Reference on EC 1.11.1.12 - phospholipid-hydroperoxide glutathione peroxidase and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Saito, Y.; Hayashi, T.; Tanaka, A.; Watanabe, Y.; Suzuki, M.; Saito, E.; Takahashi, K.
Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase. Isolation and enzymatic characterization of human selenoprotein P
J. Biol. Chem.
274
2866-2871
1999
Homo sapiens
Chambers, S.J.; Lambert, N.; Williamson, G.
Purification of a cytosolic enzyme from human liver with phospholipid hydroperoxide glutathione peroxidase activity
Int. J. Biochem.
26
1279-1286
1994
Homo sapiens
Schnurr, K.; Borchert, A.; Gerth, C.; Anton, M.; Kuhn, H.
Bacterial and nonbacterial expression of wild-type and mutant human phospholipid hydroperoxide glutathione peroxidase and purification of the mutant enzyme in the milligram scale
Protein Expr. Purif.
19
403-410
2000
Homo sapiens
Foresta, C.; Flohe, L.; Garolla, A.; Roveri, A.; Ursini, F.; Maiorino, M.
Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase
Biol. Reprod.
67
967-971
2002
Homo sapiens
Tramer, F.; Caponecchia, L.; Sgro, P.; Martinelli, M.; Sandri, G.; Panfili, E.; Lenzi, A.; Gandini, L.
Native specific activity of glutathione peroxidase (GPx-1), phospholipid hydroperoxide glutathione peroxidase (PHGPx) and glutathione reductase (GR)does not differ between normo- and hypomotile human sperm samples
Int. J. Androl.
27
88-93
2004
Homo sapiens
Utomo, A.; Jiang, X.; Furuta, S.; Yun, J.; Levin, D.S.; Wang, Y.C.; Desai, K.V.; Green, J.E.; Chen, P.L.; Lee, W.H.
Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells
J. Biol. Chem.
279
43522-43529
2004
Homo sapiens
Diaconu, M.; Tangat, Y.; Boehm, D.; Kuehn, H.; Michelmann, H.W.; Schreiber, G.; Haidl, G.; Glander, H.J.; Engel, W.; Nayernia, K.
Failure of phospholipid hydroperoxide glutathione peroxidase expression in oligoasthenozoospermia and mutations in the PHGPx gene
Andrologia
38
152-157
2006
Homo sapiens
Hattori, H.; Imai, H.; Furuhama, K.; Sato, O.; Nakagawa, Y.
Induction of phospholipid hydroperoxide glutathione peroxidase in human polymorphonuclear neutrophils and HL60 cells stimulated with TNF-alpha
Biochem. Biophys. Res. Commun.
337
464-473
2005
Homo sapiens
Januel, C.; El Hentati, F.; Carreras, M.; Arthur, J.R.; Calzada, C.; Lagarde, M.; Vericel, E.
Phospholipid-hydroperoxide glutathione peroxidase (GPx-4) localization in resting platelets, and compartmental change during platelet activation
Biochim. Biophys. Acta
1761
1228-1234
2006
Homo sapiens
Steinbrenner, H.; Bilgic, E.; Alili, L.; Sies, H.; Brenneisen, P.
Selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activity
Free Radic. Res.
40
936-943
2006
Homo sapiens
Liu, J.; Du, J.; Zhang, Y.; Sun, W.; Smith, B.J.; Oberley, L.W.; Cullen, J.J.
Suppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase
Hum. Gene Ther.
17
105-116
2006
Homo sapiens
Kriska, T.; Girotti, A.W.
A thin layer chromatographic method for determining the enzymatic activity of peroxidases catalyzing the two-electron reduction of lipid hydroperoxides
J. Chromatogr. B
827
58-64
2005
Homo sapiens
Scheerer, P.; Borchert, A.; Krauss, N.; Wessner, H.; Gerth, C.; Hoehne, W.; Kuhn, H.
Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4)
Biochemistry
46
9041-9049
2007
Homo sapiens (P36969), Homo sapiens
Conrad, M.; Schneider, M.; Seiler, A.; Bornkamm, G.W.
Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals
Biol. Chem.
388
1019-1025
2007
Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Cejas, P.; Garcia-Cabezas, M.A.; Casado, E.; Belda-Iniesta, C.; De Castro, J.; Fresno, J.A.; Sereno, M.; Barriuso, J.; Espinosa, E.; Zamora, P.; Feliu, J.; Redondo, A.; Hardisson, D.A.; Renart, J.; Gonzalez-Baron, M.
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinoma
Free Radic. Res.
41
681-687
2007
Homo sapiens
Ding, W.Q.; Lind, S.E.
Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity
Mol. Cancer Ther.
6
1467-1474
2007
Homo sapiens
Guo, Z.; Ran, Q.; Roberts, L.J.; Zhou, L.; Richardson, A.; Sharan, C.; Wu, D.; Yang, H.
Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice
Free Radic. Biol. Med.
44
343-352
2008
Homo sapiens
Han, X.; Fan, Z.; Yu, Y.; Liu, S.; Hao, Y.; Huo, R.; Wei, J.
Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidase
IUBMB Life
65
951-956
2013
Homo sapiens (D6W5Y2), Homo sapiens
Yu, Y.; Song, J.; Guo, X.; Wang, S.; Yang, X.; Chen, L.; Wei, J.
Characterization and structural analysis of human selenium-dependent glutathione peroxidase 4 mutant expressed in Escherichia coli
Free Radic. Biol. Med.
71
332-338
2014
Homo sapiens (P36969), Homo sapiens
Moosmayer, D.; Hilpmann, A.; Hoffmann, J.; Schnirch, L.; Zimmermann, K.; Badock, V.; Furst, L.; Eaton, J.; Viswanathan, V.; Schreiber, S.; Gradl, S.; Hillig, R.
Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162
Acta Crystallogr. D Struct. Biol.
77
237-248
2021
Homo sapiens (P36969), Homo sapiens
Corteselli, E.M.; Gibbs-Flournoy, E.; Simmons, S.O.; Bromberg, P.; Gold, A.; Samet, J.M.
Long chain lipid hydroperoxides increase the glutathione redox potential through glutathione peroxidase 4
Biochim. Biophys. Acta
1863
950-959
2019
Homo sapiens (P36969)
Borchert, A.; Kalms, J.; Roth, S.; Rademacher, M.; Schmidt, A.; Holzhutter, H.; Kuhn, H.; Scheerer, P.
Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction
Biochim. Biophys. Acta Mol. Cell Biol. Lipids
1863
1095-1107
2018
Homo sapiens (P36969), Homo sapiens
