Information on EC 2.7.11.24 - mitogen-activated protein kinase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY
2.7.11.24
-
RECOMMENDED NAME
GeneOntology No.
mitogen-activated protein kinase
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (MAPKK-activated)
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline [6]. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
ATMPK1
Q39021
-
ATMPK2
Q39022
-
BMK1
Q13164
-
BMK1
-
-
c-Jun amino-terminal kinase
P47811
-
c-Jun N-terminal kinase
-
-
c-Jun N-terminal kinase
-
-
c-Jun N-terminal kinase
-
-
c-Jun N-terminal kinase
Q91Y86, Q9WTU6
-
c-Jun N-terminal kinase
-
-
c-jun N-terminal kinase 1
-
-
c-jun N-terminal kinase 1
P45983
-
c-jun N-terminal kinase 1
-
-
c-jun N-terminal kinase 1
-
-
c-Jun N-terminal kinase 2
-
-
c-Jun N-terminal kinase 2
P45984
-
c-Jun N-terminal kinase 3
-
-
c-Jun N-terminal kinase 3
P53779
-
c-Jun N-terminal kinase 3
-
-
c-jun NH2-terminal MAPK
-
-
cell division control protein 7
P41892
-
cp38a
-
-
-
-
cp38b
-
-
-
-
CSAID binding protein
-
-
-
-
CSBP
-
-
-
-
Cytokine suppressive anti-inflammatory drug binding protein
-
-
-
-
ERK
-
-
ERK1
P27361
-
ERK1
-
-
ERK1
-
-
ERK1-MAP kinase
P21708
-
ERK1/2
-
-
ERK1/2
-
-
ERK1/2 mitogen-activated protein kinase
-
-
ERK1b
P21708
-
ERK2
-
-
ERK2
-
-
ERK3
Q16659
-
ERK3
Q61532
-
ERK5
-
-
-
-
extracellular regulated kinase
P27361, P28482
-
extracellular regulated kinase
-
-
extracellular regulated kinase-2
-
-
extracellular signal-regulated kinase
-
-
extracellular signal-regulated kinase 1
P28869
-
extracellular signal-regulated kinase 1
P42525
-
extracellular signal-regulated kinase 1
P27361
-
extracellular signal-regulated kinase 1
P21708
-
extracellular signal-regulated kinase 1/2
-
-
extracellular signal-regulated kinase 1/2
-
-
extracellular signal-regulated kinase 2
P28482
-
extracellular signal-regulated kinase 2
-
-
extracellular signal-regulated kinase 2
P63086
-
extracellular signal-regulated kinases-1/2
-
-
extracellular signal-related kinase
-
-
extracellular-regulated kinase
-
-
extracellular-regulated kinase-1
-
-
extracellular-regulated kinase-2
-
-
extracellular-signal regulated kinase 1
-
-
extracellular-signal regulated kinase 2
-
-
extracellular-signal-regulated protein kinase 3
Q61532
-
Fus3
-
-
glycogen synthase kinase-3
-
-
Gpmk1 MAP kinase
-
-
Gpmk1 MAP kinase
Gibberella zeae 08. Jan
-
-
-
JNK
-
-
JNK
-
-
JNK
P47811
-
JNK
Q91Y86, Q9WTU6
-
JNK
-
-
JNK 2
P45984
-
JNK-1
Q91Y86
-
JNK-2
Q9WTU6
-
JNK-3
Q61831
-
JNK/SAPK1c
-
-
JNK1
P45983
-
JNK1
-
-
JNK1
Q91Y86
-
JNK2
-
-
JNK2
P45984
-
JNK2
-
-
JNK2
-
-
JNK2
Q9WTU6
-
JNK3
P53779
-
JNK3
-
-
JNK3
-
-
JNKb
O42099
-
JUN N-terminal kinase 1/2
-
-
Jun-amino-terminal kinase
P92208
-
Kss1
-
-
MAP ERK 1/2 kinase
-
-
MAP kinase
-
-
MAP kinase
Q8WQG9
-
MAP kinase
-
-
MAP kinase
-
-
MAP kinase
-
-
MAP kinase
-
-
MAP kinase
Mus musculus C3H/HEN
-
-
-
MAP kinase
P14681
-
MAP kinase
P16892
-
MAP kinase
P32485
-
MAP kinase
-
-
MAP kinase
-
-
MAP kinase
-
-
MAP kinase
P26696
-
MAP kinase
-
-
MAP kinase 4
-
-
MAP kinase MXI2
-
-
-
-
MAP kinase p38 beta
-
-
-
-
MAP kinase p38 delta
-
-
-
-
MAP kinase p38 gamma
-
-
-
-
MAP kinase p38a
-
-
-
-
MAP kinase p38alpha
-
-
-
-
MAP kinase p38b
-
-
-
-
MAPK
-
-
-
-
MAPK
-
-
MAPK
-, B1VK39, B1VK40
-
MAPK
P27361, P28482
-
MAPK
Q9M6R8
-
MAPK
P21708, P63086
-
MAPK
-
-
MAPK
-
-
MAPK kinase
-
-
MAPK-activated protein kinase-2
P47812
-
MAPK2
-
-
MAPKAP kinase-2
P47812
-
mitogen- and stress-activated kinase 1
-
-
mitogen-activated ERK kinase
-
-
mitogen-activated kinase
-
-
mitogen-activated kinase
-
-
mitogen-activated kinase
-
-
mitogen-activated kinase
-
-
mitogen-activated kinase
-
-
mitogen-activated kinase
-
-
mitogen-activated protein kinase
-
-
-
-
mitogen-activated protein kinase
-
-
mitogen-activated protein kinase
-
-
mitogen-activated protein kinase
-
-
mitogen-activated protein kinase
-
-
mitogen-activated protein kinase
Q00859
-
mitogen-activated protein kinase
Fusarium solani T8
Q00859
-
-
mitogen-activated protein kinase
-
-
mitogen-activated protein kinase
-
-
mitogen-activated protein kinase
-
-
mitogen-activated protein kinase
-
-
mitogen-activated protein kinase
-
-
mitogen-activated protein kinase
P26696
-
mitogen-activated protein kinase
-
-
mitogen-activated protein kinase 1
P28482
-
mitogen-activated protein kinase 1
P63085
-
mitogen-activated protein kinase 10
P53779
-
mitogen-activated protein kinase 10
Q61831
-
mitogen-activated protein kinase 11
Q15759
-
mitogen-activated protein kinase 13
O15264
-
mitogen-activated protein kinase 13
Q9N272
-
mitogen-activated protein kinase 13
Q9WTY9
-
mitogen-activated protein kinase 14
P47811
-
mitogen-activated protein kinase 14
Q95NE7
-
mitogen-activated protein kinase 14A
O62618
-
mitogen-activated protein kinase 14B
Q9I958
-
mitogen-activated protein kinase 14B
Q9DGE1, Q9DGE2
-
mitogen-activated protein kinase 14B
O61443
-
mitogen-activated protein kinase 2
P47812
-
mitogen-activated protein kinase 3
P27361
-
mitogen-activated protein kinase 3
P21708
-
mitogen-activated protein kinase 4
P31152
-
mitogen-activated protein kinase 6
Q16659
-
mitogen-activated protein kinase 6
Q61532
-
mitogen-activated protein kinase 6
P27704
-
mitogen-activated protein kinase 7
Q13164
-
mitogen-activated protein kinase 8
Q9DGD9
-
mitogen-activated protein kinase 8
P45983
-
mitogen-activated protein kinase 8
Q91Y86
-
mitogen-activated protein kinase 8
P49185
-
mitogen-activated protein kinase 8
Q8QHK8
-
mitogen-activated protein kinase 8A
Q90327
-
mitogen-activated protein kinase 8B
O42099
-
mitogen-activated protein kinase 9
P45984
-
mitogen-activated protein kinase 9
Q9WTU6
-
mitogen-activated protein kinase 9
P49186, P49187
-
mitogen-activated protein kinase ERK-A
P40417
-
mitogen-activated protein kinase FUS3
P16892
-
mitogen-activated protein kinase HOG1
Q92207
-
mitogen-activated protein kinase HOG1
P32485
-
mitogen-activated protein kinase homolog 1
Q39021
-
mitogen-activated protein kinase homolog 1
Q40884
-
mitogen-activated protein kinase homolog 2
Q39022
-
mitogen-activated protein kinase homolog 3
Q39023
-
mitogen-activated protein kinase homolog 4
Q39024
-
mitogen-activated protein kinase homolog 5
Q39025
-
mitogen-activated protein kinase homolog 6
Q39026, Q39027
-
mitogen-activated protein kinase homolog D5
Q06060
-
mitogen-activated protein kinase homolog MMK1
Q07176
-
mitogen-activated protein kinase homolog MMK2
Q40353
-
mitogen-activated protein kinase homolog NTF3
Q40517
-
mitogen-activated protein kinase homolog NTF4
Q40532
-
mitogen-activated protein kinase homolog NTF6
Q40531
-
mitogen-activated protein kinase KSS1
P14681
-
Mitogen-activated protein kinase p38 beta
-
-
-
-
Mitogen-activated protein kinase p38 delta
-
-
-
-
Mitogen-activated protein kinase p38 gamma
-
-
-
-
Mitogen-activated protein kinase p38a
-
-
-
-
Mitogen-activated protein kinase p38alpha
-
-
-
-
Mitogen-activated protein kinase p38b
-
-
-
-
mitogen-activated protein kinase p44erk1
P27361
-
mitogen-activated protein kinase SLT2/MPK1
Q00772
-
mitogen-activated protein kinase spk1
P27638
-
mitogen-activated protein kinase spm1
Q92398
-
mitogen-activated protein kinase sty1
Q09892
-
mitogen-activated protein kinase sur-1
P39745
-
mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase
-
-
MMK2
Q40353
-
MPK2
B1VK39, B1VK40
-
MPK2
Q9M6R8
-
MsERK1
Q07176
-
MSK1
-
-
p38
-
-
p38
P47811
-
p38 alpha mitogen-activated protein kinase
-
-
p38 MAP kinase
Q9DGD9
-
p38 MAP kinase
-
-
p38 MAP kinase
Q16539
-
p38 MAP kinase
-
-
p38 MAP kinase
-
-
p38 MAP kinase alpha
-
-
p38 MAPK
P27361, P28482
-
p38 MAPK
A1ED58, A1ED59, A9UJZ9
-
p38 MAPK
Salmo salar Aquagen
A1ED58, A1ED59, A9UJZ9
-
-
p38 MAPKalpha
-
-
p38 MAPKalpha
-
-
p38 mitogen activated protein kinase
-
-
p38 mitogen-activated protein kinase
-
-
p38 mitogen-activated protein kinase
O15264
-
p38 mitogen-activated protein kinase
-
-
p38 mitogen-activated protein kinase
-
-
p38 mitogen-activated protein kinase
-
-
p38 mitogen-activated protein kinase
Q9WTY9
-
p38 mitogen-activated protein kinase
A1ED58, A1ED59, A9UJZ9
-
p38 mitogen-activated protein kinase
Salmo salar Aquagen
A1ED58, A1ED59, A9UJZ9
-
-
p38 mitogen-activated protein kinase alpha
-
-
p38 mitogen-activated protein kinase alpha
-
-
p38 mitogen-activated protein MAP kinase
-
-
p38 mitogen-activated protein MAP kinase
Mus musculus C3H/HEN
-
-
-
p38 protein
-
-
p38-2
Q15759
-
p38-delta mitogen-activated protein kinase
O15264
-
p38-delta mitogen-activated protein kinase
Q9WTY9
-
p38a
A9UJZ9
-
p38a
Salmo salar Aquagen
A9UJZ9
-
-
p38a MAP kinase
-
-
p38alpha
-
-
p38alpha
-
-
p38alpha
-
-
p38alpha kinase
-
-
p38alpha MAP kinase
-
-
p38alpha MAP kinase
-
-
p38alpha MAP kinase
P70618
-
p38alpha MAPK
P47811
-
p38alpha mitogen activated protein kinase
-
-
p38alpha mitogen-activated protein kinase
-
-
p38alpha mitogen-activated protein kinase
Q16539
-
p38alpha mitogen-activated protein kinase
P70618
-
P38alpha-MAPKAP kinase 2
-
-
p38b
-
-
-
-
p38b1
A1ED58
-
p38b1
Salmo salar Aquagen
A1ED58
-
-
p38b2
A1ED59
-
p38b2
Salmo salar Aquagen
A1ED59
-
-
p38beta
Q15759
-
p38beta
-
-
p38delta
O15264
-
p38delta
Q9WTY9
-
p38gamma
-
-
p38MAPK
-
-
p38MAPK
-
-
p46MAPK
-
-
p493F12 kinase
P53779
-
p493F12 kinase
Q61831
-
p97MAPK
Q16659
-
pathogenicity MAP kinase 1
Q92246
-
PMEK1
Q40884
-
PMK1
Q92246
-
pp42/mitogen-activated protein kinase
P63085
-
receptor-linked ribosomal protein S6
-
-
SAPK
-
-
SAPK/JNK
-
-
SAPK2A
-
-
-
-
SAPK2a/p38
-
-
SAPK2b/p38beta
-
-
SAPK3/p38gamma
-
-
SAPK4
O15264
-
SAPK4/p38delta
-
-
SAPKalphaI/JNK2
-
-
signal-regulated kinase 3
Q16659
-
SLT2 (MPK1) MAP kinase homolog
Q00772
-
Spc1 kinase
Q09892
-
sporulation-specific mitogen-activated protein kinase SMK1
P41808
-
stress-activated protein kinase
-
-
stress-activated protein kinase 2a
-
-
-
-
stress-activated protein kinase JNK
P92208
-
stress-activated protein kinase JNK1
Q8WQG9
-
stress-activated protein kinase-4
O15264
-
Sur-1 MAP kinase
P39745
-
TmkA
Q8J1Y8
-
UNC-16
Q8WQG9
-
ZmMAPK5
-
-
additional information
-
the enzyme belongs to the MAPK superfamily of enzymes
additional information
-
p39 MAPK is a member of the mitogen-activated protein kinase, MAPK, family
additional information
B1VK39, B1VK40
MPK2 is a member of the mitogen-activated protein kinase, MAPK, family
additional information
-
the enzyme belongs to the MAPK superfamily of enzymes
additional information
-
MAP kinase p38alpha is a member of the MAP kinase family
additional information
-
the enzyme belongs to the MAPK superfamily of enzymes
additional information
Q9M6R8
MPK2 belogs to the C1 subgroup of MAP kinases
additional information
-
the enzyme belongs to the MAPK superfamily of enzymes
CAS REGISTRY NUMBER
COMMENTARY
142243-02-5
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
strains 13-16-R1 and M-line
-
-
Manually annotated by BRENDA team
several strains
SwissProt
Manually annotated by BRENDA team
-
P28869
SwissProt
Manually annotated by BRENDA team
MPK2, cDNA; fox-tapeworm, gene mpk2
B1VK39
UniProt
Manually annotated by BRENDA team
MPK2, chromosomal DNA; fox-tapeworm, gene mpk2
UniProt
Manually annotated by BRENDA team
f. sp. pisi T8 strain
SwissProt
Manually annotated by BRENDA team
Fusarium solani T8
f. sp. pisi T8 strain
SwissProt
Manually annotated by BRENDA team
strain 8/1
-
-
Manually annotated by BRENDA team
Gibberella zeae 08. Jan
strain 8/1
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
four p38 isoforms alpha-delta
-
-
Manually annotated by BRENDA team
isozyme p38 MAPKalpha
Q16539
UniProt
Manually annotated by BRENDA team
isozyme p38alpha MAPK
-
-
Manually annotated by BRENDA team
isozyme p38alpha MAPK
Q16539
UniProt
Manually annotated by BRENDA team
isozymes p38alpha and p38beta
-
-
Manually annotated by BRENDA team
JNK2
SwissProt
Manually annotated by BRENDA team
a mycoparasitic fungus of soilborne plant pathogens, e.g. S. rolfsii and R.solani, strain IMI 304061
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
C3H/HeN mice
-
-
Manually annotated by BRENDA team
C57BL/6 mice
SwissProt
Manually annotated by BRENDA team
for binding studies the X-ray structure of murine p38alpha is used
SwissProt
Manually annotated by BRENDA team
for docking studies the X-ray structure of murine p38alpha is used
-
-
Manually annotated by BRENDA team
isozyme alpha of p38 MAP kinase
-
-
Manually annotated by BRENDA team
isozymes alpha, beta, gamma, and delta of p38
SwissProt
Manually annotated by BRENDA team
JNK1
SwissProt
Manually annotated by BRENDA team
JNK1; male C3H/HeN mice
SwissProt
Manually annotated by BRENDA team
JNK2
SwissProt
Manually annotated by BRENDA team
JNK2; male C3H/HeN mice
SwissProt
Manually annotated by BRENDA team
JNK3; male C3H/HeN mice
SwissProt
Manually annotated by BRENDA team
male C3H/HeN mice
-
-
Manually annotated by BRENDA team
p38 MAPK isozyme alpha
-
-
Manually annotated by BRENDA team
Mus musculus C3H/HEN
C3H/HeN mice
-
-
Manually annotated by BRENDA team
MPK2; cv. Alaska no.7, gene PsMPK2
UniProt
Manually annotated by BRENDA team
ERK2; Sprague-Dawley rats
SwissProt
Manually annotated by BRENDA team
male Sprague-Dawley rat
-
-
Manually annotated by BRENDA team
male sprague-dawley rats
-
-
Manually annotated by BRENDA team
male wistar rat
-
-
Manually annotated by BRENDA team
Sprague Dawley rat
-
-
Manually annotated by BRENDA team
Sprague-Dawley rat
-
-
Manually annotated by BRENDA team
Sprague-Dawley rats
-
-
Manually annotated by BRENDA team
encodes 6 MAPK orthologues
-
-
Manually annotated by BRENDA team
strain Aquagen standard
Swissprot
Manually annotated by BRENDA team
strain Aquagen standard
UniProt
Manually annotated by BRENDA team
strain Aquagen standard
SwissProt
Manually annotated by BRENDA team
Salmo salar Aquagen
strain Aquagen standard
Swissprot
Manually annotated by BRENDA team
Salmo salar Aquagen
strain Aquagen standard
UniProt
Manually annotated by BRENDA team
Salmo salar Aquagen
strain Aquagen standard
SwissProt
Manually annotated by BRENDA team
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5
10
-
-
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
0
70
-
-
1
37
-
degree of phosphorylation of isoforms JNK-1alpha and JNK-1beta increase with ambient temperature
PDB
SCOP
CATH
ORGANISM
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)