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2 S-adenosyl-L-methionine + kaempferol
S-adenosyl-L-homocysteine + 3,7-O-dimethylkaempferol
-
activity only of enzyme mutant POMT7-M1, D257G, not of wild-type POMT7
-
-
?
2 S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + 3,7-O-dimethylquercetin
-
activity only of enzyme mutant POMT7-M1, D257G, not of wild-type POMT7, molecular docking of quercetin into the modeled structure of Asp257Gly
-
-
?
S-adenosyl-L-methionine + (2S)-5,7,4'-trihydroxyflavanone
S-adenosyl-L-homocysteine + (2S)-5,4'-dihydroxy-7-methoxyflavanone
S-adenosyl-L-methionine + 3',4',5,7-tetrahydroxyflavanone
S-adenosyl-L-homocysteine + 3,4',5-trihydroxy-7-methoxyflavanone
-
i.e. eriodictyol, 14% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)
-
-
?
S-adenosyl-L-methionine + 3,3',4',5,7-pentahydroxyflavone
S-adenosyl-L-homocysteine + 3,3',4',5-tetrahydroxy-7-methoxyflavone
S-adenosyl-L-methionine + 3,4',5,7-tetrahydroxyflavanone
S-adenosyl-L-homocysteine + 3,4',5-trihydroxy-7-methoxyflavanone
S-adenosyl-L-methionine + 3,5,7,4'-tetrahydroxy-3'-methoxyflavone
S-adenosyl-L-homocysteine + 3,5,4'-trihydroxy-7,3'-dimethoxyflavone
S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone
S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone
S-adenosyl-L-methionine + kaempferol
S-adenosyl-L-homocysteine + 7-O-methylkaempferol
-
-
-
-
?
S-adenosyl-L-methionine + luteolin
S-adenosyl-L-homocysteine + 3,4',5-trihydroxy-7-methoxyflavanone
-
i.e. 5,7,3',4'-tetrahydroxyflavanone, 87% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)
-
-
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + 7-O-methylquercetin
additional information
?
-
S-adenosyl-L-methionine + (2S)-5,7,4'-trihydroxyflavanone
S-adenosyl-L-homocysteine + (2S)-5,4'-dihydroxy-7-methoxyflavanone
-
i.e. (2S)-naringenin, 16% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)
i.e. (2S)-sakuranetin
-
?
S-adenosyl-L-methionine + (2S)-5,7,4'-trihydroxyflavanone
S-adenosyl-L-homocysteine + (2S)-5,4'-dihydroxy-7-methoxyflavanone
-
i.e. (2S)-naringenin, 16% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)
i.e. (2S)-sakuranetin
-
?
S-adenosyl-L-methionine + 3,3',4',5,7-pentahydroxyflavone
S-adenosyl-L-homocysteine + 3,3',4',5-tetrahydroxy-7-methoxyflavone
-
i.e. quercetin, 98% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)
-
-
?
S-adenosyl-L-methionine + 3,3',4',5,7-pentahydroxyflavone
S-adenosyl-L-homocysteine + 3,3',4',5-tetrahydroxy-7-methoxyflavone
-
i.e. quercetin, 98% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)
-
-
?
S-adenosyl-L-methionine + 3,3',4',5,7-pentahydroxyflavone
S-adenosyl-L-homocysteine + 3,3',4',5-tetrahydroxy-7-methoxyflavone
-
i.e. quercetin
-
-
?
S-adenosyl-L-methionine + 3,3',4',5,7-pentahydroxyflavone
S-adenosyl-L-homocysteine + 3,3',4',5-tetrahydroxy-7-methoxyflavone
-
i.e. quercetin
i.e. rhamnetin
-
?
S-adenosyl-L-methionine + 3,4',5,7-tetrahydroxyflavanone
S-adenosyl-L-homocysteine + 3,4',5-trihydroxy-7-methoxyflavanone
-
i.e. kaempferol, 82% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)
-
-
?
S-adenosyl-L-methionine + 3,4',5,7-tetrahydroxyflavanone
S-adenosyl-L-homocysteine + 3,4',5-trihydroxy-7-methoxyflavanone
-
i.e. kaempferol
-
-
?
S-adenosyl-L-methionine + 3,5,7,4'-tetrahydroxy-3'-methoxyflavone
S-adenosyl-L-homocysteine + 3,5,4'-trihydroxy-7,3'-dimethoxyflavone
-
i.e. isorhamnetin, 57% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)
-
-
?
S-adenosyl-L-methionine + 3,5,7,4'-tetrahydroxy-3'-methoxyflavone
S-adenosyl-L-homocysteine + 3,5,4'-trihydroxy-7,3'-dimethoxyflavone
-
i.e. isorhamnetin, 57% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)
-
-
?
S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone
S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone
-
i.e. apigenin
i.e. genkwanin
-
?
S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone
S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone
-
i.e. apigenin
i.e. genkwanin
-
?
S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone
S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone
-
i.e. apigenin
i.e. genkwanin
-
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + 7-O-methylquercetin
-
-
-
-
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + 7-O-methylquercetin
-
-
i.e. rhamnetin
-
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + 7-O-methylquercetin
-
POMT7 has a high affinity toward quercetin
i.e. rhamnetin
-
?
additional information
?
-
-
POMT-7 is able to transfer a methyl group to several flavonoids containing a C-7 hydroxyl group. POMT-7 shows a higher affinity toward flavonol and flavone such as apigenin, kaempferol, luteolin, and quercetin than flavanone and isoflavone
-
-
?
additional information
?
-
-
POMT-7 is able to transfer a methyl group to several flavonoids containing a C-7 hydroxyl group. POMT-7 shows a higher affinity toward flavonol and flavone such as apigenin, kaempferol, luteolin, and quercetin than flavanone and isoflavone
-
-
?
additional information
?
-
-
the O-methyltransferase from poplar transfers a methyl group to several flavonoids that contain a 7-hydroxyl group. POMT7 has a high affinity toward quercetin, and the reaction product rhamnetin
-
-
?
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0.0298 - 0.0324
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
0.0324 - 0.0378
3,4',5,7-tetrahydroxyflavanone
0.0298 - 0.0324
kaempferol
0.0324 - 0.0378
quercetin
0.0298
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
-
i.e. quercetin, pH 7.5, 37°C, wild-type enzyme
0.0324
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
-
i.e. quercetin, pH 7.5, 37°C, mutant enzyme N257G
0.0324
3,4',5,7-tetrahydroxyflavanone
-
i.e. kaempferol, pH 7.5, 37°C, wild-type enzyme
0.0378
3,4',5,7-tetrahydroxyflavanone
-
i.e. kaempferol, pH 7.5, 37°C, mutant enzyme N257G
0.0298
kaempferol
-
pH 7.5, 37°C, recombinant wild-type POMT7
0.0324
kaempferol
-
pH 7.5, 37°C, recombinant mutant POMT7-M1
0.0324
quercetin
-
pH 7.5, 37°C, recombinant wild-type POMT7
0.0378
quercetin
-
pH 7.5, 37°C, recombinant mutant POMT7-M1
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0.064 - 0.071
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
0.064 - 0.07
3,4',5,7-tetrahydroxyflavanone
0.064
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
-
i.e. quercetin, pH 7.5, 37°C, mutant enzyme N257G
0.071
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
-
i.e. quercetin, pH 7.5, 37°C, wild-type enzyme
0.064
3,4',5,7-tetrahydroxyflavanone
-
i.e. kaempferol, pH 7.5, 37°C, wild-type enzyme
0.07
3,4',5,7-tetrahydroxyflavanone
-
i.e. kaempferol, pH 7.5, 37°C, mutant enzyme N257G
0.064
kaempferol
-
pH 7.5, 37°C, recombinant mutant POMT7-M1
0.071
kaempferol
-
pH 7.5, 37°C, recombinant wild-type POMT7
0.064
quercetin
-
pH 7.5, 37°C, recombinant wild-type POMT7
0.07
quercetin
-
pH 7.5, 37°C, recombinant mutant POMT7-M1
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1.9 - 2.4
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
1.7 - 1.9
3,4',5,7-tetrahydroxyflavanone
1.9
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
-
i.e. quercetin, pH 7.5, 37°C, mutant enzyme N257G
2.4
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
-
i.e. quercetin, pH 7.5, 37°C, wild-type enzyme
1.7
3,4',5,7-tetrahydroxyflavanone
-
i.e. kaempferol, pH 7.5, 37°C, mutant enzyme N257G
1.9
3,4',5,7-tetrahydroxyflavanone
-
i.e. kaempferol, pH 7.5, 37°C, wild-type enzyme
1.9
kaempferol
-
pH 7.5, 37°C, recombinant mutant POMT7-M1
2.4
kaempferol
-
pH 7.5, 37°C, recombinant wild-type POMT7
1.7
quercetin
-
pH 7.5, 37°C, recombinant mutant POMT7-M1
1.9
quercetin
-
pH 7.5, 37°C, recombinant wild-type POMT7
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