Application | Comment | Organism |
---|---|---|
medicine | enzyme is a target for inhibitors used in therapeutic treatment of smooth muscle disorders, such as erectile dysfunction | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Borate | noncompetitive | Homo sapiens | |
additional information | ornithine is a poor inhibitor of isozyme type II, isozyme selectivity in binding and substrate, products, and inhibitors | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4.8 | - |
L-arginine | about pH 7.0 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
additional information | extrahepatic | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-arginine + H2O | Homo sapiens | enzyme is involved in net production of ornithine, a precursor of polyamines, glutamate, and proline, enzyme is also involved in regulation of nitric oxide biosynthesis by modulating arginine availability for nitric oxide synthase | L-ornithine + urea | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme type II | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme to homogeneity | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
L-arginine + H2O = L-ornithine + urea | also hydrolyses alpha-N-substituted L-arginines and canavanine | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-arginine + H2O | - |
Homo sapiens | L-ornithine + urea | - |
? | |
L-arginine + H2O | enzyme is involved in net production of ornithine, a precursor of polyamines, glutamate, and proline, enzyme is also involved in regulation of nitric oxide biosynthesis by modulating arginine availability for nitric oxide synthase | Homo sapiens | L-ornithine + urea | - |
? | |
additional information | isozyme selectivity in binding and substrate, products, and inhibitors | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
trimer | primarily, higher order oligomers are also observed | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
type II arginase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.3 | - |
Borate | - |
Homo sapiens |