General Stability | Organism |
---|---|
stable on dialysis | Rattus norvegicus |
stable on dialysis | Saccharomyces cerevisiae |
stable on freezing and thawing | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
iodoacetamide | - |
Rattus norvegicus | |
iodoacetamide | - |
Saccharomyces cerevisiae | |
additional information | - |
Homo sapiens | |
additional information | inhibited by high salt concentrations | Rattus norvegicus | |
additional information | inhibited by high salt concentrations | Saccharomyces cerevisiae | |
p-hydroxymercuribenzoate | more than 90% inhibition at 0.5 mM | Rattus norvegicus | |
p-hydroxymercuribenzoate | - |
Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.011 | - |
protoporphyrinogen-IX | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | no metal ions required | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
33000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
protoporphyrinogen-IX + 3 O2 | Homo sapiens | penultimate step of heme and chlorophyll biosynthesis | protoporphyrin-IX + 3 H2O2 | - |
? | |
protoporphyrinogen-IX + 3 O2 | Rattus norvegicus | penultimate step of heme and chlorophyll biosynthesis | protoporphyrin-IX + 3 H2O2 | - |
? | |
protoporphyrinogen-IX + 3 O2 | Saccharomyces cerevisiae | penultimate step of heme and chlorophyll biosynthesis | protoporphyrin-IX + 3 H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0087 | - |
partially purified enzyme | Rattus norvegicus |
Storage Stability | Organism |
---|---|
-20°C, stable for several months | Rattus norvegicus |
0-4°C, stable for 1 week | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
mesoporphyrinogen-IX + 3 O2 | - |
Homo sapiens | mesoporphyrin-IX + 3 H2O2 | - |
? | |
mesoporphyrinogen-IX + 3 O2 | - |
Saccharomyces cerevisiae | mesoporphyrin-IX + 3 H2O2 | - |
? | |
mesoporphyrinogen-IX + 3 O2 | 10% of the rate of protoporphyrinogen-IX | Rattus norvegicus | mesoporphyrin-IX + 3 H2O2 | - |
? | |
protoporphyrinogen-IX + 3 O2 | - |
Homo sapiens | protoporphyrin-IX + 3 H2O2 | - |
? | |
protoporphyrinogen-IX + 3 O2 | - |
Rattus norvegicus | protoporphyrin-IX + 3 H2O2 | - |
? | |
protoporphyrinogen-IX + 3 O2 | - |
Saccharomyces cerevisiae | protoporphyrin-IX + 3 H2O2 | - |
? | |
protoporphyrinogen-IX + 3 O2 | penultimate step of heme and chlorophyll biosynthesis | Homo sapiens | protoporphyrin-IX + 3 H2O2 | - |
? | |
protoporphyrinogen-IX + 3 O2 | penultimate step of heme and chlorophyll biosynthesis | Rattus norvegicus | protoporphyrin-IX + 3 H2O2 | - |
? | |
protoporphyrinogen-IX + 3 O2 | penultimate step of heme and chlorophyll biosynthesis | Saccharomyces cerevisiae | protoporphyrin-IX + 3 H2O2 | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
45 | - |
inactivated above 45°C, half maximal activity after 100 min | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.6 | 8.8 | - |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | 10.5 | - |
Rattus norvegicus |