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Information on EC 2.1.1.69 - 5-hydroxyfuranocoumarin 5-O-methyltransferase

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IUBMB Comments
Converts bergaptol into bergapten, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities . The enzyme methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin , but has little activity on non-coumarin phenols . Caffeate, 5-hydroxyferulate and daphnetin are not substrates . Cu2+, Zn2+ and Co2+ cause enzyme inhibition . (see also EC 2.1.1.70, 8-hydroxyfuranocoumarin 8-O-methyltransferase)
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The enzyme appears in viruses and cellular organisms
Synonyms
bergaptol-5-O-methyltransferase, BMT, furanocoumarin 5-methyltransferase, furanocoumarin 5-O-methyltransferase, methyltransferase, bergaptol, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + a 5-hydroxyfurocoumarin = S-adenosyl-L-homocysteine + a 5-methoxyfurocoumarin
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converts bergaptol into bergapten. Methylates the 5-hydroxyl of some hydroxy- and methyl- coumarins, but has little activity on non-coumarin phenols
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S-adenosyl-L-methionine + bergaptol = S-adenosyl-L-homocysteine + bergapten
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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