Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2-deoxy-3-oxo 6-phosphogluconate + ?
?
2-deoxy-6-phospho-D-gluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
-
-
-
-
?
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
2-deoxy-6-phosphogluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
3-oxo-2-deoxy-6-phosphogluconate + NADP+
1-deoxyribulose 5-phosphate + CO2 + NADPH
3-oxo-2-deoxy-6-phosphogluconate + NADPH
2-deoxy-6-phosphogluconate + NADP+
6,7-dideoxy-7-phosphono-D-glucoheptonate + NADP+
?
6-O-phosphono-D-mannonic acid + NADP+
? + NADPH
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH + CO2 + H+
-
-
-
-
ir
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
beta-3-acetylpyridine adenine dinucleotide 2'-phosphate + 6-phosphogluconate
?
-
-
-
-
?
beta-nicotinamide 1-N6-ethenoadenine dinucleotide 2'-phosphate + 6-phosphogluconate
?
-
-
-
-
?
beta-nicotinamide adenine dinucleotide 3'-phosphate + 6-phosphogluconate
?
-
-
-
-
?
beta-nicotinamide hypoxanthine dinucleotide 2'-phosphate + 6-phosphogluconate
?
-
-
-
-
?
D-ribulose 5-phosphate + CO2 + NADPH
6-phospho-D-gluconate + NADP+
ribulose 5-phosphate + H2O + NADPH
?
additional information
?
-
2-deoxy-3-oxo 6-phosphogluconate + ?
?
-
-
-
-
?
2-deoxy-3-oxo 6-phosphogluconate + ?
?
-
no decarboxylation by the liver enzyme
-
-
?
2-deoxy-3-oxo 6-phosphogluconate + ?
?
-
-
-
-
?
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
-
-
-
?
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
-
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
-
oxidation, 1.5% activity of that of 6-phosphogluconate
-
-
r
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
-
via 1,2-enediol intermediate
-
-
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
-
via 1,2-enediol intermediate
-
-
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
via 1,2-enediol intermediate
-
-
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
-
via 1,2-enediol intermediate
-
-
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
-
via 1,2-enediol intermediate
-
-
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
via 1,2-enediol intermediate
-
-
?
3-keto-6-phospho-D-gluconate
D-ribulose 5-phosphate + CO2
-
via 1,2-enediol intermediate
-
-
?
3-oxo-2-deoxy-6-phosphogluconate + NADP+
1-deoxyribulose 5-phosphate + CO2 + NADPH
-
reaction requires presence of NADPH, but the reduced coenzyme does not play a redox role
-
-
?
3-oxo-2-deoxy-6-phosphogluconate + NADP+
1-deoxyribulose 5-phosphate + CO2 + NADPH
-
decarboxylation
-
-
r
3-oxo-2-deoxy-6-phosphogluconate + NADPH
2-deoxy-6-phosphogluconate + NADP+
-
-
-
-
r
3-oxo-2-deoxy-6-phosphogluconate + NADPH
2-deoxy-6-phosphogluconate + NADP+
-
reduction
-
-
r
6,7-dideoxy-7-phosphono-D-glucoheptonate + NADP+
?
-
-
-
?
6,7-dideoxy-7-phosphono-D-glucoheptonate + NADP+
?
-
-
-
?
6-O-phosphono-D-mannonic acid + NADP+
? + NADPH
-
-
-
-
?
6-O-phosphono-D-mannonic acid + NADP+
? + NADPH
-
-
-
-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH
-
-
-
-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH
-
the enzyme prefers NADP+ to NAD+ as an electron acceptor
-
-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
very low activity with NAD+
-
-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
very low activity with NAD+ with the wild-type enzyme, low activity with mutants R31T, R31I, and R31I/T32G, higher activity with mutants A30C/R31I/T32K and A30E/R31I/T32D, and high activity with mutant A30D/R31I/T32I
-
-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
the enzyme is specific for NADP+ by approximately 1100-fold compared with its specificity for NAD+
-
-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
the enzyme is specific for NADP+ by approximately 1100fold compared with its specificity for NAD+
-
-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
-
-
-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
low activity with NAD+
-
-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
the enzyme prefers NADP+ to NAD+ as an electron acceptor. Km-value for NAD+ is 38fold higher than the Km-value for NADP+
-
-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
the enzyme prefers NADP+ to NAD+ as an electron acceptor. Km-value for NAD+ is 38fold higher than the Km-value for NADP+
-
-
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
3-keto-6-phospho-D-gluconate + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
D4ZTT4
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
D4ZTT4
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Corynebacterium glutamicum ssp. flavum
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
286824, 286829, 286831, 286833, 286834, 286835, 286836, 286838, 286842, 286846, 286849, 286850, 286851, 286852, 286853, 286854, 286856, 286860, 286869, 286871, 286873, 286874, 286875, 286881, 286882, 286883, 286884, 286890, 286892, 286893, 286894, 286895, 286901, 286902, 286903 -
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
6-phosphogluconate modulates 6PGDH activity. In the forward reaction, it suppresses inhibition by NADP and decreases inhibition by NADPH by increasing the Kd of the reduced coenzyme 6fold it increases the rate of decarboxylation of the 3-keto intermediate , whereas in the reverse reaction, it decreases the Km and removes the slow step
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Drosophila sp. (in: flies)
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
286834, 286836, 286847, 286848, 286851, 286870, 286872, 286874, 286879, 286880, 286882 -
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
286834, 286836, 286837, 286838, 286839, 286841, 286846, 286849, 286850, 286881, 286890, 286892, 286895, 286897, 286903 -
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
the enzyme catalyzes a step of the pentose phosphate pathway
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
overall reaction
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
ir
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
the enzyme is involved in the oxidative pentose phosphate pathway
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
mammary gland enzyme involved in NADPH production which is essential for lipogenesis
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
286827, 286829, 286830, 286831, 286833, 286837, 286838, 286840, 286844, 286849, 286850, 286852, 286855, 286862, 286871, 286872, 286875, 286881, 286883, 286884, 286890, 286892, 286894, 286898, 286899, 286901, 286902, 286903, 286904, 286987 -
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
overall reaction
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
overall reaction
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
oxidative enzyme of pentose phosphate pathway
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
overall reaction
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
the enzyme catalyzes a step of the pentose phosphate pathway
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
286826, 286827, 286829, 286833, 286836, 286838, 286840, 286846, 286849, 286850, 286859, 286863, 286868, 286877, 286882, 286886, 286892, 286895 -
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
endosperm contains both cytosolic and plastic glycolytic and pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
286835, 286839, 286843, 286863, 286865, 286876, 286877, 286878, 286880, 286904, 286987 -
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
while the soluble enzyme (6PGDH) converted 33% of NADP+ in reaction medium upon 480 s, the immobilized enzyme performs 56% conversion of NADP+ at same time
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
pivotal enzyme links the gluconate route and the oxidative phase of the pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
the enzyme is specific for NADP+ by approximately 1100-fold compared with its specificity for NAD+
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
the enzyme is specific for NADP+ by approximately 1100fold compared with its specificity for NAD+
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
the enzyme prefers NADP+ to NAD+ as an electron acceptor
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
the enzyme preferrs NADP+ to NAD+ as an electron acceptor
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
the enzyme preferrs NADP+ to NAD+ as an electron acceptor
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
overall reaction
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
overall reaction
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
overall reaction
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
part of oxidative pentosephosphate pathway, predominant enzyme in glucose and cluconate catabolism, pathway regulation, overview
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
the glucose-6-phosphate dehydrogenase/6-phosphogluconate dehydrogenase ratio in plants infected with potato virus Y is lower than in healthy plants, with glucose 6-phosphate dehydrogenase being the regulating enzyme of the oxidative pentosephosphate pathway
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
one of the key enzymes in the pentose phosphate pathway, may be important for cell division and salt response
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
the enzyme expression and activity is independently regulated in different tissues
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
third step in pentose phosphate metabolic pathway
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
?
D-ribulose 5-phosphate + CO2 + NADPH
6-phospho-D-gluconate + NADP+
-
reverse reaction only to a very limited extent
-
-
r
D-ribulose 5-phosphate + CO2 + NADPH
6-phospho-D-gluconate + NADP+
-
-
-
-
r
ribulose 5-phosphate + H2O + NADPH
?
-
-
-
-
?
ribulose 5-phosphate + H2O + NADPH
?
-
tritium exchange reaction between tritiated ribulose 5-phosphate and water, reaction requires presence of NADPH, but the reduced coenzyme does not play a redox role
-
-
?
additional information
?
-
-
glucose-6-phosphate is no substrate
-
-
?
additional information
?
-
-
neither gluconic acid nor glucose-6-phosphate can replace 6-phosphogluconate as substrate
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
6-phosphogalactonate is no substrate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
D4ZTT4
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
D4ZTT4
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Corynebacterium glutamicum ssp. flavum
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
286824, 286829, 286831, 286833, 286834, 286835, 286836, 286838, 286842, 286846, 286849, 286850, 286851, 286852, 286853, 286854, 286856, 286860, 286869, 286871, 286873, 286874, 286875, 286881, 286882, 286883, 286884, 286890, 286892, 286893, 286894, 286895, 286901, 286902, 286903 -
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Drosophila sp. (in: flies)
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
286834, 286836, 286837, 286838, 286841, 286846, 286849, 286850, 286881, 286890, 286892, 286903 -
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
the enzyme catalyzes a step of the pentose phosphate pathway
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
ir
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
the enzyme is involved in the oxidative pentose phosphate pathway
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
mammary gland enzyme involved in NADPH production which is essential for lipogenesis
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
286827, 286833, 286837, 286838, 286840, 286844, 286849, 286850, 286855, 286871, 286881, 286884, 286890, 286892, 286894, 286898, 286899, 286902, 286903, 286987 -
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
oxidative enzyme of pentose phosphate pathway
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
the enzyme catalyzes a step of the pentose phosphate pathway
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
286826, 286827, 286833, 286836, 286838, 286840, 286846, 286849, 286850, 286868, 286877, 286886, 286892 -
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
endosperm contains both cytosolic and plastic glycolytic and pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
pivotal enzyme links the gluconate route and the oxidative phase of the pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
r
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
part of oxidative pentosephosphate pathway, predominant enzyme in glucose and cluconate catabolism, pathway regulation, overview
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
the glucose-6-phosphate dehydrogenase/6-phosphogluconate dehydrogenase ratio in plants infected with potato virus Y is lower than in healthy plants, with glucose 6-phosphate dehydrogenase being the regulating enzyme of the oxidative pentosephosphate pathway
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
one of the key enzymes in the pentose phosphate pathway, may be important for cell division and salt response
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
the enzyme expression and activity is independently regulated in different tissues
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
third step in pentose phosphate metabolic pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(-)-catechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-epicatechin gallate
-
-
(-)-epigallocatechin
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-epigallocatechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-gallocatechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(1H-indol-1-yl)(furan-2-yl)methanon
noncompetitive
(1H-indol-1-yl)(furan-2-yl)methanone
noncompetitive inhibitor
(1H-indol-1-yl)(tiyophen-2-yl)methanon
competitive
(1H-indol-1-yl)(tiyophen-2-yl)methanone
competitive inhibitor
(2E)-2-cyano-3-(5-nitrofuran-2-yl)prop-2-enoic acid
-
-
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
(4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
i.e. dorzolamide, competitive
(5-(dimethylamine)naphthalin-1-sulfonylchloride)
-
dansyl chloride, DNSCl, rapid inactivation at pH 7.5, 95% inhibition at pH 6.2
(5Z)-5-[[4-(3-fluorophenoxy)phenyl]methylidene]-2-imino-3-(2-methoxyphenyl)-1,3-thiazolidin-4-one
1,8-dihydroxy-3-methoxy-6-methyl-anthraquinone
-
-
1-(2-nitro-1-(thiophen-2-yl)ethyl)-1H-indole
competitive; competitive inhibitor
1-hydroxy-8-methoxy-anthraquinone
inhibition of the enzyme (6PGD) via chemical inhibitor 1-hydroxy-8-methoxy-anthraquinone results in an induction of senescence
11-(4-methoxyphenyl)-11H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-ol
1H-indol-1-yl(tiyophen-2-yl) methanon
-
2,6-dimethoxy-4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
2-deoxy-6-phosphono-D-gluconate
2-methyl-3-[2-(3-nitrophenyl)-2-oxoethyl]naphthalene-1,4-dione
2-methyl-5-nitrofuran-3-carboxylic acid
-
-
3,3',4,4'-tetramethyl-1H,1'H-2,2'-bipyrrole-5,5'-dicarboxylic acid
-
-
3-methyl-4-oxo-4,7-dihydro-5H-thiopyrano[3,4-b]furan-2-carboxylic acid
-
-
3-Oxo-2-deoxy-6-phosphogluconate
-
competitive inhibitor
3-phosphoglycerate
about 40% residual activity at 5 mM
4,4'-[1,4-phenylenebis(oxy-1H-benzimidazole-6,2-diyl)]dianiline
4,5-dichloro-1H-pyrrole-2-carboxylic acid
-
-
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
4-chloro-1H-pyrrole-2-carboxylic acid
-
-
4-phospho-D-erythronamide
4-phospho-D-erythronohydroxamic acid
4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
5,5'-methylenebis[2-(4-methoxyphenyl)-1H-benzimidazole]
5,6-bis(2H-1,3-benzodioxol-5-yl)-2-(3-methylphenyl)-4,7-diphenyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3,8(2H)-trione
5,6-dideoxy-6-phosphono-D-arabino-hexonate
5-(3,7,12-trioxo-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
weak inhibition
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
competitive
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
competitive
5-(ethoxycarbonyl)-3,4-dimethyl-1H-pyrrole-2-carboxylic acid
-
-
5-deoxy-5-phosphonoD-arabinonate
5-phospho-D-arabinonamide
5-phospho-D-arabinonhydrazide
5-phospho-D-arabinono-1,4-lactone
5-phospho-D-arabinonohydroxamic acid
6-deoxy-6-phosphono-D-gluconate
6-methoxy-7-hydroxycoumarin
-
scopolin
6-phospho-D-gluconate
-
substrate inhibition
7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole
-
NBD-Cl
7-[[3-(benzyloxy)phenyl][(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
amikacin
-
in vitro inhibition
amikacin sulfate
-
in vitro and in vivo inhibition
amoxicillin
-
competitive
brimonidine
competitive inhibition
ceftazidim
-
in vitro inhibition
chloramphenicol
-
in vitro inhibition
Ciprofloxacin
-
in vitro inhibition
clindamycin
-
competitive
D-5-phosphoribosyl-1-diphosphate
D-6-phosphogluconate
-
competitive substrate inhibition at pH 7
D-fructose 1,6-diphosphate
D-Fructose 1-phosphate
-
-
D-fructose 2,6-bisphosphate
-
-
D-Glucose 1,6-bisphosphate
D-glucose 6-phosphate
-
-
D-glyceraldehyde 3-phosphate
D-xylulose 5-phosphate
-
-
fructose-1,6-bisphosphate
1 mM, 30% inhibition; 1 mM, 70% decreases in activity
gentamicin sulfate
-
in vitro inhibition
Imipenem
-
noncompetitive
isepamycin
-
in vitro inhibition
levofloxacin
-
in vitro inhibition
lornoxicam
-
noncompetitive
metronidazole
-
noncompetitive
Mg2+
-
acts as an inhibitor above 20 mM
N-(4-chlorobenzoyl) indole
competitive
N-(4-chlorobenzoyl)-indole
N-[(4-chlorophenyl)(2-hydroxy-1-naphthyl)methyl]-2-phenylacetamide
ofloxacin
-
in vitro inhibition
ornidazole
-
noncompetitive
penicillin G
-
in vitro inhibition
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
physcion
1,8-dihydroxy-3-methoxy-6-methyl-anthrachinon
potassium 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate
-
-
proparacaine
competitive inhibition
ribose-5-phosphate
1 mM, 29% inhibition; 1 mM, 71% decreases in activity
sodium (4E)-4-(hydroxyimino)-3-oxo-1,2,3,4-tetrahydronaphthalene-1-sulfonate
-
-
teicoplanin
-
in vitro inhibition
Tetranitromethane
-
irreversible loss of catalytic activity
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
[(5-nitrofuran-2-yl)methylidene]propanedioic acid
-
-
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
-
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
(5Z)-5-[[4-(3-fluorophenoxy)phenyl]methylidene]-2-imino-3-(2-methoxyphenyl)-1,3-thiazolidin-4-one
-
(5Z)-5-[[4-(3-fluorophenoxy)phenyl]methylidene]-2-imino-3-(2-methoxyphenyl)-1,3-thiazolidin-4-one
-
1,5-diphospho-D-ribulose
-
1,5-diphospho-D-ribulose
-
1,5-diphospho-ribitol
-
11-(4-methoxyphenyl)-11H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-ol
-
11-(4-methoxyphenyl)-11H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-ol
-
2,6-dimethoxy-4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
-
2,6-dimethoxy-4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
-
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-deoxy-6-phosphono-D-gluconate
-
2-deoxy-6-phosphono-D-gluconate
-
-
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-deoxy-6-phosphono-D-gluconate
-
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-methyl-3-[2-(3-nitrophenyl)-2-oxoethyl]naphthalene-1,4-dione
-
2-methyl-3-[2-(3-nitrophenyl)-2-oxoethyl]naphthalene-1,4-dione
-
4,4'-[1,4-phenylenebis(oxy-1H-benzimidazole-6,2-diyl)]dianiline
-
4,4'-[1,4-phenylenebis(oxy-1H-benzimidazole-6,2-diyl)]dianiline
-
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronamide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronamide
-
-
4-phospho-D-erythronamide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronamide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronamide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronate
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronate
bio-isosteric analogue
4-phospho-D-erythronate
-
-
4-phospho-D-erythronate
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronate
bio-isosteric analogue
4-phospho-D-erythronate
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronate
-
mimics the transition state of dehydrogenation. The inhibitor forces the catalytic lysine 185 into the protonated state
4-phospho-D-erythronate
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronohydroxamic acid
-
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
4-phospho-D-erythronohydroxamic acid
-
-
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
4-phospho-D-erythronohydroxamic acid
-
conversion of the 6-PGDH inhibitor into prodrugs to increase its activity against the Trypanosoma brucei by enhancing uptake by passive permeation across the plasma membrane. Production of five different phosphate-masking groups (phosphoramidate, bis-S-acyl thioethyl esters, bis-pivaloxymethyl, cycloSaligenyl and phenyl, S-acyl thioethyl mixed phosphate esters). Prodrugs are studied for stability and activity against the intact parasites. Most prodrugs cause inhibition of the growth of the parasites. The activity of the prodrugs against the parasites appears to be related to their stability in aqueous buffer
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
4-phospho-D-erythrose
bio-isosteric analogue
4-phospho-D-erythrose
bio-isosteric analogue
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
DTNB
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
Ellman's reagent
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
Ellman's reagent
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-methylenebis[2-(4-methoxyphenyl)-1H-benzimidazole]
-
5,5'-methylenebis[2-(4-methoxyphenyl)-1H-benzimidazole]
-
5,6-bis(2H-1,3-benzodioxol-5-yl)-2-(3-methylphenyl)-4,7-diphenyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3,8(2H)-trione
-
5,6-bis(2H-1,3-benzodioxol-5-yl)-2-(3-methylphenyl)-4,7-diphenyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3,8(2H)-trione
-
5,6-dideoxy-6-phosphono-D-arabino-hexonate
-
5,6-dideoxy-6-phosphono-D-arabino-hexonate
-
5-deoxy-5-phosphonoD-arabinonate
-
5-deoxy-5-phosphonoD-arabinonate
-
5-phospho-D-arabinonamide
-
5-phospho-D-arabinonamide
-
5-phospho-D-arabinonate
-
5-phospho-D-arabinonate
-
5-phospho-D-arabinonhydrazide
-
5-phospho-D-arabinonhydrazide
-
5-phospho-D-arabinono-1,4-lactone
-
5-phospho-D-arabinono-1,4-lactone
-
5-phospho-D-arabinonohydroxamic acid
-
5-phospho-D-arabinonohydroxamic acid
-
5-phospho-D-arabinose
-
5-phospho-D-ribonate
-
5-phospho-D-ribonate
-
substrate analogue
6-deoxy-6-phosphono-D-gluconate
-
6-deoxy-6-phosphono-D-gluconate
-
6-phospho-D-galactonate
-
6-phospho-D-galactonate
-
6-phosphono-D-mannonate
competitive
6-phosphono-D-mannonate
competitive
7-[[3-(benzyloxy)phenyl][(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol
-
7-[[3-(benzyloxy)phenyl][(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol
-
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
-
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
-
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
compound shows in vitro antiparasitic activity
ADP
-
-
ampicillin
-
in vitro inhibition
ampicillin
-
in vitro inhibition
ATP
-
-
ATP
1 mM, 45% inhibition; 1 mM, 55% decreases in activity
Cd2+
-
competitive inhibition
cefepime
-
in vitro inhibition
cefepime
-
in vitro and in vivo inhibition, noncompetitive
citrate
-
-
citrate
1 mM, 16% inhibition; 1 mM, 84% decreases in activity
Cu2+
-
competitive inhibition
D-2-deoxyglucose
-
-
D-5-phosphoribosyl-1-diphosphate
-
-
D-5-phosphoribosyl-1-diphosphate
-
-
D-6-sulfogluconate
-
-
D-erythrose 4-phosphate
-
-
D-erythrose 4-phosphate
-
-
D-erythrose 4-phosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-Glucose 1,6-bisphosphate
-
-
D-Glucose 1,6-bisphosphate
-
-
D-Glucose 1,6-bisphosphate
-
-
D-glyceraldehyde 3-phosphate
-
-
D-glyceraldehyde 3-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
diphosphate
-
-
Fe3+
-
-
Fe3+
noncompetitive inhibition with respect to NADP+ and competitive inhibition with respect to 6-phospho-D-gluconate
Hg2+
-
-
iodoacetamide
-
-
MMV000563
-
MMV000720
-
MMV007199
-
MMV007228
-
MMV007273
-
MMV007384
-
MMV011895
-
MMV665972
-
MMV666125
-
N-(4-chlorobenzoyl)-indole
-
N-(4-chlorobenzoyl)-indole
competitive inhibitor
N-benzoylindole
-
N-benzoylindole
noncompetitive; noncompetitive inhibitor
N-[(4-chlorophenyl)(2-hydroxy-1-naphthyl)methyl]-2-phenylacetamide
-
N-[(4-chlorophenyl)(2-hydroxy-1-naphthyl)methyl]-2-phenylacetamide
-
NADP+
-
substrate inhibition
NADPH
-
-
NADPH
D4ZTT4
competitive inhibitor of NADP+ for wild-type enzyme and non-competitive inhibitor of NADP+ for mutant enzyme T35S; NADPH acts as a competitive inhibitor of NADP+ for the wild-type enzyme and as a non-competitive inhibitor of NADP+ for mutant enzyme T35S
NADPH
-
competitive inhibition
NADPH
-
noncompetitive inhibition versus 6-phosphogluconate
NADPH
-
6-phosphogluconate modulates 6PGDH activity. In the forward reaction, it suppresses inhibition by NADP and decreases inhibition by NADPH by increasing the Kd of the reduced coenzyme 6fold it increases the rate of decarboxylation of the 3-keto intermediate , whereas in the reverse reaction, it decreases the Km and removes the slow step
NADPH
-
product inhibition
NADPH
-
competitive inhibition
NADPH
-
competitive inhibition
NADPH
competitive inhibition versus NADP+ with 6-phospho-D-gluconate equal to its Km and at a saturating concentration
NADPH
saturating concentration at pH 7.5
NADPH
-
competitive inhibition
NADPH
-
complete inhibition
NADPH
-
competitive inhibition
NADPH
0.2 mM, activity markedly decreases, wild-type enzyme shows non-competitive inhibition, mutant enzyme S42T shows competitive inhibition; non-competitive inhibition of wild-type enzyme. Activity markedly decreases to 14% in the presence of 0.2 mM NADPH. Competitive inhibitor of NADP+ in mutant enzyme S42T
NADPH
-
competitive inhibition
netilmicin sulfate
-
in vitro inhibition
netilmicin sulfate
-
in vitro and in vivo inhibition, competitive
netilmicin sulfate
-
in vitro and in vivo inhibition
oxaloacetate
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
phosphate
-
competitive inhibitor of the substrates
phosphoenolpyruvate
-
-
phosphoenolpyruvate
1 mM, 36% inhibition; 1 mM, 64% decreases in activity
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
-
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
compound shows in vitro antiparasitic activity
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
compound shows in vitro antiparasitic activity
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
compound shows in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
compound shows low in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
-
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
compound shows low in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
compound shows low in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
compound shows low in vitro antiparasitic activity
pyridoxal 5'-phosphate
-
photooxidation
pyridoxal 5'-phosphate
-
-
pyridoxal 5'-phosphate
-
photooxidation
Rose bengal
-
photooxidation
Rose bengal
-
photooxidation
Rose bengal
-
photooxidation
sulfate
-
-
UTP
-
-
Zn2+
-
-
Zn2+
-
competitive inhibition
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
-
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
-
compound shows low in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
-
compound shows low in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
-
compound shows low in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
-
compound shows low in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
additional information
-
the activityand transcript level of 6PGDH decreases to 67% of its initial activity after 7 days of phosphate starvation
-
additional information
-
no inhibition by cefozin, decefin, streptomycin, combisid, and meronem
-
additional information
not inhibited by fumarate
-
additional information
-
not inhibited by fumarate
-
additional information
-
IC50 for antiparasitic activity of inhibitors, overview
-
additional information
-
not inhibited by ungallated catechins like (-)-epigallocatechin, (-)-gallocatechin, (-)-epicatechin, (-)-catechin, and dehydroepiandrosterone
-
additional information
-
infection with potato virus Y increases the enzyme activity but decreases the 6-phosphono-D-gluconate content, maximal decrease of 30-50% at period of the highest virus replication
-
additional information
-
no inhibition by [3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid, [(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester, (2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid, and acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
additional information
-
IC50 for antiparasitic activity of inhibitors, overview
-
additional information
-
ovariectomized rats show a decrease in mRNA level and enzyme activity in the liver, but not in white adipose tissue, which can be restored by 17beta-estradiol administration
-
additional information
-
IC50 values for antiparasitic activity of inhibitors, overview
-
additional information
-
IC50 values for antiparasitic activity of inhibitors, overview
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Acquired Immunodeficiency Syndrome
Slow-binding inhibition of 6-phosphogluconate dehydrogenase by zinc ion.
Anemia
6-Phosphogluconate dehydrogenase deficiency in an Italian family.
Anemia, Hemolytic
Combined G-6PD and 6-PGD deficiency in a Hindu boy.
Anemia, Hemolytic
Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin.
beta-Thalassemia
[Aspects of the decrease of some enzyme activities in erythrocytes of subjects with beta-thalassemia]
Breast Neoplasms
Inhibiting 6-phosphogluconate dehydrogenase selectively targets breast cancer through AMPK activation.
Breast Neoplasms
Oxidative Pentose Phosphate Pathway Enzyme 6-Phosphogluconate Dehydrogenase Plays a Key Role in Breast Cancer Metabolism.
Carcinogenesis
6PGD Upregulation is Associated with Chemo- and Immuno-Resistance of Renal Cell Carcinoma via AMPK Signaling-Dependent NADPH-Mediated Metabolic Reprograming.
Carcinogenesis
Discovery of Ebselen as an Inhibitor of 6PGD for Suppressing Tumor Growth.
Carcinoma
6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met.
Carcinoma
6PGD Upregulation is Associated with Chemo- and Immuno-Resistance of Renal Cell Carcinoma via AMPK Signaling-Dependent NADPH-Mediated Metabolic Reprograming.
Carcinoma
Pneumococcal 6-phosphogluconate-dehydrogenase, a putative adhesin, induces protective immune response in mice.
Carcinoma, Hepatocellular
6PGD inhibition sensitizes hepatocellular carcinoma to chemotherapy via AMPK activation and metabolic reprogramming.
Carcinoma, Renal Cell
6PGD Upregulation is Associated with Chemo- and Immuno-Resistance of Renal Cell Carcinoma via AMPK Signaling-Dependent NADPH-Mediated Metabolic Reprograming.
Chemical and Drug Induced Liver Injury
[Catalytic properties of 6-phosphogluconate dehydrogenase from rat liver in normal state and during toxic hepatitis]
Glioblastoma
Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance.
Glioma
Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
6-Phosphogluconate dehydrogenase deficiency in an Italian family.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Combined G-6PD and 6-PGD deficiency in a Hindu boy.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Using the fluorescence spot test for neonatal screening of G6PD deficiency.
Glucosephosphate Dehydrogenase Deficiency
6-Phosphogluconate dehydrogenase deficiency in an Italian family.
Glucosephosphate Dehydrogenase Deficiency
Using the fluorescence spot test for neonatal screening of G6PD deficiency.
Hypothyroidism
Changes of activity and kinetics of certain liver and heart enzymes of hypothyroid and T(3)-treated rats.
Infections
Cloning, expression and characterization of a cell wall surface protein, 6-phosphogluconate-dehydrogenase, of Streptococcus suis serotype 2.
Infections
Vaccination with Streptococcus suis serotype 2 recombinant 6PGD protein provides protection against S. suis infection in swine.
Iron Overload
In vitro and in vivo effects of iron on the expression and activity of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase in rat spleen.
Iron Overload
Stimulation of gene expression and activity of antioxidant related enzyme in Sprague Dawley rat kidney induced by long-term iron toxicity.
Leishmaniasis
Admixture and relationships of the population of Jacobina, Bahia, Brazil.
Leishmaniasis, Visceral
[The identification of Leishmania isolates obtained from patients and dogs with visceral leishmaniasis in the Turkmen SSR]
Leprosy
Genetic markers and leprosy in South African negroes: Part II. Erythrocyte enzyme polymorphisms.
Leprosy
The genetics of leprosy.
Leukemia
Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.
Leukemia
Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin.
Lung Neoplasms
Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence.
Lung Neoplasms
Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer.
Lung Neoplasms
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
Malaria
Erythrocyte G-6-PD and 6-PGD genetic polymorphisms in South African Negroes, with a note on G-6-PD and the malaria hypothesis.
Malaria
Genetic markers and malaria. Observations in Gujarat, India.
Neoplasm Metastasis
Physcion and Physcion 8-O-?-D-glucopyranoside: Natural Anthraquinones with Potential Anti-cancer Activities.
Neoplasms
1-Hydroxy-8-methoxy-anthraquinon Reverses Cisplatin Resistance by Inhibiting 6PGD in Cancer Cells.
Neoplasms
6-Phosphogluconate dehydrogenase fuels multiple aspects of cancer cells: From cancer initiation to metastasis and chemoresistance.
Neoplasms
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Neoplasms
6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met.
Neoplasms
A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth.
Neoplasms
Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function.
Neoplasms
Discovery of Ebselen as an Inhibitor of 6PGD for Suppressing Tumor Growth.
Neoplasms
Evidence for a direct crosstalk between malic enzyme and the pentose phosphate pathway via structural interactions.
Neoplasms
Glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities in normal canine mammary gland and in mammary tumours and their correlation with oestrogen receptors.
Neoplasms
Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence.
Neoplasms
Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer.
Neoplasms
Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.
Neoplasms
Modification of the hexokinase activity in the red blood cells of subjects with differentiated adenocarcinoma.
Neoplasms
Oxidative Pentose Phosphate Pathway Enzyme 6-Phosphogluconate Dehydrogenase Plays a Key Role in Breast Cancer Metabolism.
Neoplasms
Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance.
Neoplasms
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
Neurilemmoma
Characterization of rat schwannoma-Schwann cell hybrids.
phosphogluconate dehydrogenase (nadp+-dependent, decarboxylating) deficiency
6-Phosphogluconate dehydrogenase deficiency in an Italian family.
phosphogluconate dehydrogenase (nadp+-dependent, decarboxylating) deficiency
Combined G-6PD and 6-PGD deficiency in a Hindu boy.
Prostatic Neoplasms
A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth.
Seizures
The calculation of the cytoplasmic free [NADP+]/[NADPH] ratio in brain: effect of electroconvulsive seizure.
Starvation
Long-term effects of starvation-refeeding in the rat.
Starvation
Regulation of glucose-6 phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in the meal-fed rat.
Starvation
[Intensity of pentose phosphate metabolism of carbohydrates in various brain areas in normal and starved animals]
Uterine Cervical Neoplasms
Inhibiting 6-phosphogluconate dehydrogenase enhances chemotherapy efficacy in cervical cancer via AMPK-independent inhibition of RhoA and Rac1.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0096 - 1.42
2-deoxy-3-oxo-6-phosphogluconate
0.55 - 1.42
2-deoxy-6-phosphogluconate
0.0048 - 0.011
6,7-dideoxy-7-phosphono-D-glucoheptonate
0.00013 - 33.7
6-phospho-D-gluconate
0.006 - 3.13
6-phosphogluconate
0.0035 - 0.03
6-phosphono-D-gluconate
0.02 - 1
ribulose-5-phosphate
0.0096
2-deoxy-3-oxo-6-phosphogluconate
-
-
0.082
2-deoxy-3-oxo-6-phosphogluconate
-
-
1.42
2-deoxy-3-oxo-6-phosphogluconate
-
-
0.55
2-deoxy-6-phosphogluconate
-
-
1.4
2-deoxy-6-phosphogluconate
-
-
1.42
2-deoxy-6-phosphogluconate
-
-
0.0048
6,7-dideoxy-7-phosphono-D-glucoheptonate
pH 8.0, 20°C
0.011
6,7-dideoxy-7-phosphono-D-glucoheptonate
pH 8.0, 20°C
0.00013
6-phospho-D-gluconate
-
-
0.0058
6-phospho-D-gluconate
pH 8.0, 25°C, mutant enzyme W104L
0.0102
6-phospho-D-gluconate
-
pH 7.6, 25°C
0.011
6-phospho-D-gluconate
-
in 50 mM HEPES buffer (pH 7.5) containing 5 mM Mg2+, 0.5 mM Mn2+, and 0.5 mg bovine serum albumin, at 80°C
0.011
6-phospho-D-gluconate
80°C, pH 7.5
0.0113
6-phospho-D-gluconate
pH 8.0, 25°C, wild-type enzyme
0.0121
6-phospho-D-gluconate
mutant enzyme H186A
0.019
6-phospho-D-gluconate
-
at pH 8.0 and 25°C
0.024
6-phospho-D-gluconate
mutant enzyme T262A
0.028
6-phospho-D-gluconate
wild type enzyme
0.0284
6-phospho-D-gluconate
wild type enzyme
0.0337
6-phospho-D-gluconate
pH 8.0, 25°C, wild-type enzyme
0.04
6-phospho-D-gluconate
-
dimeric enzyme with two 6-phospho-D-gluconate bound, pH not specified in the publication, temperature not specified in the publication
0.042
6-phospho-D-gluconate
pH 7.3, 32°C, mutant enzyme S42T
0.0509
6-phospho-D-gluconate
pH 7.5
0.051
6-phospho-D-gluconate
at pH 7.5 and 22°C
0.052
6-phospho-D-gluconate
pH 7.3, 32°C, wild-type enzyme
0.07
6-phospho-D-gluconate
-
dimeric enzyme with one 6-phospho-D-gluconate bound, pH not specified in the publication, temperature not specified in the publication
0.0822
6-phospho-D-gluconate
-
free enzyme, at pH 7.5 and 25°C
0.093
6-phospho-D-gluconate
in 50 mM Tris-HCl buffer (pH 8.0), 20 mM MgCl2, at 25°C
0.095
6-phospho-D-gluconate
mutant enzyme S128A
0.107
6-phospho-D-gluconate
in 50 mM Tris-HCl buffer (pH 8.0), 20 mM MgCl2, at 25°C
0.15
6-phospho-D-gluconate
mutant enzyme K260A
0.53
6-phospho-D-gluconate
mutant enzyme N187A
0.595
6-phospho-D-gluconate
-
-
1.04
6-phospho-D-gluconate
mutant enzyme Y191A
2 - 3
6-phospho-D-gluconate
mutant enzyme R287A
3.4
6-phospho-D-gluconate
mutant enzyme R446A
33.7
6-phospho-D-gluconate
pH 8.0, 25°C
0.006
6-phosphogluconate
-
-
0.0068
6-phosphogluconate
-
pH 10
0.0069
6-phosphogluconate
-
-
0.007
6-phosphogluconate
-
-
0.0096
6-phosphogluconate
-
proplastid isoenzyme
0.01
6-phosphogluconate
-
-
0.011
6-phosphogluconate
-
-
0.012
6-phosphogluconate
-
cytosolic isoenzyme
0.0135
6-phosphogluconate
-
-
0.014
6-phosphogluconate
-
60°C or 65°C
0.0149
6-phosphogluconate
-
50 mM Tris-acetate, 5-10 mM MgCl2, pH 7.7
0.015
6-phosphogluconate
-
-
0.015
6-phosphogluconate
-
cytosolic isoenzyme
0.016
6-phosphogluconate
-
-
0.016
6-phosphogluconate
-
30°C
0.0161
6-phosphogluconate
-
50 mM Tris-acetate, pH 7.7
0.0167
6-phosphogluconate
-
10 mM Tris-acetate, 80 mM KCl, pH 7.7
0.018
6-phosphogluconate
-
plastid isoenzyme
0.02
6-phosphogluconate
-
-
0.02
6-phosphogluconate
-
43°C
0.022
6-phosphogluconate
-
45°C
0.0227
6-phosphogluconate
-
-
0.023
6-phosphogluconate
-
-
0.024
6-phosphogluconate
-
-
0.02666
6-phosphogluconate
-
-
0.031
6-phosphogluconate
-
type II
0.034
6-phosphogluconate
-
-
0.0343
6-phosphogluconate
-
-
0.035
6-phosphogluconate
-
-
0.036
6-phosphogluconate
-
-
0.04
6-phosphogluconate
-
-
0.04
6-phosphogluconate
-
-
0.04 - 0.05
6-phosphogluconate
-
heterocaryon col-3-wild-type
0.0413
6-phosphogluconate
-
10 mM Tris-acetate, pH 7.7
0.043
6-phosphogluconate
-
-
0.045
6-phosphogluconate
-
-
0.05
6-phosphogluconate
-
-
0.05
6-phosphogluconate
-
50 mM Tris-acetate, 20 mM MgCl2, KCl, pH 7.7
0.05
6-phosphogluconate
-
heterocaryon col-10-wild-type
0.052
6-phosphogluconate
-
type I
0.054
6-phosphogluconate
-
-
0.054
6-phosphogluconate
-
-
0.06
6-phosphogluconate
-
col-3-col-10
0.065
6-phosphogluconate
-
-
0.068
6-phosphogluconate
-
pH 5.93
0.071
6-phosphogluconate
-
-
0.071
6-phosphogluconate
-
pH 7
0.071
6-phosphogluconate
-
source embryo
0.08
6-phosphogluconate
-
isoenzyme 2
0.085
6-phosphogluconate
-
pH 8
0.09
6-phosphogluconate
-
-
0.09
6-phosphogluconate
-
mutant col 3
0.098
6-phosphogluconate
-
-
0.1
6-phosphogluconate
-
isoenzyme 1
0.109
6-phosphogluconate
-
plastid isoenzyme
0.11
6-phosphogluconate
-
-
0.11
6-phosphogluconate
-
-
0.11
6-phosphogluconate
-
mutant col 10
0.153
6-phosphogluconate
-
pH 8.0
0.157
6-phosphogluconate
-
-
0.204
6-phosphogluconate
-
pH 9
0.22
6-phosphogluconate
-
-
0.29
6-phosphogluconate
-
-
0.313
6-phosphogluconate
-
23.5°C
0.402
6-phosphogluconate
-
source endosperm
0.64
6-phosphogluconate
-
pH 9.5
3.13
6-phosphogluconate
-
pH 9.03
0.0035
6-phosphono-D-gluconate
-
pH 7.5, 20°C
0.0053
6-phosphono-D-gluconate
pH 8.0, 20°C
0.016
6-phosphono-D-gluconate
-
pH 7.5, 20°C
0.022
6-phosphono-D-gluconate
pH 7.5, 30°C, purified native wild-type enzyme
0.0222
6-phosphono-D-gluconate
pH 7.5, 30°C, purified recombinant mutant enzyme
0.03
6-phosphono-D-gluconate
pH 8.0, 20°C
34
CO2
-
-
1.7
MgCl2
-
cytosolic isoenzyme
2.4
MgCl2
-
proplastid isoenzyme
0.01187
NAD+
mutant enzyme A30D/R31I/T32I, at pH 7.5 and 50°C
0.0119
NAD+
recombinant His-tagged mutant A30D/R31I/T32I, pH 7.5, 50°C
0.127
NAD+
mutant enzyme A30E/R31I/T32D, at pH 7.5 and 50°C
0.127
NAD+
recombinant His-tagged mutant A30E/R31I/T32D, pH 7.5, 50°C
0.354
NAD+
mutant enzyme R31I, at pH 7.5 and 50°C
0.354
NAD+
recombinant His-tagged mutant R31I, pH 7.5, 50°C
0.362
NAD+
mutant enzyme R31I/T32G, at pH 7.5 and 50°C
0.362
NAD+
recombinant His-tagged mutant R31I/T32G, pH 7.5, 50°C
0.38
NAD+
-
in 50 mM HEPES buffer (pH 7.5) containing 5 mM Mg2+, 0.5 mM Mn2+, and 0.5 mg bovine serum albumin, at 80°C
0.404
NAD+
mutant enzyme A30C/R31I/T32K, at pH 7.5 and 50°C
0.404
NAD+
recombinant His-tagged mutant A30C/R31I/T32K, pH 7.5, 50°C
0.605
NAD+
mutant enzyme R31T, at pH 7.5 and 50°C
0.605
NAD+
recombinant His-tagged mutant R31T, pH 7.5, 50°C
1.397
NAD+
wild type enzyme, at pH 7.5 and 50°C
1.397
NAD+
recombinant His-tagged wild-type enzyme, pH 7.5, 50°C
2.5
NAD+
mutant enzyme N32E/R33I/T34I, at pH 7.5 and 70°C
3.9
NAD+
mutant enzyme N32D/R33I/T34I, at pH 7.5 and 70°C
4
NAD+
mutant enzyme N32D, at pH 7.5 and 70°C
4.3
NAD+
wild type enzyme at pH 7.5 and 70°C
4.46
NAD+
pH 7.3, 32°C, wild-type enzyme
6.6
NAD+
pH 7.3, 32°C, mutant enzyme S42T
7.5
NAD+
mutant enzyme N32D/R33L/T34S, at pH 7.5 and 70°C
0.00088
NADP+
-
-
0.002
NADP+
wild type enzyme
0.002
NADP+
mutant enzyme H186A
0.0034
NADP+
-
free enzyme, at pH 7.5 and 25°C
0.0041
NADP+
-
cytosolic isoenzyme
0.0042
NADP+
mutant enzyme T262A
0.0046
NADP+
pH 7.5, 30°C, purified native wild-type enzyme
0.0048
NADP+
pH 8.0, 25°C, mutant enzyme W104L
0.005
NADP+
wild type enzyme
0.005
NADP+
wild type enzyme, at pH 7.5 and 70°C
0.0052
NADP+
-
at pH 8.0 and 25°C
0.0054
NADP+
-
proplastid isoenzyme
0.0054
NADP+
mutant enzyme S128A
0.00571
NADP+
-
10 mM Tris-acetate, 10 mM MgCl2, pH 7.7
0.0059
NADP+
pH 7.5, 30°C, purified recombinant mutant enzyme
0.006
NADP+
-
source endosperm
0.00631
NADP+
-
10 mM Tris-acetate, 80 mM KCl, pH 7.7
0.0064
NADP+
mutant enzyme M13C
0.00676
NADP+
-
50 mM Tris-acetate, pH 7.7
0.0069
NADP+
pH 8.0, 25°C, wild-type enzyme
0.008
NADP+
-
cytosolic isoenzyme
0.00861
NADP+
-
50 mM Tris-acetate, 20 mM MgCl2, pH 7.7
0.00893
NADP+
-
10 mM Tris-acetate, pH 7.7
0.009
NADP+
pH 8.0, 25°C, wild-type enzyme
0.01
NADP+
-
wild-type, mutant col 10, heterocaryon col-10-wild-type
0.01
NADP+
-
in 50 mM HEPES buffer (pH 7.5) containing 5 mM Mg2+, 0.5 mM Mn2+, and 0.5 mg bovine serum albumin, at 80°C
0.011
NADP+
-
plastid isoenzyme
0.0139
NADP+
wild type enzyme, at pH 7.5 and 50°C
0.0139
NADP+
recombinant His-tagged wild-type enzyme, pH 7.5, 50°C
0.014
NADP+
mutant enzyme Y191A
0.015
NADP+
-
heterocaryon col 3-wild-type
0.015
NADP+
pH 7.3, 32°C, mutant enzyme S42T
0.016
NADP+
mutant enzyme K260A
0.018
NADP+
-
heterocaryon col-3-col-10
0.018
NADP+
at pH 7.5 and 22°C
0.019
NADP+
mutant enzyme M13F
0.019
NADP+
mutant enzyme M13Q
0.019
NADP+
D4ZTT4
pH 7.3, 32°C, wild-type enzyme
0.02
NADP+
-
type I and II
0.023
NADP+
-
plastid isoenzyme
0.025
NADP+
-
source of enzyme: peak I
0.026
NADP+
mutant enzyme M13V
0.0265
NADP+
mutant enzyme R31I, at pH 7.5 and 50°C
0.0265
NADP+
recombinant His-tagged mutant R31I, pH 7.5, 50°C
0.0298
NADP+
mutant enzyme N187A
0.03
NADP+
-
mutant col-3
0.03
NADP+
-
source of enzyme: whole cells
0.032
NADP+
-
source embryo
0.032
NADP+
mutant enzyme M13I
0.033
NADP+
-
source of enzyme: peak II
0.0355
NADP+
mutant enzyme R31T, at pH 7.5 and 50°C
0.0355
NADP+
recombinant His-tagged mutant R31T, pH 7.5, 50°C
0.042
NADP+
D4ZTT4
pH 7.3, 32°C, mutant enzyme T35S
0.049
NADP+
in 50 mM Tris-HCl buffer (pH 8.0), 20 mM MgCl2, at 25°C
0.058
NADP+
pH 7.3, 32°C, wild-type enzyme
0.064
NADP+
mutant enzyme R446A
0.073
NADP+
mutant enzyme R287A
0.1044
NADP+
mutant enzyme R31I/T32G, at pH 7.5 and 50°C
0.1044
NADP+
recombinant His-tagged mutant R31I/T32G, pH 7.5, 50°C
0.118
NADP+
in 50 mM Tris-HCl buffer (pH 8.0), 20 mM MgCl2, at 25°C
0.228
NADP+
mutant enzyme A30D/R31I/T32I, at pH 7.5 and 50°C
0.228
NADP+
recombinant His-tagged mutant A30D/R31I/T32I, pH 7.5, 50°C
0.66
NADP+
mutant enzyme A30E/R31I/T32D, at pH 7.5 and 50°C
0.66
NADP+
recombinant His-tagged mutant A30E/R31I/T32D, pH 7.5, 50°C
0.698
NADP+
mutant enzyme A30C/R31I/T32K, at pH 7.5 and 50°C
0.698
NADP+
recombinant His-tagged mutant A30C/R31I/T32K, pH 7.5, 50°C
2.3
NADP+
mutant enzyme N32D, at pH 7.5 and 70°C
70
NADP+
mutant enzyme N32D/R33I/T34I, at pH 7.5 and 70°C
79
NADP+
mutant enzyme N32E/R33I/T34I, at pH 7.5 and 70°C
100
NADP+
Km above 100 mM, mutant enzyme N32D/R33L/T34S, at pH 7.5 and 70°C
0.00022
NADPH
-
-
0.02
ribulose-5-phosphate
-
-
1
ribulose-5-phosphate
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.00128
(-)-catechin gallate
Mus musculus
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C
0.00121
(-)-epicatechin gallate
Mus musculus
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C
0.00072
(-)-epigallocatechin gallate
Mus musculus
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C
0.00145
(-)-gallocatechin gallate
Mus musculus
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C
0.349
(1H-indol-1-yl)(furan-2-yl)methanone
Rattus norvegicus
pH 8, 25°C
0.00336
(1H-indol-1-yl)(tiyophen-2-yl)methanone
Rattus norvegicus
pH 8, 25°C
0.0058
(2E)-2-cyano-3-(5-nitrofuran-2-yl)prop-2-enoic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
1.41
(4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
Homo sapiens
-
-
0.0013 - 0.0029
(5Z)-5-[[4-(3-fluorophenoxy)phenyl]methylidene]-2-imino-3-(2-methoxyphenyl)-1,3-thiazolidin-4-one
0.99
1-(2-nitro-1-(thiophen-2-yl)ethyl)-1H-indole
Rattus norvegicus
pH 8, 25°C
0.0035 - 0.0042
11-(4-methoxyphenyl)-11H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-ol
0.0018 - 0.0021
2,6-dimethoxy-4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
0.0027 - 0.0049
2-methyl-3-[2-(3-nitrophenyl)-2-oxoethyl]naphthalene-1,4-dione
0.028
2-methyl-5-nitrofuran-3-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.114
3,3',4,4'-tetramethyl-1H,1'H-2,2'-bipyrrole-5,5'-dicarboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.051
3-methyl-4-oxo-4,7-dihydro-5H-thiopyrano[3,4-b]furan-2-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.0016 - 0.0021
4,4'-[1,4-phenylenebis(oxy-1H-benzimidazole-6,2-diyl)]dianiline
0.042
4,5-dichloro-1H-pyrrole-2-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.043
4-chloro-1H-pyrrole-2-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.042
4H-thieno[3,2-b]pyrrole-5-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.0024 - 0.0025
5,5'-methylenebis[2-(4-methoxyphenyl)-1H-benzimidazole]
0.0018 - 0.0027
5,6-bis(2H-1,3-benzodioxol-5-yl)-2-(3-methylphenyl)-4,7-diphenyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3,8(2H)-trione
0.00253
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
Homo sapiens
-
-
0.0601
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
Homo sapiens
-
-
0.045
5-(ethoxycarbonyl)-3,4-dimethyl-1H-pyrrole-2-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.0022 - 0.0031
7-[[3-(benzyloxy)phenyl][(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol
1.526
Al3+
Ctenopharyngodon idella
-
at pH 8.0 and 25°C
287.4
amoxicillin
Homo sapiens
-
25°C, pH 8.0
0.109
brimonidine
Homo sapiens
pH and temperature not specified in the publication
0.045
Cd2+
Ctenopharyngodon idella
-
at pH 8.0 and 25°C
117.4
clindamycin
Homo sapiens
-
25°C, pH 8.0
0.293
Cu2+
Ctenopharyngodon idella
-
at pH 8.0 and 25°C
0.225
Fe3+
Rattus norvegicus
pH 7.6, and temperature not specified in the publication
0.43
Imipenem
Homo sapiens
-
25°C, pH 8.0
0.17
lornoxicam
Homo sapiens
-
25°C, pH 8.0
0.23
metronidazole
Homo sapiens
-
25°C, pH 8.0
0.0035 - 0.0042
MMV000563
0.0022 - 0.0031
MMV000720
0.0013 - 0.0029
MMV007199
0.0018 - 0.0027
MMV007228
0.0018 - 0.0021
MMV007273
0.0024 - 0.0025
MMV007384
0.0016 - 0.0021
MMV011895
0.0027 - 0.0049
MMV666125
0.00219
N-(4-chlorobenzoyl)-indole
Rattus norvegicus
pH 8, 25°C
0.00275
N-benzoylindole
Rattus norvegicus
pH 8, 25°C
0.004 - 0.0043
N-[(4-chlorophenyl)(2-hydroxy-1-naphthyl)methyl]-2-phenylacetamide
21.79
ornidazole
Homo sapiens
-
25°C, pH 8.0
0.053
potassium 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.602
proparacaine
Homo sapiens
pH and temperature not specified in the publication
0.073
sodium (4E)-4-(hydroxyimino)-3-oxo-1,2,3,4-tetrahydronaphthalene-1-sulfonate
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
46.39
Vancomycin
Homo sapiens
-
25°C, pH 8.0
0.099
Zn2+
Ctenopharyngodon idella
-
at pH 8.0 and 25°C
0.056
[(5-nitrofuran-2-yl)methylidene]propanedioic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.0013
(5Z)-5-[[4-(3-fluorophenoxy)phenyl]methylidene]-2-imino-3-(2-methoxyphenyl)-1,3-thiazolidin-4-one
Homo sapiens
25°C, pH 8.0
0.0029
(5Z)-5-[[4-(3-fluorophenoxy)phenyl]methylidene]-2-imino-3-(2-methoxyphenyl)-1,3-thiazolidin-4-one
Plasmodium falciparum
25°C, pH 8.0
0.0035
11-(4-methoxyphenyl)-11H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-ol
Homo sapiens
25°C, pH 8.0
0.0042
11-(4-methoxyphenyl)-11H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-ol
Plasmodium falciparum
25°C, pH 8.0
0.0018
2,6-dimethoxy-4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
Homo sapiens
25°C, pH 8.0
0.0021
2,6-dimethoxy-4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
Plasmodium falciparum
25°C, pH 8.0
0.0027
2-methyl-3-[2-(3-nitrophenyl)-2-oxoethyl]naphthalene-1,4-dione
Plasmodium falciparum
25°C, pH 8.0
0.0049
2-methyl-3-[2-(3-nitrophenyl)-2-oxoethyl]naphthalene-1,4-dione
Homo sapiens
25°C, pH 8.0
0.0016
4,4'-[1,4-phenylenebis(oxy-1H-benzimidazole-6,2-diyl)]dianiline
Plasmodium falciparum
25°C, pH 8.0
0.0021
4,4'-[1,4-phenylenebis(oxy-1H-benzimidazole-6,2-diyl)]dianiline
Homo sapiens
25°C, pH 8.0
0.0024
5,5'-methylenebis[2-(4-methoxyphenyl)-1H-benzimidazole]
Homo sapiens
25°C, pH 8.0
0.0025
5,5'-methylenebis[2-(4-methoxyphenyl)-1H-benzimidazole]
Plasmodium falciparum
25°C, pH 8.0
0.0018
5,6-bis(2H-1,3-benzodioxol-5-yl)-2-(3-methylphenyl)-4,7-diphenyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3,8(2H)-trione
Plasmodium falciparum
25°C, pH 8.0
0.0027
5,6-bis(2H-1,3-benzodioxol-5-yl)-2-(3-methylphenyl)-4,7-diphenyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3,8(2H)-trione
Homo sapiens
25°C, pH 8.0
0.0022
7-[[3-(benzyloxy)phenyl][(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol
Homo sapiens
25°C, pH 8.0
0.0031
7-[[3-(benzyloxy)phenyl][(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol
Plasmodium falciparum
25°C, pH 8.0
0.0035
MMV000563
Homo sapiens
pH 8.0, 25°C
0.0042
MMV000563
Plasmodium falciparum
pH 8.0, 25°C
0.0022
MMV000720
Homo sapiens
pH 8.0, 25°C
0.0031
MMV000720
Plasmodium falciparum
pH 8.0, 25°C
0.0013
MMV007199
Homo sapiens
pH 8.0, 25°C
0.0029
MMV007199
Plasmodium falciparum
pH 8.0, 25°C
0.0018
MMV007228
Plasmodium falciparum
pH 8.0, 25°C
0.0027
MMV007228
Homo sapiens
pH 8.0, 25°C
0.0018
MMV007273
Homo sapiens
pH 8.0, 25°C
0.0021
MMV007273
Plasmodium falciparum
pH 8.0, 25°C
0.0024
MMV007384
Homo sapiens
pH 8.0, 25°C
0.0025
MMV007384
Plasmodium falciparum
pH 8.0, 25°C
0.0016
MMV011895
Plasmodium falciparum
pH 8.0, 25°C
0.0021
MMV011895
Homo sapiens
pH 8.0, 25°C
0.004
MMV665972
Plasmodium falciparum
pH 8.0, 25°C
0.0043
MMV665972
Homo sapiens
pH 8.0, 25°C
0.0027
MMV666125
Plasmodium falciparum
pH 8.0, 25°C
0.0049
MMV666125
Homo sapiens
pH 8.0, 25°C
0.004
N-[(4-chlorophenyl)(2-hydroxy-1-naphthyl)methyl]-2-phenylacetamide
Plasmodium falciparum
25°C, pH 8.0
0.0043
N-[(4-chlorophenyl)(2-hydroxy-1-naphthyl)methyl]-2-phenylacetamide
Homo sapiens
25°C, pH 8.0
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
three-dimensional structure homology modeling of wild-type 6PGDH from Moorella thermoacetica and mutants based on the structure of human enzyme 6PGDH, PDB ID 2JKV
drug target
abrogating 6-phosphogluconate dehydrogenase Y481 phosphorylation (pY481) dramatically attenuates epidermal growth factor receptor(EGF) promotes glioma cell proliferation, tumor growth and resistance to ionizing radiation. 6PGD pY481 is associated with Fyn expression, the malignancy and prognosis of human glioblastoma. Critical role of Fyn-dependent 6-phosphogluconate dehydrogenase (6PGD) phosphorylation in EGF-promoted tumor growth and radiation resistance
drug target
blockade of 6-phosphogluconate dehydrogenase reprograms CD8+ T cell metabolism to support superior effector function with higher tumoricidal activity. This metabolic checkpoint represents a key therapeutic target for cancer immunotherapies
drug target
Plasmodium falciparum 6-phosphogluconate dehydrogenase is an antimalarial drug target
drug target
targeting 6-phosphogluconate dehydrogenase (6PGD) and NADPH production is sufficient to block growth of acute myeloid leukemia cell lines resistant to the chemotherapeutics daunorubicin and cytarabine. Stromal cell-mediated resistance to targeted inhibition of oncogenic FLT3 kinase activity by quizartinib is circumvented by 6PGD knockdown
drug target
the enzyme (6PGD) is a putative therapeutic drug target in breast cancer treatment. Targeting 6PGD not only reduces cell proliferation through cell cycle arrest and apoptosis induction but also activates p53 and decreases the stem cell-like characteristics of breast cancer cells. Inhibition of 6PGD alters the stem cell characteristics and mammosphere formation capabilities of MCF-7 cells, opening new avenues to prevent cancer recurrance after surgery or chemotherapy. Inhibition of 6PGD via chemical inhibitor 1-hydroxy-8-methoxy-anthraquinone results in an induction of senescence, which, together with the cell cycle arrest and apoptosis induction, might be orchestrated by p53 activation
drug target
the enzyme is an attractive antimalarial drug target due to its central role in metabolism
drug target
the enzyme is critically involved in the development of anaplastic thyroid carcinoma resistance to oxorubicin. Inhibiting 6-phosphogluconate dehydrogenase reverses doxorubicin resistance in anaplastic thyroid cancer via inhibiting NADPH-dependent metabolic reprogramming
drug target
the enzyme might serve as promising therapeutic target for the treatment of cancers in which the enzyme (6PGD) is aberrantly overexpressed
evolution
phylogenetic analysis of cyanobacterial 6-phosphogluconate dehydrogenases (6PGDH) reveals that an amino acid residue at position 42 in Sy6PGDH is highly conserved for each order of cyanobacteria, but Synechocystis 6PGDH (Sy6PGDH) is phylogenetically unique. In Sy6PGDH, a single amino acid substitution at position 42 from serine to threonine enhances the affinity for NADP+ and alters the mode of inhibition by NADPH
evolution
phylogenetic analysis of cyanobacterial 6PGDHs reveales that the amino acid residue at position 42 in Sy6PGDH is highly conserved
malfunction
-
enzyme suppression decreases lipogenesis and RNA biosynthesis and elevates reactive oxygen species levels in cancer cells, attenuating cell proliferation and tumor growth
malfunction
-
mutations of the chloroplast-localized enzyme cause a rough endosperm seed phenotype with reduced embryo oil and endosperm starch and altered carbon flux into starch
malfunction
blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function
malfunction
disruption of glucose-6-phosphate dehydrogenase (ZWF1), 6-phosphogluconate dehydrogenase GND1 and 6-phosphogluconate dehydrogenase GND2 genes can decrease the ability of yeast cells to reproduction in the exponential phase of culture
malfunction
enzyme suppression causes a characteristic ER-dilation phenotype that is associated with increased extracellular matrix protein inside cells as well as decreased secretion
malfunction
-
disruption of glucose-6-phosphate dehydrogenase (ZWF1), 6-phosphogluconate dehydrogenase GND1 and 6-phosphogluconate dehydrogenase GND2 genes can decrease the ability of yeast cells to reproduction in the exponential phase of culture
-
metabolism
pentose phosphate pathway
metabolism
-
phosphogluconate pathway, bacterial 6-phosphogluconate dehydrogenase is a constitutive enzyme, bacterial enzyme is active in young, non-inoculated mesquite seedlings growing under hydroponic conditions, external gluconate has no effect on the activity of 6-phosphogluconate dehydrogenase
metabolism
-
enzyme-mediated production of D-ribulose 5-phosphate inhibits adenine monophosphate-activated protein kinase activation by disrupting the active tumor suppressor liver kinase B1 complex, thereby activating acetyl-CoA carboxylase 1 and lipogenesis
metabolism
6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase
metabolism
6-phosphogluconate dehydrogenase links cytosolic carbohydrate metabolism to protein secretion via modulation of glutathione levels
metabolism
inhibition of the enzyme (6PGD) in MCF-7 cells reduces cell proliferation and shows a significant decrease in glucose consumption and an increase in glutamine consumption, resulting in an important alteration in the metabolism of these cells
metabolism
key enzyme catalyzing the third step in the reaction involving the oxidative phase of the pentose phosphate pathway
metabolism
no difference in reactive oxygen species production levels is observed after inhibition of the enzyme (6PGD), indicating that 6PGD, in contrast to glucose 6-phosphate dehydrogenase, is not involved in redox balance
metabolism
the enzyme catalyzes a step of the pentose phosphate pathway
metabolism
the enzyme catalyzes a step of the pentose phosphate pathway
metabolism
the enzyme is involved in the oxidative pentose phosphate pathway
metabolism
the enzyme plays a key role in breast cancer metabolism
metabolism
upon epidermal growth factor receptor (EGFR) activation, the enzyme (6PGD) is phosphorylated at tyrosine 481 by Src family kinase Fyn. This phosphorylation enhances 6PGD activity by increasing its binding affinity to NADP+ and therefore activates the pentose phosphate pathway for NADPH and ribose-5-phosphate, which consequently detoxifies intracellular reactive oxygen species (ROS) and accelerates DNA synthesis
metabolism
-
phosphogluconate pathway, bacterial 6-phosphogluconate dehydrogenase is a constitutive enzyme, bacterial enzyme is active in young, non-inoculated mesquite seedlings growing under hydroponic conditions, external gluconate has no effect on the activity of 6-phosphogluconate dehydrogenase
-
metabolism
-
6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase
-
physiological function
-
the enzyme is important for oxidative triphosphate and lipogenesis, as well as proliferative and tumor growth potential of cancer cells
physiological function
-
the enzyme is involved in tellurite detoxification and resistance in Escherichia coli
physiological function
the peroxisomal isoform is mainly involved in xenobiotic response, growth, and developmental processes
physiological function
acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming
physiological function
in the oxidative pentose phosphate pathway, 6-phosphogluconate dehydrogenase (6PGDH) is one of the enzymes that catalyzes reactions generating NADPH
physiological function
D4ZTT4
in the oxidative pentose phosphate pathway, 6-phosphogluconate dehydrogenase (6PGDH) is one of the enzymes that catalyzes reactions generating NADPH
physiological function
-
isoenzyme PGD3 is critical for endosperm starch accumulation. The cytosolic isozymes, PGD1 and PGD2, are not required for kernel development
physiological function
key enzyme of the oxidative pentose phosphate pathway
physiological function
the enzyme (Os6PGDH1) plays a pivotal role in rice growth and also in the resistance of rice to brown planthopper (BPH) Nilaparvata lugens by modulating jasmonic acid, ethylene, and H2O2 pathways
physiological function
the enzyme involved in carbohydrate metabolism, is required for endoplasmic reticulum structural integrity and protein secretion
physiological function
the enzyme is a modulator of CD8+ T cell activation and differentiation
physiological function
the enzyme is commonly upregulated and plays important roles in many human cancers
physiological function
the enzyme is involved in the oxidative branch of the pentose phosphate pathway
physiological function
the enzyme is responsible for NADPH formation in the pentose phosphate pathway
physiological function
the enzyme plays an important function in various biochemical processes as it generates reducing power ofthe cell
physiological function
the NADPH produced by 6PGD is crucial for antioxidant defense and redox regulation and ribose 5-phosphate is essential for DNA and RNA synthesis in the rapidly growing parasite
physiological function
-
the enzyme is responsible for NADPH formation in the pentose phosphate pathway
-
physiological function
-
key enzyme of the oxidative pentose phosphate pathway
-
physiological function
-
the enzyme is involved in tellurite detoxification and resistance in Escherichia coli
-
physiological function
-
in the oxidative pentose phosphate pathway, 6-phosphogluconate dehydrogenase (6PGDH) is one of the enzymes that catalyzes reactions generating NADPH
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.