Information on EC 3.5.3.1 - arginase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
3.5.3.1
-
RECOMMENDED NAME
GeneOntology No.
arginase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-arginine + H2O = L-ornithine + urea
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C-N bond cleavage
-
-
hydrolysis of linear amidines
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Arginine and proline metabolism
-
-
Arginine biosynthesis
-
-
arginine metabolism
-
-
Biosynthesis of antibiotics
-
-
Biosynthesis of secondary metabolites
-
-
canavanine degradation
-
-
L-arginine degradation I (arginase pathway)
-
-
L-arginine degradation VI (arginase 2 pathway)
-
-
L-arginine degradation VII (arginase 3 pathway)
-
-
L-citrulline biosynthesis
-
-
L-Ndelta-acetylornithine biosynthesis
-
-
Metabolic pathways
-
-
putrescine biosynthesis IV
-
-
urea cycle
SYSTEMATIC NAME
IUBMB Comments
L-arginine amidinohydrolase
Also hydrolyses alpha-N-substituted L-arginines and canavanine.
CAS REGISTRY NUMBER
COMMENTARY hide
9000-96-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
7702
-
-
Manually annotated by BRENDA team
7702
-
-
Manually annotated by BRENDA team
Bacillus brevis Nagano
-
-
-
Manually annotated by BRENDA team
Bacillus brevis TT02-8
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
Capra capra
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
fruit bat
-
-
Manually annotated by BRENDA team
isoforms arginase-I and arginase-II
-
-
Manually annotated by BRENDA team
Glycine hispida
var. Cheepewa
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain 43504, gene rocF
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Leishmania mexicana MNYC/BZ/62/M379
-
UniProt
Manually annotated by BRENDA team
gray
-
-
Manually annotated by BRENDA team
Mus musculus B6/129
hybrid B6/129
-
-
Manually annotated by BRENDA team
multiple forms
-
-
Manually annotated by BRENDA team
no activity in Sus scrofa
in enterocytes of suckling piglets or in rapidly growing porcine placentae
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Pista pacifica
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
E1F1
-
-
Manually annotated by BRENDA team
E1F1
-
-
Manually annotated by BRENDA team
Vigna catjang
-
-
-
Manually annotated by BRENDA team
enzyme additionally shows lectin function, binding to the cell wall of both homologous and heterologous algae
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
-
the disulfide bond is important for the overall stability and folding of the protein. Mutant proteins lacking the disulfide bond start to unfold at lower temperature than the wild-type. In the mutant proteins, the Tm of the holoenzyme is 4C higher than that of the apoenzyme indicating that in the absence of the disulfide bond the metal ions have relatively larger role in the stability of the mutant proteins compared to the wild-type
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-nitro-3-guanidinobenzene + H2O
3-nitrobenzenamine + urea
show the reaction diagram
-
synthetic chromophoric substrate, low activity
-
-
?
4-guanidino-2-nitrophenylacetic acid + H2O
4-amino-2-nitrophenylacetate + urea
show the reaction diagram
-
-
-
-
?
4-guanidino-3-nitrobenzoic acid + H2O
4-amino-3-nitrobenzoate + urea
show the reaction diagram
-
-
-
-
?
agmatine + H2O
1,4-diaminobutane + urea
show the reaction diagram
argininic acid + H2O
urea + 5-amino-2-hydroxypentanoate
show the reaction diagram
-
-
-
-
?
canavanine + H2O
urea + NH2OCH2CH2CH(NH2)COOH
show the reaction diagram
D-arginine + H2O
D-ornithine + urea
show the reaction diagram
isoform LeARG1, 2.2% of the activity with L-arginine, LeARG2, 3.6% of the activity with L-arginine
-
-
?
L-arginine + H2O
?
show the reaction diagram
-
-
-
-
-
L-arginine + H2O
L-ornithine
show the reaction diagram
-
-
-
-
?
L-arginine + H2O
L-ornithine + urea
show the reaction diagram
L-homoarginine + H2O
L-2,6-diaminohexanoate + urea
show the reaction diagram
isoform LeARG1, 14% of the activity with L-arginine, LeARG2, 13% of the activity with L-arginine
-
-
?
L-phenylalanine + H2O
2-oxo-3-phenylpropanoate + NH3
show the reaction diagram
L-thioarginine + H2O
(2S)-2-amino-5-mercaptopentanoate + urea
show the reaction diagram
-
-
-
-
?
p-nitrophenyl glyoxal + arginine
?
show the reaction diagram
-
-
-
-
?
S-(4-aminobutyl)isothiourea + H2O
?
show the reaction diagram
-
-
-
-
?
thioguanidino-valeric acid + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-arginine + H2O
?
show the reaction diagram
-
-
-
-
-
L-arginine + H2O
L-ornithine + urea
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Fe
-
cysteine-iron promotes arginase activity
Guanidinium chloride
-
the single mutant R308A changes to a trimeric and kinetically cooperative form, whereas the other enzyme variants are not altered
Magnesium
-
stabilizes the protein. In the absence of Mg2+, a complete loss of secondary structure is observed for certain elements
Manganese
-
the more deeply buried Mn2+ ion A is coordinated by residues His193, Asp216, Asp220 and Asp323. The second metal, Mn2+B is co-ordinated by His218, Asp216, Asp323, Asp325
Zn2+
Vigna catjang
-
38% of the activity with Mn2+
additional information
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(-)-epicatechin
(2S)-2-amino-3-(2-amino-1H-imidazol-5-yl)propanoic acid
(2S)-2-amino-5-(1H-imidazol-2-ylamino)pentanoic acid
-
2-aminoimidazole amino acid inhibitor in which the 2-aminoimidazole moiety serves as a guanidine mimetic
(2S,5E)-2-amino-7-oxohept-5-enoic acid
-
-
(R)-2-amino-6-borono-2-[2-(piperidin-1-yl)ethyl]hexanoic acid
-
-
(R)-2-amino-6-borono2[1-(3,4-dichlorobenzyl)piperidin-4-yl]hexanoic acid
-
-
(S)-(2-boronoethyl)-L-cysteine
-
boronic acid-based transition state analogue, classical competitive inhibition at pH 7.5, slow-binding inhibition at pH 9.5
(S)-2-amino-7-oxoheptanoic acid
2(S)-amino-6-boronohexanoic acid
2-(1H-indol-3-yl)ethanol
2-(5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)hydrazinecarbothioamide
non-competitive inhibitor, 79% inhibition at 1 mM
2-(aminomethyl)-6-borononorleucine
-
-
2-(S)-amino-5-(2-aminoimidazol-1-yl)pentanoic acid
-
2-aminoimidazole amino acid inhibitor in which the 2-aminoimidazole moiety serves as a guanidine mimetic
2-(S)-amino-6-boronohexanoic acid
-
-
2-amino-6-borono-2-(difluoromethyl)-hexanoic acid
-
-
-
2-amino-6-borono-2-butylhexanoic acid
-
-
2-amino-6-borono-2-methyl-hexanoic acid
-
-
-
2-amino-6-boronohexanoic acid
2-mercaptoethanol
2-mercaptopropionate
5 mM, isoform LeARG1, 38% residual activity, LeARG2, 38% residual activity; 5 mM, isoform LeARG1, 38% residual activity, LeARG2, 38% residual activity
2-oxoarginine
-
-
2-[(benzylamino)methyl]-6-borononorleucine
-
-
3-Mercaptopropionate
5 mM, isoform LeARG1, 24% residual activity, LeARG2, 26% residual activity; 5 mM, isoform LeARG1, 24% residual activity, LeARG2, 26% residual activity
5-hydroxy-L-tryptophan
5-hydroxytryptamine
5-methyl-2-(trifluoromethyl)-N-[3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
57% inhibition at 1 mM
5-methyl-7-(1H-1,2,4-triazol-1-yl)-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidine
47% inhibition at 1 mM
5-methyl-7-(1H-pyrrol-1-yl)-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidine
38% inhibition at 1 mM
5-methyl-7-(4-trifluorophenylamine)-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidine
52% inhibition at 1 mM
-
5-methyl-7-(pyrrolidin-1-yl)-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidine
10% inhibition at 1 mM
5-methyl-N-(naphthalen-2-yl)-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
29% inhibition at 1 mM
5-methyl-N-phenyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
1% inhibition at 1 mM
6-borono-2-(2-hydroxyethyl)norleucine
-
-
6-borono-2-(3-methoxypropyl)norleucine
-
-
6-borono-2-(hydroxymethyl)norleucine
-
-
6-borono-2-ethylnorleucine
-
-
6-borono-2-methylnorleucine
-
-
6-borono-2-propan-2-ylnorleucine
-
-
6-borono-2-[2-(4-hydroxypiperidin-1-yl)ethyl]norleucine
-
-
6-borono-2-[2-(diethylamino)ethyl]norleucine
-
-
6-borono-2-[2-(morpholin-4-yl)ethyl]norleucine
-
-
6-borono-2-[2-(pyrrolidin-1-yl)ethyl]norleucine
-
-
7-(4-chlorophenylamine)-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidine
42% inhibition at 1 mM
-
acetyl hydroxamate
-
-
-
adenosine
-
-
agmatine
Al3+
-
no inhibition of isozyme I, 33% inhibition of isozyme II
alpha-(4-boronobutyl)histidine
-
-
alpha-(4-boronobutyl)phenylalanine
-
-
Ba2+
-
80% residual activity at 1.5 mM
blasticidin S
Bacillus brevis TT02-8
-
-
Borate
Boric acid
-
-
Chloroquine
-
inhibits arginase in a dose-dependent manner, and displays a linear competitive inhibition on sickle erythrocyte arginase
citrate
-
buffer
citrulline
-
-
Creatine
cycloheximide
-
inhibits protein synthesis
D-arginine
-
-
D-tryptophan
diethyl dicarbonate
diethylene triamine-nitric oxide
-
50% inhibition at 2 mM
dithiothreitol
DL-homocysteine
-
-
DTT
-
50% inhibition at 0.025 mM
edeine B1
Bacillus brevis TT02-8
-
-
flavanol-rich cocoa
fluoride
-
substrate inhibition of liver enzyme at concentration above 4 mM, the kidney enzyme is more sensitive and is inhibited uncompetitively, at narrow L-arginie concentration, at 1 mM, preincubation with F- does not affect the enzymes
gamma-guanidinobutyrate
glutathione
Bacillus brevis TT02-8
-
-
Guanidinium chloride
-
-
Guanidinoacetic acid
-
-
HgCl2
Bacillus brevis TT02-8
-
-
hydrogen peroxide
-
50% inhibition at 0.003 mM
hydroxylamine
-
-
imidazole-3-lactate
indole
indole-3-L-lactic acid
indole-propionic acid
-
-
Indolepropionic acid
-
-
Indospicine
-
-
Inosine
-
-
Insulin
-
reduces arginase activity
-
iodoacetamide
-
-
L-2-amino-3-guanidinopropionic acid
-
-
L-argininamide
-
-
L-Argininic acid
L-canavanine
L-cysteine
L-glutamate
-
-
L-histidine
strongly blocked SmARG-activity
L-homoarginine
L-isoleucine
L-leucine
L-lysine
L-methionine
-
-
L-N5-(1-iminoethyl)-ornithine
-
-
L-N6-(1-iminoethyl)-lysine
-
-
L-norvaline
-
blocks arginase activity in Actinobacillus actinomycetemcomitans-lipopolysaccharide-stimulated cells
L-ornithine
L-proline
L-thiocitrulline
-
-
L-tryptophan
L-valine
lysine
-
-
Mercaptoacetate
5 mM, isoform LeARG1, 28% residual activity, LeARG2, 26% residual activity; 5 mM, isoform LeARG1, 28% residual activity, LeARG2, 26% residual activity
Mg2+
-
64% residual activity at 1.5 mM
N-(2,6-difluorophenyl)-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
8% inhibition at 1 mM
N-(3,4-dichlorophenyl)-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
3% inhibition at 1 mM
N-(3,5-dichlorophenyl)-2,5-bis(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
47% inhibition at 1 mM
N-(3,5-dichlorophenyl)-2,5-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
23% inhibition at 1 mM
N-(3,5-dichlorophenyl)-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
71% inhibition at 1 mM
N-(3,5-dimethoxyphenyl)-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
39% inhibition at 1 mM
N-(3-chlorophenyl)-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
51% inhibition at 1 mM
N-(4-methoxyphenyl)-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
5% inhibition at 1 mM
N-acetyl-5-hydroxytryptamine
N-bromosuccinimide
Bacillus brevis TT02-8
-
-
N-hydroxy-nor-L-arginine
-
-
N-hydroxyl-L-arginine
-
-
Na2AsO4
-
-
-
Nomega-amino-L-arginine
-
-
Nomega-hydroxy-L-arginine
Nomega-hydroxy-nor-arginine
-
Nomega-hydroxy-nor-L-arginine
Nomega-Nitro-L-arginine
-
-
Nomega-nitro-L-arginine methyl ester
-
i.e. L-NAME, inhibition of enzyme from liver and colon cancer cells in vitro and in vivo
nor-N-hydroxy-L-arginine
-
-
nor-NOHA
-
competitive inhibitor of both isoforms of arginase
nor-Nomega-hydroxy-L-arginine
-
p-hydroxymercuribenzoate
Pb2+
-
74% inhibition of isozyme I, 92% inhibition of isozyme II
PEG-SOD
-
polyethylene glycol, covalently linked to superoxide dismutase. Significantly inhibits the arginase activity induced by cysteine-iron, indicating that oxygen species may be responsible in part for the observed increase in arginase activity
-
Polymyxin B
-
blocks arginase activity in Actinobacillus actinomycetemcomitans-lipopolysaccharide-stimulated cells
propargylglycine
-
-
S-(2-aminoethyl)isothiourea
-
-
S-(2-boronoethyl)-L-cysteine
S-(2-boronomethyl)-L-cysteine
-
i.e. BMC, 50% inhibition at 3.8 mM, pH 7.4, or at 7.5 mM, pH 9.0
S-(2-boronomethyl)-L-homocysteine
-
i.e. BMHC, 50% inhibition at 0.35 mM, pH 7.4, or above 1 mM, pH 9.0
S-(3-aminopropyl)isothiourea
-
-
S-(boronoethyl)-L-cysteine
-
-
S-methyl-L-thiocitrulline
-
-
S-nitrosoglutathione
-
50% inhibition at 0.050 mM
Sodium fluoride
-
noncompetitive
sodium nitroprusside
-
50% inhibition at 0.005 mM
tryptamine
tyramine
Woodward's reagent K
-
complete inactivation, reactivation by 0.5 M hydroxylamine. Reactivated enzyme can be inactivated again
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cysteine
-
effect of cysteine on arginase activity, effect of increasing concentrations of cysteine alone or in combination with iron (II) sulfate on the enhancement of arginase activity in human sickle erythrocytes or purified arginase-1 from Bos taurus liver
dexamethasone
-
augments arginase activity in Actinobacillus actinomycetemcomitans-lipopolysaccharide-stimulated cells
FeSO4
-
effect of cysteine on arginase activity, effect of increasing concentrations of cysteine alone or in combination with iron (II) sulfate on the enhancement of arginase activity in human sickle erythrocytes or purified arginase-1 from Bos taurus liver
hydralazine
-
treatment with 20 mg/kg/day hydralazine for 5 weeks causes increased arginase activity in hypertensive rats
IL-4
-
interleukin IL-4, up to 16-fold stimulation of enzyme activity in RAW-264.7 cell, in combinantion with rolipram additional activation. No stimulation of enzyme in alveolar macrophages by IL-4 alone, but increase of stimulation by forskolin and 3-isobutyl-1-methylxanthine, IBMX, in presence of IL-4
-
interleukin-4
-
augments arginase activity in Actinobacillus actinomycetemcomitans-lipopolysaccharide-stimulated cells
-
L-arginine
-
strong substrate activation of the kidney enzyme at concentrations above 4 mM
lipopolysaccharide
low-density lipoprotein
-
ArgI expression is potently induced by both oxidized and acetylated low-density lipoprotein in macrophages, this effect is mediated by peroxisome proliferator-activated receptors
-
putrescine
-
activating
TGF-beta
-
transforming growth factor, up to 5-fold stimulation, further stimulation in combination with rolipram
-
thrombin
thrombin receptor antagonist peptide
-
endothelial cell exposition to 10 U/ml thrombin receptor antagonist peptide for 4 h leads to increased arginase activity
-
Trx1
-
thioredoxin Trx1, stimulation by acting as a chaperone
-
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.6
1-nitro-3-guanidinobenzene
-
pH 9.0
0.01
4-guanidino-2-nitrophenylacetic acid
-
pH 9.0
0.007
4-guanidino-3-nitrobenzoic acid
-
pH 9.0
2.5
agmatine
-
37C, pH 9.0, mutant N149D
0.69 - 130
L-Arg
0.02 - 146
L-arginine
22.2
L-canavanine
Bacillus brevis TT02-8
-
-
22.1 - 57.5
L-phenylalanine
0.5
L-thioarginine
-
pH 9.0
4
S-(4-aminobutyl)isothiourea
-
pH 9.0
2.1
thioguanidino-valeric acid
-
pH 9.0
additional information
additional information
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0015
1-nitro-3-guanidinobenzene
Rattus norvegicus
-
pH 9.0
0.09
4-guanidino-2-nitrophenylacetic acid
Rattus norvegicus
-
pH 9.0
0.058
4-guanidino-3-nitrobenzoic acid
Rattus norvegicus
-
pH 9.0
2200
L-Arg
Mammalia
-
-
0.013 - 1132
L-arginine
0.25 - 0.94
L-phenylalanine
300
L-thioarginine
Rattus norvegicus
-
pH 9.0
3.33
S-(4-aminobutyl)isothiourea
Rattus norvegicus
-
pH 9.0
0.013
thioguanidino-valeric acid
Rattus norvegicus
-
pH 9.0
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.03 - 2600
L-arginine
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.3
(2S)-2-amino-3-(2-amino-1H-imidazol-5-yl)propanoic acid
-
pH not specified in the publication, temperature not specified in the publication
0.5
(2S)-2-amino-5-(1H-imidazol-2-ylamino)pentanoic acid
-
pH not specified in the publication, temperature not specified in the publication
0.36
(2S,5E)-2-amino-7-oxohept-5-enoic acid
-
pH 9.5
0.00003 - 0.00031
(S)-(2-boronoethyl)-L-cysteine
0.06
(S)-2-amino-7-oxoheptanoic acid
0.0000085 - 0.053
2(S)-amino-6-boronohexanoic acid
0.017
2-(5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)hydrazinecarbothioamide
at pH 9.5 and 37C
0.004
2-(S)-amino-5-(2-aminoimidazol-1-yl)pentanoic acid
-
pH not specified in the publication, temperature not specified in the publication
0.00015
2-(S)-amino-6-boronohexanoic acid
-
pH 9.5, 25C, supramolecular tandem assay method
0.3
Borate
-
-
0.023 - 0.041
Chloroquine
39 - 56
Guanidinium chloride
0.0442 - 0.0808
hydroxylamine
0.0362 - 0.0658
iodoacetamide
3.1 - 5.6
L-lysine
0.05 - 7.8
L-ornithine
5.5
L-proline
-
-
0.0016 - 0.061
Nomega-hydroxy-L-arginine
0.000051
Nomega-hydroxy-nor-L-arginine
-
pH 7.5, 22C
0.0305 - 0.0857
propargylglycine
0.000125 - 0.013
S-(2-boronoethyl)-L-cysteine
0.38 - 1.84
Sodium fluoride
additional information
additional information
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.8 - 5.3
2-(1H-indol-3-yl)ethanol
0.0165
2-(5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)hydrazinecarbothioamide
Leishmania amazonensis
O96394
at pH 9.5 and 37C
0.00135 - 0.00207
2-(aminomethyl)-6-borononorleucine
0.00022
2-(S)-amino-6-boronohexanoic acid
Bos taurus
-
pH 9.5, 25C, supramolecular tandem assay method
0.0045
2-amino-6-borono-2-butylhexanoic acid
Homo sapiens
-
arginase II, at pH 7.4 and 37C
0.00145 - 0.00192
2-amino-6-boronohexanoic acid
0.03
2-mercaptoethanol
Helicobacter pylori