Application | Comment | Organism |
---|---|---|
medicine | prostaglandin D2 produced by hematopoietic prostaglandin D synthase contributes to lipopolysaccharide-induced fever | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDJ300520 | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | Rattus norvegicus | - |
Prostaglandin D2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Rattus norvegicus | Prostaglandin D2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
H-PGDS | - |
Rattus norvegicus |
Hematopoietic prostaglandin D synthase | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | oral pretreatment with the inhibitor EDJ300520 prevents the lipopolysaccharide-induced PGD2 increase in plasma and lungs | down |
Rattus norvegicus | the synthesis of PGD2 is increased in plasma and lungs in response to systemic lipopolysaccharide injection | up |