Reference on EC 3.5.4.16 - GTP cyclohydrolase I and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schoedon, G.; Curtis, H.C.; Niederwieser, A.
Localization of GTP cyclohydrolase I in human peripheral blood smears using a specific monoclonal antibody and an immune-alkaline phosphatase labeling technique
Biochem. Biophys. Res. Commun.
148
1232-1236
1987
Homo sapiens
Sawada, M.; Horikoshi, T.; Masada, M.; Akino, M.; Sugimoto, T.M.; Matsuura, S.; Nagatsu, T.
A sensitive assay of GTP cyclohydrolase I activity in rat and human tissues using radioimmunoassay of neopterin
Anal. Biochem.
154
361-366
1986
Homo sapiens, Rattus norvegicus
Blau, N.; Niederwieser, A.
The application of 8-aminoguanosine triphosphate, a new inhibitor of GTP cyclohydrolase I, to the purification of the enzyme from human liver
Biochim. Biophys. Acta
880
26-31
1986
Homo sapiens
Hatakeyama, K.; Harada, T.; Kagamiyama, H.
IMP dehydrogenase inhibitors reduce intracellular tetrahydrobiopterin levels through reduction of intracellular GTP levels
J. Biol. Chem.
267
20734-20739
1992
Homo sapiens, Rattus norvegicus
Sakamoto, H.; Fujita, K.; Idegame, M.; Teradaira, R.; Kuzuya, H.
Different complex forms of human liver GTP cyclohydrolase I
Biogenic Amines
12
55-67
1996
Homo sapiens
-
Suzuki, T.; Ohye, T.; Inagaki, H.; Nagatsu, T.; Ichinose, H.
Characterization of wild-type and mutants of recombinant human GTP-cyclohydrolase I: Relationship to etiology of dopa-responsive dystonia
J. Neurochem.
73
2510-2516
1999
Homo sapiens
Suzuki, T.; Kurita, H.; Ichinose, H.
GTP cyclohydrolase I utilizes metal-free GTP as its substrate
Eur. J. Biochem.
271
349-355
2004
Homo sapiens
Auerbach, G.; Herrmann, A.; Bracher, A.; Bader, G.; Gutlich, M.; Fischer, M.; Neukamm, M.; Garrido-Franco, M.; Richardson, J.; Nar, H.; Huber, R.; Bacher, A.
Zinc plays a key role in human and bacterial GTP cyclohydrolase I
Proc. Natl. Acad. Sci. USA
97
13567-13572
2000
Escherichia coli, Homo sapiens (P30793), Homo sapiens
Zhang, L.; Rao, F.; Zhang, K.; Khandrika, S.; Das, M.; Vaingankar, S.M.; Bao, X.; Rana, B.K.; Smith, D.W.; Wessel, J.; Salem, R.M.; Rodriguez-Flores, J.L.; Mahata, S.K.; Schork, N.J.; Ziegler, M.G.; OConnor, D.T.
Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk
J. Clin. Invest.
117
2658-2671
2007
Homo sapiens (P30793), Homo sapiens
Lopez-Laso, E.; Camino, R.; Mateos, M.E.; Perez-Navero, J.L.; Ochoa, J.J.; Lao-Villadoniga, J.I.; Ormazabal, A.; Artuch, R.
Dopa-responsive infantile hypokinetic rigid syndrome due to dominant guanosine triphosphate cyclohydrolase 1 deficiency
J. Neurol. Sci.
256
90-93
2007
Homo sapiens
Wang, W.; Zolty, E.; Falk, S.; Summer, S.; Zhou, Z.; Gengaro, P.; Faubel, S.; Alp, N.; Channon, K.; Schrier, R.
Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1
Am. J. Physiol. Renal Physiol.
294
F571-F576
2008
Homo sapiens
Chiou, Y.W.; Hwu, W.L.; Lee, Y.M.
Hsp27 decreases inclusion body formation from mutated GTP-cyclohydrolase I protein
Biochim. Biophys. Acta
1782
169-179
2008
Homo sapiens
Du, Y.H.; Guan, Y.Y.; Alp, N.J.; Channon, K.M.; Chen, A.F.
Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension
Circulation
117
1045-1054
2008
Homo sapiens
Souza, C.P.; Valadares, E.R.; Trindade, A.L.; Rocha, V.L.; Oliveira, L.R.; Godard, A.L.
Mutation in intron 5 of GTP cyclohydrolase 1 gene causes dopa-responsive dystonia (Segawa syndrome) in a Brazilian family
Genet. Mol. Res.
7
687-694
2008
Homo sapiens
Chavan, B.; Beazley, W.; Wood, J.M.; Rokos, H.; Ichinose, H.; Schallreuter, K.U.
H2O2 increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo
J. Inherit. Metab. Dis.
32
86-94
2009
Homo sapiens
Chiarini, A.; Armato, U.; Pacchiana, R.; Dal Pra, I.
Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions
Proteomics
9
1850-1860
2009
Homo sapiens
Hu, F.Y.; Xu, Y.M.; Yu, L.H.; Ma, M.Y.; He, X.H.; Zhou, D.
A novel missense mutation in GTP cyclohydrolase I (GCH1) gene causes dopa-responsive dystonia in Chinese Han population
Eur. J. Neurol.
18
362-364
2011
Homo sapiens
Ionova, I.A.; Vasquez-Vivar, J.; Cooley, B.C.; Khanna, A.K.; Whitsett, J.; Herrnreiter, A.; Migrino, R.Q.; Ge, Z.D.; Regner, K.R.; Channon, K.M.; Alp, N.J.; Pieper, G.M.
Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection
Am. J. Physiol. Heart Circ. Physiol.
299
H88-H96
2010
Homo sapiens, Mus musculus, Mus musculus C57BL6
Li, L.; Rezvan, A.; Salerno, J.; Husain, A.; Kwon, K.; Jo, H.; Harrison, D.; Chen, W.
GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide
Circ. Res.
106
328-336
2010
Homo sapiens
Wolkow, P.P.; Kosiniak-Kamysz, W.; Osmenda, G.; Wilk, G.; Bujak-Gizycka, B.; Ignacak, A.; Kanitkar, M.; Walus-Miarka, M.; Harrison, D.G.; Korbut, R.; Malecki, M.T.; Guzik, T.J.
GTP cyclohydrolase I gene polymorphisms are associated with endothelial dysfunction and oxidative stress in patients with type 2 diabetes mellitus
PLoS ONE
9
e108587
2014
Homo sapiens (P30793), Homo sapiens
