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Literature summary for 3.5.3.1 extracted from

  • Gannon, P.O.; Godin-Ethier, J.; Hassler, M.; Delvoye, N.; Aversa, M.; Poisson, A.O.; Peant, B.; Alam Fahmy, M.; Saad, F.; Lapointe, R.; Mes-Masson, A.M.
    Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer (2010), PLoS ONE, 5, e12107.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine both ARG1 and ARG2 are expressed by hormone-sensitive and hormone-refractory prostate cancer cell lines, with the LNCaP cells having the highest arginase activity. In prostate tissue samples, ARG2 is more expressed in normal and non-malignant prostatic tissues compared to tumor tissues. Following androgen stimulation of LNCaP cells with 10 nM R1881, both ARG1 and ARG2 are overexpressed. The regulation of arginase expression following androgen stimulation is dependent on the androgen receptor. This observation is correlated in vivo in patients by immunohistochemistry. Patients treated by androgen-deprivation therapy prior to surgery have lower ARG2 expression in both nonmalignant and malignant tissues. ARG1 and ARG2 are enzymatically active and their decreased expression by siRNA results in reduced overall arginase activity and L-arginine metabolism. The decreased ARG1 and ARG2 expression also translates with diminished LNCaP cells cell growth and increased peripheral blood mononuclear cell activation following exposure to LNCaP cells conditioned media. Interleukin-8 is also upregulated following androgen stimulation and it directly increases the expression of ARG1 and ARG2 in the absence of androgens Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
LNCaP cell
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Homo sapiens
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prostate cancer cell
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Homo sapiens
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Expression

Organism Comment Expression
Homo sapiens both ARG1 and ARG2 are expressed by hormone-sensitive and hormone-refractory prostate cancer cell lines, with the LNCaP cells having the highest arginase activity. In prostate tissue samples, ARG2 is more expressed in normal and non-malignant prostatic tissues compared to tumor tissues. Following androgen stimulation of LNCaP cells with 10 nM R1881, both ARG1 and ARG2 are overexpressed. The regulation of arginase expression following androgen stimulation is dependent on the androgen receptor. Interleukin-8 is also upregulated following androgen stimulation and it directly increases the expression of ARG1 and ARG2 in the absence of androgens additional information

General Information

General Information Comment Organism
physiological function ARG1 and ARG2 are enzymatically active in hormone-sensitive and hormone-refractory prostate cancer cell lines and their decreased expression by siRNA results in reduced overall arginase activity and L-arginine metabolism. The decreased ARG1 and ARG2 expression also translates with diminished LNCaP cells cell growth and increased peripheral blood mononuclear cell activation following exposure to LNCaP cells conditioned media. Interleukin-8 is also upregulated following androgen stimulation and it directly increases the expression of ARG1 and ARG2 in the absence of androgens Homo sapiens