EC Number   |
Posttranslational Modification |
Reference |
|---|
   3.5.3.15 | no modification |
the potential Asn-linked glycosylation site, Asn542-Glu543-Ser544 has no carbohydrate moiety |
209419 |
| 3.5.3.15 | proteolytic modification |
PAD4 autodeimination does not alter the activity, substrate specificity, or calcium dependence of this isozyme. Six in vitro sites of autodeimination are identified: R123, R156, R205, R419, R484, and R639. Autodeimination of PAD4 reduces protein-protein interactions |
718900 |
| 3.5.3.15 | side-chain modification |
methylation of Arg106 is a naturally occuring modification of the enzyme that affects deimination of Arg residues |
209418 |
| 3.5.3.15 | side-chain modification |
methylation of Arg107 is a naturally occuring modification of the enzyme that affects deimination of Arg residues |
209418 |
| 3.5.3.15 | sumoylation |
ADI is also sumoylated, which may modulate its activity |
699105 |
