Cloned (Comment) | Organism |
---|---|
gene Ace-mtp-2, DNA and amino acid seuence determination and analysis, recombinant expression in Escherichia coli strains BL21 and Rosetta and Pichia pastoris strain X33 | Ancylostoma ceylanicum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the protease has a putative signal peptide and is secreted | Ancylostoma ceylanicum | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc metalloprotease | Ancylostoma ceylanicum |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
26700 | - |
x * 26700, about, sequence calculation | Ancylostoma ceylanicum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ancylostoma ceylanicum | Q0Z889 | gene Ace-mtp-2 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the protease has a putative signal peptide, 11 potential phosphorylation sites, and two disulfide bridges revealed by computational analysis | Ancylostoma ceylanicum |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | highest enzyme expression level occurs in the adult stage of the parasite | Ancylostoma ceylanicum | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 26700, about, sequence calculation | Ancylostoma ceylanicum |
Synonyms | Comment | Organism |
---|---|---|
Ace-MTP-2 | - |
Ancylostoma ceylanicum |
Ancylostoma ceylanicum metalloprotease 2 | - |
Ancylostoma ceylanicum |
astacin-like metalloprotease | - |
Ancylostoma ceylanicum |
General Information | Comment | Organism |
---|---|---|
additional information | the protease has a putative signal peptide, 11 potential phosphorylation sites, and two disulfide bridges revealed by computational analysis | Ancylostoma ceylanicum |
physiological function | the protease is working at the hostparasite interface and is likely be exposed to the hosts immune response. Recombinant Ace-MTP-2 amplifies the in vitro release of TNFalpha and induces release of IFNgamma by lipopolysaccharide activated THP-1 macrophages, overview | Ancylostoma ceylanicum |