EC Number   |
General Information |
Reference |
|---|
   3.4.22.B71 | evolution |
SUMO-specific protease 2 (SENP2) is a de-SUMOylation protease family member |
731631 |
| 3.4.22.B71 | evolution |
the enzyme belongs to the SENP/ULP protease family |
732884 |
| 3.4.22.B71 | malfunction |
differential localization of nucleoporins upon codepletion of SENP1 and SENP2 in HeLa cells, immunohistochemic analysis, overview |
732483 |
| 3.4.22.B71 | malfunction |
enzyme SENP2 knockout MEF cells show increased glucose uptake and lactate production along with decreased ATP levels. SENP2 knockout embryonic fibroblasts exhibit increased levels of phosphorylated AKT. Inhibiting AKT phosphorylation by LY294002 rescues the phenotype induced by SENP2 deficiency in embryonic fibroblasts. Knockout of SENP2 leads to increased aerobic glycolysis in MEF cells |
732727 |
| 3.4.22.B71 | malfunction |
in SENP2 null embryo, SUMOylated Pc2/CBX4 accumulates and Pc2/CBX4 occupancy on the promoters of PcG target genes is markedly increased, leading to repression of Gata4 and Gata6 transcription |
716221 |
| 3.4.22.B71 | malfunction |
knockdown of SENP2 leads to a strong attenuation of adipogenesis with a marked decrease in PPARgamma and C/EBPalpha mRNA levels. Knockdown of SENP2 also causes a marked reduction in the level of C/EBPbeta protein but not in that of C/EBPbeta mRNA |
716210 |
| 3.4.22.B71 | malfunction |
overexpression of enzyme SENP2 reduces the glucose uptake and lactate production, increasing the cellular ATP levels in MCF-7 cells. The MCF-7 cells overexpressing enzyme SENP2 exhibit decreased expression levels of key glycolytic enzymes and an increased rate of glucose oxidation compared with control MCF-7 cells, indicating inhibited glycolysis but enhanced oxidative mitochondrial respiration. The cells have a reduced amount of phosphorylated AKT |
732727 |
| 3.4.22.B71 | malfunction |
RNA interference SENP2 knockdown produces no detectable phenotypes, while overexpression of SENP2, but not other SUMO-specific isopeptidases, causes a defect in chromosome congression that depends on its precise kinetochore targeting. Isozyme SENP2 overexpression uniquely induces prometaphase arrest |
732481 |
| 3.4.22.B71 | malfunction |
SENP2 ablation disturbs the p53-Mdm2 pathway, affecting the expansion of trophoblast progenitors and their maturation |
716658 |
| 3.4.22.B71 | malfunction |
silencing the expression of enzyme SENP2 significantly induces the expression of MMP13 , forced MMP13 expression is sufficient to restore cell invasion in SENP2 overexpressed T24 bladder cancer cells |
731631 |
