Application | Comment | Organism |
---|---|---|
analysis | computational docking method for analysis of the docking of both aromatic and aliphatic bisphosphonates to the Trypanosoma brucei PGK | Trypanosoma brucei |
analysis | first quantitative analysis of the binding of alkyl bisphosphonates to yeast PGK, with activities being predicted within, on average, a factor of 4 over a 2500x overall range in activity | Saccharomyces cerevisiae |
analysis | first quantitative analysis of the inhibition of human phosphoglycerate kinase by aromatic bisphosphonates by 3D-QSAR (CoMFA, CoMSIA) and pharmacophore modeling methods | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | aromatic bisphosphonate inhibitors | Homo sapiens | |
additional information | aliphatic bisphosphonate inhibitors | Saccharomyces cerevisiae | |
additional information | aromatic and aliphatic bisphosphonates | Trypanosoma brucei |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Trypanosoma brucei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Trypanosoma brucei | P07378 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + 3-phospho-D-glyceroyl phosphate | - |
Homo sapiens | ATP + 3-phospho-D-glycerate | - |
? | |
ADP + 3-phospho-D-glyceroyl phosphate | - |
Saccharomyces cerevisiae | ATP + 3-phospho-D-glycerate | - |
? | |
ADP + 3-phospho-D-glyceroyl phosphate | - |
Trypanosoma brucei | ATP + 3-phospho-D-glycerate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3-phosphoglycerate kinase | - |
Homo sapiens |
3-phosphoglycerate kinase | - |
Saccharomyces cerevisiae |
3-phosphoglycerate kinase | - |
Trypanosoma brucei |
PGK | - |
Homo sapiens |
PGK | - |
Saccharomyces cerevisiae |
PGK | - |
Trypanosoma brucei |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
IC50 values are predicted within a factor of ca. 4 over a 2500x range in activity | Saccharomyces cerevisiae | additional information | |
additional information | - |
the IC50 values are predicted within a factor of 2 over the 240x experimental range in activity | Homo sapiens | additional information |