Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | p38 MAPK is activated by phosphorylation | Gallus gallus | |
N-acetylsphingosine | i.e. C2-ceramide, an intracellular mediator of apoptosis, cell-permeable N-acetylsphingosine activates mitochondrial p38 MAPK | Gallus gallus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition by PD98059 | Gallus gallus | |
SB202190 | specific p38 MAPK inhibitor | Gallus gallus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | p38 MAPK | Gallus gallus | 5829 | - |
mitochondrion | p38 MAPK | Gallus gallus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Gallus gallus | ceramide activation of mitochondrial p38 mitogen-activated protein kinase is a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | p38 MAPK is activated by phosphorylation | Gallus gallus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiac myocyte | - |
Gallus gallus | - |
embryo | ventricular cells | Gallus gallus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | ceramide activation of mitochondrial p38 mitogen-activated protein kinase is a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis | Gallus gallus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
p38 MAPK | - |
Gallus gallus |