EC Number   |
Expression |
Reference |
|---|
    3.5.3.1 | down |
arginase AI activity and its mRNA level are significantly decreased in cirrhotic liver |
710703 |
| 3.5.3.1 | down |
arginase type I is down regulated during parasite infections |
753605 |
| 3.5.3.1 | down |
coinhibitory and costimulatory molecules PD-1 and CTLA-4 on the Gr-1+CD11b+ myeloid-derived suppression cells regulate the activity and expression of arginase I. The blockage and silencing of PD-1, CTLA-4 or both PD-1 and CTLA4 molecules can significantly reduce arginase I activity and expression induced with tumor-associated factor. CD80 deficiency also decreases the arginase I expression and activity |
711659 |
| 3.5.3.1 | more |
both ARG1 and ARG2 are expressed by hormone-sensitive and hormone-refractory prostate cancer cell lines, with the LNCaP cells having the highest arginase activity. In prostate tissue samples, ARG2 is more expressed in normal and non-malignant prostatic tissues compared to tumor tissues. Following androgen stimulation of LNCaP cells with 10 nM R1881, both ARG1 and ARG2 are overexpressed. The regulation of arginase expression following androgen stimulation is dependent on the androgen receptor. Interleukin-8 is also upregulated following androgen stimulation and it directly increases the expression of ARG1 and ARG2 in the absence of androgens |
713369 |
| 3.5.3.1 | up |
arginase AII activity and its mRNA level are significantly raised in cirrhotic liver |
710703 |
| 3.5.3.1 | up |
arginase type I is induced by proinflammatory stimuli |
753605 |
| 3.5.3.1 | up |
exposure to ONOO- generator SIN-1 or to H2O2 increases arginase I expression and arginase activity by 35% and 50%, respectively, which is prevented by ROCK inhibitor, Y-27632, PKC inhibitor, Gö6976 or siRNA to p115-Rho GEF. The oxidative species ONOO- and H2O2 increase arginase activity/expression through PKC-mediated activation of RhoA/Rho kinase pathway |
719198 |
| 3.5.3.1 | up |
increase in activity to both biotic and abiotic stress |
753847 |
| 3.5.3.1 | up |
stimulated by cytokines, inflammatory stimuli, cAMP |
701646 |
