EC Number   |
Protein Variants |
Reference |
|---|
   3.5.3.15 | A112G |
K0.5 for Ca2+ higher than wild-type, kcat/Km ([histone H4]-L-Arg) lower than wild-type, kcat/Km (Nalpha-benzoyl L-arginine ethyl ester) lower than wild-type |
718900 |
| 3.5.3.15 | A82V |
K0.5 for Ca2+ lower than wild-type, kcat/Km ([histone H4]-L-Arg) lower than wild-type, kcat/Km (Nalpha-benzoyl L-arginine ethyl ester) lower than wild-type |
718900 |
| 3.5.3.15 | A82V/A112G |
naturally occuring single-nucleotide polymorphisms and site-directed mutagenesis, the SNP-PADI4 mutant haplotype shows a higher risk of rheumatoid arthritis due to correlation with the RA gene, because the mutant shows increased activity, compared to the wild-type PADI4, which promotes the autoimmune disease and apoptosis, overview |
684511 |
| 3.5.3.15 | C351A |
inactive |
-, 752497 |
| 3.5.3.15 | C351S |
the mutant is catalytically inactive, exhibiting less than 0.01% wild type activity |
711019 |
| 3.5.3.15 | C434A |
small decrase in kcat/Km value |
755469 |
| 3.5.3.15 | C645A |
inactive mutant |
666755 |
| 3.5.3.15 | C645A |
no enzymic activity, catalytic residue |
653328 |
| 3.5.3.15 | C645A |
site-directed mutagemesis, inactive mutant, substrate-bound structure analysis |
666755 |
| 3.5.3.15 | C647A |
loss of activity |
752353 |
