Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | Canis lupus familiaris | pathway overview | cortisol + NADP+ | - |
ir | |
additional information | Canis lupus familiaris | high local cortisol concentrations generated via the 11beta-HSD1 pathway within the liver likely contribute to the regulation of hepatic glucose, fat, and protein metabolism | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | - |
Canis lupus familiaris | - |
hepatocyte | primary | Canis lupus familiaris | - |
liver | hepatic artery, portal vein, and hepatic vein, local cortisol concentrations, overview | Canis lupus familiaris | - |
viscus | splanchnic activity | Canis lupus familiaris | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
splanchnic, visceral, and hepatic net cortisol balance, cortisol uptake, and cortisol production, overview | Canis lupus familiaris |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | pathway overview | Canis lupus familiaris | cortisol + NADP+ | - |
ir | |
additional information | high local cortisol concentrations generated via the 11beta-HSD1 pathway within the liver likely contribute to the regulation of hepatic glucose, fat, and protein metabolism | Canis lupus familiaris | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta hydroxysteroid dehydrogenase type 1 | - |
Canis lupus familiaris |
isozyme 11beta-HSD1 | - |
Canis lupus familiaris |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Canis lupus familiaris |