1.1.1.44: phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

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For detailed information about phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), go to the full flat file.

Word Map on EC 1.1.1.44

1.1.1.44

glucose-6-phosphate

pentose

acp

gpi

malic

lipogenic

allozymes

pelteobagrus

monomorphic

srebp-1

4.1.3.8

fulvidraco

duffy

physcion

tropica

zymodemes

medicine

synthesis

pharmacology

biotechnology

agriculture

Reaction

Synonyms

6-GPD, 6-P-gluconate dehydrogenase, 6-Pgd, 6-PGDH, 6-PGDHase, 6-phospho-D-gluconate dehydrogenase, 6-phospho-D-gluconate-NADP+ oxidoreductase, decarboxylating, 6-phosphogluconate dehydrogenase, 6-phosphogluconate dehydrogenase (decarboxylating), 6-phosphogluconate dehydrogenase 1, 6-phosphogluconate dehydrogenase Gnd1, 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate-dehydrogenase, 6-phosphogluconate:NADP oxidoreductase, 6-phosphogluconic carboxylase, 6-phosphogluconic dehydrogenase, 6-phosphonogluconate dehydrogenase, 6PDH, 6PG DH, 6PGD, 6PGDH, 6PGDH/Gnd1, 6PGDH1, 6PGDH2, 6PGDH3, At1G64190, At3g02360, At5g41670, D-gluconate-6-phosphate dehydrogenase, GCG1, gnd, GND1, Gnd1p, Gnd2p, GNTZII, LlPDH, Moth_1283, Os6PGDH1, Os6PGDH2, p6PGDH, peroxisomal 6-phosphogluconate dehydrogenase, Pgd, PGD1, PGD2, PGD3, phosphogluconic acid dehydrogenase, TM0438, YpjI, zwf3

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

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Results	in table
24	Activating Compound
27534	AA Sequence
13	Application
1	CAS Registry Number
37	Cloned(Commentary)
114	Cofactor
31	Crystallization (Commentary)
192	Disease/ Diagnostics
6	Expression
52	General Information
13	General Stability
73	IC50 Value
569	Inhibitors
47	kcat/KM [mM/s]
90	Ki Value [mM]
283	KM Value [mM]
78	Localization
22	Metals/Ions
129	Molecular Weight [Da]
270	Natural Substrates/ Products (Substrates)
6	Organic Solvent Stability
976	Organism
8	Pathway
74	PDB ID
69	pH Optimum
10	pH Range
5	pH Stability
8	pI Value
4	Posttranslational Modification
50	Protein Variants
99	Purification (Commentary)
2	Reaction
4	Reaction Type
331	Reference
216	Source Tissue
66	Specific Activity [micromol/min/mg]
21	Storage Stability
439	Substrates and Products (Substrate)
129	Subunits
223	Synonyms
1	Systematic Name
31	Temperature Optimum [°C]
7	Temperature Range [°C]
26	Temperature Stability [°C]
70	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 1.1.1.44 - phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

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nitrosylation

2 entries

phosphoprotein

Homo sapiens

P52209

Y481 phosphorylation is essential for epidermal growth factor receptor (EGFR) activation-enhanced 6PGD activity

761976

additional information

Homo sapiens

P52209

hyperactivation is mediated through post-transcriptional and post-translational modifications by YTH domain family 2 (YTHDF2), Nrf2 (nuclear factor erythroid 2-related factor 2), EGFR (epidermal growth factor receptor) and via direct structural interactions with ME1 (malic enzyme 1)

760658