitive function and synaptic plasticity.
SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1?-dependent glycolysis.
SirT1 modulates the estrogen-insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice.
SIRT1 negatively regulates the mammalian target of rapamycin.
SIRT1 plays a Protective role in Intervertebral Disc Degeneration in a Puncture-Induced Rodent model.
SIRT1 redresses tissue inhibitor of matrix metalloproteinase-1/matrix metalloproteinase-9 imbalance in the development of mouse emphysema and human COPD.
SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression.
Sirt1 restrains lung inflammasome activation in a murine model of sepsis.
SIRT1, is it a tumor promoter or tumor suppressor?
SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation.
SIRT1-PGC1?-NF?B Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease.
SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux.
SIRT2 Contributes to the Regulation of Intestinal Cell Proliferation and Differentiation.
SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis.
SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.
SIRT2 deficiency prevents age-related bone loss in rats by inhibiting osteoclastogenesis.
SIRT2 directs the replication stress response through CDK9 deacetylation.
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.
SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice.
SIRT2 Regulates LPS-Induced Renal Tubular CXCL2 and CCL2 Expression.
SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.
SIRT3 Attenuates MPTP-Induced Nigrostriatal Degeneration Via Enhancing Mitochondrial Antioxidant Capacity.
SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3?.
SIRT3 consolidates heterochromatin and counteracts senescence.
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome.
SIRT3 deficiency delays diabetic skin wound healing via oxidative stress and necroptosis enhancement.
Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice.
Sirt3 Deficiency Does not Augment Hypoxia-Induced Pulmonary Hypertension.
Sirt3 deficiency exacerbates diabetic cardiac dysfunction: Role of Foxo3A-Parkin-mediated mitophagy.
SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1?-LIPIN 1 pathway and increasing CD36 through Nrf2.
SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts.
SIRT3 deficiency exacerbates p53/Parkin?mediated mitophagy inhibition and promotes mitochondrial dysfunction: Implication for aged hearts.
SIRT3 deficiency impairs mitochondrial and contractile function in the heart.
Sirt3 deficiency impairs neurovascular recovery in ischemic stroke.
Sirt3 Deficiency Increased the Vulnerability of Pancreatic Beta Cells to Oxidative Stress-Induced Dysfunction.
SIRT3 deficiency increases mitochondrial oxidative stress and promotes migration of retinal pigment epithelial cells.
SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity.
SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels.
SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis.
SIRT3 Deficiency Promotes High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Correlation with Impaired Intestinal Permeability through Gut Microbial Dysbiosis.
SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis.
SIRT3 Deficiency Sensitizes Angiotensin-II-Induced Renal Fibrosis.
Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer.
SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction.
SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions.
Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1?/VEGF Signaling and Blood-Brain Barrier Integrity.
Sirt3 Protects Against Thoracic Aortic Dissection Formation by Reducing Reactive Oxygen Species, Vascular Inflammation, and Apoptosis of Smooth Muscle Cells.
SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.
SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo.
SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation.
Sirtuin 1 deficiency decreases bone mass and increases bone marrow adiposity in a mouse model of chronic energy deficiency.
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Sirtuin 2 mutations in human cancers impair its function in genome maintenance.
Sirtuin 3 deficiency accelerates Angiotensin II-induced skeletal muscle atrophy.
Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing Angiogenesis.
Sirtuin 3 deficiency aggravates angiotensin II-induced hypertensive cardiac injury by the impairment of lymphangiogenesis.
Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury.
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Sirtuin 3 deficiency does not impede digit regeneration in mice.
Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation.
Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.
Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis.
Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis.
Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis.
SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION.
Sirtuin1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Injured Podocytes.
Sirtuin3 deficiency exacerbates carbon tetrachloride-induced hepatic injury in mice.
Sirtuins and renal diseases: relationship with aging and diabetic nephropathy.
Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice.
The effect of Sirt1 deficiency on Ca2+ and Na+ regulation in mouse ventricular myocytes.
The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis.
The Sirt1 activator resveratrol improved hematopoiesis in pancytopenia mice induced by irradiation.
The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells.
[Effect of SIRT1 deficiency on function of brown adipose tissue in obese mice].
[SIRT1 deficiency in CD4+T cells induces acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation].
Protein Deficiency
Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice with Poor Remote Memory.
Proteinuria
Epigenetic regulation through SIRT1 in podocytes.
Late intervention in the remnant kidney model attenuates proteinuria but not glomerular filtration rate decline.
Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.
Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC-1? mediated attenuation of mitochondrial oxidative stress.
Role of Transcription Factor Acetylation in Diabetic Kidney Disease.
Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway.
SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease.
SIRT1: Mechanism and Protective in Diabetic Nephropathy.
The effects of compound centella formula on OxInflammation and silent information regulator 1 in a high-fat diet/streptozotocin-induced diabetic kidney disease rat model.
[Alpha-mangostin attenuates focal segmental glomerulosclerosis of mice induced by adriamycin].
Psoriasis
A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis.
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Abnormal histone modifications in PBMCs from patients with psoriasis vulgaris.
Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-?B and MAPKs signaling pathways.
Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-? in psoriatic patients.
Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis.
Histone Deacetylase 1 and Sirtuin 1 Expression in Psoriatic Skin: A Comparison between Guttate and Plaque Psoriasis.
Induction of differentiation in psoriatic keratinocytes by propylthiouracil and fructose.
Inhibiting Protein Kinase Activity of Pyruvate Kinase M2 by SIRT2 Deacetylase Attenuates Psoriasis.
Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, Sirt1.
Salidroside inhibits MAPK, NF-?B, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation.
Sirt1 Protects against Oxidative Stress-Induced Apoptosis in Fibroblasts from Psoriatic Patients: A New Insight into the Pathogenetic Mechanisms of Psoriasis.
SIRT1, a Class III histone deacetylase, regulates LPS-induced inflammation in human keratinocytes and mediates the anti-inflammatory effects of hinokitiol.
STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation.
The Role of Forkhead Box Class O3A and SIRT1 Gene Variants in Early-Onset Psoriasis.
Pulmonary Arterial Hypertension
Effect of Aldosterone on Senescence and Proliferation Inhibition of Endothelial Progenitor Cells Induced by Sirtuin 1 (SIRT1) in Pulmonary Arterial Hypertension.
Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension.
Resveratrol Prevents Right Ventricle Dysfunction, Calcium Mishandling, and Energetic Failure via SIRT3 Stimulation in Pulmonary Arterial Hypertension.
Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation: role in pulmonary arterial hypertension.
Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.
Targeting histone acetylation in pulmonary hypertension and right ventricular hypertrophy.
Pulmonary Disease, Chronic Obstructive
3,4,5-Trihydroxycinnamic acid exerts a protective effect on pulmonary inflammation in an experimental animal model of COPD.
A highly significant association between Cathepsin S gene polymorphisms rs12068264 and chronic obstructive pulmonary disease susceptibility in Han Chinese population.
A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9.
Aerobic Exercise Alleviates Inflammation, Oxidative Stress, and Apoptosis in Mice with Chronic Obstructive Pulmonary Disease.
Associations of the NRF2/KEAP1 pathway and antioxidant defense gene polymorphisms with chronic obstructive pulmonary disease.
Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway.
Correlations of Silent Information Regulator of Transcription 1 (SIRT1) Expression, Inflammatory Factors, and Oxidative Stress with Pulmonary Function in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD).
Curcumin ameliorates chronic obstructive pulmonary disease by modulating autophagy and endoplasmic reticulum stress through regulation of SIRT1 in a rat model.
Decreased Serum Sirtuin-1 in COPD.
Different patterns of lung sirtuin expression in smokers with and without chronic obstructive pulmonary disease.
Disruption of SIRT1-mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease.
Dysfunction of endothelial progenitor cells from smokers and COPD patients due to increased DNA damage and senescence.
Effects of conjugated linoleic acid supplementation on serum levels of interleukin-6 and sirtuin 1 in COPD patients.
Erythromycin Regulates Cigarette Smoke-Induced Proinflammatory Mediator Release Through Sirtuin 1-Nuclear Factor ?B Axis in Macrophages and Mice Lungs.
Exogenous neutrophil elastase enters bronchial epithelial cells and suppresses cigarette smoke extract-induced heme oxygenase-1 by cleaving sirtuin 1.
Fengbaisan suppresses endoplasmic reticulum stress by up-regulating SIRT1 expression to protect rats with chronic obstructive pulmonary diseases.
Function of hesperidin alleviating inflammation and oxidative stress responses in COPD mice might be related to SIRT1/PGC-1?/NF-?B signaling axis.
Future treatments for chronic obstructive pulmonary disease and its comorbidities.
Inhibition of miR-494-3p alleviates oxidative stress-induced cell senescence and inflammation in the primary epithelial cells of COPD patients.
LINC00987 Ameliorates COPD by Regulating LPS-Induced Cell Apoptosis, Oxidative Stress, Inflammation and Autophagy Through Let-7b-5p/SIRT1 Axis.
LncRNA?mediated SIRT1/FoxO3a and SIRT1/p53 signaling pathways regulate type II alveolar epithelial cell senescence in patients with chronic obstructive pulmonary disease.
Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes.
Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1? in rats with COPD.
Melatonin protects against COPD by attenuating apoptosis and endoplasmic reticulum stress via upregulating SIRT1 expression in rats.
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.
Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins.
Resveratrol attenuates left ventricular remodeling in old rats with COPD induced by cigarette smoke exposure and LPS instillation.
Role of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease induced by cigarette smoke.
Role of sirtuins in chronic obstructive pulmonary disease.
Senotherapy: A New Horizon for COPD Therapy.
Shelterin TPP1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirt1 Deacetylase in Chronic Obstructive Pulmonary Disease.
Silent information regulator, Sirtuin 1, and age-related diseases.
SIRT1 Activity in Peripheral Blood Mononuclear Cells Correlates with Altered Lung Function in Patients with Chronic Obstructive Pulmonary Disease.
SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients.
SIRT1 attenuates endoplasmic reticulum stress and apoptosis in rat models of COPD.
Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease.
SIRT1 protects against cigarette smoke-induced lung oxidative stress via FOXO3-dependent mechanism.
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
SIRT1 redresses tissue inhibitor of matrix metalloproteinase-1/matrix metalloproteinase-9 imbalance in the development of mouse emphysema and human COPD.
SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease.
Sirtuin 1 and aging theory for chronic obstructive pulmonary disease.
Sirtuin 3 Inhibits Airway Epithelial Mitochondrial Oxidative Stress in Cigarette Smoke-Induced COPD.
Sirtuin gene polymorphisms are associated with chronic obstructive pulmonary disease in patients in Mu?la province.
Ticagrelor Increases SIRT1 and HES1 mRNA Levels in Peripheral Blood Cells from Patients with Stable Coronary Artery Disease and Chronic Obstructive Pulmonary Disease.
Vestibular rehabilitation ameliorates chronic dizziness through the SIRT1 axis.
Pulmonary Edema
Resveratrol attenuates spinal cord injury-induced inflammatory damage in rat lungs.
Pulmonary Fibrosis
Aerobic Exercise Alleviates Inflammation, Oxidative Stress, and Apoptosis in Mice with Chronic Obstructive Pulmonary Disease.
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis.
CMH-Small Molecule Docks into SIRT1, Elicits Human IPF-Lung Fibroblast Cell Death, Inhibits Ku70-deacetylation, FLIP and Experimental Pulmonary Fibrosis.
Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease.
p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis.
Sirt1 antisense long non-coding RNA attenuates pulmonary fibrosis through sirt1-mediated epithelial-mesenchymal transition.
SIRT1 Protects Against Systemic Sclerosis-related Pulmonary Fibrosis by Decreasing Pro-inflammatory and Pro-fibrotic Processes.
SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.
SIRT3 Overexpression Ameliorates Asbestos-Induced Pulmonary Fibrosis, mt-DNA Damage, and Lung Fibrogenic Monocyte Recruitment.
Sirtuin 3 Deregulation Promotes Pulmonary Fibrosis.
Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts.
Targeting anti-aging protein sirtuin (Sirt) in the diagnosis of idiopathic pulmonary fibrosis.
Pulpitis
MicroRNA-506 Is Involved in Regulation of the Occurrence of Lipopolysaccharides (LPS)-Induced Pulpitis by Sirtuin 1 (SIRT1).
Purpura, Thrombocytopenic, Idiopathic
SIRT1 single-nucleotide polymorphisms are associated with corticosteroid sensitivity in primary immune thrombocytopenia patients.
Radiation Fibrosis Syndrome
Manganese porphyrin, MnTE-2-PyP, treatment protects the prostate from radiation-induced fibrosis (RIF) by activating the NRF2 signaling pathway and enhancing SOD2 and sirtuin activity.
Radiculopathy
SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons.
Rectal Neoplasms
Bouchardatine suppresses rectal cancer in mice by disrupting its metabolic pathways via activating the SIRT1-PGC-1?-UCP2 axis.
Relative Energy Deficiency in Sport
Beneficial Effects of Concentrated Growth Factors and Resveratrol on Human Osteoblasts In Vitro Treated with Bisphosphonates.
Renal Insufficiency
Spironolactone ameliorates endothelial dysfunction through inhibition of the AGE/RAGE axis in a chronic renal failure rat model.
Renal Insufficiency, Chronic
Activation of Sirtuin-1 Promotes Renal Fibroblast Activation and Aggravates Renal Fibrogenesis.
Glucagon?like peptide?1 protects mouse podocytes against high glucose?induced apoptosis, and suppresses reactive oxygen species production and proinflammatory cytokine secretion, through sirtuin 1 activation in vitro.
Obesity and kidney disease: potential mechanisms.
Renal protective effect of sirtuin 1.
Resveratrol-poor Red Wines Modulate SIRT1 in Human Renal Cells.
Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease.
Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway.
The decreased SIRT1 level may account for the lipid profile in chronic kidney disease.
Reperfusion Injury
Anesthetic preconditioning increases sirtuin 2 gene expression in a renal ischemia reperfusion injury model.
Caffeic acid attenuates rat liver reperfusion injury through sirtuin 3-dependent regulation of mitochondrial respiratory chain.
Cardiomyocyte Specific Deletion of Sirt1 Gene Sensitizes Myocardium to Ischemia and Reperfusion Injury.
Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1.
Cross-Talk Between Sirtuin 1 and High-Mobility Box 1 in Steatotic Liver Graft Preservation.
CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia-reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation.
Danggui-Shaoyao-San (DSS) Ameliorates Cerebral Ischemia-Reperfusion Injury via Activating SIRT1 Signaling and Inhibiting NADPH Oxidases.
Diallyl trisulfide ameliorates myocardial ischemia-reperfusion injury by reducing oxidative stress and endoplasmic reticulum stress-mediated apoptosis in type 1 diabetic rats: role of SIRT1 activation.
Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy.
Exendin-4 Protects Against Myocardial Ischemia-Reperfusion Injury by Upregulation of SIRT1 and SIRT3 and Activation of AMPK.
Exploring the role of orexin B-sirtuin 1-HIF-1? in diabetes-mellitus induced vascular endothelial dysfunction and associated myocardial injury in rats.
Hydrogen Sulfide Ameliorates Lung Ischemia-Reperfusion Injury Through SIRT1 Signaling Pathway in Type 2 Diabetic Rats.
Inhibiting microRNA-29a protects myocardial ischemia-reperfusion injury by targeting SIRT1 and regulating NLRP3 and apoptosis pathway.
Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D.
MicroRNA-30c abrogation protects against spinal cord ischemia reperfusion injury through modulating SIRT1.
MiR-7-5p Enhances Cerebral Ischemia-Reperfusion Injury by Degrading sirt1 mRNA.
MLN4924 Exerts a Neuroprotective Effect against Oxidative Stress via Sirt1 in Spinal Cord Ischemia-Reperfusion Injury.
Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression.
Muscone alleviates myocardial ischemia-reperfusion injury via inhibition of oxidative stress and enhancement of SIRT3.
Poly(ADP-ribose) polymerase inhibition prevents reactive oxygen species induced inhibition of aldehyde dehydrogenase2 activity.
PPAR? Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury.
Quercetin attenuates ischemia reperfusion injury by protecting the blood-brain barrier through Sirt1 in MCAO rats.
Renal protective effects of resveratrol.
Resveratrol increase myocardial Nrf2 expression in type 2 diabetic rats and alleviate myocardial ischemia/reperfusion injury (MIRI).
Rno-microRNA-30c-5p promotes myocardial ischemia reperfusion injury in rats through activating NF-?B pathway and targeting SIRT1.
Roles of SIRT3 in heart failure: from bench to bedside.
Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients.
SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury.
Sirt1 Activation by Post-ischemic Treatment With Lumbrokinase Protects Against Myocardial Ischemia-Reperfusion Injury.
SIRT1 activation by pterostilbene attenuates the skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia reperfusion injury.
SIRT1 alleviates hepatic ischemia-reperfusion injury via the miR-182-mediated XBP1/NLRP3 pathway.
SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease.
SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice.
SIRT1 protects against myocardial ischemia-reperfusion injury via activating eNOS in diabetic rats.
SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke.
SIRT3 a Major Player in Attenuation of Hepatic Ischemia-Reperfusion Injury by Reducing ROS via Its Downstream Mediators: SOD2, CYP-D, and HIF-1?.
SIRT3 as a potential therapeutic target for heart failure.
SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts.
SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications.
Sirt3 inhibits cerebral ischemia-reperfusion injury through normalizing Wnt/?-catenin pathway and blocking mitochondrial fission.
Sirt3 modulate renal ischemia-reperfusion injury through enhancing mitochondrial fusion and activating the ERK-OPA1 signaling pathway.
SIRT3-mediated cardiac remodeling/repair following myocardial infarction.
Sirtinol abrogates late phase of cardiac ischemia preconditioning in rats.
Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice.
Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy.
Sirtuin 1: A Dilemma in Transplantation.
Sirtuin-3 mediates sex differences in kidney ischemia-reperfusion injury.
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.
Suppression of miR-34a Expression in the Myocardium Protects Against Ischemia-Reperfusion Injury Through SIRT1 Protective Pathway.
SUV39H1 mediated SIRT1 trans-repression contributes to cardiac ischemia-reperfusion injury.
The function of nicotinamide phosphoribosyltransferase in the heart.
The H3K9 histone methyltransferase G9a modulates renal ischemia reperfusion injury by targeting Sirt1.
The novel relationship between Sirt3 and autophagy in myocardial ischemia-reperfusion.
The relationship between coronary artery disease and SIRT1 protein.
[Cordyceps sinensis protects HK2 cells from ischemia-reperfusion injury through Sirt1 pathway].
[Effect of Shexiang Tongxin dripping pills on coronary microcirculation disorder and cardiac dysfunction in a porcine model of myocardial ischemia-reperfusion injury].
[Role of short-term starvation in alleviating hepatic ischemia-reperfusion injury in mice and possible mechanism of action].
Respiratory Distress Syndrome
Protective effect of SIRT3 on acute lung injury by increasing manganese superoxide dismutase-mediated antioxidation.
The Role of SIRT1 in Autophagy in Lipopolysaccharide-Induced Mouse Type II Alveolar Epithelial Cells.
Respiratory Distress Syndrome, Newborn
Budesonide and Poractant Alfa prevent bronchopulmonary dysplasia via triggering SIRT1 signaling pathway.
Retinal Degeneration
CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1.
Neuroprotective role of retinal SIRT3 against acute photo-stress.
PARP1 Impedes SIRT1-Mediated Autophagy during Degeneration of the Retinal Pigment Epithelium under Oxidative Stress.
Retinal aging and sirtuins.
Role of Sirtuins in Retinal Function Under Basal Conditions.
Sirt1 involvement in rd10 mouse retinal degeneration.
SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-?B pathway.
Sirtuin 1 participates in the process of age-related retinal degeneration.
The Resveratrol Prodrug JC19 Delays Retinal Degeneration in rd10 Mice.
The role of SIRT1 in ocular aging.
Retinal Diseases
SIRT1 activation protects against autoimmune T cell-driven retinal disease in mice via inhibition of IL-2/Stat5 signaling.
The role of sirt1 in the retinal ganglion cells cultured by high glucose.
Retinal Neovascularization
Potential suppression of the high glucose and insulin-induced retinal neovascularization by Sirtuin 3 in the human retinal endothelial cells.
Retinitis Pigmentosa
Sirt1 involvement in rd10 mouse retinal degeneration.
The reason for the amelioration of N-methyl-N-nitrosourea-induced retinitis pigmentosa in rats by hydrogen-rich saline.
Retinoblastoma
Angiotensin II-induced overexpression of sirtuin 1 contributes to enhanced expression of Gi? proteins and hyperproliferation of vascular smooth muscle cells.
Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1.
Expression of SIRT2 and SIRT6 in retinoblastoma.
MicroRNA?506 regulates apoptosis in retinoblastoma cells by targeting sirtuin 1.
microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials.
Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells.
p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle.
Sirt1 increases skeletal muscle precursor cell proliferation.
Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury.
Sirtuin1 Expression and Correlation with Histopathological Features in Retinoblastoma.
Rhabdomyosarcoma
SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth.
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Rheumatic Diseases
Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension.
Rhinitis, Allergic
HIF1? Deficiency in Dendritic Cells Attenuates Symptoms and Inflammatory Indicators of Allergic Rhinitis in a SIRT1-Dependent Manner.
Resveratrol-mediated SIRT1 activation attenuates ovalbumin-induced allergic rhinitis in mice.
SIRT1 attenuates murine allergic rhinitis by downregulated HMGB 1/TLR4 pathway.
TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression.
Rift Valley Fever
Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses.
Sarcoma
Elevated levels of serum MiR-152 and miR-24 in uterine sarcoma: potential for inducing autophagy via SIRT1 and deacetylated LC3.
ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis.
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas.
SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth.
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Sirtuin 2 in Endometrial Cancer: A Potential Regulator for Cell Proliferation, Apoptosis and RAS/ERK Pathway.
The emerging and diverse roles of sirtuins in cancer: a clinical perspective.
Sarcoma, Alveolar Soft Part
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Sarcoma, Clear Cell
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Sarcoma, Ewing
Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing's sarcoma cells: resveratrol suppresses and SRT1720 enhances etoposide- and vincristine-induced anticancer activity.
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma.
The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line.
Sarcoma, Synovial
SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth.
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Sarcopenia
[Sir2 gene]
Schistosomiasis
Computer-Aided Drug Design for the Identification of Novel Antischistosomal Compounds.
Scleroderma, Systemic
Histone deacetylase SIRT1 is reduced in systemic sclerosis and abrogates fibrotic responses by targeting TGF-ß signaling.
Mitochondrial Sirtuins in Skin and Skin Cancers.
Sirt1 ameliorates systemic sclerosis by targeting the mTOR pathway.
Sirt1 regulates canonical TGF-? signalling to control fibroblast activation and tissue fibrosis.
SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis.
Scrapie
Aberrant Decrease of the Endogenous SIRT3 and Increases of Acetylated Proteins in Scrapie Infected Cell Line SMB-S15 and in the Brains of Experimental Mice.
Scrapie Infection in Experimental Rodents and SMB-S15 Cells Decreased the Brain Endogenous Levels and Activities of Sirt1.
Seizures
Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy.
Sirtuin 1 activation enhances the PGC-1?/mitochondrial antioxidant system pathway in status epilepticus.
Targeting of microRNA-199a-5p protects against pilocarpine-induced status epilepticus and seizure damage via SIRT1-p53 cascade.
Seminoma
Estradiol via estrogen receptor beta influences ROS levels through the transcriptional regulation of SIRT3 in human seminoma TCam-2 cells.
Sepsis
Acetylation-Dependent Regulation of Notch Signaling in Macrophages by SIRT1 Affects Sepsis Development.
Aloin Reduces HMGB1-Mediated Septic Responses and Improves Survival in Septic Mice by Activation of the SIRT1 and PI3K/Nrf2/HO-1 Signaling Axis.
Antioxidant and Cardioprotective Effects of EPA on Early Low-Severity Sepsis through UCP3 and SIRT3 Upholding of the Mitochondrial Redox Potential.
BML-111 Reduces Neuroinflammation and Cognitive Impairment in Mice With Sepsis via the SIRT1/NF-?B Signaling Pathway.
Celecoxib Enhances the Efficacy of Low-Dose Antibiotic Treatment against Polymicrobial Sepsis in Mice and Clinical Isolates of ESKAPE Pathogens.
Clinical significance of sirtuin 1 level in sepsis: correlation with disease risk, severity, and mortality risk.
Coronavirus (Covid-19) sepsis: revisiting mitochondrial dysfunction in pathogenesis, aging, inflammation, and mortality.
Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis.
Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia.
Dexmedetomidine Protects Against Septic Liver Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT1 Signaling Pathway.
Effect of miR-132 on lung injury in sepsis rats via regulating Sirt1 expression.
Emerging Evidence concerning the Role of Sirtuins in Sepsis.
Epigenetic coordination of acute systemic inflammation: potential therapeutic targets.
Ethanol Exposure Attenuates Immune Response in Sepsis via Sirtuin 2 Expression.
Exosomal lncRNA-p21 derived from mesenchymal stem cells protects epithelial cells during LPS-induced acute lung injury by sponging miR-181.
Ghrelin Alleviates Intestinal Dysfunction in Sepsis Through the KLF4/MMP2 Regulatory Axis by Activating SIRT1.
Histone deacetylase III as a potential therapeutic target for the treatment of lethal sepsis.
Impact of the Dual Deletion of the Mitochondrial Sirtuins SIRT3 and SIRT5 on Anti-microbial Host Defenses.
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis.
Inhibiting miR-22 Alleviates Cardiac Dysfunction by Regulating Sirt1 in Septic Cardiomyopathy.
Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis.
Inhibition of miR-181a attenuates sepsis-induced inflammation and apoptosis by activating Nrf2 and inhibiting NF-?B pathways via targeting SIRT1.
Interferon ? protects against lethal endotoxic and septic shock through SIRT1 upregulation.
Interleukin 6 increases dysfunction of organs in sepsis rats through sirtuin 1.
LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2?/Notch3 pathways.
MCPIP1 alleviated lipopolysaccharide-induced liver injury by regulating SIRT1 via modulation of microRNA-9.
Melatonin Alleviates Cardiac Dysfunction Via Increasing Sirt1-Mediated Beclin-1 Deacetylation and Autophagy During Sepsis.
Melatonin Attenuates Sepsis-Induced Acute Lung Injury Through Improvement of Epithelial Sodium Channel-Mediated Alveolar Fluid Clearance Via Activation of SIRT1/SGK1/Nedd4-2 Signaling Pathway.
Melatonin Attenuates Sepsis-Induced Small-Intestine Injury by Upregulating SIRT3-Mediated Oxidative-Stress Inhibition, Mitochondrial Protection, and Autophagy Induction.
Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice.
MicroRNA-181a-5p Regulates Inflammatory Response of Macrophages in Sepsis.
MiRNA-133a aggravates inflammatory responses in sepsis by targeting SIRT1.
NAD(+) dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65.
NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance.
PHARMACOLOGICAL SIRT1 ACTIVATION IMPROVES MORTALITY AND MARKEDLY ALTERS TRANSCRIPTIONAL PROFILES THAT ACCOMPANY EXPERIMENTAL SEPSIS.
Polydatin Alleviates Septic Myocardial Injury by Promoting SIRT6-Mediated Autophagy.
Polydatin protects against lipopolysaccharide-induced endothelial barrier disruption via SIRT3 activation.
Protective Effect of Sirtuin 3 on CLP-Induced Endothelial Dysfunction of Early Sepsis by Inhibiting NF-?B and NLRP3 Signaling Pathways.
Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway.
Reduced silent information regulator 1 signaling exacerbates sepsis-induced myocardial injury and mitigates the protective effect of a liver X receptor agonist.
Research progress on SIRT1 and sepsis.
Resveratrol alleviates sepsis?induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF?? and myocardial apoptosis via activation of Sirt1.
Resveratrol reduces acute lung injury in a LPS?induced sepsis mouse model via activation of Sirt1.
Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-?B and HMGB1 pathways through the upregulation of SIRT1.
Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis.
Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus via upregulation of SIRT1 in a sepsis model.
Sirt1 Activation Markedly Alters Transcription Profiles and Improves Outcome in Experimental Sepsis.
SirT1 activator represses the transcription of TNF?? in THP?1 cells of a sepsis model via deacetylation of H4K16.
SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome.
SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells.
SIRT1 Mediates Septic Cardiomyopathy in a Murine Model of Polymicrobial Sepsis.
SIRT1 regulates inflammation response of macrophages in sepsis mediated by long noncoding RNA.
Sirt1 restrains lung inflammasome activation in a murine model of sepsis.
Sirt1 S-nitrosylation induces acetylation of HMGB1 in LPS-activated RAW264.7 cells and endotoxemic mice.
SIRT1-mediated HMGB1 deacetylation suppresses sepsis-associated acute kidney injury.
Sirt3 is a novel target to treat sepsis induced myocardial dysfunction by acetylated modulation of critical enzymes within cardiac tricarboxylic acid cycle.
Sirtuin 2 expression levels may predict the progression of sepsis survivors to chronic critical illness.
Sirtuin 2 Regulates Microvascular Inflammation during Sepsis.
Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis.
Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice.
Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice.
Sirtuins and Immuno-Metabolism of Sepsis.
Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice.
SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis.
The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock.
The clinical significance of the SIRT2 expression level in the early stage of sepsis patients.
Tubeimoside I improves endothelial function in sepsis via activation of SIRT3.
[Activation of NOD-like receptor protein 3 inflammasome mediates inflammatory response and apoptosis in septic intestinal injury model].
[Effects of resveratrol-mediated inhibition of NOD-like receptor protein 3 inflammasomevia activating silent information regulator 1 on the injury of intestinal mucosal barrier function after sepsis].
[Role of deacetylase sirtuins in sepsis: beneficial or harmful?]
Sepsis-Associated Encephalopathy
Regulation of Sirtuin 3-Mediated Deacetylation of Cyclophilin D Attenuated Cognitive Dysfunction Induced by Sepsis-Associated Encephalopathy in Mice.
Sertoli Cell-Only Syndrome
microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials.
Shock, Septic
Interferon ? protects against lethal endotoxic and septic shock through SIRT1 upregulation.
Selective Inhibition of SIRT2 Improves Outcomes in a Lethal Septic Model.
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
The clinical significance of the SIRT2 expression level in the early stage of sepsis patients.
The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock.
Skin Diseases
Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, Sirt1.
Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1.
Skin Neoplasms
Dual role of SIRT1 in UVB-induced skin tumorigenesis.
Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin.
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.
SIRT1 Inhibition Restores Apoptotic Sensitivity in p53-Mutated Human Keratinocytes.
SIRT2 as a new player in epigenetic programming of keratinocyte differentiation and a candidate tumor suppressor.
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease.
The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer.
Therapeutic potential of resveratrol: the in vivo evidence.
Sleep Apnea, Obstructive
Association between proteomics and obstructive sleep apnea phenotypes in a community-based cohort of women.
Effect of Nasal CPAP on SIRT1 and Endothelial Function in Obstructive Sleep Apnea Syndrome.
Effect of oral appliance on circulating leukocyte telomere length and SIRT1 in obstructive sleep apnea.
Effects of nasal CPAP on exhaled SIRT1 and tumor necrosis factor-? in patients with obstructive sleep apnea.
Sleep Deprivation
Melatonin modifies SOX2+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-term sleep deprivation.
Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats.
Sirtuin 3: a molecular pathway linking sleep deprivation to neurological diseases.
Sleep Wake Disorders
Impact of circadian disruption on health; SIRT1 and Telomeres.
Small Cell Lung Carcinoma
Sirtuin 3 induces apoptosis and necroptosis by regulating mutant p53 expression in small?cell lung cancer.
Soft Tissue Neoplasms
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Solitary Fibrous Tumors
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Spasm
SIRT1-mediated deacetylation of NF-?B inhibits the MLCK/MLC2 pathway and the expression of ET-1, thus alleviating the development of coronary artery spasm.
Spinal Cord Injuries
An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury.
Effects of Sirtuin 1 on microglia in spinal cord injury: involvement of Wnt/?-catenin signaling pathway.
MicroRNA?138?5p regulates the development of spinal cord injury by targeting SIRT1.
Resveratrol Activated Sonic Hedgehog Signaling to Enhance Viability of NIH3T3 Cells in Vitro via Regulation of Sirt1.
Silencing of miR-324-5p alleviates rat spinal cord injury by Sirt1.
SIRT1 inhibits apoptosis in in vivo and in vitro models of spinal cord injury via microRNA-494.
The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases.
The Serum SIRT1 Protein is Associated with the Severity of Injury and Neurological Recovery in Mice with Traumatic Spinal Cord Injury.
Spinal Cord Ischemia
MicroRNA-30c abrogation protects against spinal cord ischemia reperfusion injury through modulating SIRT1.
Spinal Stenosis
Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis.
Spinocerebellar Ataxias
Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7.
Squamous Cell Carcinoma of Head and Neck
A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.
Altered expression of SIRT gene family in head and neck squamous cell carcinoma.
Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma.
Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1.
Determination of SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, and RAGE rs1800625 Single Gene Polymorphisms in Patients with Laryngeal Squamous Cell Carcinoma.
DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing-a possible predictive biomarker for malignant transformation.
Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-?B, and SIRT1 Signaling Pathway.
Identification of novel SIRT3 inhibitor scaffolds by virtual screening.
Loss of Mitochondrial Tumor Suppressor Genes Expression Is Associated with Unfavorable Clinical Outcome in Head and Neck Squamous Cell Carcinoma: Data from Retrospective Study.
MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers.
Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.
Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis.
SIRT1 acts as a potential tumor suppressor in oral squamous cell carcinoma.
SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients.
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.
ST Elevation Myocardial Infarction
Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.
MicroRNA-33 and SIRT1 influence the coronary thrombus burden in hyperglycemic STEMI patients.
Staphylococcal Infections
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Starvation
A metabolic throttle regulates the epigenetic state of rDNA.
AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation.
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy.
Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts.
Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.
Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues.
Deacetylation of HSD17B10 by SIRT3 regulates cell growth and cell resistance under oxidative and starvation stresses.
Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation.
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice.
Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells.
Dysregulation of the SIRT1/OCT6 Axis Contributes to Environmental Stress-Induced Neural Induction Defects.
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.
Inverse Association of Circulating SIRT1 and Adiposity: A Study on Underweight, Normal Weight, and Obese Patients.
Linking sirtuins, IGF-I signaling, and starvation.
MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular senescence.
Muscle Wasting in Fasting Requires Activation of NF-?B and Inhibition of AKT/Mechanistic Target of Rapamycin (mTOR) by the Protein Acetylase, GCN5.
Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C.
PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1.
Serum withdrawal up-regulates human SIRT1 gene expression in a p53-dependent manner.
Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes.
Sir2D, a Sirtuin family protein, regulates adenylate cyclase A expression through interaction with the MybB transcription factor early in Dictyostelium development upon starvation.
SIRT1 accelerates the progression of activity-based anorexia.
SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation.
SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy.
SIRT1 Functions as a Negative Regulator of Eukaryotic Poly(A)RNA Transport.
SIRT1 mediates FOXA2 breakdown by deacetylation in a nutrient-dependent manner.
Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy.
SIRT2 Affects Primary Cilia Formation by Regulating mTOR Signaling in Retinal Pigmented Epithelial Cells.
SIRT2 knockdown increases basal autophagy and prevents post-slippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors.
SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis.
Thyroid hormone regulation of Sirtuin 1 expression and implications to integrated responses in fasted mice.
Status Epilepticus
Sirtuin 1 activation enhances the PGC-1?/mitochondrial antioxidant system pathway in status epilepticus.
Sirtuin 1 Regulates Mitochondrial Biogenesis and Provides an Endogenous Neuroprotective Mechanism Against Seizure-Induced Neuronal Cell Death in the Hippocampus Following Status Epilepticus.
Transcriptional Response of Polycomb Group Genes to Status Epilepticus in Mice is Modified by Prior Exposure to Epileptic Preconditioning.
Stomach Neoplasms
Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer.
Activating Transcription Factor 4 Confers a Multidrug Resistance Phenotype to Gastric Cancer Cells through Transactivation of SIRT1 Expression.
Altered Expression of CD44, SIRT1, CXCR4, miR-21, miR-34a, and miR-451 Genes in MKN-45 Cell Line After Docetaxel Treatment.
Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation.
Association of sirtuins with clinicopathological parameters and overall survival in gastric cancer.
Circ-sirt1 inhibits growth and invasion of gastric cancer by sponging miR-132-3p/miR-212-3p and upregulating sirt1 expression.
Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients.
Diet-induced obesity promotes murine gastric cancer growth through a nampt/sirt1/c-myc positive feedback loop.
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.
Forkhead Transcription Factor FOXO1 Inhibits Angiogenesis in Gastric Cancer in Relation to SIRT1.
High glucose promotes gastric cancer chemoresistance in vivo and in vitro.
Hsa-miR-34a-5p reverses multidrug resistance in gastric cancer cells by targeting the 3'-UTR of SIRT1 and inhibiting its expression.
Jaridon 6, a new diterpene from Rabdosia rubescens (Hemsl.) Hara, can display anti-gastric cancer resistance by inhibiting SIRT1 and inducing autophagy.
Lentivirus-mediated siRNA targeting VEGF inhibits gastric cancer growth in vivo.
MicroRNA-34a regulates proliferation and apoptosis of gastric cancer cells by targeting silent information regulator 1.
miR-1301-3p Promotes Cell Proliferation and Facilitates Cell Cycle Progression via Targeting SIRT1 in Gastric Cancer.
MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells.
miR-543 promotes gastric cancer cell proliferation by targeting SIRT1.
MiRNA-12129 Suppresses Cell Proliferation and Block Cell Cycle Progression by Targeting SIRT1 in GASTRIC Cancer.
Prognostic and clinical value of Sirt1 expression in gastric cancer: A systematic meta-analysis.
Regulation of SIRT3 signal related metabolic reprogramming in gastric cancer by
Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells.
SIRT1 counteracted the activation of STAT3 and NF-?B to repress the gastric cancer growth.
SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer.
Sirt1 Gene Expression and Gastric Epithelial Cells Tumor Stage in Patients with Helicobacter pylori Infection
SIRT1 inhibits chemoresistance and cancer stemness of gastric cancer by initiating an AMPK/FOXO3 positive feedback loop.
SIRT1 inhibits gastric cancer proliferation and metastasis via STAT3/MMP-13 signaling.
SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment.
SIRT1 is downregulated in gastric cancer and leads to G1-phase arrest via NF-?B/Cyclin D1 signaling.
SIRT1 suppresses the migration and invasion of gastric cancer by regulating ARHGAP5 expression.
SIRT1-targeted miR-543 autophagy inhibition and epithelial-mesenchymal transition promotion in Helicobacter pylori CagA-associated gastric cancer.
SIRT2 Promotes the Migration and Invasion of Gastric Cancer through RAS/ERK/JNK/MMP-9 Pathway by Increasing PEPCK1-Related Metabolism.
SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells.
SIRT3 Expression as a Biomarker for Better Prognosis in Gastric Cancer.
SIRT3 inhibits cell proliferation in human gastric cancer through down-regulation of Notch-1.
The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers.
Upregulation of SIRT1 gene in gastric adenocarcinoma.
Stomatitis
Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation-induced oral mucositis in mice.
Stroke
A critical role for interferon regulatory factor 9 in cerebral ischemic stroke.
A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia.
Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats.
c-myc protects mice from ischemia stroke through elevating microRNA-200b-5p-regulated SIRT1 expression.
Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke.
Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling.
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.
Effects of rosuvastatin on neuronal apoptosis in cerebral ischemic stroke rats via Sirt1/NF-kappa B signaling pathway.
Emerging Roles of Sirtuins in Ischemic Stroke.
Evaluation of the Neuroprotective Effect of Sirt3 in Experimental Stroke.
Icariin Inhibits Hydrogen Peroxide-Mediated Cytotoxicity by Up-regulating Sirtuin Type 1-Dependent Catalase and Peroxiredoxin.
Impact of curcumin on sirtuins: A review.
Inhibition of calcium/calmodulin-dependent protein kinase kinase (CaMKK) exacerbates impairment of endothelial cell and blood-brain barrier after stroke.
Ischemia Injury induces mPTP opening by reducing Sirt3.
Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice.
Localization and Expression of Sirtuins 1, 2, 6 and Plasticity-Related Proteins in the Recovery Period after a Photothrombotic Stroke in Mice.
Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.
Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats.
Muscle-specific sirtuin1 gain-of-function ameliorates skeletal muscle atrophy in a pre-clinical mouse model of cerebral ischemic stroke.
Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance.
Neuroprotective Effects of Exercise Postconditioning After Stroke via SIRT1-Mediated Suppression of Endoplasmic Reticulum (ER) Stress.
Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-?B and Nrf2/Keap-1 Signaling.
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons.
Overexpression of sirtuin 2 and its association with prognosis in acute ischemic stroke patients.
Plasma levels of sirtuin-1 in patients with cerebrovascular stroke.
Prognostic value of Sirtuin1 in acute ischemic stroke and its correlation with functional outcomes.
Promotion of Momordica Charantia polysaccharides on neural stem cell proliferation by increasing SIRT1 activity after cerebral ischemia/reperfusion in rats.
Resveratrol and ischemic preconditioning in the brain.
Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases.
Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats.
Silent information regulator 1 protects the brain against cerebral ischemic damage.
SIRT1 regulation modulates stroke outcome.
SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.
Sirt3 deficiency impairs neurovascular recovery in ischemic stroke.
Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1?/VEGF Signaling and Blood-Brain Barrier Integrity.
SIRT3 protects cells from hypoxia via PGC-1?- and MnSOD-dependent pathways.
Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease.
Sirtuins: a possible clinical implication in cardio- and cerebro- vascular systems.
The Role of Sirt1 in Ischemic Stroke: Pathogenesis and Therapeutic Strategies.
The Role SIRT2 in Programmed Necrosis: Implications for Stroke and Neurodegenerative Disorders.
Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced parkinsonism.
Using ultrasound three-dimensional speckle tracking technology to explore the role of SIRT1 in ventricular remodeling after myocardial infarction.
Subarachnoid Hemorrhage
Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway.
Berberine Ameliorates Subarachnoid Hemorrhage Injury via Induction of Sirtuin 1 and Inhibiting HMGB1/Nf-?B Pathway.
Inhibition of the Peroxisome Proliferator-Activated Receptor gamma Coactivator 1-alpha (PGC-1?)/Sirtuin 3 (SIRT3) Pathway Aggravates Oxidative Stress After Experimental Subarachnoid Hemorrhage.
Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH).
Oleanolic acid exerts neuroprotective effects in subarachnoid hemorrhage rats through SIRT1-mediated HMGB1 deacetylation.
Role of SIRT1 in Isoflurane Conditioning-Induced Neurovascular Protection against Delayed Cerebral Ischemia Secondary to Subarachnoid Hemorrhage.
SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.
SIRT1 Activation: A Potential Strategy for Harnessing Endogenous Protection Against Delayed Cerebral Ischemia After Subarachnoid Hemorrhage.
SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage.
SIRT1 mediates hypoxic preconditioning induced attenuation of neurovascular dysfunction following subarachnoid hemorrhage.
SIRT3 Expression Decreases with Reactive Oxygen Species Generation in Rat Cortical Neurons during Early Brain Injury Induced by Experimental Subarachnoid Hemorrhage.
SIRT3 protects against early brain injury following subarachnoid hemorrhage via promoting mitochondrial fusion in an AMPK dependent manner.
Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats.
Tauroursodeoxycholic acid attenuates neuronal apoptosis via the TGR5/ SIRT3 pathway after subarachnoid hemorrhage in rats.
Sudden Unexpected Death in Epilepsy
Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy.
Synovitis
Oleanolic Acid Decreases IL-1?-Induced Activation of Fibroblast-Like Synoviocytes via the SIRT3-NF-?B Axis in Osteoarthritis.
Synucleinopathies
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
Tauopathies
A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model.
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
SIRT1 Deacetylates SC35 and Suppresses Its Function in Tau Exon 10 Inclusion.
SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.
Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice.
SIRT1 regulates O-GlcNAcylation of tau through OGT.
Teratoma
SIRT1 Is Necessary for Proficient Telomere Elongation and Genomic Stability of Induced Pluripotent Stem Cells.
Teratozoospermia
SirT1 is required in the male germ cell for differentiation and fecundity in mice.
[Advances in the studies of teratospermia-related genes].
Thrombocytopenia
Antioxidant and anti-inflammatory properties of alpha lipoic acid protect against valproic acid induced liver injury.
Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia.
Thrombosis
A Novel Antithrombotic Mechanism Mediated by the Receptors of the Kallikrein/Kinin and Renin-Angiotensin Systems.
Aqueous Extract of Whitmania Pigra Whitman Alleviates Thrombus Burden via Sirtuin 1/NF-?B Pathway.
BDNFVal66met polymorphism: a potential bridge between depression and thrombosis.
Brain-derived neurotrophic factor Val66Met polymorphism in depression and thrombosis: SIRT1 as a possible mediator.
Danhong Huayu Koufuye prevents venous thrombosis through antiinflammation via Sirtuin 1/NF-?B signaling pathway.
Deep Vein Thrombosis is Modulated by Inflammation Regulated via Sirtuin 1/NF-?B Signalling Pathway in a Rat Model.
Indoxyl Sulfate Promotes Arterial Thrombosis in Rat Model via Increased Levels of Complex TF/VII, PAI-1, Platelet Activation as Well as Decreased Contents of SIRT1 and SIRT3.
Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.
MicroRNA-33 and SIRT1 influence the coronary thrombus burden in hyperglycemic STEMI patients.
Novel anti-thrombotic mechanisms mediated by Mas receptor as result of balanced activities between the kallikrein/kinin and the renin-angiotensin systems.
Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor.
SIRT1 - an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis.
Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells.
SIRT1 prevents pulmonary thrombus formation induced by arachidonic acid via downregulation of PAF receptor expression in platelets.
Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice.
Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia.
Spatholobi Caulis dispensing granule reduces deep vein thrombus burden through antiinflammation via SIRT1 and Nrf2.
Thyroid Cancer, Papillary
Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas.
Sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers.
Vitamin D, FOXO3a, and Sirtuin1 in Hashimoto's Thyroiditis and Differentiated Thyroid Cancer.
Thyroid Diseases
Association between functional SIRT1 polymorphisms and the clinical characteristics of patients with autoimmune thyroid disease.
Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease.
Thyroid Neoplasms
Function of miR-212 as a tumor suppressor in thyroid cancer by targeting SIRT1.
MicroRNA-1225-5p inhibits the development and progression of thyroid cancer via targeting sirtuin 3.
Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas.
Sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers.
SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency.
[Retracted] Function of miR?212 as a tumor suppressor in thyroid cancer by targeting SIRT1.
Tics
Upregulation of mitochondrial NAD(+) levels impairs the clonogenicity of SSEA1(+) glioblastoma tumor-initiating cells.
Tongue Neoplasms
Retraction Note: Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis.
Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis.
Trauma, Nervous System
SIRT1 regulation modulates stroke outcome.
Trichothiodystrophy Syndromes
Dynamic partnership between TFIIH, PGC-1? and SIRT1 is impaired in trichothiodystrophy.
Trigeminal Neuralgia
Puerarin Attenuates Complete Freund's Adjuvant-Induced Trigeminal Neuralgia and Inflammation in a Mouse Model via Sirt1-Mediated TGF-?1/Smad3 Inhibition.
Triple Negative Breast Neoplasms
AMPK inhibits MTDH expression via GSK3? and SIRT1 activation: potential role in triple negative breast cancer cell proliferation.
Combination of sirtuin 3 and hyperoxia diminishes tumorigenic properties of MDA-MB-231 cells.
Cyanidin-3-glucoside induces mesenchymal to epithelial transition via activating Sirt1 expression in triple negative breast cancer cells.
Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype.
Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent ?-H2AX and telomerase regulation in triple-negative breast cancer.
Expression of FOXM1 and related proteins in breast cancer molecular subtypes.
Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer.
Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a.
Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.
Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer.
SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer.
Structure-based identification of novel sirtuin inhibitors against triple negative breast cancer: An in silico and in vitro study.
Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells.
Trypanosomiasis
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.
Tuberculosis
A Sir2 family protein Rv1151c deacetylates HU to alter its DNA binding mode in Mycobacterium tuberculosis.
Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight.
Cloning and characterization of NAD-dependent protein deacetylase (Rv1151c) from Mycobacterium tuberculosis.
Cyclic AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis.
Cyclic AMP-dependent protein lysine acylation in mycobacteria regulates fatty acid and propionate metabolism.
Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis.
Host sirtuin 2 as an immunotherapeutic target against tuberculosis.
Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy.
Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis.
Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control.
Papers of note in Science Immunology2 (9).
Phosphorylation Modulates Catalytic Activity of Mycobacterial Sirtuins.
Reversible acetylation and inactivation of Mycobacterium tuberculosis acetyl-CoA synthetase is dependent on cAMP.
Role of Sirt1 in innate immune mechanisms against Mycobacterium tuberculosis via the inhibition of TAK1 activation.
Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax.
SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions.
Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death.
Sirtuin inhibits M. tuberculosis -induced apoptosis in macrophage through glycogen synthase kinase-3?.
The dominant model analysis of Sirt3 genetic variants is associated with susceptibility to tuberculosis in a Chinese Han population.
Tuberous Sclerosis
Alterations in expression levels of genes in p53-related pathways determined using RNA-Seq analysis in patients with breast cancer following CIK therapy.
Cartilage Ablation of Sirt1 Causes Inhibition of Growth Plate Chondrogenesis by Hyperactivation of mTORC1 Signaling.
Cypermethrin Activates Autophagosome Formation Albeit Inhibits Autophagy Owing to Poor Lysosome Quality: Relevance to Parkinson's Disease.
Ginsenoside Rg1 Inhibits Cell Proliferation and Induces Markers of Cell Senescence in CD34+CD38- Leukemia Stem Cells Derived from KG1? Acute Myeloid Leukemia Cells by Activating the Sirtuin 1 (SIRT1)/Tuberous Sclerosis Complex 2 (TSC2) Signaling Pathway.
Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice.
udp-3-o-acyl-n-acetylglucosamine deacetylase deficiency
Stoichiometry of site-specific lysine acetylation in an entire proteome.
ulp1 peptidase deficiency
SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism.
Ureteral Obstruction
Activation of Sirtuin-1 Promotes Renal Fibroblast Activation and Aggravates Renal Fibrogenesis.
CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a Sirt1-independent manner.
Downregulation of angiotensin type 1 receptor and nuclear factor-?B by sirtuin 1 contributes to renoprotection in unilateral ureteral obstruction.
Exosomes derived from GDNF-modified human adipose mesenchymal stem cells ameliorate peritubular capillary loss in tubulointerstitial fibrosis by activating the SIRT1/eNOS signaling pathway.
Renal protective effects of resveratrol.
Sirt1 activation protects the mouse renal medulla from oxidative injury.
SIRT1 attenuates renal fibrosis by repressing HIF-2?.
Urethral Obstruction
Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2.
Urinary Bladder Neoplasms
Capsaicin attenuates cell migration via SIRT1 targeting and inhibition to enhance cortactin and ?-catenin acetylation in bladder cancer cells.
Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1).
HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin.
LncRNA MST1P2/miR-133b axis affects the chemoresistance of bladder cancer to cisplatin-based therapy via Sirt1/p53 signaling.
Selective Cytotoxicity of Kaempferia parviflora Extracts in Human Cell Lines.
SIRT1 Gene Polymorphisms Are Associated with Urinary Bladder Cancer in an Iranian Population.
SIRT1 promotes GLUT1 expression and bladder cancer progression via regulation of glucose uptake.
SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis.
Uterine Cervical Neoplasms
?2-AR activation induces chemoresistance by modulating p53 acetylation through upregulating Sirt1 in cervical cancer cells.
Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense.
Decreased Expression of MiR-138-5p by LncRNA H19 in Cervical Cancer Promotes Tumor Proliferation.
Development of Substrate-Derived Sirtuin Inhibitors with Potential Anticancer Activity.
Effect of the SIRT3-AMPK/PPAR pathway on invasion and migration of cervical cancer cells.
Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.
Knockdown of SIRT1 inhibits proliferation and promotes apoptosis of paclitaxel-resistant human cervical cancer cells.
Metformin combined with nelfinavir induces SIRT3/mROS-dependent autophagy in human cervical cancer cells and xenograft in nude mice.
MiR-29a function as tumor suppressor in cervical cancer by targeting SIRT1 and predict patient prognosis.
Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells.
SIRT1 and gynecological malignancies (Review).
SIRT2 expression exhibits potential to serve as a biomarker for disease surveillance and prognosis in the management of cervical cancer patients.
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases.
Sirtuin1 expression predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer.
The deacetylase SIRT1 regulates the replication properties of human papillomavirus 16 E1 and E2.
The PIK3CA E542K and E545K mutations promote glycolysis and proliferation via induction of the ?-catenin/SIRT3 signaling pathway in cervical cancer.
[Expression Level of SIRT2 in Cervical Cancer Tissue and Its Clinical Significance].
Uterine Neoplasms
Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer.
Uveitis
SIRT1 activation protects against autoimmune T cell-driven retinal disease in mice via inhibition of IL-2/Stat5 signaling.
The role of SIRT1 in ocular aging.
TNF? Regulates SIRT1 Cleavage during Ocular Autoimmune Disease.
Varicocele
Seminal SIRT1-oxidative stress relationship in infertile oligoasthenoteratozoospermic men with varicocele after its surgical repair.
Vascular Calcification
Intermedin1-53 attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1.
Loss of SIRT1 in diabetes accelerates DNA damage induced vascular calcification.
Peroxisome Proliferator-Activated Receptor-? Coactivator-1? Inhibits Vascular Calcification Through Sirtuin 3-Mediated Reduction of Mitochondrial Oxidative Stress.
Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease.
Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway.
Suppression of SIRT1 in Diabetic Conditions Induces Osteogenic Differentiation of Human Vascular Smooth Muscle Cells via RUNX2 Signalling.
The Interplay of SIRT1 and Wnt Signaling in Vascular Calcification.
[Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Regulatory Mechanism of Mammalian Sirtuin SIRT1 in Vascular calcification: impact of vascular smooth muscle cell senescence].
[Molecular mechanism of vascular calcification: essential role of mammalian sirtuin SIRT1 in cellular senescence].
[Regulatory Mechanisms and Practical Management in Vascular Calcification. Molecular Mechanism of Vascular Aging : Impact of Vascular Smooth Muscle Cell Calcification via Cellular Senescence.]
Vascular Diseases
A Label-free Sirtuin 1 Assay based on Droplet-Electrospray Ionization Mass Spectrometry.
CO ameliorates endothelial senescence induced by 5-fluorouracil through SIRT1 activation.
Cross-talk between SIRT1 and p66Shc in vascular diseases.
Harnessing the Power of SIRT1 and Non-coding RNAs in Vascular Disease.
Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases.
Impact of Short-Term Hypoxia on Sirtuins as Regulatory Elements in HUVECs.
Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects.
Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle.
Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease.
SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice.
SIRT1 Antagonizes Oxidative Stress in Diabetic Vascular Complication.
SIRT1 as a Novel Potential Treatment Target for Vascular Aging and Age-related Vascular Diseases.
SIRT1 mediates the actions of PPAR? on the oxLDL-triggered migration and proliferation of vascular smooth muscle cells.
SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.
Sirtuin 1 stabilization by HuR represses TNF-? and glucose induced E-Selectin release and endothelial cell adhesiveness in vitro. Relevance to human metabolic syndrome.
The role of SIRT2 in vascular-related and heart-related diseases: A review.
The Role of Sirtuin-1 in the Vasculature: Focus on Aortic Aneurysm.
The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging.
Vascular System Injuries
Protective Role of Endogenous Kallistatin in Vascular Injury and Senescence by Inhibiting Oxidative Stress and Inflammation.
SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice.
Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer's Disease.
Targeting cardiovascular disease with novel SIRT1 pathways.
Vasospasm, Intracranial
SIRT1 mediates hypoxic preconditioning induced attenuation of neurovascular dysfunction following subarachnoid hemorrhage.
Venous Thrombosis
Danhong Huayu Koufuye prevents venous thrombosis through antiinflammation via Sirtuin 1/NF-?B signaling pathway.
Data for DHK effect on thrombus weight, blood coagulation, blood cell counts and whole blood viscosity in deep vein thrombosis rats.
Deep Vein Thrombosis is Modulated by Inflammation Regulated via Sirtuin 1/NF-?B Signalling Pathway in a Rat Model.
LncRNA Sirt1-AS upregulates Sirt1 to attenuate aging related deep venous thrombosis.
Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice.
Ventricular Dysfunction
Mitochondrial Hyperacetylation in the Failing Hearts of Obese Patients Mediated Partly by a Reduction in SIRT3: The Involvement of the Mitochondrial Permeability Transition Pore.
Ventricular Dysfunction, Left
Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress.
Vesicular Stomatitis
SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis.
SIRT1 stabilizes PML promoting its sumoylation.
Virus Diseases
Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity.
Enhanced Viral Replication by Cellular Replicative Senescence.
Expression and role of SIRT1 in hepatocellular carcinoma.
Histone deficiency and accelerated replication stress in T cell aging.
How much successful are the medicinal chemists in modulation of SIRT1: A critical review.
Intricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens.
Involvement of FOXO transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type II-induced apoptosis.
Melatonin Inhibits Dengue Virus Infection via the Sirtuin 1-Mediated Interferon Pathway.
Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway.
SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty.
Sirtuin activators and inhibitors.
Transcriptome Profiling Reveals a Novel Mechanism of Antiviral Immunity Upon Sacbrood Virus Infection in Honey Bee Larvae (Apis cerana).
Use of the Monte Carlo Method for OECD Principles-Guided QSAR Modeling of SIRT1 Inhibitors.
Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach.
Vitamin D Deficiency
Effect of vitamin D supplementation in combination with weight loss diet on lipid profile and sirtuin 1 in obese subjects with vitamin D deficiency: a double blind randomized clinical trial.
Vitiligo
Development and in vitro assessment of psoralen and resveratrol co-loaded ultradeformable liposomes for the treatment of vitiligo.
SIRT1 regulates MAPK pathways in vitiligo skin: insight into the molecular pathways of cell survival.
SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo.
The long noncoding RNA MALAT1 suppresses miR-211 to confer protection from ultraviolet-mediated DNA damage in vitiligo epidermis by upregulating sirtuin 1.
Werner Syndrome
Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney.
Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML.
Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
Wilms Tumor
Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Conversion of White to Beige Fat in Mice.
SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation.
Xeroderma Pigmentosum
Dual role of SIRT1 in UVB-induced skin tumorigenesis.
Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C.
Sirt1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells.