Information on EC 5.3.99.2 - Prostaglandin-D synthase

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The expected taxonomic range for this enzyme is: Euteleostomi

EC NUMBER
COMMENTARY
5.3.99.2
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RECOMMENDED NAME
GeneOntology No.
Prostaglandin-D synthase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
show the reaction diagram
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PATHWAY
KEGG Link
MetaCyc Link
Arachidonic acid metabolism
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C20 prostanoid biosynthesis
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase
Brings about the opening of the epidioxy bridge. Some enzymes require glutathione.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
beta-Trace
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Beta-trace protein
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glutathione dependent prostaglandine D2 synthase
O73888
i.e. PGDS
Glutathione-dependent PGD synthetase
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glutathione-dependent prostaglandin D2 synthase
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Glutathione-independent PGD synthetase
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H-PGDS
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H-PGDS
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H-PGDS
O60760
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H-PGDS
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haematopoietic PGD synthase
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haematopoietic prostaglandin D synthase
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Hematopoietic prostaglandin D synthase
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Hematopoietic prostaglandin D synthase
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Hematopoietic prostaglandin D synthase
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Hematopoietic prostaglandin D synthase
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i.e. H-PGDS
Hematopoietic prostaglandin D synthase
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Hematopoietic prostaglandin D synthase
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Hematopoietic prostaglandin D synthase
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i.e. PGDS
hematopoietic prostaglandin D2 synthase
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hematopoietic prostaglandin D2 synthase
O60760
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hematopoietic prostaglandin D2 synthase
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HPGDS
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Isomerase, prostaglanin R2 D-
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L-PGDS
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also called beta-trace
L-PGDS
P41222
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L-PGDS
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also called beta-trace
L-PGDS
O09114
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L-prostaglandin D synthase
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L-prostaglandin D synthase
P41222
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L-prostaglandin D synthase
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L-type prostaglandin synthase
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lipocalin type prostaglandin D synthase
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lipocalin-prostaglandin D synthase
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lipocalin-type PGD synthase
O09114
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lipocalin-type Pgds
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lipocalin-type prostaglandin d synthase
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lipocalin-type prostaglandin d synthase
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i.e. L-PGDS
lipocalin-type prostaglandin d synthase
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lipocalin-type prostaglandin d synthase
O09114
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lipocalin-type prostaglandin d synthase
O09114
; i.e. L-PGDS
lipocalin-type prostaglandin d synthase
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lipocalin-type prostaglandin D2 synthase
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lipocalin-type prostaglandin D2 synthase
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lipocaline-type prostaglandin D synthase
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PGD synthase
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PGD2 synthase
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PGD2 synthetase
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PGDS
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PGDS
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PGDS
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PGDS2
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PGH-PGD isomerase
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PGH2 D-isomerase
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Prostaglandin D synthase
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Prostaglandin D synthase
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Prostaglandin D2 synthase
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Prostaglandin D2 synthase
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prostaglandin D2 synthetase
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prostaglandin synthase
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Prostaglandin-D synthase
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Prostaglandin-D synthase
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Prostaglandin-H2 D-isomerase
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Prostaglandin-H2 D-isomerase
O09114
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Prostaglandin-R-prostaglandin D isomerase
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PTGDS
P41222
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CAS REGISTRY NUMBER
COMMENTARY
52227-78-8
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
bull
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Manually annotated by BRENDA team
homologue of lipocalin-type prostaglandin synthase, no enzymic activity
SwissProt
Manually annotated by BRENDA team
low activity
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Manually annotated by BRENDA team
homologue of lipocalin-type prostaglandin synthase, weak enzymic activity
SwissProt
Manually annotated by BRENDA team
isoform liocalin-type prostaglandin D-synthase
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Manually annotated by BRENDA team
lipocalin-type prostaglandin D synthase. Isoform is identical to beta-trace, a major protein in human cerebrospinal fluid, and acts as both a PGD2-producing enzyme and as an extracellular transporter for lipophilic ligands
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Manually annotated by BRENDA team
lipocalin-type prostaglandin-D synthase
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Manually annotated by BRENDA team
patients with acute inflammatory demyelinating polyneuropathy
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Manually annotated by BRENDA team
patients with HIV infection
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Manually annotated by BRENDA team
patients with osteoarthritis
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Manually annotated by BRENDA team
patients with stable coronary artery disease who underwent diagnostic coronary angiography
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Manually annotated by BRENDA team
recombinant enzyme
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Manually annotated by BRENDA team
ApcMin/+ mice bearing a defect in the adenomatous polyposis coli gene which leads to development of many adenomas
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Manually annotated by BRENDA team
hematopoietic prostaglandin D2 synthase
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Manually annotated by BRENDA team
isoform lipocalin-type prostaglandin-D synthase
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Manually annotated by BRENDA team
Kunming White, outbred
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Manually annotated by BRENDA team
mouse model of globoid cell leukodystrophy or Krabbe’s disease, of Tay-Sachs disease, Sandhoff disease, GM1 gangliosidosis and Niemann-Pick type C1 disease
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-
Manually annotated by BRENDA team
recombinant protein
SwissProt
Manually annotated by BRENDA team
low activity
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Manually annotated by BRENDA team
diabetic Goto-Kakizaki
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Manually annotated by BRENDA team
isoform lipocalin-type prostaglandin D synthase
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Manually annotated by BRENDA team
Ursus sp.
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Manually annotated by BRENDA team