Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Canis lupus familiaris | 5737 | - |
nucleus | - |
Canis lupus familiaris | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
75000 | - |
active enzyme, SDS-PAGE | Canis lupus familiaris |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mammary epithelium | mammary alveolar luminal epithelial cell | Canis lupus familiaris | - |
mammary gland | - |
Canis lupus familiaris | - |
mammary gland tumor cell line | CMT-25 cell | Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 L-Arg + H2O | citrullination activity is limited to diestrus with histone H3 | Canis lupus familiaris | histone H3 L-citrulline + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAD2 | - |
Canis lupus familiaris |
peptidylarginine deiminase 2 | - |
Canis lupus familiaris |
Organism | Comment | Expression |
---|---|---|
Canis lupus familiaris | PAD2 expression is low in anestrus | down |
Canis lupus familiaris | estrogen or progesterone do not upregulate PAD2 transcription and translation | additional information |
Canis lupus familiaris | epidermal growth factor upregulates PAD2 transcription and translation. PAD2 expression varies across the estrous cycle, with expression initiating during mammary gland proliferation in estrus/early diestrus and increasing through lactation during diestrus. PAD2 mRNA and protein levels are highest in alveolar unit epithelium during late diestrus | up |
General Information | Comment | Organism |
---|---|---|
physiological function | PAD2 plays a regulatory role in the expression of lactation related genes via histone citrullination during diestrus | Canis lupus familiaris |