We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments Also oxidizes, more slowly, the cis isomer and 2-hydroxycyclohexanone.
The expected taxonomic range for this enzyme is: Acinetobacter sp.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH + H+
Also oxidizes, more slowly, the cis-isomer and 2-hydroxy-cyclohexanone
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase
Also oxidizes, more slowly, the cis isomer and 2-hydroxycyclohexanone.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
trans-cyclohexane-1,2-diol + NAD+
2-hydroxycyclohexan-1-one + NADH
-
metabolic pathway of trans-cyclohexan-1,2-diol to adipate
-
r
trans-cyclohexane-1,2-diol + NAD+
2-hydroxycyclohexan-1-one + NADH + H+
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
trans-cyclohexane-1,2-diol + NAD+
2-hydroxycyclohexan-1-one + NADH
-
metabolic pathway of trans-cyclohexan-1,2-diol to adipate
-
r
trans-cyclohexane-1,2-diol + NAD+
2-hydroxycyclohexan-1-one + NADH + H+
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NAD+
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.85
-
cell extracts, grown on trans-cyclohexan-1,2-diol
26.5
-
partially purified
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
7
-
reduction of 2-hydroxycyclohexan-1-one
9.5 - 10
-
oxidation of trans-cyclohexane-1,2-diol
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
induction of enzyme formation by trans-cyclohexan-1,2-diol containing medium
brenda
-
induction of enzyme formation by trans-cyclohexan-1,2-diol containing medium
brenda
-
induction of enzyme formation by trans-cyclohexan-1,2-diol containing medium
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
L181F
-
random mutagenesis, A site mutant
L181F/I263N
-
random mutagenesis, A site mutant
V78I/A82F/A328F/T438I
-
random mutagenesis, B site mutant
V78I/A82I/A328N
-
random mutagenesis, B site mutant
additional information
-
whole-cell-catalyzed multiple regio- and stereoselective functionalizations in cascade reactions enabled by directed evolution: in Escherichia coli, expression of the recombinant enzyme leads to four different mutant whole cells, each leading to one of the three possible stereoisomeric forms of 1,2-cyclohexanediol, namely (R,R)-5, (S,S)-5, (S,R)-5 (meso), or (R,S)-5 (also meso), in a multi-step sequence, overview. Starting from the achiral substrates cyclohexane, cyclohexanol, or cyclohexanone, cyclohexane-1,2-diols as functionalized products are shown to be accessible in three different stereoisomeric forms
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
functional recombinant expression in Escherichia coli
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Davey, J.F.; Trudgill, P.W.
The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species
Eur. J. Biochem.
74
115-127
1977
Acinetobacter sp., Acinetobacter sp. TD63
brenda
Li, A.; Ilie, A.; Sun, Z.; Lonsdale, R.; Xu, J.; Reetz, M.
Whole-cell-catalyzed multiple regio- and stereoselective functionalizations in cascade reactions enabled by directed evolution
Angew. Chem. Int. Ed. Engl.
55
12026-12029
2016
Bacillus megaterium
brenda
Select items on the left to see more content.
html completed
HOME
login
history
all enzymes
BRENDA home
History
Enzyme Nomenclature
1.1.1.174 cyclohexane-1,2-diol dehydrogenase
top
Information
