EC Number   |
Application |
Reference |
|---|
   3.2.2.27 | analysis |
fluorescence method for sensitive detection of uracil-DNA glycosylase using TdT-activated Endonuclease IV-assisted hyperbranched signal amplification. The method exhibits high sensitivity with a limit of detection of 0.090 U/ml for pure uracil-DNA glycosylase and shows a dynamic range from 0.1 to 50 U/ml, and can be applied for accurate detection of uracil-DNA glycosylase in HeLa nuclear extract. The method can be used for discrimination of uracil-DNA glycosylase from other DNA glycosylases |
752289 |
| 3.2.2.27 | drug development |
inhibitor design and development, inhibition of UNG could be a rational strategy for the treatment of infections with poxviruses |
694422 |
| 3.2.2.27 | drug development |
the UDG from Mycobacterium smegmatis might be a useful target for inhibitor design |
-, 692153 |
| 3.2.2.27 | medicine |
inhibition of UNG is a rational therapeutic strategy for infections with poxviruses |
-, 690882 |
| 3.2.2.27 | molecular biology |
UDG forms an apyrimidinic site, where an uracil base is removed, and facilitates the reactions of various DNA-repairing enzymes, such as AP endonuclease, DNA polymerase, and DNA ligase, it is thus useful in applications to remove uracil-DNA. Use of UDG to control carry-over contamination in PCR |
-, 690585, 691406 |
| 3.2.2.27 | more |
the UDG mutant ight be useful as a varicella vaccine |
-, 710680 |
