EC Number   |
Source Tissue |
Reference |
|---|
   1.1.1.146 | 3T3-L1 cell |
- |
686411, 697625, 700121, 700180, 712594, 740806 |
| 1.1.1.146 | 3T3-L1 cell |
differentiation of cells causes a strong increase in 11beta-hydroxysteroid dehydrogenase protein levels, occuring late in the differentiation protocol. Reduction of 11beta-hydroxysteroid dehydrogenase activity in 3T3-L1 fibroblasts, achieved by pharmacological inhibition or adenovirally mediated delivery of short hairpin RNA constructs, specifically blocks the ability of inactive glucocorticoids to drive 3T3-L1 differentiation. Even modest increases in exogenous 11beta-hydroxysteroid dehydrogenase expression in 3T3-L1 fibroblasts, to levels comparable with endogenous 1 11beta-hydroxysteroid dehydrogenase in differentiated 3T3-L1 adipocytes, are sufficient to block adipogenesis |
692987 |
| 1.1.1.146 | abdominal adipose tissue |
11beta-HSD1 activity is increased in visceral adipose tissue in prepubertal children with normal weight |
698167 |
| 1.1.1.146 | adenocarcinoma cell |
rectum, sigmoid colon |
655162 |
| 1.1.1.146 | adipocyte |
- |
668379, 669504, 697625, 700121, 700179, 700180, 712594, 740806 |
| 1.1.1.146 | adipocyte |
epididymal fat, presence of a functional glucose-6-phosphate-transporter hexose-6-phosphate dehydrogenase 11beta-hydroxysteroid dehydrogenase type 1 system |
692078 |
| 1.1.1.146 | adipocyte |
methionine restriction induces isoform 11beta-HSD1 activity in all types of adipose tissue examined, correlating with increased tissue corticosterone. Inverse relationship between 11beta-HSD1 activity and adipocyte size is observed. Methionine restriction additionally increases adipose triglyceride lipase and acetyl-coenzyme A carboxylase protein levels |
688225 |
| 1.1.1.146 | adipose tissue |
- |
669504, 700178, 711383, 711387, 711752, 711800, 740146, 740803, 740806, 740917, 760680, 760682, 760868 |
| 1.1.1.146 | adipose tissue |
11beta-hydroxysteroid dehydrogenase mRNA level together with the markers of late adipocyte differentiation are significantly lower in orbital adipose tissue than in subcutaneous tissue. In primary cultures of orbital preadipocytes, there is predominant 11beta-hydroxysteroid dehydrogenase 1 oxoreductase activity with minimal dehydrogenase activity. Orbital adipocytes are smaller, less differentiated and express low levels of 11beta-hydroxysteroid dehydrogenase, but abundant glucocorticoid receptor compared with subcutaneous omental depots |
693379 |
| 1.1.1.146 | adipose tissue |
expression of isozyme 11beta-HSD1, in situ hybridization, overview |
670065 |
