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(2,4-dichlorophenyl)hydrazine
-
-
(2-bromo-4-fluorophenyl)hydrazine
-
-
(4-chloro-2-fluorophenyl)hydrazine
-
-
1-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenyl)-3-(3-(trifluoromethyl)phenyl)urea
-
-
1-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenyl)-3-(4-chlorophenyl)urea
-
-
1-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenyl)-3-methylurea
-
-
2,4-dichloro-N-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenylcarbamoyl)benzamide
-
-
2,6-dichloro-N-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenylcarbamoyl)benzamide
-
-
2-(2,4-dichloro-5-propoxyphenyl)-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
-
2-(3-amino-4-chlorophenyl)-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
-
2-(4-bromo-2-fluoro-5-hydroxyphenyl)-3-(prop-2-en-1-yloxy)-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
-
2-(4-bromo-2-fluoro-5-hydroxyphenyl)-3-hydroxy-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
-
2-(4-chloro-2-ethoxy-5-nitrophenyl)-3-hydroxy-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
-
2-(4-chloro-2-fluoro-5-methoxyphenyl)-3-hydroxyoctahydro-1H-isoindol-1-one
-
-
2-(4-chloro-2-fluoro-5-methoxyphenyl)-3-methoxy-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
-
2-(4-chloro-2-fluoro-5-methoxyphenyl)hexahydro-1H-isoindole-1,3(2H)-dione
-
-
2-(4-chloro-2-fluoro-5-propoxy-phenyl)-2,3,4,5,6,7-hexahydro-isoindol-1-one
-
-
2-(4-chloro-2-fluoro-5-[(3-fluorobenzyl)oxy]phenyl)-3-hydroxy-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
-
2-(4-chloro-5-ethoxy-2-fluorophenyl)-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
-
2-(4-chloro-5-[(3-chlorobenzyl)oxy]-2-fluorophenyl)-3-(prop-2-en-1-yloxy)-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
-
2-(4-chloro-5-[(3-chlorobenzyl)oxy]-2-fluorophenyl)-3-ethoxy-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
-
2-(4-chloro-5-[(3-chlorobenzyl)oxy]-2-fluorophenyl)-3-methoxy-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
-
2-(5-allyloxy-4-chloro-2-fluorophenyl)-2,3,4,5,6,7-hexahydro-isoindol-1-one
-
-
2-(6-(1,3-dioxoisoindolin-2-yl)-7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)acetonitrile
-
-
2-(7-fluoro-2-methyl-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-5-methylisoindoline-1,3-dione
-
-
2-(7-fluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-5-methylisoindoline-1,3-dione
-
-
2-(7-fluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-dione
-
-
2-chloro-N-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenylcarbamoyl)-6-fluorobenzamide
-
-
2-[2,4-dichloro-5-(prop-2-en-1-yloxy)phenyl]-3-hydroxy-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
-
2-[4-chloro-2-fluoro-5-(prop-2-en-1-yloxy)phenyl]-3-(prop-2-en-1-yloxy)-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
-
2-[4-chloro-2-fluoro-5-(prop-2-en-1-yloxy)phenyl]-3-hydroxy-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
-
2-[4-chloro-2-fluoro-5-(prop-2-en-1-yloxy)phenyl]-3-hydroxyoctahydro-1H-isoindol-1-one
-
-
2-[4-chloro-2-fluoro-5-(prop-2-yn-1-yloxy)phenyl]-3-hydroxyoctahydro-1H-isoindol-1-one
-
-
2-[4-chloro-2-fluoro-5-(propan-2-yloxy)phenyl]-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
-
2-[4-chloro-5-(cyclopentyloxy)-2-fluorophenyl]-3-hydroxyoctahydro-1H-isoindol-1-one
-
-
3-(2-bromo-4-fluoro-5-nitrophenyl)-5-tert-butyl-1,3,4-oxadiazol-2(3H)-one
-
-
3-(2-bromo-4-fluorophenyl)-5-tert-butyl-1,3,4-oxadiazol-2(3H)-one
-
-
3-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenyl)-1,1-diisopropylurea
-
-
3-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)phenyl)-1,1-diisopropylurea
-
-
3-(5-amino-2,4-dichlorophenyl)-5-tert-butyl-1,3,4-oxadiazol-2(3H)-one
-
-
3-(5-amino-2-bromo-4-fluorophenyl)-5-tert-butyl-1,3,4-oxadiazol-2(3H)-one
-
-
3-(5-amino-4-chloro-2-fluorophenyl)-5-tert-butyl-1,3,4-oxadiazol-2(3H)-one
-
-
3-(6-bromo-2-[(3-methylbut-2-en-1-yl)sulfanyl]-1,3-benzothiazol-5-yl)-5-tert-butyl-1,3,4-oxadiazol-2(3H)-one
-
-
3-chloro-N-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenyl)-2,2-dimethylpropanamide
-
-
3-[6-bromo-2-(prop-2-yn-1-ylsulfanyl)-1,3-benzothiazol-5-yl]-5-tert-butyl-1,3,4-oxadiazol-2(3H)-one
-
-
3-[6-bromo-2-(prop-2-yn-1-ylsulfanyl)-1,3-benzothiazol-5-yl]-5-tert-butyl-1,3,4-thiadiazol-2(3H)-one
-
-
4-fluoro-2-(7-fluoro-2-methyl-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-dione
-
-
5-tert-butyl-3-(2,4-dichloro-5-nitrophenyl)-1,3,4-oxadiazol-2(3H)-one
-
-
5-tert-butyl-3-(2,4-dichlorophenyl)-1,3,4-oxadiazol-2(3H)-one
-
-
5-tert-butyl-3-(2-[(3,3-dichloroprop-2-en-1-yl)sulfanyl]-6-fluoro-1,3-benzothiazol-5-yl)-1,3,4-oxadiazol-2(3H)-one
-
-
5-tert-butyl-3-(4-chloro-2-fluoro-5-nitrophenyl)-1,3,4-oxadiazol-2(3H)-one
-
-
5-tert-butyl-3-(4-chloro-2-fluorophenyl)-1,3,4-oxadiazol-2(3H)-one
-
-
5-tert-butyl-3-(6-chloro-2-[(3,3-dichloroprop-2-en-1-yl)sulfanyl]-1,3-benzothiazol-5-yl)-1,3,4-oxadiazol-2(3H)-one
-
-
5-tert-butyl-3-[6-chloro-2-(prop-2-en-1-ylsulfanyl)-1,3-benzothiazol-5-yl]-1,3,4-oxadiazol-2(3H)-one
-
-
5-tert-butyl-3-[6-chloro-2-(prop-2-yn-1-ylsulfanyl)-1,3-benzothiazol-5-yl]-1,3,4-oxadiazol-2(3H)-one
-
-
5-tert-butyl-3-[6-chloro-2-(prop-2-yn-1-ylsulfanyl)-1,3-benzothiazol-5-yl]-1,3,4-thiadiazol-2(3H)-one
-
-
5-tert-butyl-3-[6-fluoro-2-(prop-2-en-1-ylsulfanyl)-1,3-benzothiazol-5-yl]-1,3,4-oxadiazol-2(3H)-one
-
-
5-tert-butyl-3-[6-fluoro-2-(prop-2-yn-1-ylsulfanyl)-1,3-benzothiazol-5-yl]-1,3,4-oxadiazol-2(3H)-one
-
-
5-tert-butyl-3-[6-fluoro-2-(prop-2-yn-1-ylsulfanyl)-1,3-benzothiazol-5-yl]-1,3,4-thiadiazol-2(3H)-one
-
-
bilirubin
-
inhibition potency with recombinant wild-type and mutant enzymes, overview
biliverdin IX hydrochloride
-
inhibition potency with recombinant wild-type and mutant enzymes, overview
cobalt-protoporphyrin
-
-
diphenylene iodonium
-
50% inhibition at 0.1 mM
ethyl (2,4-dichloro-5-[(E)-[(2-hydroxynaphthalen-1-yl)methylidene]amino]phenoxy)acetate
-
-
-
ethyl (2,4-dichloro-5-[[(Z)-[4-oxo-2-[(propan-2-yl)oxy]-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]phenoxy)acetate
-
-
-
ethyl (2,4-dichloro-5-[[(Z)-[6-fluoro-4-oxo-2-[(propan-2-yl)oxy]-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]phenoxy)acetate
-
-
-
ethyl (2,4-dichloro-5-[[(Z)-[6-nitro-4-oxo-2-[(propan-2-yl)oxy]-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]phenoxy)acetate
-
-
-
ethyl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
-
ethyl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
-
ethyl ([6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
-
ethyl 2-((5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-2(3H)-yl)-6-fluorobenzothiazol-2-yl)sulfanyl)propanoate
-
with a broad spectrum of postemergence herbicidal activity
ethyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-2-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)-2-phenylacetate
-
-
ethyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-2-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)acetate
-
-
ethyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-2-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)propanoate
-
-
ethyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)butanoate
-
-
ethyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)propanoate
-
-
ethyl 2-([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)-2-methylpropanoate
-
-
ethyl 2-([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)-2-methylpropanoate
-
-
ethyl 2-([6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl)propanoate
-
-
ethyl 2-[2-chloro-4-fluoro-5-(1-hydroxy-3-oxooctahydro-2H-isoindol-2-yl)phenoxy]propanoate
-
-
ethyl 2-[2-chloro-5-(1,3-dioxooctahydro-2H-isoindol-2-yl)-4-fluorophenoxy]propanoate
-
-
ethyl 3-([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)butanoate
-
-
ethyl 3-([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)propanoate
-
-
ethyl 3-([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)propanoate
-
-
ethyl 3-([6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl)propanoate
-
-
ethyl 4-([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)butanoate
-
-
ethyl 4-([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)butanoate
-
-
ethyl 4-([6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl)butanoate
-
-
ethyl [2,4-dichloro-5-[(E)-(2,5-dihydroxybenzylidene)amino]phenoxy]acetate
-
-
-
ethyl [2,4-dichloro-5-[(E)-(2-hydroxy-3-methoxybenzylidene)amino]phenoxy]acetate
-
-
-
ethyl [2,4-dichloro-5-[(E)-(2-hydroxy-4-methylbenzylidene)amino]phenoxy]acetate
-
-
-
ethyl [2,4-dichloro-5-[(E)-(5-chloro-2-hydroxybenzylidene)amino]phenoxy]acetate
-
-
-
ethyl [2-chloro-4-fluoro-5-(1-hydroxy-3-oxooctahydro-2H-isoindol-2-yl)phenoxy]acetate
-
-
ethyl [2-chloro-5-(1,3-dioxooctahydro-2H-isoindol-2-yl)-4-fluorophenoxy]acetate
-
-
ethyl [[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
ethyl [[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
heme
-
0.001 mM cause 25% inhibition
metalloporphyrin
-
Mn- and Co-protoporphyrin, weak inhibition by Cd-, Ni- and Fe-protoporphyrin, 5 min preincubation
-
methyl (2E)-4-([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)but-2-enoate
-
-
methyl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
-
methyl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
-
methyl ([6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
-
methyl 2-((5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-6-fluorobenzothiazol-2-yl)thio)acetate
-
-
methyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-2-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)acetate
-
-
methyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-2-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)propanoate
-
-
methyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)butanoate
-
-
methyl 3-[2-chloro-5-(3,5-dimethyl-2,6-dioxo-4-sulfanylidene-1,3,5-triazinan-1-yl)-4-fluorophenyl]-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxylate
-
i.e. BaR-2
-
methyl acifluorfen
-
inhibition potency with recombinant wild-type and mutant enzymes, overview
methyl [[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
methyl [[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
methyl [[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
methyl [[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
N'-(2,4-dichlorophenyl)-2,2-dimethylpropanehydrazide
-
-
N'-(2-bromo-4-fluorophenyl)-2,2-dimethylpropanehydrazide
-
-
N'-(4-chloro-2-fluorophenyl)-2,2-dimethylpropanehydrazide
-
-
N-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenylcarbamoyl)-3-(trifluoromethoxy)benzamide
-
-
N-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenylcarbamoyl)benzamide
-
-
N-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)phenylcarbamoyl)benzamide
-
-
pentoxazone
-
derived from chlorphthalim
phenyl 2-[[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 2-[[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 2-[[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl]-2-methylpropanoate
-
-
phenyl 2-[[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 2-[[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]-2-methylpropanoate
-
-
phenyl 2-[[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 2-[[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl]-2-methylpropanoate
-
-
phenyl 2-[[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 2-[[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]-2-methylpropanoate
-
-
phenyl 2-[[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl]-2-methylpropanoate
-
-
phenyl 2-[[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 2-[[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl]-2-methylpropanoate
-
-
phenyl 2-[[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 2-[[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]-2-methylpropanoate
-
-
phenyl 2-[[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 2-[[6-chloro-5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 3-[[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 3-[[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 3-[[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 3-[[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 3-[[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 3-[[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 3-[[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 3-[[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 3-[[6-chloro-5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
-
phenyl 4-[[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl]butanoate
-
-
phenyl 4-[[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]butanoate
-
-
phenyl 4-[[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl]butanoate
-
-
phenyl 4-[[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]butanoate
-
-
phenyl 4-[[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl]butanoate
-
-
phenyl 4-[[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl]butanoate
-
-
phenyl 4-[[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]butanoate
-
-
phenyl [[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
phenyl [[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
phenyl [[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
phenyl [[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
phenyl [[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
phenyl [[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
phenyl [[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
propan-2-yl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
-
propan-2-yl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
-
propan-2-yl ([6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
-
propan-2-yl [[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
propan-2-yl [[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
propan-2-yl [[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
propan-2-yl [[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
propyl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
-
propyl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
-
propyl ([6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
-
propyl [[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
propyl [[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
propyl [[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
propyl [[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
S-(5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-6-fluorobenzothiazol-2-yl) O-methyl carbonothioate
-
-
S-[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl] O-phenyl carbonothioate
-
-
S-[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl] O-ethyl carbonothioate
-
-
S-[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl] O-phenyl carbonothioate
-
-
S-[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl] O-ethyl carbonothioate
-
-
S-[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl] O-methyl carbonothioate
-
-
S-[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl] O-phenyl carbonothioate
-
-
S-[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl] O-ethyl carbonothioate
-
-
S-[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl] O-methyl carbonothioate
-
-
S-[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl] O-phenyl carbonothioate
-
-
tert-butyl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
-
tert-butyl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
-
tert-butyl [[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
-
acifluorfen
-
-
acifluorfen
-
competitive
acifluorfen
-
inhibition potency with recombinant wild-type and mutant enzymes, overview
oxadiargyl
-
derived from chlorphthalim
oxadiargyl
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i.e. 3-[2,4-dichloro-5-(2-propynyloxy)phenyl]-5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-(3H)-one, an important PPO-inhibiting commercial herbicide
oxadiazon
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derived from chlorphthalim
sulfentrazone
-
derived from chlorphthalim
additional information
-
-
-
additional information
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inhibited by diphenylether herbicides; inhibited by tetrahydrophtalimide
-
additional information
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bioactive conformation analysis of cyclic imides as protoporphyrinogen oxidase inhibitor by combining density functional theory-based conformation calculations, quantitative structureactivity relationship analysis, and molecular docking and dynamic simulations, detailed overview
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additional information
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design, syntheses and crystal structures of N-phenyl pyrrolidin-2-ones and N-phenyl-1H-pyrrol-2-ones as protoporphyrinogen oxidase inhibitors, quantitative structure-activity relationships, overview
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additional information
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design and synthesis of benzothiazole analogues of oxadiargyl, evaluation as enzyme inhibitors, quantitative structure-activity relationships, overview. Herbicidal potencies of inhibitors in several different plants, overview
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additional information
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quantitative structure-activity relationships of 1,3,4-thiadiazol-2(3H)-ones and 1,3,4-oxadiazol-2(3H)-ones as human protoporphyrinogen oxidase inhibitors, 23 1,3,4-thiadiazol-2(3H)-ones bearing benzothiazole substructure are designed and synthesized, overview
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additional information
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design and syntheses of N-(benzothiazol-5-yl)-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione and N-(benzothiazol-5-yl)isoindoline-1,3-dione as potent protoporphyrinogen oxidase inhibitors, herbicidal activities of the compounds, overview
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additional information
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mechanism of substrate recognition and feedback inhibition of protoporphyrinogen oxidase, overview
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additional information
prediction of the resistance associated with target mutations in enzyme PPO and analysis of the resistance mechanisms of typical PPO-inhibiting herbicides by a computational protocol, computational mutation scanning (CMS), using the human enzyme structure for the modeling, interaction patterns, overview. Ab initio quantum mechanics calculations are performed for inhibitor optimization at the HF/6-31+G level to determine the electrostatic potential by using the restrained electrostatic potential (RESP) method according to the Merz-Singh-Kollman scheme
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additional information
analysis of the mechanism of substrate recognition and feedback inhibition of protoporphyrinogen oxidase, kinetics, overview
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Adenocarcinoma
Protoporphyrinogen oxidase is involved in the fluorescence intensity of 5-aminolevulinic acid-mediated laser-based photodynamic endoscopic diagnosis for early gastric cancer.
Anemia
The ubiquitous mitochondrial protein unfoldase CLPX regulates erythroid heme synthesis by control of iron utilization and heme synthesis enzyme activation and turnover.
Anemia, Hypochromic
montalcino, A zebrafish model for variegate porphyria.
Carcinogenesis
?-catenin Mutations Are Not Involved in Early-stage Hepatocarcinogenesis Induced by Protoporphyrinogen Oxidase Inhibitors in Mice.
Carcinoma
Protoporphyrinogen oxidase is involved in the fluorescence intensity of 5-aminolevulinic acid-mediated laser-based photodynamic endoscopic diagnosis for early gastric cancer.
Carcinoma, Hepatocellular
Hepatocellular carcinoma in variegate porphyria: a serious complication.
Colonic Neoplasms
Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment.
Congenital Abnormalities
Novel PPOX exonic mutation inducing aberrant splicing in a patient with homozygous variegate porphyria.
Coproporphyria, Hereditary
A next-generation-sequencing panel for mutational analysis of dominant acute hepatic porphyrias.
Coproporphyria, Hereditary
International Porphyria Molecular Diagnostic Collaborative: an evidence-based database of verified pathogenic and benign variants for the porphyrias.
Coproporphyria, Hereditary
Modulation of penetrance by the wild-type allele in dominantly inherited erythropoietic protoporphyria and acute hepatic porphyrias.
Coproporphyria, Hereditary
Seven Novel Mutations in Bulgarian Patients with Acute Hepatic Porphyrias (AHP).
Coproporphyria, Hereditary
The porphyrias.
Dehydration
Stress effects of flumioxazin herbicide on grapevine ( Vitis vinifera L.) grown in vitro.
Genetic Diseases, Inborn
Clinical exome sequencing: results from 2819 samples reflecting 1000 families.
Glioblastoma
Protoporphyrin IX fluorescence kinetics in C6 glioblastoma cells after delta-aminolevulinic acid incubation: effect of a protoporphyrinogen oxidase inhibitor.
Glioma
TCGA mRNA Expression Analysis of the Heme Biosynthesis Pathway in Diffusely Infiltrating Gliomas: A Comparison of Typically 5-ALA Fluorescent and Non-Fluorescent Gliomas.
Heart Septal Defects, Ventricular
Different effects of an N-phenylimide herbicide on heme biosynthesis between human and rat erythroid cells.
Heart Septal Defects, Ventricular
Histological changes in rat embryonic blood cells as a possible mechanism for ventricular septal defects produced by an N-phenylimide herbicide.
Heart Septal Defects, Ventricular
Mechanism of Developmental Effects in Rats Caused by an N-Phenylimide Herbicide: Transient Fetal Anemia and Sequelae during Mid-to-Late Gestation.
hydroxymethylbilane synthase deficiency
Variegate porphyria with coexistent decrease in porphobilinogen deaminase activity.
Intellectual Disability
Molecular characterization of homozygous variegate porphyria.
Leukemia, Erythroblastic, Acute
Cloning, sequence, and expression of mouse protoporphyrinogen oxidase.
Liver Diseases, Alcoholic
Coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase activities in human liver biopsies with special reference to alcoholic liver disease.
Liver Neoplasms
Biallelic inactivation of protoporphyrinogen oxidase and hydroxymethylbilane synthase is associated with liver cancer in acute porphyrias.
Metabolic Diseases
Clinical and biochemical characteristics and genotype-phenotype correlation in Finnish variegate porphyria patients.
Metabolic Diseases
Diagnosis of variegate porphyria--hard to get?
Neoplasms
Biallelic inactivation of protoporphyrinogen oxidase and hydroxymethylbilane synthase is associated with liver cancer in acute porphyrias.
Neoplasms
Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment.
Neoplasms
Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development.
Neoplasms
Photodynamic therapy using a protoporphyrinogen oxidase inhibitor.
Neoplasms
RRM analysis of protoporphyrinogen oxidase.
Neoplasms
Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism.
Photosensitivity Disorders
Molecular characterization of homozygous variegate porphyria.
Porphyria, Acute Intermittent
A next-generation-sequencing panel for mutational analysis of dominant acute hepatic porphyrias.
Porphyria, Acute Intermittent
Acute porphyrias in the Argentinean population: a review.
Porphyria, Acute Intermittent
Biallelic inactivation of protoporphyrinogen oxidase and hydroxymethylbilane synthase is associated with liver cancer in acute porphyrias.
Porphyria, Acute Intermittent
Chester porphyria: biochemical studies of a new form of acute porphyria.
Porphyria, Acute Intermittent
Diagnostic strategies for autosomal dominant acute porphyrias: retrospective analysis of 467 unrelated patients referred for mutational analysis of the HMBS, CPOX, or PPOX gene.
Porphyria, Acute Intermittent
Evidence for involvement of a second genetic locus on chromosome 11q in porphyrin metabolism.
Porphyria, Acute Intermittent
Genetic and biochemical studies in Argentinean patients with variegate porphyria.
Porphyria, Acute Intermittent
International Porphyria Molecular Diagnostic Collaborative: an evidence-based database of verified pathogenic and benign variants for the porphyrias.
Porphyria, Acute Intermittent
Modulation of penetrance by the wild-type allele in dominantly inherited erythropoietic protoporphyria and acute hepatic porphyrias.
Porphyria, Acute Intermittent
Seven Novel Mutations in Bulgarian Patients with Acute Hepatic Porphyrias (AHP).
Porphyria, Acute Intermittent
The porphyrias.
Porphyria, Acute Intermittent
Variegate porphyria with coexistent decrease in porphobilinogen deaminase activity.
Porphyria, Variegate
A case of association between hepatocellular carcinoma and porphyria variegata.
Porphyria, Variegate
A Case Report of Porphyria Variegata Management in the Emergency Department.
Porphyria, Variegate
A next-generation-sequencing panel for mutational analysis of dominant acute hepatic porphyrias.
Porphyria, Variegate
A R59W mutation in human protoporphyrinogen oxidase results in decreased enzyme activity and is prevalent in South Africans with variegate porphyria.
Porphyria, Variegate
A spectrum of novel mutations in the protoporphyrinogen oxidase gene in 13 families with variegate porphyria.
Porphyria, Variegate
Acute porphyrias in the Argentinean population: a review.
Porphyria, Variegate
Antioxidants restore protoporphyrinogen oxidase in variegate porphyria patients.
Porphyria, Variegate
Biallelic inactivation of protoporphyrinogen oxidase and hydroxymethylbilane synthase is associated with liver cancer in acute porphyrias.
Porphyria, Variegate
Characterisation of the flavin adenine dinucleotide binding region of
Porphyria, Variegate
Chester porphyria: biochemical studies of a new form of acute porphyria.
Porphyria, Variegate
Clinical and biochemical characteristics and genotype-phenotype correlation in Finnish variegate porphyria patients.
Porphyria, Variegate
Cloning and characterization of the yeast HEM14 gene coding for protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides.
Porphyria, Variegate
Coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase activities in human liver biopsies with special reference to alcoholic liver disease.
Porphyria, Variegate
Demystification of Chester porphyria: a nonsense mutation in the Porphobilinogen Deaminase gene.
Porphyria, Variegate
Diagnosis of variegate porphyria--hard to get?
Porphyria, Variegate
Effect of tiagabine and topiramate on porphyrin metabolism in an in vivo model of porphyria.
Porphyria, Variegate
Enzyme antioxidant defences and oxidative damage in red blood cells of variegate porphyria patients.
Porphyria, Variegate
Enzyme defects in the porphyrias and their relevance to the biochemical abnormalities in these disorders.
Porphyria, Variegate
Expression and characterization of six mutations in the protoporphyrinogen oxidase gene among Finnish variegate porphyria patients.
Porphyria, Variegate
Extended haplotype studies in South African and Dutch variegate porphyria families carrying the recurrent p.R59W mutation confirm a common ancestry.
Porphyria, Variegate
Functional Characterization of Five Protoporphyrinogen oxidase Missense Mutations Found in Argentinean Variegate Porphyria Patients.
Porphyria, Variegate
Functional studies of mutations in the human protoporphyrinogen oxidase gene in variegate porphyria.
Porphyria, Variegate
Gene symbol: PPOX. Disease: Porphyria, variegate.
Porphyria, Variegate
Gene symbol: PPOX. Disease: variegate porphyria.
Porphyria, Variegate
Genetic analysis of variegate porphyria (VP) in Italy: identification of six novel mutations in the protoporphyrinogen oxidase (PPOX) gene.
Porphyria, Variegate
Genetic and biochemical studies in Argentinean patients with variegate porphyria.
Porphyria, Variegate
Gne symbol: PPOX. Disease: variegate porphyria.
Porphyria, Variegate
Haplotype analysis excludes the functional protoporphyrinogen oxidase promoter polymorphism -1081G>A as a modifying factor in the clinical expression of variegate porphyria.
Porphyria, Variegate
Hepatocellular carcinoma in variegate porphyria: a case report and literature review.
Porphyria, Variegate
Hepatocellular carcinoma in variegate porphyria: a serious complication.
Porphyria, Variegate
Homozygous variegate porphyria in South Africa: genotypic analysis in two cases.
Porphyria, Variegate
Homozygous variegate porphyria. A severe skin disease of infancy.
Porphyria, Variegate
Homozygous variegate porphyria: a compound heterozygote with novel mutations in the protoporphyrinogen oxidase gene.
Porphyria, Variegate
Homozygous variegate porphyria: identification of mutations on both alleles of the protoporphyrinogen oxidase gene in a severely affected proband.
Porphyria, Variegate
Identification and characterisation of a deletion (537delAT) in the protoporphyrinogen oxidase gene in a South African variegate porphyria family.
Porphyria, Variegate
Identification of a founder mutation in the protoporphyrinogen oxidase gene in variegate porphyria patients from chile.
Porphyria, Variegate
Identification of a recurrent mutation in the protoporphyrinogen oxidase gene in Swiss patients with variegate porphyria: clinical and genetic implications.
Porphyria, Variegate
Identification of the first variegate porphyria mutation in an indigenous black South African and further evidence for heterogeneity in variegate porphyria.
Porphyria, Variegate
Identification of three mutations and associated haplotypes in the protoporphyrinogen oxidase gene in South African families with variegate porphyria.
Porphyria, Variegate
International Porphyria Molecular Diagnostic Collaborative: an evidence-based database of verified pathogenic and benign variants for the porphyrias.
Porphyria, Variegate
Kinetic and physical characterisation of recombinant wild-type and mutant human protoporphyrinogen oxidases.
Porphyria, Variegate
King George III and porphyria: an elemental hypothesis and investigation.
Porphyria, Variegate
Lack of the R59W South African founder effect mutation in protoporphyrinogen oxidase in a British patient with homozygous variegate porphyria.
Porphyria, Variegate
Mitochondrial targeting of human protoporphyrinogen oxidase.
Porphyria, Variegate
Molecular analysis reveals a high mutation frequency in the first untranslated exon of the PPOX gene and largely excludes variegate porphyria in a subset of clinically affected Afrikaner families.
Porphyria, Variegate
Molecular basis of variegate porphyria: a de novo insertion mutation in the protoporphyrinogen oxidase gene.
Porphyria, Variegate
Molecular basis of variegate porphyria: a missense mutation in the protoporphyrinogen oxidase gene.
Porphyria, Variegate
Molecular characterization of homozygous variegate porphyria.
Porphyria, Variegate
montalcino, A zebrafish model for variegate porphyria.
Porphyria, Variegate
mRNA-based therapy in a rabbit model of variegate porphyria offers new insights into the pathogenesis of acute attacks.
Porphyria, Variegate
Mutations in the protoporphyrinogen oxidase gene in patients with variegate porphyria.
Porphyria, Variegate
Mutations in the translation initiation codon of the protoporphyrinogen oxidase gene underlie variegate porphyria.
Porphyria, Variegate
Nine novel mutations in the protoporphyrinogen oxidase gene in Swedish families with variegate porphyria.
Porphyria, Variegate
Novel heterozygous mutation of protoporphyrinogen oxidase gene in a Chinese patient with variegate porphyria.
Porphyria, Variegate
Novel human pathological mutations. Gene symbol: PPOX. Disease: porphyria, variegate.
Porphyria, Variegate
Novel PPOX exonic mutation inducing aberrant splicing in a patient with homozygous variegate porphyria.
Porphyria, Variegate
Partial characterization and assignment of the gene for protoporphyrinogen oxidase and variegate porphyria to human chromosome 1q23.
Porphyria, Variegate
Partial protoporphyrinogen oxidase (PPOX) gene deletions, due to different Alu-mediated mechanisms, identified by MLPA analysis in patients with variegate porphyria.
Porphyria, Variegate
Plasma fluorescence scanning and fecal porphyrin analysis for the diagnosis of variegate porphyria: precise determination of sensitivity and specificity with detection of protoporphyrinogen oxidase mutations as a reference standard.
Porphyria, Variegate
Protoporphyrin accumulation by mitogen stimulated lymphocytes and protoporphyrinogen oxidase activity in patients with porphyria variegata and erythropoietic protoporphyria: evidence for deficiency of protoporphyrinogen oxidase and ferrochelatase in both diseases.
Porphyria, Variegate
Protoporphyrinogen oxidase and ferrochelatase in porphyria variegata.
Porphyria, Variegate
Protoporphyrinogen oxidase and porphobilinogen deaminase in variegate porphyria.
Porphyria, Variegate
Protoporphyrinogen oxidase in porphyria variegata. A report of the findings in 7 families.
Porphyria, Variegate
Protoporphyrinogen oxidase: complete genomic sequence and polymorphisms in the human gene.
Porphyria, Variegate
Quantitative Structural Insight into Human Variegate Porphyria Disease.
Porphyria, Variegate
Recovery from a variegate porphyria by a liver transplantation.
Porphyria, Variegate
Recurrent missense mutation in the protoporphyrinogen oxidase gene underlies variegate porphyria.
Porphyria, Variegate
Seven Novel Mutations in Bulgarian Patients with Acute Hepatic Porphyrias (AHP).
Porphyria, Variegate
Single-strand conformational polymorphism and denaturing gradient gel electrophoresis in screening for variegate porphyria: identification of two new mutations.
Porphyria, Variegate
Spectrum of mutations in the HFE gene implicated in haemochromatosis and porphyria.
Porphyria, Variegate
Swiss patients with variegate porphyria have unique mutations.
Porphyria, Variegate
The assessment of noncoding variant of PPOX gene in variegate porphyria reveals post-transcriptional role of the 5' untranslated exon 1.
Porphyria, Variegate
The enzymatic defect in variegate prophyria. Studies with human cultured skin fibroblasts.
Porphyria, Variegate
The genetic basis of "Scarsdale Gourmet Diet" variegate porphyria: a missense mutation in the protoporphyrinogen oxidase gene.
Porphyria, Variegate
The inherited enzymatic defect in porphyria variegata.
Porphyria, Variegate
The porphyrias.
Porphyria, Variegate
Three novel mutations in the protoporphyrinogen oxidase gene in Japanese patients with variegate porphyria.
Porphyria, Variegate
Transient Worsening of Photosensitivity due to Cholelithiasis in a Variegate Porphyria Patient.
Porphyria, Variegate
Two new mutations (H106P and L178V) in the protoporphyrinogen oxidase gene in Argentinean patients with variegate porphyria.
Porphyria, Variegate
Two new mutations in the PPOX gene in a patient with variegate porphyria.
Porphyria, Variegate
Variegate porphyria in a 46-year-old patient taking sibutramine for weight loss.
Porphyria, Variegate
Variegate porphyria in South Africa, 1688-1996--new developments in an old disease.
Porphyria, Variegate
Variegate porphyria in Western Australian Aboriginal patients.
Porphyria, Variegate
Variegate porphyria in Western Europe: identification of PPOX gene mutations in 104 families, extent of allelic heterogeneity, and absence of correlation between phenotype and type of mutation.
Porphyria, Variegate
Variegate porphyria with coexistent decrease in porphobilinogen deaminase activity.
Porphyria, Variegate
Variegate porphyria.
Porphyria, Variegate
Variegate porphyria: diagnostic value of fluorometric scanning of plasma porphyrins.
Porphyria, Variegate
Variegate porphyria: identification of a nonsense mutation in the protoporphyrinogen oxidase gene.
Porphyria, Variegate
Variegate porphyria: past, present and future.
Porphyria, Variegate
[Identification of mutations in the protoporphyrin oxidase gene and its diagnostic implications in porphyria variegata in Chile]
Porphyria, Variegate
[Solarium-induced pseudoporphyria and variegate porphyria as rare differential diagnoses of porphyria cutanea tarda]
Porphyrias
A next-generation-sequencing panel for mutational analysis of dominant acute hepatic porphyrias.
Porphyrias
Acute hepatic porphyrias: Identification of 46 hydroxymethylbilane synthase, 11 coproporphyrinogen oxidase, and 20 protoporphyrinogen oxidase novel mutations.
Porphyrias
Biallelic inactivation of protoporphyrinogen oxidase and hydroxymethylbilane synthase is associated with liver cancer in acute porphyrias.
Porphyrias
Characteristics of human protoporphyrinogen oxidase in controls and variegate porphyrias.
Porphyrias
Characterization of Variegate Porphyria Mutations Using a Minigene Approach.
Porphyrias
Chester porphyria: biochemical studies of a new form of acute porphyria.
Porphyrias
Digenic Inheritance of Mutations in the Coproporphyrinogen Oxidase and Protoporphyrinogen Oxidase Genes in a Unique Type of Porphyria.
Porphyrias
Evidence for involvement of a second genetic locus on chromosome 11q in porphyrin metabolism.
Porphyrias
Functional Characterization of Five Protoporphyrinogen oxidase Missense Mutations Found in Argentinean Variegate Porphyria Patients.
Porphyrias
Gene symbol: PPOX. Disease: Porphyria, variegate.
Porphyrias
Gene symbol: PPOX. Disease: variegate porphyria.
Porphyrias
Gne symbol: PPOX. Disease: variegate porphyria.
Porphyrias
International Porphyria Molecular Diagnostic Collaborative: an evidence-based database of verified pathogenic and benign variants for the porphyrias.
Porphyrias
Modulation of penetrance by the wild-type allele in dominantly inherited erythropoietic protoporphyria and acute hepatic porphyrias.
Porphyrias
Molecular characterization of porphyrias in Italy: a diagnostic flow-chart.
Porphyrias
Novel human pathological mutations. Gene symbol: PPOX. Disease: porphyria, variegate.
Porphyrias
Overrepresentation of the founder PPOX gene mutation R59W in a South African patient with severe clinical manifestation of porphyria.
Porphyrias
Protoporphyrinogen oxidase as a molecular target for diphenyl ether herbicides.
Porphyrias
Seven Novel Mutations in Bulgarian Patients with Acute Hepatic Porphyrias (AHP).
Porphyrias
Swiss patients with variegate porphyria have unique mutations.
Porphyrias
The porphyrias.
Porphyrias
The ubiquitous mitochondrial protein unfoldase CLPX regulates erythroid heme synthesis by control of iron utilization and heme synthesis enzyme activation and turnover.
Porphyrias
Uroporphyrinogen decarboxylase and protoporphyrinogen oxidase in dual porphyria.
Porphyrias, Hepatic
A Case Report of Porphyria Variegata Management in the Emergency Department.
Porphyrias, Hepatic
Acute hepatic porphyrias: Identification of 46 hydroxymethylbilane synthase, 11 coproporphyrinogen oxidase, and 20 protoporphyrinogen oxidase novel mutations.
Porphyrias, Hepatic
Hepatocellular carcinoma in variegate porphyria: a serious complication.
Porphyrias, Hepatic
Identification of a recurrent mutation in the protoporphyrinogen oxidase gene in Swiss patients with variegate porphyria: clinical and genetic implications.
Porphyrias, Hepatic
International Porphyria Molecular Diagnostic Collaborative: an evidence-based database of verified pathogenic and benign variants for the porphyrias.
Porphyrias, Hepatic
Mutations in the protoporphyrinogen oxidase gene in patients with variegate porphyria.
Porphyrias, Hepatic
Mutations in the translation initiation codon of the protoporphyrinogen oxidase gene underlie variegate porphyria.
Porphyrias, Hepatic
Novel PPOX exonic mutation inducing aberrant splicing in a patient with homozygous variegate porphyria.
Porphyrias, Hepatic
Recovery from a variegate porphyria by a liver transplantation.
Porphyrias, Hepatic
Recurrent missense mutation in the protoporphyrinogen oxidase gene underlies variegate porphyria.
Porphyrias, Hepatic
The genetic basis of "Scarsdale Gourmet Diet" variegate porphyria: a missense mutation in the protoporphyrinogen oxidase gene.
Porphyrias, Hepatic
The porphyrias.
Porphyrias, Hepatic
Variegate porphyria: diagnostic value of fluorometric scanning of plasma porphyrins.
Porphyrias, Hepatic
Variegate porphyria: past, present and future.
Protoporphyria, Erythropoietic
Protoporphyrin accumulation by mitogen stimulated lymphocytes and protoporphyrinogen oxidase activity in patients with porphyria variegata and erythropoietic protoporphyria: evidence for deficiency of protoporphyrinogen oxidase and ferrochelatase in both diseases.
Protoporphyria, Erythropoietic
The porphyrias.
protoporphyrinogen oxidase deficiency
Cloning and characterization of the yeast HEM14 gene coding for protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides.
protoporphyrinogen oxidase deficiency
Molecular characterization of homozygous variegate porphyria.
Seizures
Molecular characterization of homozygous variegate porphyria.
Skin Diseases
Variegate porphyria in South Africa, 1688-1996--new developments in an old disease.
Stomach Neoplasms
Protoporphyrinogen oxidase is involved in the fluorescence intensity of 5-aminolevulinic acid-mediated laser-based photodynamic endoscopic diagnosis for early gastric cancer.
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0.000025
1-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenyl)-3-(3-(trifluoromethyl)phenyl)urea
-
-
0.000028
1-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenyl)-3-(4-chlorophenyl)urea
-
-
0.00037
1-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenyl)-3-methylurea
-
-
0.000027
2,4-dichloro-N-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenylcarbamoyl)benzamide
-
-
0.000013
2,6-dichloro-N-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenylcarbamoyl)benzamide
-
-
0.0003
2-(2,4-dichloro-5-propoxyphenyl)-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.02764
2-(3-amino-4-chlorophenyl)-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.04135
2-(4-bromo-2-fluoro-5-hydroxyphenyl)-3-(prop-2-en-1-yloxy)-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.01935
2-(4-bromo-2-fluoro-5-hydroxyphenyl)-3-hydroxy-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.3586
2-(4-chloro-2-ethoxy-5-nitrophenyl)-3-hydroxy-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.131
2-(4-chloro-2-fluoro-5-methoxyphenyl)-3-hydroxyoctahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
17.99
2-(4-chloro-2-fluoro-5-methoxyphenyl)-3-methoxy-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
44.77
2-(4-chloro-2-fluoro-5-methoxyphenyl)hexahydro-1H-isoindole-1,3(2H)-dione
-
pH not specified in the publication, temperature not specified in the publication
0.000095
2-(4-chloro-2-fluoro-5-propoxy-phenyl)-2,3,4,5,6,7-hexahydro-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.00078
2-(4-chloro-2-fluoro-5-[(3-fluorobenzyl)oxy]phenyl)-3-hydroxy-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0002
2-(4-chloro-5-ethoxy-2-fluorophenyl)-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.06658
2-(4-chloro-5-[(3-chlorobenzyl)oxy]-2-fluorophenyl)-3-(prop-2-en-1-yloxy)-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.00702
2-(4-chloro-5-[(3-chlorobenzyl)oxy]-2-fluorophenyl)-3-ethoxy-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
40.6
2-(4-chloro-5-[(3-chlorobenzyl)oxy]-2-fluorophenyl)-3-methoxy-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.00012
2-(5-allyloxy-4-chloro-2-fluorophenyl)-2,3,4,5,6,7-hexahydro-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.001
2-(6-(1,3-dioxoisoindolin-2-yl)-7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)acetonitrile
-
-
0.0048
2-(7-fluoro-2-methyl-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-5-methylisoindoline-1,3-dione
-
-
0.0028
2-(7-fluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-5-methylisoindoline-1,3-dione
-
-
0.0033
2-(7-fluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-dione
-
-
0.0000083
2-chloro-N-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenylcarbamoyl)-6-fluorobenzamide
-
-
16.62
2-[2,4-dichloro-5-(prop-2-en-1-yloxy)phenyl]-3-hydroxy-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.03313
2-[4-chloro-2-fluoro-5-(prop-2-en-1-yloxy)phenyl]-3-(prop-2-en-1-yloxy)-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
40.6
2-[4-chloro-2-fluoro-5-(prop-2-en-1-yloxy)phenyl]-3-hydroxy-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.04483
2-[4-chloro-2-fluoro-5-(prop-2-en-1-yloxy)phenyl]-3-hydroxyoctahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.06363
2-[4-chloro-2-fluoro-5-(prop-2-yn-1-yloxy)phenyl]-3-hydroxyoctahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.00069
2-[4-chloro-2-fluoro-5-(propan-2-yloxy)phenyl]-2,3,4,5,6,7-hexahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.02464
2-[4-chloro-5-(cyclopentyloxy)-2-fluorophenyl]-3-hydroxyoctahydro-1H-isoindol-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.00023
3-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenyl)-1,1-diisopropylurea
-
-
0.00029
3-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)phenyl)-1,1-diisopropylurea
-
-
0.01863
3-(6-bromo-2-[(3-methylbut-2-en-1-yl)sulfanyl]-1,3-benzothiazol-5-yl)-5-tert-butyl-1,3,4-oxadiazol-2(3H)-one
-
pH 7.4, temperature not specified in the publication
0.00087
3-chloro-N-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenyl)-2,2-dimethylpropanamide
-
-
0.01112
3-[6-bromo-2-(prop-2-yn-1-ylsulfanyl)-1,3-benzothiazol-5-yl]-5-tert-butyl-1,3,4-oxadiazol-2(3H)-one
-
pH 7.4, temperature not specified in the publication
0.0207
3-[6-bromo-2-(prop-2-yn-1-ylsulfanyl)-1,3-benzothiazol-5-yl]-5-tert-butyl-1,3,4-thiadiazol-2(3H)-one
-
pH and temperature not specified in the publication
0.0879
4-chloro-phthalimide
-
pH not specified in the publication, temperature not specified in the publication
0.005
4-fluoro-2-(7-fluoro-2-methyl-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-dione
-
-
0.01092
5-tert-butyl-3-(2-[(3,3-dichloroprop-2-en-1-yl)sulfanyl]-6-fluoro-1,3-benzothiazol-5-yl)-1,3,4-oxadiazol-2(3H)-one
-
pH 7.4, temperature not specified in the publication
0.01024
5-tert-butyl-3-(6-chloro-2-[(3,3-dichloroprop-2-en-1-yl)sulfanyl]-1,3-benzothiazol-5-yl)-1,3,4-oxadiazol-2(3H)-one
-
pH 7.4, temperature not specified in the publication
0.00311
5-tert-butyl-3-[6-chloro-2-(prop-2-en-1-ylsulfanyl)-1,3-benzothiazol-5-yl]-1,3,4-oxadiazol-2(3H)-one
-
pH 7.4, temperature not specified in the publication
0.00861
5-tert-butyl-3-[6-chloro-2-(prop-2-yn-1-ylsulfanyl)-1,3-benzothiazol-5-yl]-1,3,4-oxadiazol-2(3H)-one
-
pH 7.4, temperature not specified in the publication
0.0214
5-tert-butyl-3-[6-chloro-2-(prop-2-yn-1-ylsulfanyl)-1,3-benzothiazol-5-yl]-1,3,4-thiadiazol-2(3H)-one
-
pH and temperature not specified in the publication
0.01592
5-tert-butyl-3-[6-fluoro-2-(prop-2-en-1-ylsulfanyl)-1,3-benzothiazol-5-yl]-1,3,4-oxadiazol-2(3H)-one
-
pH 7.4, temperature not specified in the publication
0.00973
5-tert-butyl-3-[6-fluoro-2-(prop-2-yn-1-ylsulfanyl)-1,3-benzothiazol-5-yl]-1,3,4-thiadiazol-2(3H)-one
-
pH and temperature not specified in the publication
0.00011 - 0.00472
acifluorfen
0.0008
cobalt-protoporphyrin
-
noncompetitive
0.00101
ethyl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
pH 7.4, temperature not specified in the publication
0.00158
ethyl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
pH 7.4, temperature not specified in the publication
0.00696
ethyl ([6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
pH 7.4, temperature not specified in the publication
0.00142
ethyl 2-((5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-2(3H)-yl)-6-fluorobenzothiazol-2-yl)sulfanyl)propanoate
-
pH 7.4, temperature not specified in the publication
0.00009
ethyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-2-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)-2-phenylacetate
-
-
0.00006
ethyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-2-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)acetate
-
-
0.00011
ethyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-2-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)propanoate
-
-
0.000045
ethyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)butanoate
-
-
0.00012
ethyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)propanoate
-
-
0.00135
ethyl 2-([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)-2-methylpropanoate
-
pH 7.4, temperature not specified in the publication
0.00154
ethyl 2-([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)-2-methylpropanoate
-
pH 7.4, temperature not specified in the publication
0.00813
ethyl 2-([6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl)propanoate
-
pH 7.4, temperature not specified in the publication
0.04807
ethyl 2-[2-chloro-4-fluoro-5-(1-hydroxy-3-oxooctahydro-2H-isoindol-2-yl)phenoxy]propanoate
-
pH not specified in the publication, temperature not specified in the publication
11.02
ethyl 2-[2-chloro-5-(1,3-dioxooctahydro-2H-isoindol-2-yl)-4-fluorophenoxy]propanoate
-
pH not specified in the publication, temperature not specified in the publication
0.00169
ethyl 3-([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)butanoate
-
pH 7.4, temperature not specified in the publication
0.00025
ethyl 3-([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)propanoate
-
pH 7.4, temperature not specified in the publication
0.00032
ethyl 3-([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)propanoate
-
pH 7.4, temperature not specified in the publication
0.00169
ethyl 3-([6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl)propanoate
-
pH 7.4, temperature not specified in the publication
0.00202
ethyl 4-([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)butanoate
-
pH 7.4, temperature not specified in the publication
0.0007
ethyl 4-([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)butanoate
-
pH 7.4, temperature not specified in the publication
0.00583
ethyl 4-([6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl)butanoate
-
pH 7.4, temperature not specified in the publication
0.1238
ethyl [2-chloro-4-fluoro-5-(1-hydroxy-3-oxooctahydro-2H-isoindol-2-yl)phenoxy]acetate
-
pH not specified in the publication, temperature not specified in the publication
0.01524
ethyl [2-chloro-5-(1,3-dioxooctahydro-2H-isoindol-2-yl)-4-fluorophenoxy]acetate
-
pH not specified in the publication, temperature not specified in the publication
0.00034
ethyl [[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
pH and temperature not specified in the publication
0.00748
methyl (2E)-4-([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)but-2-enoate
-
pH 7.4, temperature not specified in the publication
0.00107
methyl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
pH 7.4, temperature not specified in the publication
0.00399
methyl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
pH 7.4, temperature not specified in the publication
0.00746
methyl ([6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
pH 7.4, temperature not specified in the publication
0.00122
methyl 2-((5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-6-fluorobenzothiazol-2-yl)thio)acetate
-
pH 7.5, 22°C, recombinant enzyme
0.0000398
methyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-2-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)acetate
-
-
0.000049
methyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-2-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)propanoate
-
-
0.0000081
methyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)butanoate
-
-
0.00225
methyl [[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
pH 7.5, 22°C, recombinant enzyme
0.00305
methyl [[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
pH and temperature not specified in the publication
0.00392
methyl [[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
pH 7.5, 22°C, recombinant enzyme
0.000034
N-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenylcarbamoyl)-3-(trifluoromethoxy)benzamide
-
-
0.000089
N-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenylcarbamoyl)benzamide
-
-
0.0062
N-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)phenylcarbamoyl)benzamide
-
-
0.00029
phenyl 2-[[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
pH 7.5, 22°C, recombinant enzyme
0.132
phenyl 2-[[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
pH 7.5, 22°C, recombinant enzyme
0.0344
phenyl 2-[[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl]-2-methylpropanoate
-
pH and temperature not specified in the publication
0.012
phenyl 2-[[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
pH and temperature not specified in the publication
0.00346
phenyl 2-[[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]-2-methylpropanoate
-
pH and temperature not specified in the publication
0.0435
phenyl 2-[[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl]-2-methylpropanoate
-
pH and temperature not specified in the publication
0.173
phenyl 2-[[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
pH and temperature not specified in the publication
0.00166
phenyl 2-[[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]-2-methylpropanoate
-
pH 7.5, 22°C, recombinant enzyme
0.0008
phenyl 2-[[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
pH 7.5, 22°C, recombinant enzyme
0.0859
phenyl 2-[[6-chloro-5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
pH 7.5, 22°C, recombinant enzyme
0.00011
phenyl 3-[[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
pH 7.5, 22°C, recombinant enzyme
0.00552
phenyl 3-[[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
pH 7.5, 22°C, recombinant enzyme
0.00128
phenyl 3-[[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
pH and temperature not specified in the publication
0.00589 - 0.00926
phenyl 3-[[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
0.0275
phenyl 3-[[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
pH and temperature not specified in the publication
0.00032
phenyl 3-[[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
pH 7.5, 22°C, recombinant enzyme
0.00376
phenyl 3-[[6-chloro-5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
pH 7.5, 22°C, recombinant enzyme
0.0177
phenyl 4-[[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl]butanoate
-
pH and temperature not specified in the publication
0.00867
phenyl 4-[[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]butanoate
-
pH and temperature not specified in the publication
2.45
phenyl 4-[[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl]butanoate
-
pH and temperature not specified in the publication
0.00075
phenyl 4-[[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]butanoate
-
pH 7.5, 22°C, recombinant enzyme
0.00025
phenyl [[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
pH 7.5, 22°C, recombinant enzyme
0.00582
phenyl [[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
pH and temperature not specified in the publication
0.0156
phenyl [[6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
pH and temperature not specified in the publication
0.00166
phenyl [[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
pH 7.5, 22°C, recombinant enzyme
0.00217
propan-2-yl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
pH 7.4, temperature not specified in the publication
0.00117
propan-2-yl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
pH 7.4, temperature not specified in the publication
0.00597
propan-2-yl ([6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
pH 7.4, temperature not specified in the publication
0.00021
propan-2-yl [[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
pH 7.5, 22°C, recombinant enzyme
0.0015
propan-2-yl [[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
pH 7.5, 22°C, recombinant enzyme
0.00126
propan-2-yl [[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
pH and temperature not specified in the publication
0.00098
propyl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
pH 7.4, temperature not specified in the publication
0.0007
propyl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
pH 7.4, temperature not specified in the publication
0.0031
propyl ([6-bromo-5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
pH 7.4, temperature not specified in the publication
0.00028
propyl [[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
pH 7.5, 22°C, recombinant enzyme
0.00124
propyl [[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
pH 7.5, 22°C, recombinant enzyme
0.00131
propyl [[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
pH and temperature not specified in the publication
0.00008
S-(5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-6-fluorobenzothiazol-2-yl) O-methyl carbonothioate
-
pH 7.5, 22°C, recombinant enzyme
0.00051
S-[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl] O-phenyl carbonothioate
-
pH 7.5, 22°C, recombinant enzyme
0.00033
S-[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl] O-ethyl carbonothioate
-
pH 7.4, temperature not specified in the publication
0.0013
S-[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl] O-ethyl carbonothioate
-
pH 7.4, temperature not specified in the publication
0.00072
S-[5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl] O-methyl carbonothioate
-
pH 7.4, temperature not specified in the publication
0.0002
S-[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl] O-phenyl carbonothioate
-
pH and temperature not specified in the publication
0.00004
S-[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl] O-ethyl carbonothioate
-
pH and temperature not specified in the publication
0.00052
S-[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl] O-methyl carbonothioate
-
pH 7.5, 22°C, recombinant enzyme
0.00047
S-[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl] O-phenyl carbonothioate
-
pH 7.5, 22°C, recombinant enzyme
0.00084
tert-butyl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-chloro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
pH 7.4, temperature not specified in the publication
0.00159
tert-butyl ([5-(5-tert-butyl-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl)acetate
-
pH 7.4, temperature not specified in the publication
0.00018
tert-butyl [[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
pH 7.5, 22°C, recombinant enzyme
0.00011
acifluorfen
-
recombinant mutant R59I, pH 8.2
0.00018
acifluorfen
-
recombinant mutant R59K, pH 8.2
0.00023
acifluorfen
-
recombinant wild-type, pH 8.2
0.00027
acifluorfen
-
recombinant mutant R59S, pH 8.2
0.00031
acifluorfen
-
recombinant mutant G14A, pH 8.2
0.00033
acifluorfen
-
recombinant mutant R59W, pH 8.2
0.003
acifluorfen
-
recombinant mutant R168C, pH 8.2
0.00472
acifluorfen
-
recombinant mutant Y348C, pH 7.8
0.00589
phenyl 3-[[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
pH and temperature not specified in the publication
0.00926
phenyl 3-[[5-(5-tert-butyl-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
pH and temperature not specified in the publication
0.00072
sulfentrazone
-
pH not specified in the publication, temperature not specified in the publication
0.00072
sulfentrazone
-
pH 7.4, temperature not specified in the publication
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A172V
-
site-directed mutagenesis, 99.8% reduced activity compared to the wild-type enzyme, 99% complementation of enzyme-deficient Escherichia coli strain SAS38X
D143V
-
site-directed mutagenesis, 99.6% reduced activity compared to the wild-type enzyme, 89% complementation of enzyme-deficient Escherichia coli strain SAS38X
D349A
-
the mutant enzyme maintains 8.05% of wild type activity
D349E
-
the mutant enzyme maintains 84.78% of wild type activity
D349R
-
the mutant enzyme maintains 2.48% of wild type activity
del281H
-
site-directed mutagenesis, inactive mutant, no complementation of enzyme-deficient Escherichia coli strain SAS38X
G11A
-
site-directed mutagenesis, 0.02% activity compared to the wild-type enzyme
G14A
-
site-directed mutagenesis, 42.6% activity compared to the wild-type enzyme
G232R
-
site-directed mutagenesis, inactive mutant, no complementation of enzyme-deficient Escherichia coli strain SAS38X
G40E
-
site-directed mutagenesis, inactive mutant, no complementation of enzyme-deficient Escherichia coli strain SAS38X
G453R
-
site-directed mutagenesis, nearly inactive mutant, but 89% complementation of enzyme-deficient Escherichia coli strain SAS38X
G453V
-
site-directed mutagenesis, inactive mutant, no complementation of enzyme-deficient Escherichia coli strain SAS38X
G9A
-
site-directed mutagenesis, 0.52% activity compared to the wild-type enzyme
H20A
-
targets the mitochondrion
H20E
-
targets the mitochondrion
H20G
-
targets the mitochondrion
H20K
-
targets the mitochondrion
H20S
-
targets the mitochondrion
I12T
naturally occurring mutation in a finnish variegate porphyria patient, genotype-phenotype analysis, highly reduced activity
I283N
-
naturally occurring mutation involved in pathology of variegate porphyria
L154P
-
site-directed mutagenesis, 99.6% reduced activity compared to the wild-type enzyme, 93% complementation of enzyme-deficient Escherichia coli strain SAS38X
L15F
-
site-directed mutagenesis, 97.4% reduced activity compared to the wild-type enzyme, 49% complementation of enzyme-deficient Escherichia coli strain SAS38X
L295P
-
site-directed mutagenesis, inactive mutant, no complementation of enzyme-deficient Escherichia coli strain SAS38X
L401F
naturally occurring mutation in a finnish variegate porphyria patient, genotype-phenotype analysis, inactive mutant
L444P
-
site-directed mutagenesis, inactive mutant, no complementation of enzyme-deficient Escherichia coli strain SAS38X
L73P
-
site-directed mutagenesis, 97.6% reduced activity compared to the wild-type enzyme, complete complementation of enzyme-deficient Escherichia coli strain SAS38X
L85P
-
site-directed mutagenesis, inactive mutant, no complementation of enzyme-deficient Escherichia coli strain SAS38X
R168H
-
site-directed mutagenesis, 99.8% reduced activity compared to the wild-type enzyme, 68% complementation of enzyme-deficient Escherichia coli strain SAS38X
R38P
-
site-directed mutagenesis, 99.2% reduced activity compared to the wild-type enzyme, 59% complementation of enzyme-deficient Escherichia coli strain SAS38X
R59A
-
the mutant enzyme maintains 44.13% of wild type activity
R59E
-
the mutant enzyme maintains 22.72% of wild type activity
R59I
-
site-directed mutagenesis, 1.5% activity compared to the wild-type enzyme
R59S
-
site-directed mutagenesis, 2.6% activity compared to the wild-type enzyme
S350P
-
site-directed mutagenesis, inactive mutant, no complementation of enzyme-deficient Escherichia coli strain SAS38X
T366A
-
the mutant enzyme maintains 65.45% of wild type activity
V158M
-
site-directed mutagenesis, 91.8% reduced activity compared to the wild-type enzyme, 97% complementation of enzyme-deficient Escherichia coli strain SAS38X
V282D
-
site-directed mutagenesis, inactive mutant, no complementation of enzyme-deficient Escherichia coli strain SAS38X
V290L
-
site-directed mutagenesis, 98.8% reduced activity compared to the wild-type enzyme, 93% complementation of enzyme-deficient Escherichia coli strain SAS38X
V335G
-
site-directed mutagenesis, inactive mutant, no complementation of enzyme-deficient Escherichia coli strain SAS38X
V84G
-
site-directed mutagenesis, 99.8% reduced activity compared to the wild-type enzyme, 88% complementation of enzyme-deficient Escherichia coli strain SAS38X
Y348C
-
site-directed mutagenesis, 8.6% activity compared to the wild-type enzyme
F331A
-
site-directed mutagenesis of ring A, the mutant shows decreased activity compared to the wild-type enzyme
F331A
site-directed mutagenesis, calculation of free binding energy shifts
F331T
-
site-directed mutagenesis of ring A, the mutant shows increased activity compared to the wild-type enzyme
F331T
site-directed mutagenesis, calculation of free binding energy shifts
G169A
-
site-directed mutagenesis of ring C, the mutant shows decreased activity compared to the wild-type enzyme
G169A
site-directed mutagenesis, calculation of free binding energy shifts
H20P
-
site-directed mutagenesis, 0.16% activity compared to the wild-type enzyme
H20P
-
abolishes mitochondrial targeting, presumably through disruption of the protoporphyrinogen oxidase alpha-helix
L166N
-
site-directed mutagenesis of ring C, the mutant shows decreased activity compared to the wild-type enzyme
L166N
site-directed mutagenesis, calculation of free binding energy shifts
L334V
-
site-directed mutagenesis of ring A, the mutant shows highly increased activity compared to the wild-type enzyme
L334V
site-directed mutagenesis, calculation of free binding energy shifts
M368K
-
site-directed mutagenesis of ring A, the mutant shows increased activity compared to the wild-type enzyme
M368K
site-directed mutagenesis, calculation of free binding energy shifts
M368Q
-
site-directed mutagenesis of ring A, the mutant shows decreased activity compared to the wild-type enzyme
M368Q
site-directed mutagenesis, calculation of free binding energy shifts
R152C
naturally occurring mutation in a finnish variegate porphyria patient, genotype-phenotype analysis, highly reduced activity
R152C
-
site-directed mutagenesis, 99.4% reduced activity compared to the wild-type enzyme, 86% complementation of enzyme-deficient Escherichia coli strain SAS38X
R168C
-
reduced activity
R168C
-
site-directed mutagenesis, 17.5% activity compared to the wild-type enzyme
R168C
-
targets the mitochondrion
R168S
-
site-directed mutagenesis of ring A, the mutant shows decreased activity compared to the wild-type enzyme
R168S
site-directed mutagenesis, calculation of free binding energy shifts
R59K
-
site-directed mutagenesis, 37.6% activity compared to the wild-type enzyme
R59K
-
the mutant enzyme maintains 82.46% of wild type activity
R59W
-
significantly decreased activity, causes variagate porphyria
R59W
-
reducued activity, lacks FAD-cofactor
R59W
-
site-directed mutagenesis, 0.28% activity compared to the wild-type enzyme, highly reduced FAD binding
R59W
-
targets the mitochondrion
R59W
-
the mutation dramatically decreases the activity of the enzyme
R97G
-
site-directed mutagenesis of ring A, the mutant shows increased activity compared to the wild-type enzyme
R97G
site-directed mutagenesis, calculation of free binding energy shifts
V170T
-
site-directed mutagenesis of ring B, the mutant shows increased activity compared to the wild-type enzyme
V170T
site-directed mutagenesis, calculation of free binding energy shifts
additional information
construction of frameshift, deletion and insertion mutants, construction of N-terminally truncated mutants, determination of subcellular localization in expressing COS-1 cells, genotype-phenotype analysis of naturally occurring mutations in a finnish variegate porphyria patients, overview
additional information
-
construction of frameshift, deletion and insertion mutants, construction of N-terminally truncated mutants, determination of subcellular localization in expressing COS-1 cells, genotype-phenotype analysis of naturally occurring mutations in a finnish variegate porphyria patients, overview
additional information
-
identification of 9 mutation, including nonsense and deletion mutations, in the enzyme-encoding gene PPOX in italian population, mutations are associated with variegate porphyria, VP
additional information
-
identification of several mutations of the enzyme encoding gene, responsible for variegate porphyria, overview
additional information
-
constructs with reduction to 12 residues (PPOX12-GFP) and then subsequent increases to 14 (PPOX14-GFP), 15 (PPOX15-GFP) and 16 (PPOX16-GFP) residue constructs, lead to an abolition of mitochondrial targeting, however, a 17-residue construct (PPOX17-GFP) does effect mitochondrial targeting
additional information
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detection of a naturally mutation designated 1082-1083insC in the Swiss population that is responsible for the variegate porphyria, an autosomal dominant genetic defectand one of the acute hepatic porphyrias, overview
additional information
computational mutation scanning of enzyme PPO
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