Information on EC 2.1.1.378 - [methyl-Co(III) glycine betaine-specific corrinoid protein]-tetrahydrofolate methyltransferase

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IUBMB Comments
This enzyme, characterized from the anaerobic bacterium Desulfitobacterium hafniense Y51, catalyses a similar reaction to that of EC 2.1.1.258, 5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase, but in the opposite direction, transferring a methyl group from a methylated corrinoid protein to tetrahydrofolate. The corrinoid protein is specifically methylated by EC 2.1.1.376, glycine betaine---corrinoid protein Co-methyltransferase.
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The expected taxonomic range for this enzyme is: Desulfitobacterium hafniense
Reaction Schemes
a [methyl-Co(III) glycine betaine-specific corrinoid protein]
+
=
a [Co(I) glycine betaine-specific corrinoid protein]
+
Synonyms
DSY3157, methylCbl:THF methyltransferase, methylcobalamin:tetrahydrofolate methyltransferase, MtgA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a [methyl-Co(III) glycine betaine-specific corrinoid protein] + tetrahydrofolate = a [Co(I) glycine betaine-specific corrinoid protein] + 5-methyltetrahydrofolate
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PATHWAY SOURCE
PATHWAYS
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