Cloned (Comment) | Organism |
---|---|
overexpression of isozyme LPP1 in Rat2 fibroblasts | Rattus norvegicus |
separate overexpression of isozymes LPP1, LPP2, or LPP3 in HEK-293 cells reducing lysophosphatidic acid-stimulated p42/p44 MAPK activation | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of LPP3 or LPP1 knockout mice, the embryonic fibroblasts of these transgenic mice show diacylglycerol levels and reduced phosphatidic acid levels | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
caveola | - |
Mus musculus | 5901 | - |
caveola | - |
Homo sapiens | 5901 | - |
caveola | - |
Rattus norvegicus | 5901 | - |
caveola | - |
Canis lupus familiaris | 5901 | - |
membrane | integral | Mus musculus | 16020 | - |
membrane | integral | Homo sapiens | 16020 | - |
membrane | integral | Rattus norvegicus | 16020 | - |
membrane | integral | Canis lupus familiaris | 16020 | - |
additional information | the enzymes act intra- and extracellularly | Mus musculus | - |
- |
additional information | the enzymes act intra- and extracellularly | Homo sapiens | - |
- |
additional information | the enzymes act intra- and extracellularly | Rattus norvegicus | - |
- |
additional information | the enzymes act intra- and extracellularly, the subcellular localization influences the physiological role of the isozymes | Canis lupus familiaris | - |
- |
plasma membrane | the enzymes act on the cytoplasmic and the cell surface side of the membrane | Mus musculus | 5886 | - |
plasma membrane | the enzymes act on the cytoplasmic and the cell surface side of the membrane | Homo sapiens | 5886 | - |
plasma membrane | the enzymes act on the cytoplasmic and the cell surface side of the membrane | Rattus norvegicus | 5886 | - |
plasma membrane | the enzymes act on the cytoplasmic and the cell surface side of the membrane, isozyme LPP1 is located at the apical membrane, isozyme LPP3 is located at the basolateral membrane | Canis lupus familiaris | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
lysophosphatidic acid + H2O | Mus musculus | - |
monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | Homo sapiens | - |
monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | Rattus norvegicus | - |
monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | Canis lupus familiaris | - |
monoacylglycerol + phosphate | - |
? | |
additional information | Mus musculus | LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview | ? | - |
? | |
additional information | Homo sapiens | LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview | ? | - |
? | |
additional information | Rattus norvegicus | LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview | ? | - |
? | |
additional information | Canis lupus familiaris | LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
isozymes LPP1, LPP-2, and LPP-3 | - |
Homo sapiens | - |
isozymes LPP1, LPP-2, and LPP-3 | - |
Mus musculus | - |
isozymes LPP1, LPP-2, and LPP-3 | - |
Rattus norvegicus | - |
isozymes LPP1, LPP-2, and LPP-3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Mus musculus | - |
blood platelet | - |
Homo sapiens | - |
blood platelet | - |
Rattus norvegicus | - |
blood platelet | - |
Canis lupus familiaris | - |
HEK-293 cell | - |
Homo sapiens | - |
kidney | - |
Canis lupus familiaris | - |
MDCK cell | Madine-Darby kidney cell line | Canis lupus familiaris | - |
ovary | - |
Homo sapiens | - |
ovary cancer cell | shows reduced LPP1 activity | Homo sapiens | - |
preadipocyte | - |
Mus musculus | - |
preadipocyte | - |
Homo sapiens | - |
preadipocyte | - |
Rattus norvegicus | - |
preadipocyte | - |
Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide 1-phosphate + H2O | - |
Mus musculus | ceramide + phosphate | - |
? | |
ceramide 1-phosphate + H2O | - |
Homo sapiens | ceramide + phosphate | - |
? | |
ceramide 1-phosphate + H2O | - |
Rattus norvegicus | ceramide + phosphate | - |
? | |
ceramide 1-phosphate + H2O | - |
Canis lupus familiaris | ceramide + phosphate | - |
? | |
lysophosphatidic acid + H2O | - |
Mus musculus | monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | - |
Homo sapiens | monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | - |
Rattus norvegicus | monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | - |
Canis lupus familiaris | monoacylglycerol + phosphate | - |
? | |
additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview | Mus musculus | ? | - |
? | |
additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview | Homo sapiens | ? | - |
? | |
additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview | Rattus norvegicus | ? | - |
? | |
additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview | Canis lupus familiaris | ? | - |
? | |
phosphatidic acid + H2O | - |
Mus musculus | diacylglycerol + phosphate | - |
? | |
phosphatidic acid + H2O | - |
Homo sapiens | diacylglycerol + phosphate | - |
? | |
phosphatidic acid + H2O | - |
Rattus norvegicus | diacylglycerol + phosphate | - |
? | |
phosphatidic acid + H2O | - |
Canis lupus familiaris | diacylglycerol + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | - |
Mus musculus | sphingosine + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | - |
Homo sapiens | sphingosine + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | - |
Rattus norvegicus | sphingosine + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | - |
Canis lupus familiaris | sphingosine + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipid phosphate phosphatase | - |
Mus musculus |
lipid phosphate phosphatase | - |
Homo sapiens |
lipid phosphate phosphatase | - |
Rattus norvegicus |
lipid phosphate phosphatase | - |
Canis lupus familiaris |
LPP | - |
Mus musculus |
LPP | - |
Homo sapiens |
LPP | - |
Rattus norvegicus |
LPP | - |
Canis lupus familiaris |