Literature summary for 3.4.22.B71 extracted from

Cubenas-Potts, C.; Goeres, J.D.; Matunis, M.J.
SENP1 and SENP2 affect spatial and temporal control of sumoylation in mitosis (2013), Mol. Biol. Cell, 24, 3483-3495.

Search for more literature for 3.4.22.B71

Cloned(Commentary)

Cloned (Comment)	Organism
expression of GFP-tagged SENP2 in HeLa cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	the enzyme SENP2 is targeted to kinetochores in mitosis. SENP2 targeting occurs through a mechanism dependent on the Nup107-160 subcomplex of the nuclear pore complex and is modulated through interactions with karyopherin alpha	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9HC62	-	-

Synonyms

Synonyms	Comment	Organism
SENP2	-	Homo sapiens
small ubiquitin-related modifier-specific isopeptidase	-	Homo sapiens
SUMO-specific isopeptidase	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	RNA interference SENP2 knockdown produces no detectable phenotypes, while overexpression of SENP2, but not other SUMO-specific isopeptidases, causes a defect in chromosome congression that depends on its precise kinetochore targeting. Isozyme SENP2 overexpression uniquely induces prometaphase arrest	Homo sapiens
physiological function	enzyme SENP2 is an important mediator of precise spatial and temporal control of sumoylation in mitosis required for chromosome segregation	Homo sapiens

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Release 2023.1 (January 2023)