Activating Compound | Comment | Organism | Structure |
---|---|---|---|
diacylglycerol | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Akt | PKCalpha inhibits Akt activity that is necessary for proper ubiquitin-specific protease 8 expression | Homo sapiens | ADP + phosphorylated Akt | - |
? | |
ATP + myristoylated alanine-rich C kinase substrate | a major PKC substrate | Homo sapiens | ADP + phosphorylated myristoylated alanine-rich C kinase substrate | - |
? | |
additional information | PKCalpha modulates the levels of ubiquitinated epidermal growth factor receptor through Akt and ubiquitin-specific protease 8, PKCalpha is necessary for diacylglycerol kinase delta to modulate ubiquitin-specific protease 8 levels | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKCalpha | - |
Homo sapiens |
protein kinase Calpha | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | knockdown of diacylglycerol kinase delta enhances PKCalpha activity | up |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of PKCalpha almost completely reduces myristoylated alanine-rich C kinase substrate phosphorylation, indicating that PKCalpha is responsible for the majority of phosphorylated myristoylated alanine-rich C kinase substrate in the cells | Homo sapiens |