Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | mechanical strain activates ERK but not p38 MAPK. ERK1/2, but not p38 MAPK, exhibits dose-dependent FGF2-, epidermal growth factor- or sodium pervanadate-induced activation | Gallus gallus |
Application | Comment | Organism |
---|---|---|
additional information | constitutively active p38 MAPK serves an essential, permissive role in mechanically induced changes in ERK activation and in the accumulation of hyaluronan-rich extracellular matrices that serve a key role in joint development, constitutively active p38 influences the duration and extent of ERK1/2 activation and hyperphosphorylation of one of its downstream targets c-Fos | Gallus gallus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibition of the MEK-ERK pathway by either U0126 or PD98059 has no discernable effect on p38 MAPK phosphorylation, U0126 treatment also fails to modify pervanadate-induced p38 MAPK activity | Gallus gallus | |
SB202190 | selective to p38 MAPKalpha and -beta isoforms, enhances strain-induced ERK1/2 activation but also restricts strain-induced ERK1/2 activation at longer times | Gallus gallus | |
SB202190 | inhibition of p38 MAPK and modulation of ERK, enhanced strain-induced ERK1/2 activation at 20 min and its restriction after 24 h | Rattus norvegicus | |
SB203580 | selective to p38 MAPKalpha and -beta isoforms, addition to AS cells reveals marked reduction in coat size, both basal and strain-induced hyaluronan release is significantly reduced, enhances strain-induced ERK1/2 activation but also restricts strain-induced ERK1/2 activation at longer times | Gallus gallus | |
SB203580 | inhibition of p38 MAPK and modulation of ERK, enhanced strain-induced ERK1/2 activation at 20 min and its restriction after 24 h | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Gallus gallus | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Gallus gallus | - |
epiphysis | chondrocytes in epiphyses and bordering vascular canals express lower levels of total (inactive plus active) and active p38 MAPK | Gallus gallus | - |
additional information | AS cell, inactive plus active p38 MAPK is predominantly expressed in cells of the fibrocartilaginous articular surface of joint elements | Gallus gallus | - |
osteoblast | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
ERK1/2 | - |
Gallus gallus |
ERK1/2 | - |
Rattus norvegicus |
p38 MAPK | - |
Gallus gallus |
p38 MAPK | - |
Rattus norvegicus |