Gene ontology ID
GO:0070371
Definition
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell
Comment
Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2 and should not be confused with cascades that involve other ERK kinases.
Synonyms
1. ERK cascade
2. ERK1 and ERK2 signaling pathway
3. ERK1 and ERK2 signalling pathway
4. ERK1 cascade
5. ERK1/2 cascade
6. ERK2 cascade
7. extracellular signal-regulated kinase 1/2 (ERK1/2) cascade
8. extracellular signal-regulated kinase 1/2 cascade
9. MAPK1 cascade
10. MAPK3 cascade
References
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is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
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at least 1 tissue/ enzyme/ localization link in this branch
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tissue/ enzyme/ localization link to BRENDA