Disease on EC 1.14.11.53 - mRNA N6-methyladenine demethylase
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Abortion, Habitual
The m6A demethylase ALKBH5 controls trophoblast invasion at the maternal-fetal interface by regulating the stability of CYR61 mRNA.
Adenocarcinoma
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling.
Adenocarcinoma of Lung
ALKBH5-m6A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia.
Adenocarcinoma of Lung
ALKBH5-mediated m6A demethylation of lncRNA RMRP plays an oncogenic role in lung adenocarcinoma.
Adenocarcinoma of Lung
Identification of pathology-specific regulators of m6A RNA modification to optimize lung cancer management in the context of predictive, preventive, and personalized medicine.
Adenoma, Oxyphilic
The N6 -methyladenosine (m6 A) erasers alkylation repair homologue 5 (ALKBH5) and fat mass and obesity-associated protein (FTO) are prognostic biomarkers in patients with clear cell renal carcinoma.
Adenomyosis
m6A RNA Methylation Regulators Contribute to Eutopic Endometrium and Myometrium Dysfunction in Adenomyosis.
Aneurysm, Dissecting
KIAA1429 and ALKBH5 Oppositely Influence Aortic Dissection Progression via Regulating the Maturation of Pri-miR-143-3p in an m6A-Dependent Manner.
Arthritis, Rheumatoid
Decreased ALKBH5, FTO, and YTHDF2 in Peripheral Blood Are as Risk Factors for Rheumatoid Arthritis.
Atherosclerosis
Fat mass and obesity-associated protein attenuates lipid accumulation in macrophage foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice.
Bacterial Infections
Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA.
Bone Resorption
Circ_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation.
Bone Resorption
Downregulated fat mass and obesity-associated protein inhibits bone resorption and osteoclastogenesis by nuclear factor-kappa B inactivation.
Brain Neoplasms
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Breast Neoplasms
ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2.
Breast Neoplasms
Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin.
Breast Neoplasms
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA.
Breast Neoplasms
Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells.
Breast Neoplasms
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Breast Neoplasms
RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3.
Breast Neoplasms
Structural characteristics of small-molecule inhibitors targeting FTO demethylase.
Carcinogenesis
A positive-feedback loop between HBx and ALKBH5 promotes hepatocellular carcinogenesis.
Carcinogenesis
Active Site Breathing of Human Alkbh5 Revealed by Solution NMR and Accelerated Molecular Dynamics.
Carcinogenesis
ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2.
Carcinogenesis
ALKBH5-mediated m6A demethylation of lncRNA RMRP plays an oncogenic role in lung adenocarcinoma.
Carcinogenesis
Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Carcinogenesis
Downregulation of Fat Mass and Obesity Associated (FTO) Promotes the Progression of Intrahepatic Cholangiocarcinoma.
Carcinogenesis
Fat mass and obesity-associated protein promotes the tumorigenesis and development of liver cancer.
Carcinogenesis
Fat mass and obesity-associated protein regulates tumorigenesis of arecoline-promoted human oral carcinoma.
Carcinogenesis
FTO modifies the m6A level of MALAT and promotes bladder cancer progression.
Carcinogenesis
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling.
Carcinogenesis
N 6-methyladenosine binding induces a metal-centered rearrangement that activates the human RNA demethylase Alkbh5.
Carcinogenesis
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
Carcinogenesis
Novel insights into the interplay between m6A modification and noncoding RNAs in cancer.
Carcinogenesis
RNA demethylase ALKBH5 promotes ovarian carcinogenesis in a simulated tumour microenvironment through stimulating NF-?B pathway.
Carcinogenesis
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Carcinogenesis
Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5.
Carcinoma
A positive feedback loop between AlkB homolog 5 and miR-193a-3p promotes growth and metastasis in esophageal squamous cell carcinoma.
Carcinoma
ALKBH5 promotes the proliferation of renal cell carcinoma by regulating AURKB expression in an m6A-dependent manner.
Carcinoma
Fat mass and obesity-associated protein regulates tumorigenesis of arecoline-promoted human oral carcinoma.
Carcinoma
m6 A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis.
Carcinoma
m6A demethylase ALKBH5 suppression contributes to esophageal squamous cell carcinoma progression.
Carcinoma
N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1? signalling axis.
Carcinoma
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
Carcinoma
Structural characteristics of small-molecule inhibitors targeting FTO demethylase.
Carcinoma
The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor.
Carcinoma
The N6 -methyladenosine (m6 A) erasers alkylation repair homologue 5 (ALKBH5) and fat mass and obesity-associated protein (FTO) are prognostic biomarkers in patients with clear cell renal carcinoma.
Carcinoma, Hepatocellular
ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1.
Carcinoma, Non-Small-Cell Lung
N6-methyladenosine ALKBH5 promotes non-small cell lung cancer progress by regulating TIMP3 stability.
Carcinoma, Ovarian Epithelial
ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2.
Carcinoma, Renal Cell
ALKBH5 promotes the proliferation of renal cell carcinoma by regulating AURKB expression in an m6A-dependent manner.
Carcinoma, Renal Cell
N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1? signalling axis.
Carcinoma, Renal Cell
The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor.
Carcinoma, Renal Cell
The N6 -methyladenosine (m6 A) erasers alkylation repair homologue 5 (ALKBH5) and fat mass and obesity-associated protein (FTO) are prognostic biomarkers in patients with clear cell renal carcinoma.
Carcinoma, Squamous Cell
Identification of pathology-specific regulators of m6A RNA modification to optimize lung cancer management in the context of predictive, preventive, and personalized medicine.
Carcinoma, Squamous Cell
Structural characteristics of small-molecule inhibitors targeting FTO demethylase.
Cholangiocarcinoma
M6A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma.
Colitis
m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity.
Colonic Neoplasms
ALKBH5 Holds Prognostic Values and Inhibits the Metastasis of Colon Cancer.
Colonic Neoplasms
ALKBH5 promotes colon cancer progression by decreasing methylation of the lncRNA NEAT1.
Colonic Neoplasms
Potential Impact of ALKBH5 and YTHDF1 on Tumor Immunity in Colon Adenocarcinoma.
Colonic Neoplasms
RNA N6-methyladenosine demethylase FTO regulates PD-L1 expression in colon cancer cells.
Colorectal Neoplasms
FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis.
Colorectal Neoplasms
FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell.
Colorectal Neoplasms
Proteome-wide Interrogation of Small GTPases Regulated by N6-Methyladenosine Modulators.
COVID-19
Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication.
Dehydration
Alpha-ketoglutarate-dependent dioxygenase homolog 10B, an N6 -methyladenosine mRNA demethylase, plays a role in salt stress and abscisic acid responses in Arabidopsis thaliana.
Diabetes Mellitus
FTO rs9939609 polymorphism is associated with metabolic disturbances and response to HCV therapy in HIV/HCV-coinfected patients.
Diabetes Mellitus, Type 2
Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype.
Diabetes Mellitus, Type 2
FTO rs9939609 polymorphism is associated with metabolic disturbances and response to HCV therapy in HIV/HCV-coinfected patients.
Diabetes Mellitus, Type 2
Human and Arabidopsis alpha-ketoglutarate-dependent dioxygenase homolog proteins-New players in important regulatory processes.
Diabetes Mellitus, Type 2
Structural characteristics of small-molecule inhibitors targeting FTO demethylase.
Digestive System Neoplasms
Emerging Roles of N6-Methyladenosine Demethylases and Its Interaction with Environmental Toxicants in Digestive System Cancers.
Encephalomyelitis
m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity.
Encephalomyelitis, Autoimmune, Experimental
m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity.
Endometrial Neoplasms
ALKBH5 regulates IGF1R expression to promote the Proliferation and Tumorigenicity of Endometrial Cancer.
Endometrial Neoplasms
Estrogen promotes fat mass and obesity-associated protein nuclear localization and enhances endometrial cancer cell proliferation via the mTOR signaling pathway.
Esophageal Neoplasms
N6-methyladenosine demethylase ALKBH5 suppresses malignancy of esophageal cancer by regulating microRNA biogenesis and RAI1 expression.
Esophageal Squamous Cell Carcinoma
A positive feedback loop between AlkB homolog 5 and miR-193a-3p promotes growth and metastasis in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
m6 A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis.
Esophageal Squamous Cell Carcinoma
m6A demethylase ALKBH5 suppression contributes to esophageal squamous cell carcinoma progression.
Exanthema
Decreased Peripheral Blood ALKBH5 Correlates with Markers of Autoimmune Response in Systemic Lupus Erythematosus.
Glioblastoma
3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line.
Glioblastoma
ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2.
Glioblastoma
m6A-RNA Demethylase FTO Inhibitors Impair Self-Renewal in Glioblastoma Stem Cells.
Glioblastoma
Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors.
Glioblastoma
Structural characteristics of small-molecule inhibitors targeting FTO demethylase.
Glioma
A Risk Signature Consisting of Eight m6A Methylation Regulators Predicts the Prognosis of Glioma.
Glioma
ALKBH5 Promotes the Proliferation of Glioma Cells via Enhancing the mRNA Stability of G6PD.
Glioma
miRNA-193a-3p Regulates the AKT2 Pathway to Inhibit the Growth and Promote the Apoptosis of Glioma Cells by Targeting ALKBH5.
Glioma
The m6A RNA Demethylase ALKBH5 Promotes Radioresistance and Invasion Capability of Glioma Stem Cells.
Glioma
Warburg effect-promoted exosomal circ_0072083 releasing up-regulates NANGO expression through multiple pathways and enhances temozolomide resistance in glioma.
Graves Disease
Inclusion of ALKBH5 as a candidate gene for the susceptibility of autoimmune thyroid disease.
Hepatoblastoma
ALKBH5 Gene Polymorphisms and Hepatoblastoma Susceptibility in Chinese Children.
Hirschsprung Disease
m6A demethylase ALKBH5 suppresses proliferation and migration of enteric neural crest cells by regulating TAGLN in Hirschsprung's disease.
Infarction, Middle Cerebral Artery
N6-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury.
Infections
A positive-feedback loop between HBx and ALKBH5 promotes hepatocellular carcinogenesis.
Infections
m6A mRNA Methylation Regulates Epithelial Innate Antimicrobial Defense Against Cryptosporidial Infection.
Infertility
Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies infertility-associated variant and two missense mutations.
Insulin Resistance
FTO rs9939609 polymorphism is associated with metabolic disturbances and response to HCV therapy in HIV/HCV-coinfected patients.
Leukemia
Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis.
Leukemia
Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors.
Leukemia
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis.
Leukemia, Myeloid, Acute
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Structural characteristics of small-molecule inhibitors targeting FTO demethylase.
Liver Neoplasms
Fat mass and obesity-associated protein promotes the tumorigenesis and development of liver cancer.
Lung Neoplasms
Identification of pathology-specific regulators of m6A RNA modification to optimize lung cancer management in the context of predictive, preventive, and personalized medicine.
Lung Neoplasms
m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2-mediated YAP activity in NSCLC.
Lung Neoplasms
N6-methyladenosine ALKBH5 promotes non-small cell lung cancer progress by regulating TIMP3 stability.
Lung Neoplasms
Suppression of m6A mRNA modification by DNA hypermethylated ALKBH5 aggravates the oncological behavior of KRAS mutation/LKB1 loss lung cancer.
Lupus Erythematosus, Systemic
Decreased Peripheral Blood ALKBH5 Correlates with Markers of Autoimmune Response in Systemic Lupus Erythematosus.
Lupus Erythematosus, Systemic
The study of METTL14, ALKBH5, and YTHDF2 in peripheral blood mononuclear cells from systemic lupus erythematosus.
Lymphatic Metastasis
N6-methyladenosine RNA methylation regulators contribute to the progression of prostate cancer.
Lymphoma, B-Cell
MYC promotes cancer progression by modulating m6 A modifications to suppress target gene translation.
Melanoma
ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment.
Melanoma
ALKBH5-mediated m6A demethylation of FOXM1 mRNA promotes progression of uveal melanoma.
Melanoma
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Melanoma
Proteome-wide Interrogation of Small GTPases Regulated by N6-Methyladenosine Modulators.
Metabolic Diseases
NADP modulates RNA m6A methylation and adipogenesis via enhancing FTO activity.
Metabolic Syndrome
FTO rs9939609 polymorphism is associated with metabolic disturbances and response to HCV therapy in HIV/HCV-coinfected patients.
Mouth Neoplasms
Fat mass and obesity-associated protein regulates tumorigenesis of arecoline-promoted human oral carcinoma.
mrna n6-methyladenine demethylase deficiency
ALKBH5-Modified HMGB1-STING Activation Contributes to Radiation Induced Liver Disease via Innate Immune Response.
mrna n6-methyladenine demethylase deficiency
m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity.
mrna n6-methyladenine demethylase deficiency
M6A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma.
Myocardial Infarction
ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1.
Neoplasm Metastasis
A positive feedback loop between AlkB homolog 5 and miR-193a-3p promotes growth and metastasis in esophageal squamous cell carcinoma.
Neoplasm Metastasis
ALKBH5 Holds Prognostic Values and Inhibits the Metastasis of Colon Cancer.
Neoplasm Metastasis
ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1.
Neoplasm Metastasis
ALKBH5-mediated m6A demethylation of FOXM1 mRNA promotes progression of uveal melanoma.
Neoplasm Metastasis
FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis.
Neoplasm Metastasis
Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells.
Neoplasm Metastasis
m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2-mediated YAP activity in NSCLC.
Neoplasm Metastasis
N6-methyladenosine RNA methylation regulators contribute to the progression of prostate cancer.
Neoplasm Metastasis
The biological function of m6A demethylase ALKBH5 and its role in human disease.
Neoplasms
3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line.
Neoplasms
A positive-feedback loop between HBx and ALKBH5 promotes hepatocellular carcinogenesis.
Neoplasms
ALKBH5 Inhibited Cell Proliferation and Sensitized Bladder Cancer Cells to Cisplatin by m6A-CK2?-Mediated Glycolysis.
Neoplasms
ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation.
Neoplasms
ALKBH5 promotes the proliferation of renal cell carcinoma by regulating AURKB expression in an m6A-dependent manner.
Neoplasms
ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment.
Neoplasms
ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1.
Neoplasms
ALKBH5 suppresses tumor progression via an m6A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma.
Neoplasms
ALKBH5-HOXA10 loop-mediated JAK2 m6A demethylation and cisplatin resistance in epithelial ovarian cancer.
Neoplasms
ALKBH5-m6A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia.
Neoplasms
ALKBH5-mediated m6A demethylation of FOXM1 mRNA promotes progression of uveal melanoma.
Neoplasms
ALKBH5-mediated m6A-demethylation of USP1 regulated T-cell acute lymphoblastic leukemia cell glucocorticoid resistance by Aurora B.
Neoplasms
Clinical and Prognostic Pan-Cancer Analysis of N6-Methyladenosine Regulators in Two Types of Hematological Malignancies: A Retrospective Study Based on TCGA and GTEx Databases.
Neoplasms
Comprehensive Analysis of Expression Regulation for RNA m6A Regulators With Clinical Significance in Human Cancers.
Neoplasms
Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression.
Neoplasms
Deregulation of UBE2C-mediated autophagy repression aggravates NSCLC progression.
Neoplasms
Development and validation of a m6A RNA methylation regulators-based signature for predicting the prognosis of head and neck squamous cell carcinoma.
Neoplasms
Effect of N6-Methyladenosine Regulators on Progression and Prognosis of Triple-Negative Breast Cancer.
Neoplasms
Emerging Roles of N6-Methyladenosine Demethylases and Its Interaction with Environmental Toxicants in Digestive System Cancers.
Neoplasms
Expression patterns and prognostic value of m6A-related genes in colorectal cancer.
Neoplasms
Fat mass and obesity-associated protein regulates tumorigenesis of arecoline-promoted human oral carcinoma.
Neoplasms
Hypoxia induces an endometrial cancer stem-like cell phenotype via HIF-dependent demethylation of SOX2 mRNA.
Neoplasms
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA.
Neoplasms
Identification of a m6A RNA methylation regulators-based signature for predicting the prognosis of clear cell renal carcinoma.
Neoplasms
Identification of m6A-related genes and m6A RNA methylation regulators in pancreatic cancer and their association with survival.
Neoplasms
Identification of Specific N6-methyladenosine RNA Demethylase FTO Inhibitors by Single Quantum Dot-Based FRET Nanosensor.
Neoplasms
Long noncoding RNA GAS5-AS1 suppresses growth and metastasis of cervical cancer by increasing GAS5 stability.
Neoplasms
m6 A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis.
Neoplasms
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling.
Neoplasms
m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2-mediated YAP activity in NSCLC.
Neoplasms
M6A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma.
Neoplasms
m6A demethylase ALKBH5 suppression contributes to esophageal squamous cell carcinoma progression.
Neoplasms
m6A demethylase FTO induces NELL2 expression by inhibiting E2F1 m6A modification leading to metastasis of non-small cell lung cancer.
Neoplasms
m6A RNA methylation regulators have prognostic value in papillary thyroid carcinoma.
Neoplasms
METTL3-induced UCK2 m6A hypermethylation promotes melanoma cancer cell metastasis via the WNT/?-catenin pathway.
Neoplasms
N 6-methyladenosine binding induces a metal-centered rearrangement that activates the human RNA demethylase Alkbh5.
Neoplasms
N6-methyladenosine ALKBH5 promotes non-small cell lung cancer progress by regulating TIMP3 stability.
Neoplasms
N6-methyladenosine demethylase ALKBH5 suppresses malignancy of esophageal cancer by regulating microRNA biogenesis and RAI1 expression.
Neoplasms
N6-Methyladenosine detected in RNA of testicular germ cell tumors is controlled by METTL3, ALKBH5, YTHDC1/F1/F2, and HNRNPC as writers, erasers, and readers.
Neoplasms
Novel methylated DNA markers accurately discriminate Lynch syndrome associated colorectal neoplasia.
Neoplasms
Novel positioning from obesity to cancer: FTO, an m6A RNA demethylase, regulates tumour progression.
Neoplasms
Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors.
Neoplasms
RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner.
Neoplasms
RNA demethylase ALKBH5 promotes ovarian carcinogenesis in a simulated tumour microenvironment through stimulating NF-?B pathway.
Neoplasms
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Neoplasms
RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma.
Neoplasms
The Emerging Roles of RNA m6A Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance.
Neoplasms
The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor.
Neoplasms
The N6 -methyladenosine (m6 A) erasers alkylation repair homologue 5 (ALKBH5) and fat mass and obesity-associated protein (FTO) are prognostic biomarkers in patients with clear cell renal carcinoma.
Neoplasms
The role of N6-methyladenosine RNA methylation in the heat stress response of sheep (Ovis aries).
Neoplasms
Warburg effect-promoted exosomal circ_0072083 releasing up-regulates NANGO expression through multiple pathways and enhances temozolomide resistance in glioma.
Neoplasms, Germ Cell and Embryonal
N6-Methyladenosine detected in RNA of testicular germ cell tumors is controlled by METTL3, ALKBH5, YTHDC1/F1/F2, and HNRNPC as writers, erasers, and readers.
Neuralgia
N6-Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons.
Neuroinflammatory Diseases
m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity.
Obesity
Association of FTO rs1421085 with obesity, diet, physical activity, and socioeconomic status: A longitudinal birth cohort study.
Obesity
Curcumin prevents obesity by targeting TRAF4-induced ubiquitylation in m6 A-dependent manner.
Obesity
Erasing m6A-dependent transcription signature of stress-sensitive genes triggers antidepressant actions.
Obesity
Fat mass and obesity-associated protein attenuates lipid accumulation in macrophage foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice.
Obesity
FTO mRNA Expression in Extremely Obese and Type 2 Diabetic Human Omental and Subcutaneous Adipose Tissues.
Obesity
FTO rs9939609 polymorphism is associated with metabolic disturbances and response to HCV therapy in HIV/HCV-coinfected patients.
Obesity
Human and Arabidopsis alpha-ketoglutarate-dependent dioxygenase homolog proteins-New players in important regulatory processes.
Obesity
Identification of Specific N6-methyladenosine RNA Demethylase FTO Inhibitors by Single Quantum Dot-Based FRET Nanosensor.
Obesity
Lose weight with traditional chinese medicine? Potential suppression of fat mass and obesity-associated protein.
Obesity
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
Obesity
Novel positioning from obesity to cancer: FTO, an m6A RNA demethylase, regulates tumour progression.
Obesity
Resveratrol Attenuates High-Fat Diet Induced Hepatic Lipid Homeostasis Disorder and Decreases m6A RNA Methylation.
Obesity
The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage.
Obesity
The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity.
Osteoporosis
Downregulated fat mass and obesity-associated protein inhibits bone resorption and osteoclastogenesis by nuclear factor-kappa B inactivation.
Osteoporosis
RNA N6-methyladenosine demethylase FTO promotes osteoporosis through demethylating Runx2 mRNA and inhibiting osteogenic differentiation.
Osteosarcoma
ALKBH5 suppresses tumor progression via an m6A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma.
Ovarian Neoplasms
ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2.
Ovarian Neoplasms
RNA demethylase ALKBH5 promotes ovarian carcinogenesis in a simulated tumour microenvironment through stimulating NF-?B pathway.
Pancreatic Neoplasms
ALKBH5 gene is a novel biomarker that predicts the prognosis of pancreatic cancer: A retrospective multicohort study.
Pancreatic Neoplasms
ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation.
Pancreatic Neoplasms
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling.
Pancreatic Neoplasms
m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling.
Pancreatic Neoplasms
RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner.
Pancreatic Neoplasms
Screening and Identifying m6A Regulators as an Independent Prognostic Biomarker in Pancreatic Cancer Based on The Cancer Genome Atlas Database.
Pancreatic Neoplasms
The role of the fat mass and obesity-associated protein in the proliferation of pancreatic cancer cells.
Peripheral Arterial Disease
Loss of m6A demethylase ALKBH5 promotes post-ischemic angiogenesis via post-transcriptional stabilization of WNT5A.
Pre-Eclampsia
[ALKBH5 suppresses migration and invasion of human trophoblast cells by inhibiting epithelial-mesenchymal transition].
Prostatic Neoplasms
Comprehensive analysis of m6A regulators prognostic value in prostate cancer.
Pulmonary Disease, Chronic Obstructive
Potential Impact of ALKBH5 and YTHDF1 on Tumor Immunity in Colon Adenocarcinoma.
Pulmonary Disease, Chronic Obstructive
The YTH Domain Family of N6-Methyladenosine "Readers" in the Diagnosis and Prognosis of Colonic Adenocarcinoma.
Reperfusion Injury
N6-methyladenosine demethylase FTO impairs hepatic ischemia-reperfusion injury via inhibiting Drp1-mediated mitochondrial fragmentation.
Squamous Cell Carcinoma of Head and Neck
Analysis of Genetic Alteration Signatures and Prognostic Values of m6A Regulatory Genes in Head and Neck Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
Genomic and transcriptomic alterations in m6A regulatory genes are associated with tumorigenesis and poor prognosis in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
Stomach Neoplasms
ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1.
Thyroid Diseases
Inclusion of ALKBH5 as a candidate gene for the susceptibility of autoimmune thyroid disease.
Thyroid Neoplasms
Comprehensive Analysis of Expression Regulation for RNA m6A Regulators With Clinical Significance in Human Cancers.
Thyroiditis
Inclusion of ALKBH5 as a candidate gene for the susceptibility of autoimmune thyroid disease.
Urinary Bladder Neoplasms
ALKBH5 Inhibited Cell Proliferation and Sensitized Bladder Cancer Cells to Cisplatin by m6A-CK2?-Mediated Glycolysis.
Urinary Bladder Neoplasms
Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression.
Urinary Bladder Neoplasms
N6-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer.
Virus Diseases
Human and Arabidopsis alpha-ketoglutarate-dependent dioxygenase homolog proteins-New players in important regulatory processes.
Virus Diseases
N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication.
Virus Diseases
The RNA helicase DDX46 inhibits innate immunity by entrapping m(6)A-demethylated antiviral transcripts in the nucleus.
Wilms Tumor
ALKBH5 gene polymorphisms and Wilms tumor risk in Chinese children: A five-center case-control study.
Wilms Tumor
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
Wilms Tumor
N6-methyladenosine mediates the cellular proliferation and apoptosis via microRNAs in arsenite-transformed cells.
Wilms Tumor
N6-methyladenosine RNA methylation regulators contribute to the progression of prostate cancer.
Zika Virus Infection
Dynamics of Human and Viral RNA Methylation during Zika Virus Infection.
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