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Literature summary for 2.7.10.2 extracted from

  • Roskoski, R.Jr.
    Src protein-tyrosine kinase structure and regulation (2004), Biochem. Biophys. Res. Commun., 324, 1155-1164.
    View publication on PubMed
Search for more literature for 2.7.10.2

Activating Compound

Activating Compound Comment Organism Structure
additional information activation loop structure of Src and of Csk, autophosphorylation sites Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ as MgATP- Rous sarcoma virus
Mg2+ as MgATP2- Gallus gallus
Mg2+ as MgATP2-, binds to Asp404, physiological cation, can be substituted by Mn2+ Homo sapiens
Mn2+
-
 Gallus gallus
Mn2+
-
 Rous sarcoma virus
Mn2+ binds to Asp404, can substitute for Mg2+ Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Gallus gallus
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?
ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?
ATP + a [protein]-L-tyrosine Rous sarcoma virus
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?
additional information Gallus gallus Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview ?
-
 ?
additional information Homo sapiens Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview ?
-
 ?
additional information Rous sarcoma virus Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Homo sapiens
-
-
-
Rous sarcoma virus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein enzyme autophosphorylates at the activation loop for activation, inhibition by phosphorylation at the regulatory tyrosine residue, phosphorylation sites, detailed overview Gallus gallus
phosphoprotein enzyme autophosphorylates at the activation loop for activation, inhibition by phosphorylation at the regulatory tyrosine residue, phosphorylation sites, detailed overview Rous sarcoma virus
phosphoprotein enzyme autophosphorylates at Tyr416 the activation loop for activation, inhibition of Src by phosphorylation at the regulatory tyrosine Tyr527 residue by the C-terminal Src kinase Csk, phosphorylation sites, detailed overview Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate structure-function relation ship, active site structure, catalytic mechanism involving the catalytic base Asp386 and enzyme regulation, overview Homo sapiens
a
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate structure-function relationship, active site structure, catalytic mechanism and enzyme regulation, overview Gallus gallus
a
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate structure-function relationship, active site structure, catalytic mechanism and enzyme regulation, overview Rous sarcoma virus
a

Source Tissue

Source Tissue Comment Organism Textmining
bladder Frk, Src, Fyn, Yes Homo sapiens
-
brain Frk, Src, Fyn, Yes Homo sapiens
-
breast Frk, Brk, Src, Fyn, Yes Homo sapiens
-
colon Brk, Frk, Src, Fyn, Yes Homo sapiens
-
hematopoietic cell Blk, Fgr, Hck, Lck, and Lyn, primarily, Src, Fyn, Yes Homo sapiens
-
keratinocyte Srm, Src, Fyn, Yes Homo sapiens
-
lymphoid cell Frk, Src, Fyn, Yes Homo sapiens
-
additional information Src is dormant during most of the cell cycle, Src, Fyn, Yes are expressed in all cell types Homo sapiens
-
prostate Brk, Src, Fyn, Yes Homo sapiens
-
small intestine Brk, Src, Fyn, Yes Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
 Gallus gallus ADP + a [protein]-L-tyrosine phosphate
-
 ?
ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?
ATP + a [protein]-L-tyrosine
-
 Rous sarcoma virus ADP + a [protein]-L-tyrosine phosphate
-
 ?
ATP + a [protein]-L-tyrosine substrate docking-site and binding structure of Src involving R279, R281, and R283 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?
additional information Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview Gallus gallus ?
-
 ?
additional information Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview Homo sapiens ?
-
 ?
additional information Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview Rous sarcoma virus ?
-
 ?

Subunits

Subunits Comment Organism
More enzyme consists of an N-terminal myristoyl group, a unique segment, a SH2 and a SH3 domain, protein-tyrosine kinase domain, and a C-terminal regulatory domain, Src protein-tyrosine kinase structure and organization, overview Gallus gallus
More enzyme consists of an N-terminal myristoyl group, a unique segment, a SH2 and a SH3 domain, protein-tyrosine kinase domain, and a C-terminal regulatory domain, Src protein-tyrosine kinase structure and organization, overview Rous sarcoma virus
More enzyme consists of an N-terminal myristoyl group, a unique segment, a SH2 and a SH3 domain, protein-tyrosine kinase domain, and a C-terminal regulatory domain, Src protein-tyrosine kinase structure and organization, overview, active and inactive conformation of Src, structure of Csk Homo sapiens

Synonyms

Synonyms Comment Organism
Blk
-
 Homo sapiens
Brk
-
 Homo sapiens
C-terminal Src kinase
-
 Homo sapiens
Csk
-
 Homo sapiens
Fgr
-
 Homo sapiens
FRK
-
 Homo sapiens
Fyn
-
 Homo sapiens
HCK
-
 Homo sapiens
Lck
-
 Homo sapiens
Lyn
-
 Homo sapiens
More the Src kinase family contains 11 members, i.e. protein tyrosine kinases Blk, Brk, Fgr, Frk, Fyn, Hck, Lck, Lyn, Src, Srm, and Yes Homo sapiens
PTK
-
 Homo sapiens
Src
-
 Gallus gallus
Src
-
 Homo sapiens
Src protein-tyrosine kinase
-
 Gallus gallus
Src protein-tyrosine kinase
-
 Homo sapiens
Src protein-tyrosine kinase
-
 Rous sarcoma virus
Srm
-
 Homo sapiens
v-Src
-
 Rous sarcoma virus
Yes
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP as MgATP-, binding site structure Homo sapiens
ATP as MgATP2-, binding site structure Gallus gallus
ATP as MgATP2-, binding site structure Rous sarcoma virus