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Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase and Organism(s) Gallus gallus

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EC Tree
IUBMB Comments
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
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This record set is specific for:
Gallus gallus
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The taxonomic range for the selected organisms is: Gallus gallus
The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
70 kDa zeta-associated protein
-
-
-
-
ACTR-IIB
-
-
-
-
ACTRIIA
-
-
-
-
Agammaglobulinaemia tyrosine kinase
-
-
-
-
Amylovoran biosynthesis membrane-associated protein amsA
-
-
-
-
ATK
-
-
-
-
B cell progenitor kinase
-
-
-
-
B lymphocyte kinase
-
-
-
-
B-cell/myeloid kinase
-
-
-
-
BCR-ABL tyrosine kinase
-
-
-
-
BMK
-
-
-
-
BMP type II receptor
-
-
-
-
BMP-2/BMP-4 receptor
-
-
-
-
Bone marrow kinase BMX
-
-
-
-
bone morphogenetic protein receptor type IB
-
BPK
-
-
-
-
Breast tumor kinase
-
-
-
-
Bruton's tyrosine kinase
-
-
-
-
c-ABL
-
-
-
-
c-FER
-
-
-
-
C-FES
-
-
-
-
C-SRC
C-SRC kinase
-
-
-
-
C-YES
-
-
-
-
CADTK
-
-
-
-
CAK beta
-
-
-
-
Calcium-dependent tyrosine kinase
-
-
-
-
Cell adhesion kinase beta
-
-
-
-
D-ash
-
-
-
-
DFer
-
-
-
-
Dsrc28C
-
-
-
-
ectoprotein kinase
-
-
-
-
Epithelial and endothelial tyrosine kinase
-
-
-
-
EPS I polysaccharide export protein epsB
-
-
-
-
focal adhesion kinase 1
-
-
-
-
gene lck protein kinase
-
-
-
-
gene lck tyrosine kinase
-
-
-
-
Hematopoietic consensus tyrosine-lacking kinase
-
-
-
-
Hemopoietic cell kinase
-
-
-
-
IL-2-inducible T-cell kinase
-
-
-
-
Itk
-
-
-
-
JAK protein tyrosine kinase
-
-
-
-
Kinase EMB
-
-
-
-
Kinase EMT
-
-
-
-
Kinase TLK
-
-
-
-
kinase, protein (phosphorylating tyrosine)
-
-
-
-
kinase, protein p56lck (phosphorylating)
-
-
-
-
L-JAK
-
-
-
-
Lck Tyrosine kinase
-
-
-
-
Leukocyte janus kinase
-
-
-
-
LIM domain kinase 2
-
LIM-kinase
-
LSK
-
-
-
-
nonreceptor protein tyrosine kinase
-
-
-
-
NTK38
-
-
-
-
Nuclear tyrosine protein kinase RAK
-
-
-
-
ORF6
-
-
-
-
p150
-
-
-
-
p55-BLK
-
-
-
-
P55-FGR
-
-
-
-
p56-HCK
-
-
-
-
p56-HCK/p59-HCK
-
-
-
-
P56-LCK
-
-
-
-
p56lck kinase
-
-
-
-
p56lck protein kinase
-
-
-
-
p56lck protein tyrosine kinase
-
-
-
-
p56lck tyrosine kinase
-
-
-
-
P57-STK
-
-
-
-
P59-FYN
-
-
-
-
p59-HCK/p60-HCK
-
-
-
-
P60-SRC
-
-
-
-
p60-YRK
-
-
-
-
P61-YES
-
-
-
-
p94-FER
-
-
-
-
phosphotyrosyl-protein kinase
-
-
-
-
PP125FAK
Protein kinase (tyrosine-phosphorylating)
-
-
-
-
protein kinase A
-
-
-
-
Protein kinase BATK
-
-
-
-
Protein kinase HYL
-
-
-
-
Protein kinase Lck
-
-
-
-
Protein kinase NTK
-
-
-
-
Protein kinase p56-LCK
-
-
-
-
Protein kinase p56lck
-
-
-
-
Protein p56c-lck kinase
-
-
-
-
Protein p56lck tyrosine kinase
-
-
-
-
Protein tyrosine kinase
-
-
-
-
protein tyrosine kinase 2beta
-
-
-
-
Protein tyrosine kinase lck
-
-
-
-
Protein tyrosine kinase p56lck
-
-
-
-
Protein tyrosine kinase pp56lck
-
-
-
-
Protein-tyrosine kinase C-TKL
-
-
-
-
Protein-tyrosine kinase CYL
-
-
-
-
proto-oncogene serine/threonine-protein kinase mos
-
proto-oncogene tyrosine-protein kinase FYN
-
proto-oncogene tyrosine-protein kinase LCK
-
proto-oncogene tyrosine-protein kinase SRC
-
proto-oncogene tyrosine-protein kinase YES
-
proto-oncogene tyrosine-protein kinase YRK
-
PTK
-
-
-
-
PTK-RL-18
-
-
-
-
PTK70
-
-
-
-
Quek1
-
-
-
-
Related adhesion focal tyrosine kinase
-
-
-
-
Resting lymphocyte kinase
-
-
-
-
Rlk/Txk
-
-
-
-
S-domain receptor-like protein kinase
-
-
-
-
SLK
-
-
-
-
Spleen tyrosine kinase
-
-
-
-
Src protein-tyrosine kinase
-
-
src-kinase
-
-
-
-
SRC-related intestinal kinase
-
-
-
-
Syk-related tyrosine kinase
-
-
-
-
SYN
-
-
-
-
T cell-specific protein-tyrosine kinase
-
-
-
-
T-cell-specific kinase
-
-
-
-
Tyrosine kinase
-
-
-
-
Tyrosine kinase ARG
-
-
-
-
Tyrosine kinase lck
-
-
-
-
Tyrosine kinase p56lck
-
-
-
-
Tyrosine phosphokinase
-
-
-
-
Tyrosine protein kinase
-
-
-
-
Tyrosine protein kinase p56lck
-
-
-
-
Tyrosine-protein kinase brk
-
-
-
-
tyrosine-protein kinase CSK
-
Tyrosine-protein kinase CTK
-
-
-
-
Tyrosine-protein kinase Lyk
-
-
-
-
Tyrosine-protein kinase TYRO 10
-
-
-
-
Tyrosine-specific protein kinase
-
-
-
-
Tyrosylprotein kinase
-
-
-
-
v-fps Protein-tyrosine kinase
-
-
-
-
WEE1hu
-
-
-
-
YES related kinase
-
-
-
-
Yes-related kinase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
structure-function relationship, active site structure, catalytic mechanism and enzyme regulation, overview
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
CAS REGISTRY NUMBER
COMMENTARY hide
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
AEEEIYGEFEAKKKK + ATP
? + ADP
show the reaction diagram
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
it is likely that LIMK is involved in developmental or oncogenic processes through interactions with these LIM-containing proteins
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
phosphorylates the regulatory C-terminal tyrosine residue present on cytoplasmic tyrosine kinases of the Src family
-
-
?
denatured enolase + ATP
phosphorylated denatured enolase + ADP
show the reaction diagram
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
it is likely that LIMK is involved in developmental or oncogenic processes through interactions with these LIM-containing proteins
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
phosphorylates the regulatory C-terminal tyrosine residue present on cytoplasmic tyrosine kinases of the Src family
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ATP
-
as MgATP2-, binding site structure
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
as MgATP2-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Gleevec
also known as STI-571 or imatinib
p-fluorosulfonylbenzoyl 5'-adenosine
inactivates tyrosine protein kinase activity of p60src by reacting with lysine 295
additional information
completely inhibited by an excess of substrate peptide
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
the overall activity kcat of the catalytic domain Src, Src-CD, including the C-terminal tail for two exogenous substrates, the Src substrate peptide AEEEIYGEFEAKKKK and denatured enolase is about 10 times higher than that of wild-type Src. The kcat values for phosphorylation of the Src substrate peptide are similar for the unphosphorylated and monophosphorylated Src-CD, 50 min-1, but the apparent Km values differ significantly, approximately 0.003 mM and 0.010 mM, respectively
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
the overall activity kcat of the catalytic domain Src, Src-CD, including the C-terminal tail for two exogenous substrates, the Src substrate peptide AEEEIYGEFEAKKKK and denatured enolase is about 10 times higher than that of wild-type Src. The kcat values for phosphorylation of the Src substrate peptide are similar for the unphosphorylated and monophosphorylated Src-CD, 50 min-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
faintly expressed
Manually annotated by BRENDA team
expression at low level
Manually annotated by BRENDA team
faintly expressed
Manually annotated by BRENDA team
faintly expressed
Manually annotated by BRENDA team
expression in T lymphocytes but not in B lymphocytes
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
JAK2_CHICK
1129
0
129847
Swiss-Prot
other Location (Reliability: 2)
FYN_CHICK
534
0
60265
Swiss-Prot
other Location (Reliability: 1)
SRC_CHICK
533
0
60010
Swiss-Prot
other Location (Reliability: 3)
YRK_CHICK
536
0
60002
Swiss-Prot
other Location (Reliability: 1)
BTK_CHICK
657
0
75879
Swiss-Prot
other Location (Reliability: 4)
YES_CHICK
541
0
60792
Swiss-Prot
other Location (Reliability: 2)
KSYK_CHICK
613
0
69901
Swiss-Prot
other Location (Reliability: 2)
FAK1_CHICK
1053
0
119207
Swiss-Prot
other Location (Reliability: 2)
WEE2_CHICK
565
0
63301
Swiss-Prot
other Location (Reliability: 1)
LCK_CHICK
508
0
58140
Swiss-Prot
other Location (Reliability: 1)
CSK_CHICK
450
0
50751
Swiss-Prot
other Location (Reliability: 1)
A0A0A0MQ53_CHICK
636
0
72422
TrEMBL
other Location (Reliability: 2)
A0A3Q2TZP7_CHICK
479
0
53724
TrEMBL
other Location (Reliability: 4)
F1NXT2_CHICK
824
0
94191
TrEMBL
other Location (Reliability: 2)
A0A1D5P276_CHICK
574
0
63975
TrEMBL
Mitochondrion (Reliability: 4)
A0A3Q2U9D2_CHICK
1102
0
124787
TrEMBL
Mitochondrion (Reliability: 3)
A0A3Q2U1T2_CHICK
499
0
56531
TrEMBL
other Location (Reliability: 3)
F1NQU9_CHICK
534
0
60183
TrEMBL
other Location (Reliability: 1)
Q98946_CHICK
87
0
10235
TrEMBL
other Location (Reliability: 2)
O42291_CHICK
1106
0
124751
TrEMBL
other Location (Reliability: 1)
E1C2F6_CHICK
533
0
60641
TrEMBL
other Location (Reliability: 3)
Q2P9U8_CHICK
652
0
74724
TrEMBL
other Location (Reliability: 2)
A0A3Q2UIT4_CHICK
537
0
60694
TrEMBL
other Location (Reliability: 1)
R4GJW5_CHICK
641
0
70966
TrEMBL
Mitochondrion (Reliability: 2)
A0A3Q3B2A8_CHICK
1165
0
134075
TrEMBL
Secretory Pathway (Reliability: 2)
Q5F400_CHICK
539
0
59708
TrEMBL
Mitochondrion (Reliability: 2)
A0A3Q2TXU4_CHICK
1140
0
131275
TrEMBL
other Location (Reliability: 2)
R4GK19_CHICK
1175
0
130734
TrEMBL
other Location (Reliability: 2)
Q5ZMB9_CHICK
492
0
56202
TrEMBL
other Location (Reliability: 2)
A0A3Q2U639_CHICK
589
0
66431
TrEMBL
other Location (Reliability: 1)
A0A3Q3AEB9_CHICK
605
0
69871
TrEMBL
other Location (Reliability: 2)
A0A3Q2UHM8_CHICK
1038
0
116293
TrEMBL
other Location (Reliability: 3)
R9PXP6_CHICK
556
0
62433
TrEMBL
other Location (Reliability: 1)
A0A1D5PZX7_CHICK
885
0
99470
TrEMBL
other Location (Reliability: 2)
E1BTC3_CHICK
992
0
113465
TrEMBL
Mitochondrion (Reliability: 5)
F1NZY8_CHICK
630
0
73232
TrEMBL
other Location (Reliability: 5)
E1C7Z1_CHICK
822
0
94527
TrEMBL
other Location (Reliability: 2)
Q9PWM9_CHICK
1150
0
133116
TrEMBL
other Location (Reliability: 1)
A0A1D5NY34_CHICK
1085
0
122921
TrEMBL
other Location (Reliability: 2)
Q5ZLF2_CHICK
657
0
75893
TrEMBL
other Location (Reliability: 4)
A0A1D5NXK5_CHICK
684
0
78559
TrEMBL
other Location (Reliability: 4)
A0A1D5PJY8_CHICK
1101
0
120616
TrEMBL
other Location (Reliability: 1)
A0A1D5PPL3_CHICK
1120
0
122969
TrEMBL
other Location (Reliability: 3)
A0A1L1RWW2_CHICK
550
0
61526
TrEMBL
Mitochondrion (Reliability: 4)
E1BXA3_CHICK
490
0
55395
TrEMBL
other Location (Reliability: 1)
A0A1D5PLI1_CHICK
1134
0
123977
TrEMBL
other Location (Reliability: 2)
Q90778_CHICK
824
0
94219
TrEMBL
other Location (Reliability: 2)
E1BYL7_CHICK
526
0
59568
TrEMBL
Mitochondrion (Reliability: 2)
F1NP54_CHICK
508
0
58198
TrEMBL
other Location (Reliability: 1)
A0A3Q2UBF5_CHICK
1051
0
118977
TrEMBL
other Location (Reliability: 2)
F1NQU4_CHICK
1129
0
129907
TrEMBL
other Location (Reliability: 2)
E1C2C8_CHICK
447
0
50328
TrEMBL
other Location (Reliability: 4)
F1N996_CHICK
491
0
56186
TrEMBL
Mitochondrion (Reliability: 5)
F1NCD9_CHICK
1111
0
121501
TrEMBL
Secretory Pathway (Reliability: 5)
E1BU42_CHICK
609
0
69017
TrEMBL
other Location (Reliability: 2)
A0A1I7Q3Z0_CHICK
539
0
60764
TrEMBL
other Location (Reliability: 3)
Q5ZI88_CHICK
630
0
73249
TrEMBL
other Location (Reliability: 5)
A0A3Q2U1G4_CHICK
630
0
72499
TrEMBL
other Location (Reliability: 2)
Q9YI46_CHICK
67
0
7369
TrEMBL
other Location (Reliability: 2)
Q5ZJT6_CHICK
574
0
63971
TrEMBL
Mitochondrion (Reliability: 4)
A0A1D5PXS9_CHICK
450
0
50780
TrEMBL
other Location (Reliability: 1)
A0A1D5PIY0_CHICK
1159
0
126607
TrEMBL
other Location (Reliability: 2)
E1BTT3_CHICK
629
0
72669
TrEMBL
other Location (Reliability: 2)
F1NMJ9_CHICK
1150
0
133012
TrEMBL
other Location (Reliability: 1)
A0A1D5P353_CHICK
533
0
59703
TrEMBL
other Location (Reliability: 1)
A0A3Q2UET3_CHICK
1079
0
121278
TrEMBL
Mitochondrion (Reliability: 2)
A0A3Q3AH40_CHICK
514
0
58128
TrEMBL
Mitochondrion (Reliability: 5)
A0A1D5PK82_CHICK
1212
0
136645
TrEMBL
Mitochondrion (Reliability: 3)
A0A1D5P360_CHICK
491
0
56074
TrEMBL
other Location (Reliability: 2)
MOS_CHICK
349
0
38263
Swiss-Prot
-
LIMK2_CHICK
642
0
72468
Swiss-Prot
-
BMR1B_CHICK
502
1
56766
Swiss-Prot
-
Q92063_CHICK
359
0
39793
TrEMBL
-
PAXI_CHICK
559
0
61243
Swiss-Prot
other Location (Reliability: 1)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
60911
x * 60911, calculation from nucleotide sequence
additional information
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 60911, calculation from nucleotide sequence
additional information
-
enzyme consists of an N-terminal myristoyl group, a unique segment, a SH2 and a SH3 domain, protein-tyrosine kinase domain, and a C-terminal regulatory domain, Src protein-tyrosine kinase structure and organization, overview
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
-
enzyme autophosphorylates at the activation loop for activation, inhibition by phosphorylation at the regulatory tyrosine residue, phosphorylation sites, detailed overview
side-chain modification
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
in complex with gleevec
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
catalytic domain Src including the C-terminal tail Src-CD, expressed in Schizosaccharomyces pombe
crystal structure of chicken Src which is phosphorylated at Tyr527
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
analysis of cDNAs of the proto-oncogene c-src
catalytic domain Src including the C-terminal tail Src-CD, expressed in Schizosaccharomyces pombe
isolation of cDNA
unique domain of the yrk protein expressed in bacteria
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cooper, J.A.; Gould, K.L.; Cartwright, C.A.; Hunter, T.
Tyr527 is phosphorylated in pp60c-src: implications for regulation
Science
231
1431-1434
1986
Gallus gallus (P00523)
Manually annotated by BRENDA team
Dorai, T.; Levy, J.B.; Kang, L.; Brugge, J.S.; Wang, L.H.
Analysis of cDNAs of the proto-oncogene c-src: heterogeneity in 5' exons and possible mechanism for the genesis of the 3' end of v-src
Mol. Cell. Biol.
11
4165-4176
1991
Gallus gallus (P00523), Gallus gallus
Manually annotated by BRENDA team
Feng, S.; Chen, J.K.; Yu, H.; Simon, J.A.; Schreiber, S.L.
Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions
Science
266
1241-1247
1994
Gallus gallus (P00523)
Manually annotated by BRENDA team
Gould, K.L.; Woodgett, J.R.; Cooper, J.A.; Buss, J.E.; Shalloway, D.; Hunter, T.
Protein kinase C phosphorylates pp60src at a novel site
Cell
42
849-857
1985
Gallus gallus (P00523)
Manually annotated by BRENDA team
Kamps, M.P.; Taylor, S.S.; Sefton, B.M.
Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinase have homologous ATP-binding sites
Nature
310
589-592
1984
Gallus gallus (P00523)
Manually annotated by BRENDA team
Smart, J.E.; Oppermann, H.; Czernilofsky, A.P.; Purchio, A.F.; Erikson, R.L.; Bishop, J.M.
Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src)
Proc. Natl. Acad. Sci. USA
78
6013-6017
1981
Gallus gallus (P00523)
Manually annotated by BRENDA team
Takeya, T.; Hanafusa, H.
Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus
Cell
32
881-890
1983
Gallus gallus (P00523), Gallus gallus, Rous sarcoma virus (P00526), Rous sarcoma virus
Manually annotated by BRENDA team
Weijland, A.; Neubauer, G.; Courtneidge, S.A.; Mann, M.; Wierenga, R.K.; Superti-Furga, G.
The purification and characterization of the catalytic domain of Src expressed in Schizosaccharomyces pombe. Comparison of unphosphorylated and tyrosine phosphorylated species
Eur. J. Biochem.
240
756-764
1996
Gallus gallus (P00523)
Manually annotated by BRENDA team
Williams, J.C.; Weijland, A.; Gonfloni, S.; Thompson, A.; Courtneidge, S.A.; Superti-Furga, G.; Wierenga, R.K.
The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions
J. Mol. Biol.
274
757-775
1997
Gallus gallus (P00523), Gallus gallus
Manually annotated by BRENDA team
Yu, H.; Rosen, M.K.; Schreiber, S.L.
1H and 15N assignments and secondary structure of the Src SH3 domain
FEBS Lett.
324
87-92
1993
Gallus gallus (P00523)
Manually annotated by BRENDA team
Marcelle, C.; Eichmann, A.
Molecular cloning of a family of protein kinase genes expressed in the avian embryo
Oncogene
7
2479-2487
1992
Gallus gallus (P09324)
Manually annotated by BRENDA team
Sudol, M.; Kieswetter, C.; Zhao, Y.H.; Dorai, T.; Wang, L.H.; Hanafusa, H.
Nucleotide sequence of a cDNA for the chick yes proto-oncogene: comparison with the viral yes gene
Nucleic Acids Res.
16
9876
1988
Gallus gallus (P09324)
Manually annotated by BRENDA team
Zheng, X.F.; Podell, S.; Sefton, B.M.; Kaplan, P.L.
The sequence of chicken c-yes and p61c-yes
Oncogene
4
99-104
1989
Gallus gallus (P09324), Gallus gallus
Manually annotated by BRENDA team
Sabe, H.; Knudsen, B.; Okada, M.; Nada, S.; Nakagawa, H.; Hanafusa, H.
Molecular cloning and expression of chicken C-terminal Src kinase: lack of stable association with c-Src protein
Proc. Natl. Acad. Sci. USA
89
2190-2194
1992
Gallus gallus (P41239), Gallus gallus
Manually annotated by BRENDA team
Chow, L.M.; Ratcliffe, M.J.; Veillette, A.
Tkl is the avian homolog of the mammalian lck tyrosine protein kinase gene
Mol. Cell. Biol.
12
1226-1233
1992
Gallus gallus (P42683), Gallus gallus
Manually annotated by BRENDA team
Strebhardt, K.; Mullins, J.I.; Bruck, C.; Rubsamen-Waigmann, H.
Additional member of the protein-tyrosine kinase family: the src- and lck-related protooncogene c-tkl
Proc. Natl. Acad. Sci. USA
84
8778-8782
1987
Gallus gallus (P42683), Gallus gallus
Manually annotated by BRENDA team
Sudol, M.; Greulich, H.; Newman, L.; Sarkar, A.; Sukegawa, J.; Yamamoto, T.
A novel Yes-related kinase, Yrk, is expressed at elevated levels in neural and hematopoietic tissues
Oncogene
8
823-831
1993
Gallus gallus (Q02977), Gallus gallus (Q05876), Gallus gallus
Manually annotated by BRENDA team
Schaller, M.D.; Borgman, C.A.; Parson, J.T.
Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK
Mol. Cell. Biol.
13
785-791
1993
Gallus gallus (Q92063), Gallus gallus
Manually annotated by BRENDA team
Devor, B.B.; Zhang, X.; Patel, S.K.; Polte, T.R.; Hanks, S.K.
Chicken and mouse focal adhesion kinases are similar in structure at their amino termini
Biochem. Biophys. Res. Commun.
190
1084-1089
1993
Gallus gallus (Q00944), Gallus gallus
Manually annotated by BRENDA team
Schaller, M.D.; Borgman, C.A.; Cobb, B.S.; Vines, R.R.; Reynolds.A.B.; Parsons, J.T.
Pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions
Proc. Natl. Acad. Sci. USA
89
5192-5196
1992
Gallus gallus (Q00944), Gallus gallus
Manually annotated by BRENDA team
Sumitomo, S.; Saito, T.; Nohno, T.
A new receptor protein kinase from chick embryo related to type II receptor for TGF-beta
DNA Seq.
3
297-302
1993
Gallus gallus (Q05438)
Manually annotated by BRENDA team
Schmidt, M.; Oskarsson, M.K.; Dunn, J.K.; Blair, D.G.; Hughes, S.; Propst, F.; Vande Woude, G.F.
Chicken homolog of the mos proto-oncogene
Mol. Cell. Biol.
8
923-929
1988
Gallus gallus (P10741)
Manually annotated by BRENDA team
Ohashi, K.; Toshima, J.; Tajinda, K.; Nakamura, T.; Mizuno, K.
Molecular cloning of a chicken lung cDNA encoding a novel protein kinase with N-terminal two LIM/double zinc finger motifs
J. Biochem.
116
636-642
1994
Gallus gallus (P53666), Gallus gallus
Manually annotated by BRENDA team
Roskoski, R.Jr.
Src protein-tyrosine kinase structure and regulation
Biochem. Biophys. Res. Commun.
324
1155-1164
2004
Gallus gallus, Homo sapiens, Rous sarcoma virus
Manually annotated by BRENDA team
Lin, Y.L.; Roux, B.
Computational analysis of the binding specificity of Gleevec to Abl, c-Kit, Lck, and c-Src tyrosine kinases
J. Am. Chem. Soc.
135
14741-14753
2013
Mus musculus (P00520), Gallus gallus (P00523), Homo sapiens (P06239)
Manually annotated by BRENDA team