Information on EC 3.5.1.19 - nicotinamidase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY
3.5.1.19
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RECOMMENDED NAME
GeneOntology No.
nicotinamidase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
nicotinamide + H2O = nicotinate + NH3
show the reaction diagram
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nicotinamide + H2O = nicotinate + NH3
show the reaction diagram
the active site Cys159, conserved and essential, is located at the N-terminus of a6 at one side of the active site with the Zn2+ ion positioned on the other side. The metal ion is bound tightly in the AbPncA active site. The reaction proceeds in a four-stage mechanism via a tetrahedral and an acyl intermediate, overview
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REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of peptide bond
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PATHWAY
KEGG Link
MetaCyc Link
aldoxime degradation
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Metabolic pathways
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NAD salvage pathway I
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Nicotinate and nicotinamide metabolism
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pyridine nucleotide cycling (plants)
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SYSTEMATIC NAME
IUBMB Comments
nicotinamide amidohydrolase
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SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
nicotinamidase
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nicotinamidase
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nicotinamidase
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nicotinamidase PNC-1
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nicotinamidase Pnc1p
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nicotinamidase/pyrazinamidase
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nicotinamidase/pyrazinamidase
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nicotinamide amidase
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nicotinamide deaminase
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nicotinamide deaminase
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Nicotine deamidase
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Pnc1
Leishmania infantum MHOM/MA/67/ITMAP-263
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pyrazinamidase
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PZAase
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a single enzyme accounts for both pyrazinamidase activity and nicotinamidase activity
YNDase
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CAS REGISTRY NUMBER
COMMENTARY
9033-32-3
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
strain 544, ATCC 23448, gene pncA, a facultative intracellular pathogen
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Manually annotated by BRENDA team
strain 544, ATCC 23448, gene pncA, a facultative intracellular pathogen
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Manually annotated by BRENDA team
Escherichia coli K12
K12
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Manually annotated by BRENDA team
Flavobacterium peregrinum
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Manually annotated by BRENDA team
Leishmania infantum MHOM/MA/67/ITMAP-263
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Manually annotated by BRENDA team
i.e. Micrococcus lysodeiktikus
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Manually annotated by BRENDA team
strain GDI 211
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Manually annotated by BRENDA team
Pseudomonas sp. GDI 211
strain GDI 211
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Manually annotated by BRENDA team
strain CA401, strain FA18, strain FA64, strain FA86, strain FA131, strain 569B
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Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
Acinetobacter baumannii (strain AYE)
Acinetobacter baumannii (strain AYE)
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)