Reference on EC 3.1.4.39 - alkylglycerophosphoethanolamine phosphodiesterase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ward, W.H.J.; Fersht, A.R.
Asymmetry of tyrosyl-tRNA synthetase in solution
Biochemistry
27
1041-1049
1988
Homo sapiens
Fernandez-Gallardo, S.; Gijon, M.A.; Gracia, M.D.C.; Cano, E.; Sanchez Crespo, M.
Biosynthesis of platelet-activating factor in glandular gastric mucosa. Evidence for the involvement of the de novo pathway and modulation by fatty acids
Biochem. J.
254
707-714
1988
Rattus norvegicus
Kawasaki, T.; Snyder, F.
The metabolism of lyso-platelet-activating factor (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) by a calcium-dependent lysophospholipase D in rabbit kidney medulla
Biochim. Biophys. Acta
920
85-93
1987
Oryctolagus cuniculus
Tokumura, A.; Harada, K.; Fukazawa, K.; Tsukatani, H.
Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasma
Biochim. Biophys. Acta
875
31-38
1986
Rattus norvegicus
Wykle, R.L.; Kraemer, W.F.; Schremmer, J.M.
Specificity of lysophospholipase D
Biochim. Biophys. Acta
619
58-67
1980
Rattus norvegicus
Wykle, R.L.; Kraemer, W.F.; Schremmer, J.M.
Studies of lysophospholipase D of rat liver and other tissues
Arch. Biochem. Biophys.
184
149-155
1977
Rattus norvegicus
Wykle, R.L.; Schremmer, J.M.
A lysophospholipase D pathway in the metabolism of ether-linked lipids in brain microsomes
J. Biol. Chem.
249
1742-1746
1974
Rattus norvegicus
Tokumura, A.; Nishioka, Y.; Yoshimoto, O.; Shinomiya, J.; Fukazawa, K.
Substrate specificity of lysophospholipase D which produces bioactive lysophosphatidic acids in rat plasma
Biochim. Biophys. Acta
1437
235-245
1999
Rattus norvegicus
Furukawa, M.; Muguruma, k.; Frenkel, R.A.; Johnston, J.M.
Metabolic fate of platelet-activating factor in the rat enterocyte: the role of a specifiv lysophospholipase D
Arch. Biochem. Biophys.
319
274-280
1995
Rattus norvegicus
Wykle, L.; Strum, J.C.
Lysophospholipase D
Methods Enzymol.
197
583-590
1991
Rattus norvegicus
Xie, Y.; Meier, K.E.
Lysophospholipase D and its role in LPA production
Cell. Signal.
16
975-981
2004
Bos taurus, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Kishi, Y.; Okudaira, S.; Kishi, M.; Hama, K.; Shida, D.; Kitayama, J.; Yamori, T.; Aoki, J.; Fujimaki, T.; Arai, H.
Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcoholine to lysophosphatidic acid
J. Biol. Chem.
281
17492-17500
2006
Homo sapiens
Song, J.; Clair, T.; Noh, J.H.; Eun, J.W.; Ryu, S.Y.; Lee, S.N.; Ahn, Y.M.; Kim, S.Y.; Lee, S.H.; Park, W.S.; Yoo, N.J.; Lee, J.Y.; Nam, S.W.
Autotaxin (lysoPLD/NPP2) protects fibroblasts from apoptosis through its enzymatic product, lysophosphatidic acid, utilizing albumin-bound substrate
Biochem. Biophys. Res. Commun.
337
967-975
2005
Homo sapiens
Tanaka, M.; Kishi, Y.; Takanezawa, Y.; Kakehi, Y.; Aoki, J.; Arai, H.
Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma
FEBS Lett.
571
197-204
2004
Homo sapiens
Koike, S.; Keino-Masu, K.; Ohto, T.; Masu, M.
The N-terminal hydrophobic sequence of autotaxin (ENPP2) functions as a signal peptide
Genes Cells
11
133-142
2006
Rattus norvegicus
Kehlen, A.; Englert, N.; Seifert, A.; Klonisch, T.; Dralle, H.; Langner, J.; Hoang-Vu, C.
Expression, regulation and function of autotaxin in thyroid carcinomas
Int. J. Cancer
109
833-838
2004
Homo sapiens
Hama, K.; Aoki, J.; Fukaya, M.; Kishi, Y.; Sakai, T.; Suzuki, R.; Ohta, H.; Yamori, T.; Watanabe, M.; Chun, J.; Arai, H.
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1
J. Biol. Chem.
279
17634-17639
2004
Mus musculus
van Meeteren, L.A.; Ruurs, P.; Christodoulou, E.; Goding, J.W.; Takakusa, H.; Kikuchi, K.; Perrakis, A.; Nagano, T.; Moolenaar, W.H.
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate
J. Biol. Chem.
280
21155-21161
2005
Streptomyces chromofuscus
Jansen, S.; Stefan, C.; Creemers, J.W.; Waelkens, E.; Van Eynde, A.; Stalmans, W.; Bollen, M.
Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D
J. Cell Sci.
118
3081-3089
2005
Rattus norvegicus
Clair, T.; Koh, E.; Ptaszynska, M.; Bandle, R.W.; Liotta, L.A.; Schiffmann, E.; Stracke, M.L.
L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin
Lipids Health Dis.
4
DOI:10.1186/1476-511X-4-5
2005
Homo sapiens
-
Ferguson, C.G.; Bigman, C.S.; Richardson, R.D.; van Meeteren, L.A.; Moolenaar, W.H.; Prestwich, G.D.
Fluorogenic phospholipid substrate to detect lysophospholipase D/autotaxin activity
Org. Lett.
8
2023-2026
2006
Homo sapiens
Clair, T.; Koh, E.; Ptaszynska, M.; Bandle, R.W.; Liotta, L.A.; Schiffmann, E.; Stracke, M.L.
L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin
Lipids Health Dis.
4
5-5
2005
Homo sapiens
Sugimoto, S.; Sugimoto, H.; Aoyama, C.; Aso, C.; Mori, M.; Izumi, T.
Purification and characterization of lysophospholipase D from rat brain
Biochim. Biophys. Acta
1761
1410-1418
2006
Rattus norvegicus
Morishige, J.; Touchika, K.; Tanaka, T.; Satouchi, K.; Fukuzawa, K.; Tokumura, A.
Production of bioactive lysophosphatidic acid by lysophospholipase D in hen egg white
Biochim. Biophys. Acta
1771
491-499
2007
Gallus gallus
Pradere, J.P.; Tarnus, E.; Gres, S.; Valet, P.; Saulnier-Blache, J.S.
Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase
Biochim. Biophys. Acta
1771
93-102
2007
Mus musculus
Savaskan, N.E.; Rocha, L.; Kotter, M.R.; Baer, A.; Lubec, G.; van Meeteren, L.A.; Kishi, Y.; Aoki, J.; Moolenaar, W.H.; Nitsch, R.; Braeuer, A.U.
Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma
Cell. Mol. Life Sci.
64
230-243
2007
Mus musculus, Rattus norvegicus
Nakamura, K.; Ohkawa, R.; Okubo, S.; Tozuka, M.; Okada, M.; Aoki, S.; Aoki, J.; Arai, H.; Ikeda, H.; Yatomi, Y.
Measurement of lysophospholipase D/autotaxin activity in human serum samples
Clin. Biochem.
40
274-277
2007
Homo sapiens
Nakamura, K.; Nangaku, M.; Ohkawa, R.; Okubo, S.; Yokota, H.; Ikeda, H.; Aoki, J.; Yatomi, Y.
Analysis of serum and urinary lysophospholipase D/autotaxin in nephrotic syndrome
Clin. Chem. Lab. Med.
46
150-151
2008
Homo sapiens
Ferry, G.; Giganti, A.; Coge, F.; Bertaux, F.; Thiam, K.; Boutin, J.A.
Functional invalidation of the autotaxin gene by a single amino acid mutation in mouse is lethal
FEBS Lett.
581
3572-3578
2007
Mus musculus
Liu, X.W.; Sok, D.E.; Yook, H.S.; Sohn, C.B.; Chung, Y.J.; Kim, M.R.
Inhibition of lysophospholipase D activity by unsaturated lysophosphatidic acids or seed extracts containing 1-linoleoyl and 1-oleoyl lysophosphatidic acid
J. Agric. Food Chem.
55
8717-8722
2007
Bos taurus
Tanaka, M.; Okudaira, S.; Kishi, Y.; Ohkawa, R.; Iseki, S.; Ota, M.; Noji, S.; Yatomi, Y.; Aoki, J.; Arai, H.
Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid
J. Biol. Chem.
281
25822-25830
2006
Mus musculus
Jansen, S.; Callewaert, N.; Dewerte, I.; Andries, M.; Ceulemans, H.; Bollen, M.
An essential oligomannosidic glycan chain in the catalytic domain of autotaxin, a secreted lysophospholipase-D
J. Biol. Chem.
282
11084-11091
2007
Rattus norvegicus (Q64610)
Giganti, A.; Rodriguez, M.; Fould, B.; Moulharat, N.; Coge, F.; Chomarat, P.; Galizzi, J.P.; Valet, P.; Saulnier-Blache, J.S.; Boutin, J.A.; Ferry, G.
Murine and human autotaxin alpha, beta, gamma isoforms: Gene organization, tissue distribution and biochemical characterization
J. Biol. Chem.
283
7776-7789
2008
Homo sapiens, Homo sapiens (Q13822), Mus musculus, Mus musculus (Q9R1E6)
Morris, A.J.; Smyth, S.S.
Measurement of autotaxin/lysophospholipase D activity
Methods Enzymol.
434
89-104
2007
Homo sapiens, Mammalia
van Meeteren, L.A.; Ruurs, P.; Stortelers, C.; Bouwman, P.; van Rooijen, M.A.; Pradere, J.P.; Pettit, T.R.; Wakelam, M.J.; Saulnier-Blache, J.S.; Mummery, C.L.; Moolenaar, W.H.; Jonkers, J.
Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development
Mol. Cell. Biol.
26
5015-5022
2006
Mus musculus
Rose, T.M.; Prestwich, G.D.
Synthesis and evaluation of fluorogenic substrates for phospholipase D and phospholipase C
Org. Lett.
8
2575-2578
2006
Bacillus cereus, Clostridium perfringens
Haga, A.; Hashimoto, K.; Tanaka, N.; Nakamura, K.T.; Deyashiki, Y.
Scalable purification and characterization of the extracellular domain of human autotaxin from prokaryotic cells
Protein Expr. Purif.
59
9-17
2008
Homo sapiens (Q13822), Homo sapiens
Nakasaki, T.; Tanaka, T.; Okudaira, S.; Hirosawa, M.; Umemoto, E.; Otani, K.; Jin, S.; Bai, Z.; Hayasaka, H.; Fukui, Y.; Aozasa, K.; Fujita, N.; Tsuruo, T.; Ozono, K.; Aoki, J.; Miyasaka, M.
Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions
Am. J. Pathol.
173
1566-1576
2008
Mus musculus
Yuelling, L.M.; Fuss, B.
Autotaxin (ATX): a multi-functional and multi-modular protein possessing enzymatic lysoPLD activity and matricellular properties
Biochim. Biophys. Acta
1781
525-530
2008
Homo sapiens
van Meeteren, L.A.; Brinkmann, V.; Saulnier-Blache, J.S.; Lynch, K.R.; Moolenaar, W.H.
Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D
Cancer Lett.
266
203-208
2008
Homo sapiens
Federico, L.; Pamuklar, Z.; Smyth, S.S.; Morris, A.J.
Therapeutic potential of autotaxin/lysophospholipase d inhibitors
Curr. Drug Targets
9
698-708
2008
Mus musculus
Pamuklar, Z.; Federico, L.; Liu, S.; Umezu-Goto, M.; Dong, A.; Panchatcharam, M.; Fulerson, Z.; Berdyshev, E.; Natarajan, V.; Fang, X.; van Meeteren, L.A.; Moolenaar, W.H.; Mills, G.B.; Morris, A.J.; Smyth, S.S.
Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis
J. Biol. Chem.
284
7385-7394
2009
Homo sapiens
Tokumura, A.; Kume, T.; Taira, S.; Yasuda, K.; Kanzaki, H.
Altered activity of lysophospholipase D, which produces bioactive lysophosphatidic acid and choline, in serum from women with pathological pregnancy
Mol. Hum. Reprod.
15
301-310
2009
Homo sapiens
Kanda, H.; Newton, R.; Klein, R.; Morita, Y.; Gunn, M.D.; Rosen, S.D.
Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs
Nat. Immunol.
9
415-423
2008
Mus musculus
Seifert, A.; Klonisch, T.; Wulfaenger, J.; Haag, F.; Dralle, H.; Langner, J.; Hoang-Vu, C.; Kehlen, A.
The cellular localization of autotaxin impacts on its biological functions in human thyroid carcinoma cells
Oncol. Rep.
19
1485-1491
2008
Homo sapiens (Q13822), Homo sapiens
Wakelam, M.; Powner, D.; Pettitt, T.
Determination of phospholipase D, lysophospholipase D and DG kinase signaling pathways in disease states by mass spectrometry
Adv. Enzyme Regul.
48
254-260
2008
Homo sapiens
Iwasawa, Y.; Fujii, T.; Nagamatsu, T.; Kawana, K.; Okudaira, S.; Miura, S.; Matsumoto, J.; Tomio, A.; Hyodo, H.; Yamashita, T.; Oda, K.; Kozuma, S.; Aoki, J.; Yatomi, Y.; Taketani, Y.
Expression of autotaxin, an ectoenzyme that produces lysophosphatidic acid, in human placenta
Am. J. Reprod. Immunol.
62
90-95
2009
Homo sapiens
Li, S.; Zhang, J.
Lipopolysaccharide induces autotaxin expression in human monocytic THP-1 cells
Biochem. Biophys. Res. Commun.
378
264-268
2009
Homo sapiens
Hoeglund, A.B.; Howard, A.L.; Wanjala, I.W.; Pham, T.C.; Parrill, A.L.; Baker, D.L.
Characterization of non-lipid autotaxin inhibitors
Bioorg. Med. Chem.
18
769-776
2010
Homo sapiens
Jansen, S.; Andries, M.; Vekemans, K.; Vanbilloen, H.; Verbruggen, A.; Bollen, M.
Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells
Cancer Lett.
284
216-221
2009
Rattus norvegicus
Liu, S.; Murph, M.; Panupinthu, N.; Mills, G.B.
ATX-LPA receptor axis in inflammation and cancer
Cell Cycle
8
3695-3701
2009
Homo sapiens
Fotopoulou, S.; Oikonomou, N.; Grigorieva, E.; Nikitopoulou, I.; Paparountas, T.; Thanassopoulou, A.; Zhao, Z.; Xu, Y.; Kontoyiannis, D.L.; Remboutsika, E.; Aidinis, V.
ATX expression and LPA signalling are vital for the development of the nervous system
Dev. Biol.
339
451-464
2010
Mus musculus
Endo, T.; Kano, K.; Motoki, R.; Hama, K.; Okudaira, S.; Ishida, M.; Ogiso, H.; Tanaka, M.; Matsuki, N.; Taguchi, R.; Kanai, M.; Shibasaki, M.; Arai, H.; Aoki, J.
Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood
J. Biochem.
146
283-293
2009
Mus musculus
Jansen, S.; Andries, M.; Derua, R.; Waelkens, E.; Bollen, M.
Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin
J. Biol. Chem.
284
14296-14302
2009
Rattus norvegicus
Koike, S.; Keino-Masu, K.; Ohto, T.; Sugiyama, F.; Takahashi, S.; Masu, M.
Autotaxin/lysophospholipase D-mediated lysophosphatidic acid signaling is required to form distinctive large lysosomes in the visceral endoderm cells of the mouse yolk sac
J. Biol. Chem.
284
33561-33570
2009
Mus musculus
Hoeglund, A.B.; Bostic, H.E.; Howard, A.L.; Wanjala, I.W.; Best, M.D.; Baker, D.L.; Parrill, A.L.
Optimization of a pipemidic acid autotaxin inhibitor
J. Med. Chem.
53
1056-1066
2010
Homo sapiens
Ma, L.; Uchida, H.; Nagai, J.; Inoue, M.; Aoki, J.; Ueda, H.
Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain
J. Pharmacol. Exp. Ther.
333
540-546
2010
Mus musculus
Koh, E.; Bandle, R.W.; Roberts, D.D.; Stracke, M.L.; Clair, T.
Novel point mutations attenuate autotaxin activity
Lipids Health Dis.
8
4-4
2009
Homo sapiens
Im, E.; Motiejunaite, R.; Aranda, J.; Park, E.Y.; Federico, L.; Kim, T.I.; Clair, T.; Stracke, M.L.; Smyth, S.; Kazlauskas, A.
PLCgamma activation drives increased production of autotaxin in endothelial cells and LPA-dependent regression
Mol. Cell. Biol.
30
2401-2410
2010
Mus musculus
David, M.; Wannecq, E.; Descotes, F.; Jansen, S.; Deux, B.; Ribeiro, J.; Serre, C.M.; Gres, S.; Bendriss-Vermare, N.; Bollen, M.; Saez, S.; Aoki, J.; Saulnier-Blache, J.S.; Clezardin, P.; Peyruchaud, O.
Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts
PLoS ONE
5
e9741
2010
Homo sapiens, Mus musculus
Albers, H.M.; Dong, A.; van Meeteren, L.A.; Egan, D.A.; Sunkara, M.; van Tilburg, E.W.; Schuurman, K.; van Tellingen, O.; Morris, A.J.; Smyth, S.S.; Moolenaar, W.H.; Ovaa, H.
Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation
Proc. Natl. Acad. Sci. USA
107
7257-7262
2010
Mus musculus
Block, R.C.; Duff, R.; Lawrence, P.; Kakinami, L.; Brenna, J.T.; Shearer, G.C.; Meednu, N.; Mousa, S.; Friedman, A.; Harris, W.S.; Larson, M.; Georas, S.
The effects of EPA, DHA, and aspirin ingestion on plasma lysophospholipids and autotaxin
Prostaglandins Leukot. Essent. Fatty Acids
82
87-95
2010
Homo sapiens
Hausmann, J.; Christodoulou, E.; Kasiem, M.; De Marco, V.; van Meeteren, L.A.; Moolenaar, W.H.; Axford, D.; Owen, R.L.; Evans, G.; Perrakis, A.
Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein
Acta Crystallogr. Sect. F
66
1130-1135
2010
Rattus norvegicus (Q64610)
Inoue, K.; Tanaka, N.; Haga, A.; Yamasaki, K.; Umeda, T.; Kusakabe, Y.; Sakamoto, Y.; Nonaka, T.; Deyashiki, Y.; Nakamura, K.T.
Crystallization and preliminary X-ray crystallographic analysis of human autotaxin
Acta Crystallogr. Sect. F
67
450-453
2011
Homo sapiens
Tania, M.; Khan, A.; Zhang, H.; Li, J.; Song, Y.
Autotaxin: a protein with two faces
Biochem. Biophys. Res. Commun.
401
493-497
2010
Homo sapiens
Zhao, J.; He, D.; Berdyshev, E.; Zhong, M.; Salgia, R.; Morris, A.J.; Smyth, S.S.; Natarajan, V.; Zhao, Y.
Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways
Biochem. J.
439
45-55
2011
Homo sapiens
Aoyama, C.; Sugimoto, H.; Ando, H.; Yamashita, S.; Horibata, Y.; Sugimoto, S.; Satou, M.
The heterotrimeric G protein subunits Galphaq and Gbeta1 have lysophospholipase D activity
Biochem. J.
440
241-250
2011
Rattus norvegicus
Tsuboi, K.; Okamoto, Y.; Ikematsu, N.; Inoue, M.; Shimizu, Y.; Uyama, T.; Wang, J.; Deutsch, D.G.; Burns, M.P.; Ulloa, N.M.; Tokumura, A.; Ueda, N.
Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways
Biochim. Biophys. Acta
1811
565-577
2011
Mus musculus
East, J.E.; Kennedy, A.J.; Tomsig, J.L.; De Leon, A.R.; Lynch, K.R.; Macdonald, T.L.
Synthesis and structure-activity relationships of tyrosine-based inhibitors of autotaxin (ATX)
Bioorg. Med. Chem. Lett.
20
7132-7136
2010
Homo sapiens
Jiang, G.; Madan, D.; Prestwich, G.D.
Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin
Bioorg. Med. Chem. Lett.
21
5098-5101
2011
Homo sapiens
Song, Y.; Dilger, E.; Bell, J.; Barton, W.A.; Fang, X.
Large scale purification and characterization of recombinant human autotaxin/lysophospholipase D from mammalian cells
BMB Rep.
43
541-546
2010
Homo sapiens
Ueda, K.; Yoshihara, M.; Nakao, M.; Tanaka, T.; Sano, S.; Fukuzawa, K.; Tokumura, A.
Evaluation of inhibitory actions of flavonols and related substances on lysophospholipase D activity of serum autotaxin by a convenient assay using a chromogenic substrate
J. Agric. Food Chem.
58
6053-6063
2010
Homo sapiens
Saunders, L.P.; Cao, W.; Chang, W.C.; Albright, R.A.; Braddock, D.T.; De La Cruz, E.M.
Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution
J. Biol. Chem.
286
30130-30141
2011
Homo sapiens
Fulkerson, Z.; Wu, T.; Sunkara, M.; Kooi, C.V.; Morris, A.J.; Smyth, S.S.
Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells
J. Biol. Chem.
286
34654-34663
2011
Homo sapiens
Yukiura, H.; Hama, K.; Nakanaga, K.; Tanaka, M.; Asaoka, Y.; Okudaira, S.; Arima, N.; Inoue, A.; Hashimoto, T.; Arai, H.; Kawahara, A.; Nishina, H.; Aoki, J.
Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish
J. Biol. Chem.
286
43972-43983
2011
Danio rerio, Danio rerio AB
Hausmann, J.; Kamtekar, S.; Christodoulou, E.; Day, J.E.; Wu, T.; Fulkerson, Z.; Albers, H.M.; van Meeteren, L.A.; Houben, A.J.; van Zeijl, L.; Jansen, S.; Andries, M.; Hall, T.; Pegg, L.E.; Benson, T.E.; Kasiem, M.; Harlos, K.; Kooi, C.W.; Smyth, S.S.; Ovaa, H.; Bollen, M.; Morris, A.J.; Moolenaar, W.H.; Perrakis, A.
Structural basis of substrate discrimination and integrin binding by autotaxin
Nat. Struct. Mol. Biol.
18
198-204
2011
Rattus norvegicus (Q64610)
Nishimasu, H.; Okudaira, S.; Hama, K.; Mihara, E.; Dohmae, N.; Inoue, A.; Ishitani, R.; Takagi, J.; Aoki, J.; Nureki, O.
Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat. Struct. Mol. Biol.
18
205-212
2011
Mus musculus
Kawaguchi, M.; Okabe, T.; Okudaira, S.; Nishimasu, H.; Ishitani, R.; Kojima, H.; Nureki, O.; Aoki, J.; Nagano, T.
Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe
ACS Chem. Biol.
8
1713-1721
2013
Danio rerio, Mus musculus (Q9R1E6)
Hausmann, J.; Perrakis, A.; Moolenaar, W.H.
Structure-function relationships of autotaxin, a secreted lysophospholipase D
Adv. Biol. Regul.
53
112-117
2013
Rattus norvegicus
Rancoule, C.; Dusaulcy, R.; Treguer, K.; Gres, S.; Attane, C.; Saulnier-Blache, J.S.
Involvement of autotaxin/lysophosphatidic acid signaling in obesity and impaired glucose homeostasis
Biochimie
96
140-143
2014
Homo sapiens, Mus musculus
Ino, M.; Shimizu, Y.; Tanaka, T.; Tokumura, A.
Alterations of plasma levels of lysophosphatidic acid in response to fasting of rats
Biol. Pharm. Bull.
35
2059-2063
2012
Rattus norvegicus, Rattus norvegicus Wistar
Wu, T.; Kooi, C.V.; Shah, P.; Charnigo, R.; Huang, C.; Smyth, S.S.; Morris, A.J.
Integrin-mediated cell surface recruitment of autotaxin promotes persistent directional cell migration
FASEB J.
28
861-870
2014
Homo sapiens
Perrakis, A.; Moolenaar, W.H.
Autotaxin: structure-function and signaling
J. Lipid Res.
55
1010-1018
2014
Homo sapiens, Mus musculus, Streptomyces chromofuscus, Loxosceles sp.
Hozumi, H.; Hokari, R.; Kurihara, C.; Narimatsu, K.; Sato, H.; Sato, S.; Ueda, T.; Higashiyama, M.; Okada, Y.; Watanabe, C.; Komoto, S.; Tomita, K.; Kawaguchi, A.; Nagao, S.; Miura, S.
Involvement of autotaxin/lysophospholipase D expression in intestinal vessels in aggravation of intestinal damage through lymphocyte migration
Lab. Invest.
93
508-519
2013
Homo sapiens, Mus musculus, Mus musculus BALB/c
Morishige, J.; Uto, Y.; Hori, H.; Satouchi, K.; Yoshiomoto, T.; Tokumura, A.
Lysophosphatidic acid produced by hen egg white lysophospholipase D induces vascular development on extraembryonic membranes
Lipids
48
251-262
2013
Gallus gallus
Tokumura, A.; Taira, S.; Kikuchi, M.; Tsutsumi, T.; Shimizu, Y.; Watsky, M.A.
Lysophospholipids and lysophospholipase D in rabbit aqueous humor following corneal injury
Prostaglandins Other Lipid Mediat.
97
83-89
2012
Oryctolagus cuniculus
Borchani, L.; Sassi, A.; Ben Gharsa, H.; Safra, I.; Shahbazzadeh, D.; Ben Lasfar, Z.; El Ayeb, M.
The pathological effects of heminecrolysin, a dermonecrotic toxin from Hemiscorpius lepturus scorpion venom are mediated through its lysophospholipase D activity
Toxicon
68
30-39
2013
Hemiscorpius lepturus
Tsuboi, K.; Okamoto, Y.; Rahman, I.A.; Uyama, T.; Inoue, T.; Tokumura, A.; Ueda, N.
Glycerophosphodiesterase GDE4 as a novel lysophospholipase D a possible involvement in bioactive N-acylethanolamine biosynthesis
Biochim. Biophys. Acta
1851
537-548
2015
Mus musculus (Q9CRY7), Mus musculus
Rahman, I.A.; Tsuboi, K.; Hussain, Z.; Yamashita, R.; Okamoto, Y.; Uyama, T.; Yamazaki, N.; Tanaka, T.; Tokumura, A.; Ueda, N.
Calcium-dependent generation of N-acylethanolamines and lysophosphatidic acids by glycerophosphodiesterase GDE7
Biochim. Biophys. Acta
1861
1881-1892
2016
Homo sapiens (Q7L5L3), Homo sapiens, Mus musculus (Q99LY2), Mus musculus
Kise, R.; Okasato, R.; Kano, K.; Inoue, A.; Kawahara, A.; Aoki, J.
Identification and biochemical characterization of a second zebrafish autotaxin gene
J. Biochem.
165
269-275
2019
Danio rerio
Ohshima, N.; Kudo, T.; Yamashita, Y.; Mariggio, S.; Araki, M.; Honda, A.; Nagano, T.; Isaji, C.; Kato, N.; Corda, D.; Izumi, T.; Yanaka, N.
New members of the mammalian glycerophosphodiester phosphodiesterase family GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity
J. Biol. Chem.
290
4260-4271
2015
Mus musculus (Q9CRY7)
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