Application | Comment | Organism |
---|---|---|
medicine | based on the observations it is speculated that PGD2 acts as one of the immuno-modulating molecules in gastric mucosa infected with Helicobacter pylori, PGD2 might be involved in the pathophysiology of other gastric diseases, such as gastric ulcers or erosion | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
the coding region of human L-PGDS is sub-cloned into pCR-Script Amp SK+ vector | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | Homo sapiens | - |
Prostaglandin D2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
gastric mucosa | - |
Homo sapiens | - |
glandular epithelium | L-PGDS is constitutively expressed in the epithelium of the glandular base | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Homo sapiens | Prostaglandin D2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
H-PGDS | - |
Homo sapiens |
haematopoietic prostaglandin D synthase | - |
Homo sapiens |
L-PGDS | - |
Homo sapiens |
lipocalin-type prostaglandin d synthase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | level of L-PGDS mRNA expression decreases as gastritis becomes more severe | down |
Homo sapiens | L-PGDS, but not H-PGDS, is induced on fibroblasts close to infiltrating cells in the Helicobacter pylori-infected gastric mucosa | up |