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alphatomega peptide + ATP
ADP + phosphorylated-alphatomega peptide
-
an improved PKCalpha-responsive polyion complex (PIC) to measure PKCalpha activity is reported. The polycation molecule is the poly(amidoamine) (PAMAM) dendrimer modified with both cationic PKCalpha-specific peptide substrates (alphatomega, FKKQGSFAKKK-NH2) and near infrared (NIR) fluorophores (Cy5.5), and the polyanion molecule is the quencher (BHQ-3)-modified chondroitin sulfate
-
-
?
Arg-Phe-Ala-Arg-Lys-Gly-Ser-Leu-Arg-Gln-Lys-Asn-Val + ATP
Arg-Phe-Ala-Arg-Lys-Gly-phosphoSer-Leu-Arg-Gln-Lys-Asn-Val + ADP
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
ATP + a protein
ADP + phosphorylated protein
ATP + AAKIQASFRGHMARKK
ADP + AAKIQApSFRGHMARKK
-
-
-
-
?
ATP + ADAM17
ADP + phosphorylated ADAM17
-
-
-
?
ATP + ADKRRSVRIGA
ADP + ADKRRpSVRIGA
-
-
-
-
?
ATP + Akt
ADP + phosphorylated Akt
ATP + alpha1D Ca channel
ADP + phosphorylated alpha1D Ca channel
-
-
-
-
?
ATP + ARKRERTYSFGHHA
ADP + ARKRERTYpSFGHHA
-
-
-
-
?
ATP + ASQKRPSQRH
ADP + ASQKRPpSQRH
-
-
-
-
?
ATP + Bcl-xL
ADP + phosphorylated Bcl-xL
ATP + beta-catenin
ADP + phosphorylated beta-catenin
ATP + Btk
ADP + phosphorylated Btk
ATP + calcium-activated potassium channel alpha subunit Slo1
ADP + phosphorylated calcium-activated potassium channel alpha subunit Slo1
-
-
-
-
?
ATP + calcium-independent phospholipase A2
ADP + phosphorylated calcium-independent phospholipase A2
ATP + calmodulin
ADP + phosphorylated calmodulin
-
phosphorylation at Thr497 in the calmodulin-binding domain, binding is competitive to substrate endothelial nitric oxide synthase
-
-
?
ATP + casein kinase 1delta
ADP + phosphorylated casein kinase 1delta
ATP + CREB1 protein
ADP + phosphorylated CREB1 protein
-
-
-
-
?
ATP + CTP:phosphoethanolamine cytidylyltransferase
ADP + phosphorylated CTP:phosphoethanolamine cytidylyltransferase
-
phosphorylation at Ser215 and Ser223
-
-
?
ATP + diacylglycerol kinase-zeta
ADP + phosphorylated diacylglycerol kinase-zeta
ATP + EF factor 1
ADP + phosphorylated EF factor 1
-
i.e. eukaryotic translation elongation factor 1-alpha1, in vitro phosphorylation
-
-
?
ATP + endothelial nitric oxide synthase
ADP + phosphorylated endothelial nitric oxide synthase
ATP + extracellular signal-regulated kinase 2
ADP + phosphorylated extracellular signal-regulated kinase 2
-
-
-
-
?
ATP + extracellular signal-related kinase
ADP + phosphorylated extracellular signal-related kinase
-
-
-
-
?
ATP + FAFKKSFKLAG
ADP + FAFKKpSFKLAG
-
-
-
-
?
ATP + FKKQGSFAKKK
ADP + phosphorylated FKKQGSFAKKK
highly specific substrate for isozyme PKCalpha relative to other isozymes, 60% phosphorylation rate with isozyme PKCalpha, less than 20% phosphorylation rate with other PKC isozymes
-
-
?
ATP + FKLKRKGSFKKFA
ADP + FKLKRKGpSFKKFA
-
-
-
-
?
ATP + Fyn
ADP + phosphorylated Fyn
-
Fyn is a tyrosine protein kinase of the Src family, phosphorylation at a serine residue
-
-
?
ATP + Galpha-interacting, vesicle-associated protein
ADP + phosphorylated-Galpha-interacting, vesicle-associated protein
-
PKCtheta, down-regulates Galpha-interacting, vesicle-associated protein (GIV's) guanine exchange factor, GEF function by phosphorylating Ser-1689 located within GIV's GEF motif. PKCtheta specifically binds and phosphorylates GIV at S1689, and this phosphoevent abolishes GIV's ability to bind and activate trimeric G proteins Galphai
-
-
?
ATP + GluR6 kainate receptor subunit
ADP + phosphorylated GluR6 kainate receptor subunit
-
two specific residues on the GluR6 C terminus, Ser846 and Ser868, are phosphorylated by protein kinase C, PKC phosphorylation of GluR6 retains GluR6 in the endoplasmic reticulum
-
-
?
ATP + glycine transporter 2
ADP + phosphorylated glycine transporter 2
-
-
-
-
?
ATP + hematopoietic-specific G-protein Galpha15
ADP + phosphorylated hematopoietic-specific G-protein Galpha15
-
recombinant substrate expressed in COS-7 cells, phosphorylation at Ser334, mutant G-protein Galpha15 S334A is inactive as substrate for PKC
-
-
?
ATP + hematopoietic-specific G-protein Galpha15 peptide
ADP + phosphorylated hematopoietic-specific G-protein Galpha15 peptide
-
the PKC phosphorylation site peptide sequence RKGSR includes Ser334
-
-
?
ATP + hematopoietic-specific G-protein Galpha16
ADP + phosphorylated hematopoietic-specific G-protein Galpha16
-
substrate from HL-60 cells, phosphorylation at Ser336, mutant G-protein Galpha16 S336A is inactive as substrate for PKC
-
-
?
ATP + hematopoietic-specific G-protein Galpha16 peptide
ADP + phosphorylated hematopoietic-specific G-protein Galpha16 peptide
-
the PKC phosphorylation site peptide sequence KKGARSRR includes Ser336
-
-
?
ATP + histone
ADP + phosphorylated histone
ATP + histone H1
ADP + phosphorylated histone H1
ATP + histone H1-IIIS
ADP + phosphorylated histone H1-IIIS
isozyme PKCbeta
-
-
?
ATP + histone H2
ADP + phosphorylated histone H2
-
in vitro phosphorylation
-
-
?
ATP + histone H2A
ADP + phosphorylated histone H2A
-
-
-
-
?
ATP + histone H3
ADP + phosphorylated histone H3
-
in vitro phosphorylation
-
-
?
ATP + histone III-SS
ADP + phosphorylated histone III-SS
-
commercial substrate
-
-
?
ATP + histone IIIS
ADP + phosphorylated histone IIIS
poor substrate
-
-
?
ATP + hyperpolarization-activated cyclic nucleotide-gated channel 1 protein
ADP + phosphorylated hyperpolarization-activated cyclic nucleotide-gated channel 1 protein
-
-
-
-
?
ATP + inhibitory killer cell Ig-like receptor
ADP + phosphorylated inhibitory killer cell Ig-like receptor
ATP + insulin receptor
ADP + phosphorylated insulin receptor
ATP + insulin receptor substrate 1
ADP + phosphorylated insulin receptor substrate 1
ATP + insulin receptor substrate-1
ADP + phosphorylated insulin receptor substrate-1
ATP + insulin receptor substrate-3
ADP + phosphorylated insulin receptor substrate-3
-
-
-
?
ATP + insulin receptor substrate-4
ADP + phosphorylated insulin receptor substrate-4
-
-
-
?
ATP + IRS
ADP + phosphorylated IRS
ATP + IVRKATLRRLL
ADP + IVRKApTLRRLL
-
-
-
-
?
ATP + KFKRPTLRRVR
ADP + KFKRPpTLRRVR
-
-
-
-
?
ATP + KKKRFSFKKAF
ADP + KKKRFpSFKKAF
-
-
-
-
?
ATP + KLAGFSFKKNK
ADP + KLAGFpSFKKNK
-
-
-
-
?
ATP + KPCB protein
ADP + phosphorylated KPCB protein
-
-
-
-
?
ATP + lamin A
ADP + phosphorylated lamin A
-
a nuclear membrane protein, isozyme PKCalpha
-
-
?
ATP + lamin C
ADP + phosphorylated lamin C
-
a nuclear membrane protein, isozyme PKCalpha, phosphorylation at Ser572
-
-
?
ATP + LC3
ADP + phosphorylated LC3
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-
-
-
?
ATP + LLRMFSFKAPA
ADP + LLRMFpSFKAPA
-
-
-
-
?
ATP + metabotropic glutamate receptor 5
ADP + phosphorylated metabotropic glutamate receptor 5
ATP + mutant protein p22phox(P156Q)
ADP + phosphorylated mutant protein p22phox(P156Q)
-
-
-
-
?
ATP + mutant protein p22phox(T132A)
ADP + phosphorylated mutant protein p22phox(T132A)
-
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
ATP + myristoylated alanine-rich C kinase substrate
ADP + phosphorylated myristoylated alanine-rich C kinase substrate
ATP + myristoylated alanine-rich C-kinase (152-164)
ADP + phosphorylated myristoylated alanine-rich C-kinase (152-164)
-
-
-
-
?
ATP + Na,K-ATPase
ADP + phosphorylated Na,K-ATPase
ATP + NADPH oxidase
ADP + phosphorylated NADPH oxidase
ATP + NRFARKGSLRQKNV
ADP + NRFARKGpSLRQKNV
-
-
-
-
?
ATP + Par-3
ADP + phosphorylated Par-3
-
-
-
?
ATP + phosphoinositide-dependent kinase
ADP + phosphorylated phosphoinositide-dependent kinase
ATP + phospholipase D1
ADP + phosphorylated phospholipase D1
-
phosphorylation by PKC
-
-
?
ATP + phospholipase D2
ADP + phosphorylated phospholipase D2
-
phosphorylation by PKCalpha
-
-
?
ATP + PKC-alpha-derived peptide
ADP + phosphorylated PKC-alpha-derived peptide
in the presence of the classical PKC activators phosphatidylserine/diacylglycerol, PKC alpha phosphorylates a PKC-alpha pseudosubstrate-derived peptide, an epidermal-growth-factor-receptor-derived peptide, histone III-S and myelin basic protein to an equal extent, whilst PKC zeta phosphorylates only the PKC-alpha-derived peptide
-
-
?
ATP + poly(ADP-ribose) polymerase-1
ADP + phosphorylated poly(ADP-ribose) polymerase-1
-
-
-
-
?
ATP + protein
ADP + phosphoprotein
ATP + protein kinase CK2alpha
ADP + phosphorylated protein kinase CK2alpha
-
phosphorylation at serines 194 and 277
-
-
?
ATP + protein kinase CK2beta
ADP + phosphorylated protein kinase CK2beta
-
phosphorylation at serine 148
-
-
?
ATP + protein p22phox
ADP + phosphorylated protein p22phox
-
threonine 147 of protein p22phox is phosphorylated by PKC-alpha and PKC-delta isoforms in vitro
-
-
?
ATP + pyruvate dehydrogenase kinase
ADP + phosphorylated pyruvate dehydrogenase kinase
-
-
-
?
ATP + Rad53 protein
ADP + phosphorylated Rad53 protein
-
-
-
-
?
ATP + RalB
ADP + phosphorylated RalB
-
PKCalpha phosphorylates RalB on Ser-192 and Ser-198 in the hypervariable sequence and Ser-198 phosphorylation promotes activation of RalB and causes RalB relocalization from the plasma membrane to late endosomes
-
-
?
ATP + RFARKGSLRQKNV
ADP + phoshorylated RFARKGSLRQKNV
-
a commercially available peptide substrate
-
-
?
ATP + RFARKGSLRQKNV
ADP + phosphorylated RFARKGSLRQKNV
-
-
-
-
?
ATP + RFARKGSLRQKNV
ADP + RFARKGphosphoSLRQKNV
-
synthetic peptide substrate
-
-
?
ATP + ribosomal protein S6-(229-239) peptide analogue
ADP + phosphorylated ribosomal protein S6-(229-239) peptide analogue
-
-
-
?
ATP + RRFKRQGSFFYFF
ADP + RRFKRQGpSFFYFF
-
-
-
-
?
ATP + RRRRSIIFI
ADP + RRRRpSIIFI
-
-
-
-
?
ATP + RVVGGSLRGAQ
ADP + RVVGGpSLRGAQ
-
-
-
-
?
ATP + S6-(229-239) peptide
ADP + phosphorylated S6-(229-239) peptide
-
-
-
?
ATP + serine racemase
ADP + phosphorylated serine racemase
-
-
-
-
?
ATP + serotonin N-acetyltransferase
ADP + phosphorylated serotonin N-acetyltransferase
ATP + sodium channel
ADP + phosphorylated sodium channel
ATP + store-operated channel
ADP + phosphorylated store-operated channel
-
-
-
-
?
ATP + transient receptor potential protein V4
ADP + phosphorylated transient receptor potential protein vanilloid 4
-
-
-
-
?
ATP + transient receptor potential protein vanilloid 1
ADP + phosphorylated transient receptor potential protein vanilloid 1
-
-
-
-
?
ATP + transient receptor potential vanilloid 5
ADP + phosphorylated transient receptor potential vanilloid 5
-
-
-
-
?
ATP + vascular endothelial growth factor receptor 2
ADP + phosphorylated vascular endothelial growth factor receptor 2
-
phosphorylation at Ser1188 and Ser 1191
-
-
?
ATP + vasodilator-stimulated phosphoprotein
ADP + phosphorylated vasodilator-stimulated phosphoprotein
-
phosphorylation at Ser157
-
-
?
ATP + Xras2 protein
ADP + phosphorylated Xrs2 protein
-
-
-
-
?
ATP + [casein kinase 1 delta]
ADP + phosphorylated casein kinase 1 delta
casein kinase 1 delta is modulated by protein kinase C alpha by site-specific phosphorylation within the kinase domain of CK1delta
-
-
?
ATP + [low density lipoprotein receptor-related protein]
ADP + phosphorylated [low density lipoprotein receptor-related protein]
N6-phenyl-ATP + RFARKGSLRQKNV
N6-phenyl-ADP + RFARKGphosphoSLRQKNV
-
synthetic peptide substrate, recombinant isozyme PKCalpha mutant M417A
-
-
?
Nepsilon-(benzyl)-ATP + histone 3
ADP + phosphorylated histone 3
-
-
-
-
?
Nepsilon-(benzyl)-ATP + RFARKGSLRQKNV
Nepsilon-(benzyl)-ADP + RFARKGpSLRQKNV
-
-
-
-
?
Rab11 + ATP
ADP + phosphorylated Rab11
-
Rab11 is differentially phosphorylated in vitro by several purified PKC isoenzymes. Ser 177 is identified as the single PKC-phosphorylated residue in Rab11
-
-
?
additional information
?
-
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + a protein
ADP + phosphorylated protein
-
-
-
-
?
ATP + a protein
ADP + phosphorylated protein
-
-
-
-
?
ATP + Akt
ADP + phosphorylated Akt
-
phosphorylation on Ser473 by isozyme PKCbetaII
-
-
?
ATP + Akt
ADP + phosphorylated Akt
-
PKCalpha inhibits Akt activity that is necessary for proper ubiquitin-specific protease 8 expression
-
-
?
ATP + Akt
ADP + phosphorylated Akt
-
phosphorylation by PKC isozymes at Ser473, regulation of the phosphorylation activity by PKCbetaII in mast cells stimulated by stem cell factor or interaleukin-3, and in serum-stimulated fibroblasts, and in antigen-receptor stimulated T- or B-lymphocytes, overview
-
-
?
ATP + Akt
ADP + phosphorylated Akt
-
Akt substrate is protein kinase B, phosphorylation by PKC isozymes at Ser473 involving phorbol esters
-
-
?
ATP + Akt
ADP + phosphorylated Akt
-
phosphorylation on Ser473 by isozyme PKCbetaII
-
-
?
ATP + Akt
ADP + phosphorylated Akt
-
phosphorylation on Ser473 by isozyme PKCbetaII
-
-
?
ATP + Bcl-xL
ADP + phosphorylated Bcl-xL
-
recombinant human substrate, recombinant isozymes PKCepsilon and PKCzeta
-
-
?
ATP + Bcl-xL
ADP + phosphorylated Bcl-xL
-
recombinant human substrate, recombinant isozyme PKCdelta
-
-
?
ATP + beta-catenin
ADP + phosphorylated beta-catenin
-
-
-
?
ATP + beta-catenin
ADP + phosphorylated beta-catenin
-
-
-
?
ATP + Btk
ADP + phosphorylated Btk
-
specific phosphorylation leads to inhibition of Btk membrane translocation and activation and the downstream events that promote PKCbeta activation, mechanism, overview
-
-
?
ATP + Btk
ADP + phosphorylated Btk
-
specific phosphorylation of the tyrosine protein kinase at Ser180 within the Tec-homology domain
-
-
?
ATP + calcium-independent phospholipase A2
ADP + phosphorylated calcium-independent phospholipase A2
-
-
-
-
?
ATP + calcium-independent phospholipase A2
ADP + phosphorylated calcium-independent phospholipase A2
-
PKC regulates membrane-associated, calcium-independent phospholipase A2 in coronary artery endothelial cells in competition to thrombin, overview
-
-
?
ATP + casein kinase 1delta
ADP + phosphorylated casein kinase 1delta
-
phosphorylation at Ser328, Thr329, and Ser370
-
-
?
ATP + casein kinase 1delta
ADP + phosphorylated casein kinase 1delta
mutations T161A, T174A, and T176A in casein kinase 1delta (CK1delta) all result in reduced phosphorylation by PKCalpha. Most significant effects are visible for GST-CK1delta98-178,T161A and GST-CK1delta98-178,T176A with about 55% and 46% reduction compared to wild type, whereas phosphorylation of GST-CK1delta98-178,T174A is only slightly reduced. Mutation S181A in GST-CK1delta178-227,S181A reduces phosphorylation by PKCalpha by 74%, while for S191A in GST-CK1delta178-227,S191A (FP1552) only a minor reduction can be observed. GST-CK1delta227-304,S298A show no clear reduction of PKCalpha-mediated phosphate incorporation
-
-
?
ATP + casein kinase 1delta
ADP + phosphorylated casein kinase 1delta
the enzyme phosphorylates the kinase domain of casein kinase 1delta at Ser53, Thr176, and Ser181
-
-
?
ATP + diacylglycerol kinase-zeta
ADP + phosphorylated diacylglycerol kinase-zeta
-
the enzyme, especially isozyme PKCalpha, inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein
-
-
?
ATP + diacylglycerol kinase-zeta
ADP + phosphorylated diacylglycerol kinase-zeta
-
isozyme PKCalpha
-
-
?
ATP + endothelial nitric oxide synthase
ADP + phosphorylated endothelial nitric oxide synthase
-
the enzyme is responsible for the negative regulation of endothelial nitric oxide synthase, a key enzyme in nitric oxide-mediated signal transduction, phosphorylation reduces the affinity of nitric oxide synthase for calmodulin
-
-
?
ATP + endothelial nitric oxide synthase
ADP + phosphorylated endothelial nitric oxide synthase
-
phosphorylation at Thr497 in the calmodulin-binding domain, binding is competitive to substrate calmodulin
-
-
?
ATP + histone
ADP + phosphorylated histone
-
-
-
-
?
ATP + histone
ADP + phosphorylated histone
-
in presence of absence of phosphatidylserine-containing liposomes
-
-
?
ATP + histone
ADP + phosphorylated histone
-
-
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
PKD2 activated by phorbol esters efficiently phosphorylate the exogenous substrate histone H1
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
-
-
-
?
ATP + inhibitory killer cell Ig-like receptor
ADP + phosphorylated inhibitory killer cell Ig-like receptor
-
the enzyme regulates expression and function of inhibitory killer cell Ig-like receptors in NK cells, KIR negatively regulate NK cell cytotoxicity by activating Src homology 2 domain-containing protein tyrsine phospatase 1 and 2, overview
-
-
?
ATP + inhibitory killer cell Ig-like receptor
ADP + phosphorylated inhibitory killer cell Ig-like receptor
-
phosphorylation of the cytoplasmic tail, mutational analysis of kinase phosphorylation sites, e.g. Ser394, activity with substrate mutants, overview
-
-
?
ATP + insulin receptor
ADP + phosphorylated insulin receptor
-
isozyme PKCalpha
-
-
?
ATP + insulin receptor
ADP + phosphorylated insulin receptor
-
isozyme PKCalpha
-
-
?
ATP + insulin receptor
ADP + phosphorylated insulin receptor
-
isozyme PKCalpha
-
-
?
ATP + insulin receptor substrate 1
ADP + phosphorylated insulin receptor substrate 1
-
phosphorylation of insulin receptor substrate proteins on serine residues is an important posttranslational modification that is linked to insulin resistance, overview
-
-
?
ATP + insulin receptor substrate 1
ADP + phosphorylated insulin receptor substrate 1
-
a bona fide substrate for conventional isozymes PKCalpha, PKCzeta, and PKCdelta, phosphorylation of IRS1 at Ser24 in the N-terminal pleckstrin homology domain of IRS1, additionally isozyme PKCalpha is indirectly involved in Ser307 and Ser612 phosphorylation
-
-
?
ATP + insulin receptor substrate-1
ADP + phosphorylated insulin receptor substrate-1
-
-
-
-
?
ATP + insulin receptor substrate-1
ADP + phosphorylated insulin receptor substrate-1
-
-
-
-
?
ATP + insulin receptor substrate-1
ADP + phosphorylated insulin receptor substrate-1
-
-
-
?
ATP + insulin receptor substrate-1
ADP + phosphorylated insulin receptor substrate-1
Ser357 of rat insulin receptor substrate-1 is a PKC-delta phosphorylation site
-
-
?
ATP + IRS
ADP + phosphorylated IRS
-
isozymes PKCalpha and PKCdelta, phosphorylation on Ser307
-
-
?
ATP + IRS
ADP + phosphorylated IRS
-
isozymes PKCalpha and PKCdelta, phosphorylation on Ser307
-
-
?
ATP + IRS
ADP + phosphorylated IRS
-
isozymes PKCalpha and PKCdelta, phosphorylation on Ser307
-
-
?
ATP + metabotropic glutamate receptor 5
ADP + phosphorylated metabotropic glutamate receptor 5
-
isozyme-specific phosphorylation of metabotropic glutamate receptor 5 by PKCdelta blocks Ca2+ oscillation and oscillatory translocation of Ca2+-dependent PKCgamma
-
-
?
ATP + metabotropic glutamate receptor 5
ADP + phosphorylated metabotropic glutamate receptor 5
-
phosphorylation at Thr840, PKCdelta is active with wild-type substrate and mutant T840A, but not with mutant T840D, no phosphorylation by PKCgamma
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
-
-
-
?
ATP + myristoylated alanine-rich C kinase substrate
ADP + phosphorylated myristoylated alanine-rich C kinase substrate
-
a major PKC substrate
-
-
?
ATP + myristoylated alanine-rich C kinase substrate
ADP + phosphorylated myristoylated alanine-rich C kinase substrate
-
-
-
-
?
ATP + myristoylated alanine-rich C kinase substrate
ADP + phosphorylated myristoylated alanine-rich C kinase substrate
-
the substrate is involved in actincytoskeletal rearrangement in response to extra-cellular stimuli, phosphorylation of MARCKS is dramatically upregulated specifically in microglial cells after kainic acid-induced seizures, but not in other types of glial cells, overview
-
-
?
ATP + myristoylated alanine-rich C kinase substrate
ADP + phosphorylated myristoylated alanine-rich C kinase substrate
-
-
-
-
?
ATP + myristoylated alanine-rich C kinase substrate
ADP + phosphorylated myristoylated alanine-rich C kinase substrate
-
the substrate is involved in actincytoskeletal rearrangement in response to extra-cellular stimuli, phosphorylation of MARCKS is dramatically upregulated specifically in microglial cells after kainic acid-induced seizures, but not in other types of glial cells, overview
-
-
?
ATP + Na,K-ATPase
ADP + phosphorylated Na,K-ATPase
-
-
-
-
?
ATP + Na,K-ATPase
ADP + phosphorylated Na,K-ATPase
-
substrate in membrane vesicles from the rectal gland of the spiny dog fish Squalus acanthias
-
-
?
ATP + NADPH oxidase
ADP + phosphorylated NADPH oxidase
-
-
-
-
?
ATP + NADPH oxidase
ADP + phosphorylated NADPH oxidase
-
-
-
-
?
ATP + phosphoinositide-dependent kinase
ADP + phosphorylated phosphoinositide-dependent kinase
-
phosphoinositide-dependent kinases are conserved substrates of PKC
-
-
?
ATP + phosphoinositide-dependent kinase
ADP + phosphorylated phosphoinositide-dependent kinase
-
i.e. PDK, phosphorylation at Ser744 and Ser748 in the activation loop of the catalytic domain of PKD, reaction is regulated by diacylglycerol
-
-
?
ATP + phosphoinositide-dependent kinase
ADP + phosphorylated phosphoinositide-dependent kinase
-
phosphoinositide-dependent kinases are conserved substrates of PKC
-
-
?
ATP + phosphoinositide-dependent kinase
ADP + phosphorylated phosphoinositide-dependent kinase
-
i.e. PDK, phosphorylation at Ser744 and Ser748 in the activation loop of the catalytic domain of PKD
-
-
?
ATP + protein
ADP + phosphoprotein
autophosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
autophosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
autophosphorylation
-
-
?
ATP + serotonin N-acetyltransferase
ADP + phosphorylated serotonin N-acetyltransferase
-
PKC regulates the activity and stability of serotonin N-acetyltransferase in vivo, recombinant enzyme expressed in COS-7 cells
-
-
?
ATP + serotonin N-acetyltransferase
ADP + phosphorylated serotonin N-acetyltransferase
-
recombinant enzyme expressed in COS-7 cells, phosphorylation at Thr29
-
-
?
ATP + sodium channel
ADP + phosphorylated sodium channel
-
-
-
-
?
ATP + sodium channel
ADP + phosphorylated sodium channel
-
PKC mediates inhibition of sodium channels and tetrodotoxin-sensitive transient sodium current by phosphorylation by topiramate, overview
-
-
?
ATP + [low density lipoprotein receptor-related protein]
ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
involved in regulation of endocytosis and association with adaptor molecules, e.g. Shc, Dab1, or CED-6/GULP
-
-
?
ATP + [low density lipoprotein receptor-related protein]
ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
i.e. LPR, phosphorylation of cytoplasmic domain residues T63, T16, S3, S73, S76, and S79
-
-
?
ATP + [low density lipoprotein receptor-related protein]
ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
involved in regulation of endocytosis and association with adaptor molecules, e.g. Shc, Dab1, or CED-6/GULP
-
-
?
ATP + [low density lipoprotein receptor-related protein]
ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
i.e. LPR, phosphorylation of cytoplasmic domain serine and threonine residues
-
-
?
additional information
?
-
the enzyme is a phorbol ester receptor
-
-
?
additional information
?
-
-
the enzyme is a phorbol ester receptor
-
-
?
additional information
?
-
-
PKC isozymes are involved in signal transduction, required for host defense
-
-
?
additional information
?
-
preferably phosphorylates the Saccharomyces cerevisiae Pkc1p pseudosubstrate peptide and myelin basic protein, but not histones, protamine or dephosphorylated casein
-
-
?
additional information
?
-
-
preferably phosphorylates the Saccharomyces cerevisiae Pkc1p pseudosubstrate peptide and myelin basic protein, but not histones, protamine or dephosphorylated casein
-
-
?
additional information
?
-
-
the enzyme is essential for transduction of signals in a wide range of cell types, including neurons
-
-
?
additional information
?
-
-
no phosphorylation of the mutant protein p22phox (T147A) by PKC-alpha or PKC-delta in vitro
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
isozyme PKCbeta is involved in encystment
-
-
?
additional information
?
-
-
isozyme PKCbeta is involved in encystment
-
-
?
additional information
?
-
-
PKC is involved in signal transduction in the triiodothyronine-activation of forebrain, i.e. telencephalon and hypothalamus
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
constitutive enzyme
-
-
?
additional information
?
-
constitutive enzyme
-
-
?
additional information
?
-
-
constitutive enzyme
-
-
?
additional information
?
-
PKC zeta exhibits a constitutive kinase
-
-
?
additional information
?
-
PKC zeta exhibits a constitutive kinase
-
-
?
additional information
?
-
-
PKC zeta exhibits a constitutive kinase
-
-
?
additional information
?
-
in normal rat kidney cells, predominant phosphorylation of a 30000 Da protein at serine residues, constitutive low level expression in normal tissues, elevated expression levels in selected tumor cell lines, a role of PKC mu in signal transduction pathways related to growth control
-
-
?
additional information
?
-
-
in normal rat kidney cells, predominant phosphorylation of a 30000 Da protein at serine residues, constitutive low level expression in normal tissues, elevated expression levels in selected tumor cell lines, a role of PKC mu in signal transduction pathways related to growth control
-
-
?
additional information
?
-
PKC-delta desensitizes the Pkc1-mediated pathway by regulating an aspect of G protein function
-
-
?
additional information
?
-
-
PKC-delta desensitizes the Pkc1-mediated pathway by regulating an aspect of G protein function
-
-
?
additional information
?
-
enzyme may play a role in signal transduction and growth regulatory pathways unique to hematopoietic cells
-
-
?
additional information
?
-
-
enzyme may play a role in signal transduction and growth regulatory pathways unique to hematopoietic cells
-
-
?
additional information
?
-
-
activation of metabotropic glutamate receptor 5 induces translocation of PKCgamma and PKCdelta to plasma membrane and elicits cyclical translocations of myristoylated alanine-rich PKC substrate from plasma membrane to cytosol
-
-
?
additional information
?
-
-
Helicobacter pylori activates the enzyme in gastric epithelial cells limiting interleukin-8 production, induced by the pathogen, through suppression of extracellular signal-regulated kinase ERK activation, mechanism overview
-
-
?
additional information
?
-
-
identification of isozymes being involved in calcium-independent phospholipase A2 activation in coronary artery endothelial cells,overview
-
-
?
additional information
?
-
-
PKCtheta is important in regulation of immune response in T-cells, overview, PKC is involved in NF-kappaB activation pathways in vivo, overview, PKC isozymes are involved in signal transduction, and thereby in cell adhesion and migration, isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1
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-
?
additional information
?
-
-
the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview
-
-
?
additional information
?
-
-
activation of phospholipase D2 by 4beta-phorbol 12-myristate 13-acetate-induced PKCalpha does not require phosphorylation, overview
-
-
?
additional information
?
-
-
activity with wild-type and mutant substrate low density lipoprotein receptor-related protein, overview
-
-
?
additional information
?
-
-
interaction between PKCdelta and Fyn leads to phosphorylation on tyrosine and on serine, respectively, with Fyn kinase being activated by the snake venom alboaggregin-A
-
-
?
additional information
?
-
-
myristoylated alanine-rich PKC substrate is repetitively phosphorylated by oscillating gammaPKC on the plasma membrane
-
-
?
additional information
?
-
-
regulatory interactions of isozymes with other kinases, overview
-
-
?
additional information
?
-
-
activation-induced upregulation of inhibitory killer Ig-like receptors, KIR, is regulated by PKC at the posttranscriptional level via the cytoplasmic tail of KIR by stimulation of the maturation processes in the endoplasmic reticulum-Golgi and by promoting the recycling of surface KIR through sorting endosomes, isozyme PKCdelta plays a role in the exocytosis of KIR in secretory lysosomes, overview
-
-
?
additional information
?
-
-
isozyme PKC-delta inhibits colon cancer cell proliferation by selective changes in cell cycle, arresting cells in the G1 phase, and cell death regulators enhancing apoptosis using two different mechanisms, e.g. by downregulation expression of cyclin E and D1, and Bcl-2, inducing Bax expression, and altering levels of p27Kip1 and p21Waf1, PKC-delta is thus an important tumor suppressor in colonic carcinogenesis, overview
-
-
?
additional information
?
-
-
regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview
-
-
?
additional information
?
-
-
the enzyme plays a key role in the mechanism of cerebral ischemic/hypoxic preconditioning, the isozymes are differently involved in neuroprotection, overview
-
-
?
additional information
?
-
-
the enzyme plays a role in aldosterone-induced non-genomic inhibition of basolateral potassium IKCa channels in human colonic crypts
-
-
?
additional information
?
-
-
PKCbetaII specifically binds to beta-actin
-
-
?
additional information
?
-
-
PKC activation alone can target VEGFR2 for limited proteolysis, while PKC inhibition delays VEGFR2 processing but does not block this step
-
-
?
additional information
?
-
-
PKCalpha modulates the levels of ubiquitinated epidermal growth factor receptor through Akt and ubiquitin-specific protease 8, PKCalpha is necessary for diacylglycerol kinase delta to modulate ubiquitin-specific protease 8 levels
-
-
?
additional information
?
-
-
quaporin 1 can be trafficked to and from the plasma membrane in response to altered tonicity in a PKC- and microtubule-dependent manner
-
-
?
additional information
?
-
-
PKCdelta associates with caspase recruitment domain-containing membrane-associated guanylate kinase 1 (CARMA1)
-
-
?
additional information
?
-
-
PKCdelta interacts with mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) and TRAF6
-
-
?
additional information
?
-
-
the enzyme depends on basic residues for substrate recognition, autoregulation by a pseudosubstrate mechanism, overview
-
-
?
additional information
?
-
phorbol ester receptor/protein kinase
-
-
?
additional information
?
-
-
phorbol ester receptor/protein kinase
-
-
?
additional information
?
-
protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the kappaB kinase alpha
-
-
?
additional information
?
-
PKC delta is involved in fundamental cellular functions regulated by diacylglycerols and mimicked by phorbol esters
-
-
?
additional information
?
-
-
PKC delta is involved in fundamental cellular functions regulated by diacylglycerols and mimicked by phorbol esters
-
-
?
additional information
?
-
overproduction of protein kinase C causes disordered growth control in rat fibroblasts, activation of PKC may be of central importance in the process of multistage carcinogenesis
-
-
?
additional information
?
-
protein kinase Cdelta controls self-antigen-induced B-cell tolerance
-
-
?
additional information
?
-
key regulatory role in a variety of cellular functions, including apoptosis, as well as cell growth and differentiation
-
-
?
additional information
?
-
-
key regulatory role in a variety of cellular functions, including apoptosis, as well as cell growth and differentiation
-
-
?
additional information
?
-
plays a central role in the control of proliferation and differentiation of a wide range of cell types by mediating the signal transduction response to hormones and growth factors
-
-
?
additional information
?
-
-
plays a central role in the control of proliferation and differentiation of a wide range of cell types by mediating the signal transduction response to hormones and growth factors
-
-
?
additional information
?
-
protein kinase C-epsilon increases growth and cause malignant transformation when overexpressed in NIH3T3 cells the catalytic domain of PKC-epsilon, in reciprocal PKC-delta and PKC-epsilon chimeras, is responsible for conferring tumorgenicity to NIH3T3 cells, whereas both regulatory and catalytic domains of PKC-epsilon contribute to in vitro transformation
-
-
?
additional information
?
-
-
protein kinase C-epsilon increases growth and cause malignant transformation when overexpressed in NIH3T3 cells the catalytic domain of PKC-epsilon, in reciprocal PKC-delta and PKC-epsilon chimeras, is responsible for conferring tumorgenicity to NIH3T3 cells, whereas both regulatory and catalytic domains of PKC-epsilon contribute to in vitro transformation
-
-
?
additional information
?
-
-
PKC is involved in cellular processes like cell growth, cytoskeleton remodelling, and gene expression regulation, emerging and diverse roles of PKC isozymes in immune cell signalling, i.e macrophage activation, signal transduction pathway of PKC in B- and T-lymphocytes, overview, isozyme theta is associated to NFkappa-B activation in T-cells
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-
?
additional information
?
-
-
PKC mediates NF-kappaB activation, pathway overview, PKC isozymes have distinct roles in regulation of B-cell activation and function, e.g. signal transduction, isozyme PKCbeta is essential for B-cell antigen receptor-induced NF-kappaB activation and B-cell survival, isozyme PKCdelta is required for maintainance of self-reactive B-cell tolerance
-
-
?
additional information
?
-
-
PKCtheta is important in regulation of immune response in T-cells, overview, PKC is involved in NF-kappaB activation pathways in vivo, overview, PKCdelta acts as negative regulator by feedback inhibition of the CDgamma3 subunit important for immune response in T lymphocytes, overview, PKC isozymes are involved in signal transduction, and thereby in cell adhesion and migration, isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1
-
-
?
additional information
?
-
-
the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview, PKC is important in diverse biological functions, e.g. in cell proliferation, cell differentiation, immune response, cancer, and memory
-
-
?
additional information
?
-
-
PKC interacts with CARMA-1, involved in signaling from PKC to NF-kappaB
-
-
?
additional information
?
-
-
regulatory interactions of isozymes with other kinases, overview
-
-
?
additional information
?
-
-
substrate specificity of PKC isozymes, PKC isozymes interacting proteins, overview
-
-
?
additional information
?
-
-
involvement of isozyme PKCalpha in the early action of angiotensin II type 2 effects on neurite outgrowth in NG108-15 cells, the angiotensin II type 2-receptor inhibits PKC alpha and p21ras activity, inhibition of PKCalpha is not directly involved in the Rap1-MEK-p42/p44mapk cascade, overview
-
-
?
additional information
?
-
-
isozyme PKCdelta inhibits the production of proteolytic enzymes in murine mammary cells, the PKCdelta effect is mediated by the MEK/ERK pathway, overview
-
-
?
additional information
?
-
-
PKC isoform specificity of cholinergic potentiation of glucose-induced pulsatile 5-HT/insulin release from single mouse pancreatic islets, overview
-
-
?
additional information
?
-
-
PKC signalling has been suggested to play a role in Ca2+ entry, granule secretion, alphaIIbbeta3 activation and outside-in signalling, PKC also is involved in receptor desensitization, extrusion of intracellular Ca2+, secretion and actin-mediated filopodia formation, PKC negatively regulates platelet activation and the diverse processes in which active platelet are involved, detailed overview, PKC increases Ca2+ extrusion from the cytosol and desensitizes some G-protein coupled receptors, isozyme PKCdelta inhibits platelet aggregation by inhibiting VASP phosphorylation at Ser157, reducing filopodial extension, overview, PKCdelta is required for dense granule secretion following stimulation by thrombin, and plays a negative regulatory role in dense granule secretion when platelets are stimulated by convulxin, PKCtheta is also required for outside-in signalling and, as with PKCbeta, platelets deficient in PKCtheta do not fully spread on a fibrinogen-coated surface
-
-
?
additional information
?
-
-
regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview
-
-
?
additional information
?
-
-
PKCbetaII specifically binds to beta-actin
-
-
?
additional information
?
-
-
tumor necrosis factor alpha-converting enzyme activation is consequent to concomitant actions of intracellular signals mediated by protein kinase C and extracellular signal-regulated kinase as well as reduction of its endogenous inhibitor Timp3
-
-
?
additional information
?
-
PKC zeta action is involved in growth and differentiation of the collecting duct
-
-
?
additional information
?
-
-
PKC zeta action is involved in growth and differentiation of the collecting duct
-
-
?
additional information
?
-
PKC deltaIII may show a dominant negative effect against PKC deltaI
-
-
?
additional information
?
-
-
alterations in PKC isoenzyme alpha, delta, and epsilon expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy
-
-
?
additional information
?
-
-
bidirectional regulation of renal cortical Na+,K+-ATPase by PKC
-
-
?
additional information
?
-
-
calcium-dependent protein kinase C activation occurs in acutely isolated neurons during oxygen and glucose deprivation
-
-
?
additional information
?
-
-
intestinal sugar absorption is regulated by phosphorylation and turnover of protein kinase C betaII mediated by phosphatidylinositol 3-kinase and mammalian target of rapamycin-dependent pathways, PKC betaII regulation and degradation control, overview
-
-
?
additional information
?
-
-
isozyme-specific and developmental stage-specific alterations in brain PKC following exposure to a polychlorinated biphenyl mixture
-
-
?
additional information
?
-
-
PKC is involved in regulation of acetylcholine release in cholinergic nervous activity in the central nervous system in hypertension
-
-
?
additional information
?
-
-
PKC regulates Na,K-ATPase isozyme alpha1 specifically via isozyme-specific regions, while it has no effect on isozyme alpha3, overview
-
-
?
additional information
?
-
-
PKCgamma positively regulates P2X7 receptor-mediated calcium signalling in type-2 astrocytes, mechanism, overview
-
-
?
additional information
?
-
-
regulation of amphetamine-stimulated dopamine efflux by PKCbetaII, overview
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-
?
additional information
?
-
-
some PKC isozymes inhibit BKCa channel activity in pulmonary arterial smooth muscle via inhibition of cAMP-induced activation of the BKCa channel
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-
?
additional information
?
-
-
isozymes alpha, delta, and epsilon perform autophosphorylation
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-
?
additional information
?
-
-
phosphorylation by PKC is involved in regulation of hematopoietic-specific G-protein Galpha15 and Galpha16, deletion of the PKC phosphorylation site leads to inhibition of receptor-coupled phospholipase C activation
-
-
?
additional information
?
-
-
involvement of isozyme PKCalpha in the early action of angiotensin II type 2 effects on neurite outgrowth in NG108-15 cells, the angiotensin II type 2-receptor inhibits PKC alpha and p21ras activity, inhibition of PKCalpha is not directly involved in the Rap1-MEK-p42/p44mapk cascade, overview
-
-
?
additional information
?
-
-
regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview, isozyme PKCepsilon forms signaling complexes with Raf-1 and ERK, isozyme PKCtheta inactivation prevents fat-induced defects in insulin signaling and glucose transport in skeletal muscle
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-
?
additional information
?
-
-
PKCbetaII specifically binds to beta-actin
-
-
?
additional information
?
-
-
pertussis toxin-B suppresses HIV-1 Tat-mediated apoptosis by reducing its activation of phospholipase C-beta through a PKC activation pathway
-
-
?
additional information
?
-
-
PKC plays a pivotal role in desensitization of P2Y1 receptors in RBA-2 astrocytes
-
-
?
additional information
?
-
does not phosphorylate insulin receptor substrate-2
-
-
?
additional information
?
-
-
PKCepsilon associates with and inhibits activation of the mitochondrial permeability transition pore complex
-
-
?
additional information
?
-
-
thrombin-induced cyclin D1expression requires the activation of conventional PKC isoforms
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
PKC1-depleted cells arrested growth with small buds. PKC1 may regulate a previously unrecognized checkpoint in the cell cycle
-
-
?
additional information
?
-
-
PKC1-depleted cells arrested growth with small buds. PKC1 may regulate a previously unrecognized checkpoint in the cell cycle
-
-
?
additional information
?
-
-
PKC isozymes are involved in signal transduction, required for defense against fungal infection
-
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?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + a protein
ADP + a phosphoprotein
ATP + a protein
ADP + phosphorylated protein
ATP + Akt
ADP + phosphorylated Akt
-
phosphorylation by PKC isozymes at Ser473, regulation of the phosphorylation activity by PKCbetaII in mast cells stimulated by stem cell factor or interaleukin-3, and in serum-stimulated fibroblasts, and in antigen-receptor stimulated T- or B-lymphocytes, overview
-
-
?
ATP + beta-catenin
ADP + phosphorylated beta-catenin
ATP + Btk
ADP + phosphorylated Btk
-
specific phosphorylation leads to inhibition of Btk membrane translocation and activation and the downstream events that promote PKCbeta activation, mechanism, overview
-
-
?
ATP + calcium-independent phospholipase A2
ADP + phosphorylated calcium-independent phospholipase A2
-
PKC regulates membrane-associated, calcium-independent phospholipase A2 in coronary artery endothelial cells in competition to thrombin, overview
-
-
?
ATP + casein kinase 1delta
ADP + phosphorylated casein kinase 1delta
-
phosphorylation at Ser328, Thr329, and Ser370
-
-
?
ATP + CTP:phosphoethanolamine cytidylyltransferase
ADP + phosphorylated CTP:phosphoethanolamine cytidylyltransferase
-
phosphorylation at Ser215 and Ser223
-
-
?
ATP + diacylglycerol kinase-zeta
ADP + phosphorylated diacylglycerol kinase-zeta
-
the enzyme, especially isozyme PKCalpha, inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein
-
-
?
ATP + endothelial nitric oxide synthase
ADP + phosphorylated endothelial nitric oxide synthase
-
the enzyme is responsible for the negative regulation of endothelial nitric oxide synthase, a key enzyme in nitric oxide-mediated signal transduction, phosphorylation reduces the affinity of nitric oxide synthase for calmodulin
-
-
?
ATP + histone H1-IIIS
ADP + phosphorylated histone H1-IIIS
isozyme PKCbeta
-
-
?
ATP + histone H2A
ADP + phosphorylated histone H2A
-
-
-
-
?
ATP + hyperpolarization-activated cyclic nucleotide-gated channel 1 protein
ADP + phosphorylated hyperpolarization-activated cyclic nucleotide-gated channel 1 protein
-
-
-
-
?
ATP + inhibitory killer cell Ig-like receptor
ADP + phosphorylated inhibitory killer cell Ig-like receptor
-
the enzyme regulates expression and function of inhibitory killer cell Ig-like receptors in NK cells, KIR negatively regulate NK cell cytotoxicity by activating Src homology 2 domain-containing protein tyrsine phospatase 1 and 2, overview
-
-
?
ATP + insulin receptor substrate 1
ADP + phosphorylated insulin receptor substrate 1
-
phosphorylation of insulin receptor substrate proteins on serine residues is an important posttranslational modification that is linked to insulin resistance, overview
-
-
?
ATP + metabotropic glutamate receptor 5
ADP + phosphorylated metabotropic glutamate receptor 5
-
isozyme-specific phosphorylation of metabotropic glutamate receptor 5 by PKCdelta blocks Ca2+ oscillation and oscillatory translocation of Ca2+-dependent PKCgamma
-
-
?
ATP + myristoylated alanine-rich C kinase substrate
ADP + phosphorylated myristoylated alanine-rich C kinase substrate
ATP + Na,K-ATPase
ADP + phosphorylated Na,K-ATPase
-
-
-
-
?
ATP + NADPH oxidase
ADP + phosphorylated NADPH oxidase
-
-
-
-
?
ATP + phosphoinositide-dependent kinase
ADP + phosphorylated phosphoinositide-dependent kinase
ATP + protein kinase CK2alpha
ADP + phosphorylated protein kinase CK2alpha
-
phosphorylation at serines 194 and 277
-
-
?
ATP + protein kinase CK2beta
ADP + phosphorylated protein kinase CK2beta
-
phosphorylation at serine 148
-
-
?
ATP + pyruvate dehydrogenase kinase
ADP + phosphorylated pyruvate dehydrogenase kinase
-
-
-
?
ATP + Rad53 protein
ADP + phosphorylated Rad53 protein
-
-
-
-
?
ATP + serotonin N-acetyltransferase
ADP + phosphorylated serotonin N-acetyltransferase
-
PKC regulates the activity and stability of serotonin N-acetyltransferase in vivo, recombinant enzyme expressed in COS-7 cells
-
-
?
ATP + sodium channel
ADP + phosphorylated sodium channel
-
PKC mediates inhibition of sodium channels and tetrodotoxin-sensitive transient sodium current by phosphorylation by topiramate, overview
-
-
?
ATP + vasodilator-stimulated phosphoprotein
ADP + phosphorylated vasodilator-stimulated phosphoprotein
-
phosphorylation at Ser157
-
-
?
ATP + Xras2 protein
ADP + phosphorylated Xrs2 protein
-
-
-
-
?
ATP + [casein kinase 1 delta]
ADP + phosphorylated casein kinase 1 delta
casein kinase 1 delta is modulated by protein kinase C alpha by site-specific phosphorylation within the kinase domain of CK1delta
-
-
?
ATP + [low density lipoprotein receptor-related protein]
ADP + phosphorylated [low density lipoprotein receptor-related protein]
additional information
?
-
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + a protein
ADP + phosphorylated protein
-
-
-
-
?
ATP + a protein
ADP + phosphorylated protein
-
-
-
-
?
ATP + beta-catenin
ADP + phosphorylated beta-catenin
-
-
-
?
ATP + beta-catenin
ADP + phosphorylated beta-catenin
-
-
-
?
ATP + myristoylated alanine-rich C kinase substrate
ADP + phosphorylated myristoylated alanine-rich C kinase substrate
-
the substrate is involved in actincytoskeletal rearrangement in response to extra-cellular stimuli, phosphorylation of MARCKS is dramatically upregulated specifically in microglial cells after kainic acid-induced seizures, but not in other types of glial cells, overview
-
-
?
ATP + myristoylated alanine-rich C kinase substrate
ADP + phosphorylated myristoylated alanine-rich C kinase substrate
-
the substrate is involved in actincytoskeletal rearrangement in response to extra-cellular stimuli, phosphorylation of MARCKS is dramatically upregulated specifically in microglial cells after kainic acid-induced seizures, but not in other types of glial cells, overview
-
-
?
ATP + phosphoinositide-dependent kinase
ADP + phosphorylated phosphoinositide-dependent kinase
-
phosphoinositide-dependent kinases are conserved substrates of PKC
-
-
?
ATP + phosphoinositide-dependent kinase
ADP + phosphorylated phosphoinositide-dependent kinase
-
phosphoinositide-dependent kinases are conserved substrates of PKC
-
-
?
ATP + [low density lipoprotein receptor-related protein]
ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
involved in regulation of endocytosis and association with adaptor molecules, e.g. Shc, Dab1, or CED-6/GULP
-
-
?
ATP + [low density lipoprotein receptor-related protein]
ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
involved in regulation of endocytosis and association with adaptor molecules, e.g. Shc, Dab1, or CED-6/GULP
-
-
?
additional information
?
-
the enzyme is a phorbol ester receptor
-
-
?
additional information
?
-
-
the enzyme is a phorbol ester receptor
-
-
?
additional information
?
-
-
PKC isozymes are involved in signal transduction, required for host defense
-
-
?
additional information
?
-
-
the enzyme is essential for transduction of signals in a wide range of cell types, including neurons
-
-
?
additional information
?
-
isozyme PKCbeta is involved in encystment
-
-
?
additional information
?
-
-
isozyme PKCbeta is involved in encystment
-
-
?
additional information
?
-
-
PKC is involved in signal transduction in the triiodothyronine-activation of forebrain, i.e. telencephalon and hypothalamus
-
-
?
additional information
?
-
constitutive enzyme
-
-
?
additional information
?
-
constitutive enzyme
-
-
?
additional information
?
-
-
constitutive enzyme
-
-
?
additional information
?
-
PKC zeta exhibits a constitutive kinase
-
-
?
additional information
?
-
PKC zeta exhibits a constitutive kinase
-
-
?
additional information
?
-
-
PKC zeta exhibits a constitutive kinase
-
-
?
additional information
?
-
in normal rat kidney cells, predominant phosphorylation of a 30000 Da protein at serine residues, constitutive low level expression in normal tissues, elevated expression levels in selected tumor cell lines, a role of PKC mu in signal transduction pathways related to growth control
-
-
?
additional information
?
-
-
in normal rat kidney cells, predominant phosphorylation of a 30000 Da protein at serine residues, constitutive low level expression in normal tissues, elevated expression levels in selected tumor cell lines, a role of PKC mu in signal transduction pathways related to growth control
-
-
?
additional information
?
-
PKC-delta desensitizes the Pkc1-mediated pathway by regulating an aspect of G protein function
-
-
?
additional information
?
-
-
PKC-delta desensitizes the Pkc1-mediated pathway by regulating an aspect of G protein function
-
-
?
additional information
?
-
enzyme may play a role in signal transduction and growth regulatory pathways unique to hematopoietic cells
-
-
?
additional information
?
-
-
enzyme may play a role in signal transduction and growth regulatory pathways unique to hematopoietic cells
-
-
?
additional information
?
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activation of metabotropic glutamate receptor 5 induces translocation of PKCgamma and PKCdelta to plasma membrane and elicits cyclical translocations of myristoylated alanine-rich PKC substrate from plasma membrane to cytosol
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?
additional information
?
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Helicobacter pylori activates the enzyme in gastric epithelial cells limiting interleukin-8 production, induced by the pathogen, through suppression of extracellular signal-regulated kinase ERK activation, mechanism overview
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?
additional information
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identification of isozymes being involved in calcium-independent phospholipase A2 activation in coronary artery endothelial cells,overview
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additional information
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PKCtheta is important in regulation of immune response in T-cells, overview, PKC is involved in NF-kappaB activation pathways in vivo, overview, PKC isozymes are involved in signal transduction, and thereby in cell adhesion and migration, isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1
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additional information
?
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the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview
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?
additional information
?
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activation-induced upregulation of inhibitory killer Ig-like receptors, KIR, is regulated by PKC at the posttranscriptional level via the cytoplasmic tail of KIR by stimulation of the maturation processes in the endoplasmic reticulum-Golgi and by promoting the recycling of surface KIR through sorting endosomes, isozyme PKCdelta plays a role in the exocytosis of KIR in secretory lysosomes, overview
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additional information
?
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isozyme PKC-delta inhibits colon cancer cell proliferation by selective changes in cell cycle, arresting cells in the G1 phase, and cell death regulators enhancing apoptosis using two different mechanisms, e.g. by downregulation expression of cyclin E and D1, and Bcl-2, inducing Bax expression, and altering levels of p27Kip1 and p21Waf1, PKC-delta is thus an important tumor suppressor in colonic carcinogenesis, overview
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?
additional information
?
-
-
regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview
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additional information
?
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-
the enzyme plays a key role in the mechanism of cerebral ischemic/hypoxic preconditioning, the isozymes are differently involved in neuroprotection, overview
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additional information
?
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-
the enzyme plays a role in aldosterone-induced non-genomic inhibition of basolateral potassium IKCa channels in human colonic crypts
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additional information
?
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-
PKC activation alone can target VEGFR2 for limited proteolysis, while PKC inhibition delays VEGFR2 processing but does not block this step
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?
additional information
?
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-
PKCdelta associates with caspase recruitment domain-containing membrane-associated guanylate kinase 1 (CARMA1)
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?
additional information
?
-
-
PKCdelta interacts with mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) and TRAF6
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?
additional information
?
-
protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the kappaB kinase alpha
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?
additional information
?
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PKC delta is involved in fundamental cellular functions regulated by diacylglycerols and mimicked by phorbol esters
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?
additional information
?
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PKC delta is involved in fundamental cellular functions regulated by diacylglycerols and mimicked by phorbol esters
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additional information
?
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overproduction of protein kinase C causes disordered growth control in rat fibroblasts, activation of PKC may be of central importance in the process of multistage carcinogenesis
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?
additional information
?
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protein kinase Cdelta controls self-antigen-induced B-cell tolerance
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additional information
?
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key regulatory role in a variety of cellular functions, including apoptosis, as well as cell growth and differentiation
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?
additional information
?
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key regulatory role in a variety of cellular functions, including apoptosis, as well as cell growth and differentiation
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?
additional information
?
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plays a central role in the control of proliferation and differentiation of a wide range of cell types by mediating the signal transduction response to hormones and growth factors
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?
additional information
?
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-
plays a central role in the control of proliferation and differentiation of a wide range of cell types by mediating the signal transduction response to hormones and growth factors
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?
additional information
?
-
protein kinase C-epsilon increases growth and cause malignant transformation when overexpressed in NIH3T3 cells the catalytic domain of PKC-epsilon, in reciprocal PKC-delta and PKC-epsilon chimeras, is responsible for conferring tumorgenicity to NIH3T3 cells, whereas both regulatory and catalytic domains of PKC-epsilon contribute to in vitro transformation
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additional information
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protein kinase C-epsilon increases growth and cause malignant transformation when overexpressed in NIH3T3 cells the catalytic domain of PKC-epsilon, in reciprocal PKC-delta and PKC-epsilon chimeras, is responsible for conferring tumorgenicity to NIH3T3 cells, whereas both regulatory and catalytic domains of PKC-epsilon contribute to in vitro transformation
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?
additional information
?
-
-
PKC is involved in cellular processes like cell growth, cytoskeleton remodelling, and gene expression regulation, emerging and diverse roles of PKC isozymes in immune cell signalling, i.e macrophage activation, signal transduction pathway of PKC in B- and T-lymphocytes, overview, isozyme theta is associated to NFkappa-B activation in T-cells
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?
additional information
?
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PKC mediates NF-kappaB activation, pathway overview, PKC isozymes have distinct roles in regulation of B-cell activation and function, e.g. signal transduction, isozyme PKCbeta is essential for B-cell antigen receptor-induced NF-kappaB activation and B-cell survival, isozyme PKCdelta is required for maintainance of self-reactive B-cell tolerance
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-
?
additional information
?
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PKCtheta is important in regulation of immune response in T-cells, overview, PKC is involved in NF-kappaB activation pathways in vivo, overview, PKCdelta acts as negative regulator by feedback inhibition of the CDgamma3 subunit important for immune response in T lymphocytes, overview, PKC isozymes are involved in signal transduction, and thereby in cell adhesion and migration, isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1
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?
additional information
?
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the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview, PKC is important in diverse biological functions, e.g. in cell proliferation, cell differentiation, immune response, cancer, and memory
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?
additional information
?
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involvement of isozyme PKCalpha in the early action of angiotensin II type 2 effects on neurite outgrowth in NG108-15 cells, the angiotensin II type 2-receptor inhibits PKC alpha and p21ras activity, inhibition of PKCalpha is not directly involved in the Rap1-MEK-p42/p44mapk cascade, overview
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?
additional information
?
-
-
isozyme PKCdelta inhibits the production of proteolytic enzymes in murine mammary cells, the PKCdelta effect is mediated by the MEK/ERK pathway, overview
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?
additional information
?
-
-
PKC isoform specificity of cholinergic potentiation of glucose-induced pulsatile 5-HT/insulin release from single mouse pancreatic islets, overview
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?
additional information
?
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PKC signalling has been suggested to play a role in Ca2+ entry, granule secretion, alphaIIbbeta3 activation and outside-in signalling, PKC also is involved in receptor desensitization, extrusion of intracellular Ca2+, secretion and actin-mediated filopodia formation, PKC negatively regulates platelet activation and the diverse processes in which active platelet are involved, detailed overview, PKC increases Ca2+ extrusion from the cytosol and desensitizes some G-protein coupled receptors, isozyme PKCdelta inhibits platelet aggregation by inhibiting VASP phosphorylation at Ser157, reducing filopodial extension, overview, PKCdelta is required for dense granule secretion following stimulation by thrombin, and plays a negative regulatory role in dense granule secretion when platelets are stimulated by convulxin, PKCtheta is also required for outside-in signalling and, as with PKCbeta, platelets deficient in PKCtheta do not fully spread on a fibrinogen-coated surface
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?
additional information
?
-
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regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview
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?
additional information
?
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PKC zeta action is involved in growth and differentiation of the collecting duct
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?
additional information
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PKC zeta action is involved in growth and differentiation of the collecting duct
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?
additional information
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PKC deltaIII may show a dominant negative effect against PKC deltaI
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additional information
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alterations in PKC isoenzyme alpha, delta, and epsilon expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy
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additional information
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bidirectional regulation of renal cortical Na+,K+-ATPase by PKC
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?
additional information
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calcium-dependent protein kinase C activation occurs in acutely isolated neurons during oxygen and glucose deprivation
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?
additional information
?
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intestinal sugar absorption is regulated by phosphorylation and turnover of protein kinase C betaII mediated by phosphatidylinositol 3-kinase and mammalian target of rapamycin-dependent pathways, PKC betaII regulation and degradation control, overview
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?
additional information
?
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isozyme-specific and developmental stage-specific alterations in brain PKC following exposure to a polychlorinated biphenyl mixture
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?
additional information
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PKC is involved in regulation of acetylcholine release in cholinergic nervous activity in the central nervous system in hypertension
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?
additional information
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PKC regulates Na,K-ATPase isozyme alpha1 specifically via isozyme-specific regions, while it has no effect on isozyme alpha3, overview
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?
additional information
?
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PKCgamma positively regulates P2X7 receptor-mediated calcium signalling in type-2 astrocytes, mechanism, overview
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?
additional information
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regulation of amphetamine-stimulated dopamine efflux by PKCbetaII, overview
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?
additional information
?
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some PKC isozymes inhibit BKCa channel activity in pulmonary arterial smooth muscle via inhibition of cAMP-induced activation of the BKCa channel
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?
additional information
?
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involvement of isozyme PKCalpha in the early action of angiotensin II type 2 effects on neurite outgrowth in NG108-15 cells, the angiotensin II type 2-receptor inhibits PKC alpha and p21ras activity, inhibition of PKCalpha is not directly involved in the Rap1-MEK-p42/p44mapk cascade, overview
-
-
?
additional information
?
-
-
regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview, isozyme PKCepsilon forms signaling complexes with Raf-1 and ERK, isozyme PKCtheta inactivation prevents fat-induced defects in insulin signaling and glucose transport in skeletal muscle
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?
additional information
?
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pertussis toxin-B suppresses HIV-1 Tat-mediated apoptosis by reducing its activation of phospholipase C-beta through a PKC activation pathway
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?
additional information
?
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PKC plays a pivotal role in desensitization of P2Y1 receptors in RBA-2 astrocytes
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?
additional information
?
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PKC1-depleted cells arrested growth with small buds. PKC1 may regulate a previously unrecognized checkpoint in the cell cycle
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additional information
?
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PKC1-depleted cells arrested growth with small buds. PKC1 may regulate a previously unrecognized checkpoint in the cell cycle
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additional information
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PKC isozymes are involved in signal transduction, required for defense against fungal infection
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(2R)-2-[(2S)-4-[5-chloro-6-(1H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-ol
-
(2R)-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
-
-
1,1'-(1,10-decanediyl)bis[1-amino isoquinolinium] diiodide
-
-
1,1'-(1,10-decanediyl)bis[2-amino-1-methylbenzimidazolium] diiodide
-
-
1,1'-(1,10-decanediyl)bis[2-methylbenzothiazolium] diiodide
-
-
1,1'-(1,10-decanediyl)bis[2-methylbenzoxazolium] diiodide
-
-
1,1'-(1,10-decanediyl)bis[2-methylquinolinium] diiodide
-
-
1,1'-(1,10-decanediyl)bis[4-amino-2-methyl quinolinium] diiodide
-
-
1,1'-(1,10-decanediyl)bis[4-aminoquinolinium] diiodide
-
-
1,1'-(1,10-decanediyl)bis[4-N,N,dimethylaminoquinolinium] diiodide
-
-
1,1'-(1,10-decanediyl)bis[quinolinium] diiodide
-
-
1,1'-decane-1,10-diylbis(4-aminopyridinium) diiodide
-
-
1,1'-decane-1,10-diylbis[4-(dimethylamino)pyridinium]
-
-
1,6-bis[N-(1-methylquinolinium-2-methyl)amino]-hexane diiodide
-
-
1-(1,4-diazepan-1-yl)-3-(pyridin-4-yl)-2,6-naphthyridine
-
-
1-(5-isoquinolinesulfonyl)-2-methylpiperazine
-
1-(piperazin-1-yl)-3-(pyridin-4-yl)-2,6-naphthyridine
-
-
1-(tert-butyl)-3-(1-naphthyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
-
inhibits ATP analog-specific PKCdelta isoform
1-(tert-butyl)-3-(2-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
-
inhibits ATP analog-specific PKCdelta isoform
1-methoxypropan-2-yl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 49%
1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]piperidin-3-amine
-
-
1-[3-chloro-6-(1,4-diazepan-1-yl)pyridin-2-yl]-7-ethoxy-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one
-
15-chloro-11-methyl-8,9,10,11-tetrahydro-7H-16,12-(azeno)-6-oxa-2,3,11,16a-tetraazacyclotetradeca[1,2,3-cd]inden-1(2H)-one
-
2,7,11-triamino-3,6,13-trihydroxy-5-methyl-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
-
-
2,7,11-triamino-3,6-dihydroxy-5-methyl-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
-
-
2,7-diamino-3,6,13-trihydroxy-5-methyl-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
-
-
2,7-diamino-3,6-dihydroxy-5-methyl-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
-
-
2-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)-6-(2-phenylpiperazin-1-yl)pyridine-3-carbonitrile
-
2-([3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]amino)ethanol
-
-
2-([3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]oxy)ethanamine
-
-
2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carbonitrile
-
0.03 mM, inhibition: 87%
2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylic acid
-
0.03 mM, inhibition: 65%
2-fluorobenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 100%
2-methoxyethyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 57%
2-methyl-6-(phenylethynyl)-pyridine
-
complete inhibition of PKCgamma oscillation at 0.05 mM
2-methyl-N1-[3-(3-methylpyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
-
-
2-methyl-N1-[3-(pyridin-3-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
-
-
2-methyl-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
-
-
2-methylbenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 64%
3-(1-(3-(dimethylamino)propyl)-2-methyl-1H-indol-3-yl)-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
a bisindolylmaleimide analogue of BIM-1 inhibitor
3-cyanobenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 70%
3-methoxybenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 100%
3-methylbenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 67%
3-phenyl-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
-
-
3-[1-[3-(dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
Go6983, PKC-specific inhibitor, complete inhibition at 500 nM
4-amino-1,2-dimethylquinolinium
-
-
4-amino-1-decyl-2-methylquinolinium iodide
-
-
4-cyanobenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 10%
4-fluorobenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 2%
4-methylbenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 50%
4-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]piperazin-2-one
-
-
ALSTER
psi pyruvate dehydrogenase kinase peptide, selective inhibitor of deltaPKC-mediated pyruvate dehydrogenase kinase phosphorylation
-
alsterpaullone
-
7% inhibition of PKCalpha at 0.01 mM
angiotensin II type 2-receptor
-
arachidonoyl fluoromethylketone
-
inhibition of PKCgamma oscillation at 0.1 mM
benzyl 2-amino-4-(1,3-benzodioxol-5-yl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 85%
benzyl 2-amino-4-(2-fluoro-4-methoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 78%
benzyl 2-amino-4-(2-fluorophenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 57%
benzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 100%
benzyl 2-amino-4-(3-cyanophenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 25%
benzyl 2-amino-4-(3-fluorophenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 53%
benzyl 2-amino-4-(3-methoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 57%
benzyl 2-amino-4-(3-methylphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 68%
benzyl 2-amino-4-(4-methoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 86%
benzyl 2-amino-4-(4-methylphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 60%
benzyl 2-amino-4-[3-(trifluoromethyl)phenyl]thiophene-3-carboxylate
-
0.03 mM, inhibition: 29%
benzyl 2-amino-4-[4-(trifluoromethyl)phenyl]thiophene-3-carboxylate
-
0.03 mM, inhibition: 21%
betaIIV5.3
-
0.01 mM, peptide translocation inhibitor of isozyme PKC betaII
-
BIM-I
inhibits encystment in vivo
bisindolylmaleimide derivatives
bromoerol lactone
-
slight inhibition of PKCgamma oscillation at 0.1 mM
calphostin-C
-
inhibition of triiodothyronine-activation in forebrain, overview, can be partially reversed by triiodothyronone, i.e. T3
chelerythrine chloride
interacts with the catalytic domain of PKC, inhibits encystment in vivo
cheletrytrine
-
complete inhibition at 0.05 mM
compound 48/80
-
complete inhibition of PKCgamma oscillation at 0.1 mM
CRLVLASC
-
targets isozyme PKCgamma, blocks formalin-induced pain response
curcumin
-
inhibits or activates PKC dependent on Ca2+ and the presence of membranes or phosphatidylserine, respectively, in presence of phosphatidylserine curcumin activates PKC, in presence of membranes with phosphatidylserine the enzyme is inhibited, Ca2+ competes with curcumin at the regulatory domainbinding site, overview, effects on different isozymes, overview
cytochalasine D
-
inhibition of PKCgamma oscillation at 0.01 mM
EAVSLKPT
-
targets isozyme PKCepsilon, reverses psi epsilonRACK-mediated protection, and decreases formalin-induced pain response
enzastaurin
-
oral serine/threonine kinase inhibitor
epsilonV1.2
-
0.01 mM, peptide translocation inhibitor of isozyme PKC epsilon
-
ethanol
-
0.03%, inhibition of PKCgamma oscillation at 0.1 mM
ethyl 2-(carbamoylamino)-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 14%
ethyl 2-amino-4-(1,3-benzodioxol-5-yl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 100%
ethyl 2-amino-4-(2-fluoro-4-methoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 100%
ethyl 2-amino-4-(2-fluorophenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 62%
ethyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 100%
ethyl 2-amino-4-(3-cyanophenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 32%
ethyl 2-amino-4-(3-fluoro-4-methoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 100%
ethyl 2-amino-4-(3-fluorophenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 38%
ethyl 2-amino-4-(3-methoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 82%
ethyl 2-amino-4-(3-methylphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 77%
ethyl 2-amino-4-(4-aminophenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 100%
ethyl 2-amino-4-(4-methoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 100%
ethyl 2-amino-4-(4-methylphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 80%
ethyl 2-amino-4-[3-(trifluoromethyl)phenyl]thiophene-3-carboxylate
-
0.03 mM, inhibition: 16%; 0.03 mM, inhibition: 30%
ethyl 2-amino-4-[4-(dimethylamino)phenyl]thiophene-3-carboxylate
-
0.03 mM, inhibition: 100%
ethyl 4-(3,4-dimethoxyphenyl)-2-(dimethylamino)thiophene-3-carboxylate
-
0.03 mM, inhibition: 60%
ethyl 4-(3,4-dimethoxyphenyl)-2-(methylamino)thiophene-3-carboxylate
-
0.03 mM, inhibition: 32%
ethyl 4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 3%
FNGLLKIKI
-
protects from cardiac ischaemic injury
FTRKRQRAMRRVHQ
-
autoregulatory pseudosubstrate sequence, residues 24-40, lung enzyme
Go-6983
-
isoform PKCalpha-specific inhibitor
Gö6983
-
an inhibitor of isozyme PKCbeta, but not of PKCmy
H-7
-
specific PKC inhibitor
HDAPIGYD
-
protects from cardiac ischaemic injury, from graft coronary artery disease, and activates potassium current, inhibits sodium current
indirubin-3'-monoxime
-
32% inhibition of PKCalpha at 0.01 mM
K-252a
-
strong inhibition
KLFIMNL
-
targets isozyme PKCbetaI, inhibits cardiomyocyte hypertrophy
LY333531
-
specific inhibition of PKCbeta
LY379196
-
highly specific for PKCbeta, inhibits amphetamine-stimulated dopamine efflux in striatum in vivo
MDPNGLSDPYVKL
-
targets isozyme PKCbeta, blocks Ca2+ current
MRAAEDPM
-
increased injury from cardiac ischaemia
myr-PKC 19-27
-
specific protein kinase C inhibitor
N,N,N,N',N',N'-hexaethyldecane-1,10-diaminium
-
-
N-(5'-([(3S,8aS)-3-methylhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl)-4',5'-dihydro-1'H-spiro[cyclopropane-1,6'-pyrrolo[3,4-c]pyrazol]-3'-yl)pyridine-2-carboxamide
-
-
N-(5-([(2S)-2-benzyl-4-methylpiperazin-1-yl]carbonyl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-phenoxybenzamide
-
-
N-(5-([(2S)-2-benzyl-4-methylpiperazin-1-yl]carbonyl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide
-
-
N-(5-([(3S,7S,8aS)-7-fluoro-3-methylhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)pyridine-2-carboxamide
-
-
N-(5-([(3S,8aS)-3-ethylhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)pyridine-2-carboxamide
-
-
N-(5-([(3S,8aS)-7,7-difluoro-3-methylhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)pyridine-2-carboxamide
-
-
N-(5-([(8aS)-3,3-dimethylhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)pyridine-2-carboxamide
-
-
N-(6,6-dimethyl-5-([(3R,8aR)-3-methylhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)pyridine-2-carboxamide
-
0.001 mM, 13% inhibition
N-(6,6-dimethyl-5-([(3R,8aS)-3-methylhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)pyridine-2-carboxamide
-
0.001 mM, 24% inhibition
N-(6,6-dimethyl-5-([(3S,8aR)-3-methylhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)pyridine-2-carboxamide
-
-
N-(6,6-dimethyl-5-([(3S,8aS)-3-methylhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)pyridine-2-carboxamide
-
-
N-(6,6-dimethyl-5-[(4-methylpiperazin-1-yl)carbonyl]-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide
-
-
N-(6-ethyl-6-methyl-5-([(3S,8aS)-3-methylhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)pyridine-2-carboxamide
-
-
N-cyclohexa-1,3-dien-1-yl-N,N,N',N',N'-pentaphenyldecane-1,10-diaminium
-
-
N-methyl-N'-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
-
-
N-methyl-N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
-
-
N-[2-(pyridin-4-yl)pyrido[3,4-d]pyrimidin-4-yl]ethane-1,2-diamine
-
-
N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
-
-
N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,3-diamine
-
-
N-[3-(pyridin-4-yl)-2,7-naphthyridin-1-yl]ethane-1,2-diamine
-
-
N-[3-(pyridin-4-yl)isoquinolin-1-yl]ethane-1,2-diamine
-
-
N-[5-(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylcarbonyl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
-
-
N-[7-(pyridin-4-yl)-1,6-naphthyridin-5-yl]ethane-1,2-diamine
-
-
N-[7-(pyridin-4-yl)isoquinolin-5-yl]ethane-1,2-diamine
-
-
N1-(3-[2-(propan-2-ylamino)pyridin-4-yl]-2,6-naphthyridin-1-yl)-2-methylpropane-1,2-diamine
-
-
N1-[3-(2-aminopyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
-
-
N1-[3-(3-chloropyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
-
-
N1-[3-(3-fluoropyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
-
-
N6-Dimethylaminopurine
-
-
NKMKSRLRKGALKKNV
-
autoregulatory pseudosubstrate sequence, residues 24-40
phenyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 48%
phorbol 12,13-dibutyrate
-
activates Na+,K+-ATPase activity at low concentration, but inhibits it at high concentration, the inhibitory effect can be reversed by preincubation with ethoxyresorufin, 17-octadecynoic acid, wortmannin, LY294002, cytochlasin D, or latrunculin B
propan-2-yl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 100%
pyridin-4-ylmethyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
-
0.03 mM, inhibition: 53%
QEVIRNN
-
targets isozyme PKCbetaII, inhibits cardiomyocyte hypertrophy and activates potassium channels
QLMGGLHRHGAIINRKE
-
autoregulatory pseudosubstrate sequence, residues 391-407
quinolinic acid
-
inhibits the phosphorylation of the enzyme
RACK1 peptide I homologue
-
-
-
Ro 31-8220
-
i.e., 2-[1-[3-(amidinothio)propyl]-1H-indol-3-yl]-3-(1-methylindol-3-yl)-maleimide
Ro-31-7549
specific inhibitor for isozyme PKCalpha
Ro-31-8220
-
strong inhibition of PKCalpha
SFNSYELGSL
-
targets isozyme PKCdelta, protects from cardiac ischaemic injury, from cerebral injury, from graft coronary artery disease, and increases fibroblast proliferation
SIKIWD
-
targets isozyme PKCbeta
SIYRRGARRWRKLYRAN
-
targets isozyme PKCzeta, which leads to inhibition of fibroblast proliferation
SLNPEWNE
-
targets isozyme PKCbeta
thapsigargin
-
complete inhibition of PKCgamma oscillation at 0.005 mM
thymeleatoxin
-
activates Na+,K+-ATPase activity at low concentration, but inhibits it at high concentration
YGRKKRRQRRR-GSG-ALSTER
psi pyruvate dehydrogenase kinase 1 peptide, inhibits the phosphorylation of pyruvate dehydrogenase kinase but not the phosphorylation of HSP, MARCKS, STAT, GAPDH, and troponin I
-
[2-amino-4-(3,4-dimethoxyphenyl)thiophen-3-yl][(benzylamino)oxy]methanone
-
0.03 mM, inhibition: 43%
[2-amino-4-(3,4-dimethoxyphenyl)thiophen-3-yl][(ethylamino)oxy]methanone
-
0.03 mM, inhibition: 50%
[2-amino-4-(3,4-dimethoxyphenyl)thiophen-3-yl]{[(2-methoxyethyl)amino]oxy}methanone
-
0.03 mM, inhibition: 55%
[2-amino-4-(3,4-dimethoxyphenyl)thiophen-3-yl]{[(pyridin-4-ylmethyl)amino]oxy}methanone
-
0.03 mM, inhibition: 3%
{3-[5-amino-4-(ethoxycarbonyl)thiophen-3-yl]phenyl}carbamate
-
0.03 mM, inhibition: 89%
angiotensin II type 2-receptor
-
inhibits isozyme PKCalpha
-
angiotensin II type 2-receptor
-
inhibits isozyme PKCalpha
-
bisindolylmaleimide
-
relatively specific for protein kinase C
bisindolylmaleimide
-
strong inhibition of PKCalpha
bisindolylmaleimide derivatives
-
-
bisindolylmaleimide derivatives
-
-
bisindolylmaleimide I
-
-
bisindolylmaleimide I
highly selective PKCalpha inhibitor
bisindolylmaleimide I
-
-
bisindolylmaleimide I
-
PKC inhibitors induce LC3 processing and autophagosome formation. Inhibition of protein kinase C increased autophagy
calphostin C
interacts with the regulatory domain of PKC, inhibits encystment in vivo
calphostin C
-
PKC-specific inhibitor
CG53353
-
inhibitor of isozyme PKCbetaII
CG53353
-
inhibitor of isozyme PKCbetaII
CG53353
-
inhibitor of isozyme PKCbetaII
CG53353
-
0.01 mM, isozyme PKC betaII antagonist
GF 109203X
-
broad-spectrum PKC inhibitor
GF109203X
-
PKC-specific inhibitor
GF109203X
inhibits all PKC isozymes, except PKCmu
GF109203X
-
potent inhibitor
GF109203X
-
bisindolylmaleimide, broad spectrum PKC inhibitor
GF109203X
bisindolylmaleimide I; bisindolylmaleimide I
GF109203X
-
specific inhibition of PKC
GF109203X
-
inhibits classical and novel, but not atypical PKC isozymes
GF109203X
-
specific inhibitor
Go6976
-
-
Go6976
-
inhibitor of conventional (calcium-dependent) PKC isoforms
Goe6976
-
G 6976
-
slight inhibition of PKCalpha
G-6976
-
inhibits classical, but not novel and atypical PKC isozymes
G-6976
-
selective inhibition of isozymes PKCalpha, PKCbeta, and PKC-my
G-6976
-
IC50 of 2.3-7.9 nM
G6976
-
-
G6976
-
inhibits classical isozymes
G6976
-
inhibits classical isozymes
G6976
-
an inhibitor of isozymes cPKCalpha, -beta, and -my
KGDYEKILVALCGGN
-
targets isozyme PKCbeta
KGDYEKILVALCGGN
-
blocks Xenopus oocyte maturation
KQKTKTIK T
-
targets isozyme PKCbeta
KQKTKTIK T
-
blocks Xenopus oocyte maturation
Ro-32-0432
-
strong inhibition
Ro-32-0432
-
conventional PKC inhibitor
rottlerin
-
inhibits PKCdelta, but does not block its translocation
rottlerin
-
slight inhibition of PKCalpha
rottlerin
-
inhibits PKCdelta
rottlerin
-
inhibits PKCdelta
rottlerin
-
specific inhibitor of isozyme PKCdelta
rottlerin
-
selective inhibition of isozyme PKCdelta
rottlerin
-
specific for PKCdelta
rottlerin
-
a selective inhibitor of nPKCdelta and PKCtheta
rottlerin
-
PKC delta-specific inhibitor
rottlerin
-
PKC inhibitors induce LC3 processing and autophagosome formation. Inhibition of protein kinase C increased autophagy
staurosporine
-
poorly selective for, unspecific inhibitor of a broad range of protein kinases
staurosporine
-
strong inhibition
staurosporine
-
PKC inhibitory alkaloid isolated from the bacterium Lentzea albida, formerly Streptomyces staurosporeus
staurosporine
-
PKC inhibitory alkaloid isolated from the bacterium Lentzea albida, formerly Streptomyces staurosporeus
staurosporine
-
inhibits all PKC isozymes
Tween 80
-
inhibits the enzyme at high concentration
Tween 80
-
inhibits the enzyme at high concentration
Tween 80
-
inhibits the enzyme at high concentration
Tween 80
-
inhibits the enzyme at high concentration
additional information
-
synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential
-
additional information
-
synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential, sequences of the different enzyme forms, required sequence properties, overview
-
additional information
-
synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential
-
additional information
insensitive to PKC inhibitors known to interfere either with the regulatory or the catalytic domain
-
additional information
insensitive to PKC inhibitors known to interfere either with the regulatory or the catalytic domain
-
additional information
-
insensitive to PKC inhibitors known to interfere either with the regulatory or the catalytic domain
-
additional information
-
no inhibition of PKCalpha by roscovitine, and purvalanol
-
additional information
-
no inhibition of PKCdelta by bisindolylmaleimide I
-
additional information
-
no inhibition of PKCgamma oscillation by EGTA, aristolochic acid, and colchicine
-
additional information
-
no inhibition by genistein and H-89
-
additional information
-
peptides derived from the PKC-cognate proteins are useful competitive inhibitors of PKC signalling, inhibitory peptide inhibit enzyme activity and/or enzyme translocation, physiological effects, overview
-
additional information
-
inhibition of PKC by dequalinium analogues of bis-quaternary dequalinium salts, structure-activity studies on head group variations, overview, Mulliken charges on N1 of the model compounds used for correlation, overview
-
additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
-
additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
-
additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
-
additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
-
additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
-
additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
-
additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
-
additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
-
additional information
isozyme PKCalpha is not inhibited by H-89 and rottlerin
-
additional information
-
isozyme PKCalpha is not inhibited by H-89 and rottlerin
-
additional information
-
the enzyme is inhibited by its regulatory subunit masking the active site, autoregulation by a pseudosubstrate mechanism, overview
-
additional information
insensitive to caspase-3
-
additional information
-
insensitive to caspase-3
-
additional information
-
PKC isozymes interacting proteins, overview
-
additional information
-
not inhibited by 1-tert-butyl-3-(2-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
-
additional information
-
F-actin, latrunculin B, and phalloidin do not modulate the initial steps of enzyme activation process in living nerve cells
-
additional information
-
rapamycin and wortmannin inhibit PKC betaII turnover
-
additional information
-
synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1,2-diacyl-sn-glycerol
-
-
1,2-dioctanoyl-sn-glycerol
-
-
1,2-diolein
activates, required
1,2-dioleoyl-sn-glycerol
-
activates
1-oleoyl-2-acetyl-sn-glycerol
1-oleoyl-acetyl-sn-glycerol
-
0.01 mM
1-stearoyl-2-arachidonoyl-sn-glycerol
-
-
12-O-Tetradecanoylphorbol 13-acetate
12-O-tetradecanoylphorbol-13-acetate
13-O-acetylphorbol 12-myristate
-
-
4beta-phorbol 12-myristate 13-acetate
acetyl-beta-methylcholine
-
-
anionic phospholipids
-
isozymes alpha, betaI, betaII, and gamma require anionic phospholipids for activity, isozymes delta, epsilon, eta, and theta do not
-
CSF-1
-
CSF-1 increases PKCgamma Thr 410 phosphorylation and kinase activity in 32D.R cells
-
curcumin
-
inhibits or activates PKC dependent on Ca2+ and the presence of membranes or phosphatidylserine, respectively, in presence of phosphatidylserine curcumin activates PKC, in presence of membranes with phosphatidylserine the enzyme is inhibited, Ca2+ competes with curcumin at the regulatory domainbinding site, overview, effects on different isozymes, overview
Diacylglycerols
-
activate PKC isozymes
Epidermal growth factor
-
EGF, activates isozyme PKCalpha in the fetal lung during signaling involved in lung maturation, overview
gamma-linolenic acid
a combination of gamma-linolenic acid and phosphatidylserine slightly enhances PKC zeta activity
gastrin
physiological activator of PKD2 in human AGS-B cells stably transfected with the CCK(B)/gastrin receptor
hypericin
-
competes with 12-O-tetradecanoylphorbol 13-acetate for binding to the regulatory domain of PKC, localization of PKC isozymes alpha, delta, and gamma, high affinty binding and interaction witht he C1B domain of PKC, molecular modeling
Kainic acid
-
phosphorylation of MARCKS by PKC isozymes is dramatically upregulated specifically in microglial cells after kainic acid-induced seizures, but not in other types of glial cells, overview, upregulation of isozymes PKCalpha, PKCbetaI, PKCbetaII, and PKCdelta
kenpaullone
-
20% activation of PKCalpha at 0.01 mM
mezerein
-
stimulates classical, but not novel PKC isozymes
palmitate
-
activates isozyme PKCtheta, but not isozymes PKCalpha and PKCepsilon
phorbol 12,13-diacetate
-
-
phorbol 12-myristate 13-acetate
phorbol 12-myristate-13-acetate
-
activation of protein kinase C significantly attenuates starvation- or rapamycin-induced LC3 processing. Activation of protein kinase C inhibits autophagy
phorbol dibutyrate
activates
phorbol myristate acetate
-
-
phorbol-12-myristate-13-acetate
-
phorbol-ester-12-13-dibutyrate
-
phosphatidylserine-diolein
-
-
R59949
-
increases isofom PKCdelta and PKCepsilon activities in both membrane and cytosolic fractions
transforming growth factor alpha
-
TGFalpha, activates isozyme PKCalpha in the fetal lung during signaling involved in lung maturation, overview
-
zileuton
-
zileuton acts as a PKC delta activator, causing it to translocate from the cytosol to nucleus, the activation is inhibited by rottlerin
1-oleoyl-2-acetyl-sn-glycerol
-
0.01 mM
1-oleoyl-2-acetyl-sn-glycerol
-
-
12-O-Tetradecanoylphorbol 13-acetate
-
-
12-O-Tetradecanoylphorbol 13-acetate
-
activates
12-O-Tetradecanoylphorbol 13-acetate
-
activates PKC isozymes
12-O-Tetradecanoylphorbol 13-acetate
-
activates PKCalpha isozyme about 1.6fold
12-O-Tetradecanoylphorbol 13-acetate
-
modeling of complex formation with PKCgamma, competes with hypericin for binding to the regulatory domain of PKC
12-O-Tetradecanoylphorbol 13-acetate
-
activates isozyme PKCepsilon
12-O-Tetradecanoylphorbol 13-acetate
-
activates PKC
12-O-tetradecanoylphorbol-13-acetate
-
-
12-O-tetradecanoylphorbol-13-acetate
-
-
4beta-phorbol 12-myristate 13-acetate
-
-
4beta-phorbol 12-myristate 13-acetate
-
activates PKCalpha-mediated activation of phospholipase D
arachidonic acid
alone or a combination of gamma-linolenic acid and phosphatidylserine slightly enhances PKC zeta activity
arachidonic acid
slightly enhances PKC zeta activity
diacylglycerol
-
isozymes alpha, betaI, betaII, and gamma require diacylglycerol for activity, isozymes delta, epsilon, eta, and theta do not
diacylglycerol
plus phosphatidylserine, activates
diacylglycerol
dependent upon phosphatidylserine or diacylglycerol for maximal activation
diacylglycerol
-
binds to C1 domain of PKC, regulatory function for isozymes alpha, betaI, betaII, gamma, delta, epsilon, eta, and theta, overview
diacylglycerol
-
required, second messenger involved in PKC regulation
diacylglycerol
-
binds to C1 domain of PKC, regulatory function for isozymes alpha, betaI, betaII, gamma, delta, epsilon, eta, and theta, overview
diacylglycerol
-
required, second messenger involved in PKC regulation
diacylglycerol
activity is dependent on
diacylglycerol
independent of the presence of Ca2+ or diacylglycerol, when assayed with calf thymus H1 histone as a phosphate acceptor protein
diacylglycerol
-
binds to the C1 domains of isozymes PKCalpha and PKCgamma, differential roles of C1A and C1B, overview
diacylglycerol
-
activates protein kinase C
diacylglycerol
-
the membrane recruitment and activation of PKCdelta and PKCepsilon is fully dependent on their direct interaction with diacylglycerol generated by adenosine A2a receptor-induced activation of phospholipase C-gamma, through a mechanism requiring both Src and phosphatidylinositol 3-kinase activities
fatty acids
-
activation mechanism
fatty acids
-
activation mechanism
fatty acids
-
activation mechanism, isozyme PKCdelta is involved in fatty acid-induced hepatic insulin resistance
Insulin
-
activates PKC isozymes alpha, betaII, delta, and zeta in several cell types, activation mechanism
-
Insulin
-
activates PKC isozymes alpha, betaII, delta, and zeta in several cell types, activation mechanism
-
Insulin
-
activates PKC isozymes alpha, betaII, delta, and zeta in several cell types, activation mechanism, isozyme PKCdelta is involved in fatty acid-induced hepatic insulin resistance
-
phorbol 12,13-dibutyrate
-
-
phorbol 12,13-dibutyrate
-
-
phorbol 12,13-dibutyrate
-
0.001 mM
phorbol 12,13-dibutyrate
-
-
phorbol 12,13-dibutyrate
-
activates PKC, activates Na+,K+-ATPase activity at low concentration, but inhibits it at high concentration
phorbol 12-myristate 13-acetate
-
-
phorbol 12-myristate 13-acetate
100 nM
phorbol 12-myristate 13-acetate
-
-
phorbol 12-myristate 13-acetate
-
i.e. PMA
phorbol 12-myristate 13-acetate
-
i.e. PMA, inhibits IKCa channels
phorbol 12-myristate 13-acetate
-
10 nM
phorbol 12-myristate 13-acetate
-
100 nM
phorbol 12-myristate 13-acetate
-
activates PKC-mediated phosphorylation of transient receptor potential protein vanilloid 4 at Ser824
phorbol 12-myristate 13-acetate
-
-
phorbol 12-myristate 13-acetate
-
100 nM
phorbol 12-myristate 13-acetate
-
-
phorbol 12-myristate 13-acetate
-
potent activator
phorbol 12-myristate 13-acetate
-
activates PKC 4fold
phorbol 12-myristate 13-acetate
-
binds to the C1 domains of isozymes PKCalpha and PKCgamma, differential roles of C1A and C1B, overview
phorbol 12-myristate 13-acetate
-
mediates isozyme translocation
phorbol 12-myristate 13-acetate
-
stimulates IRS1 Ser24 phosphorylation in vivo
phorbol 12-myristate 13-acetate
-
-
Phorbol esters
stimulate
Phorbol esters
bind to and stimulate the kinase activity of PKC-L
phosphatidylserine
stimulates
phosphatidylserine
PKC Apl I requires much less phosphatidylserine for activation than does purified PKC Apl II
phosphatidylserine
PKC Apl I requires much less phosphatidylserine for activation than does purified PKC Apl II
phosphatidylserine
activates, required
phosphatidylserine
-
activation mechanism
phosphatidylserine
plus diacylglycerol, activates
phosphatidylserine
a combination of gamma-linolenic acid and phosphatidylserine slightly enhances PKC zeta activity
phosphatidylserine
dependent upon phosphatidylserine or diacylglycerol for maximal activation
phosphatidylserine
-
activation mechanism
phosphatidylserine
-
activation mechanism
Phospholipid
strict dependence on the presence of phospholipids
Phospholipid
dependent on
Phospholipid
activity is dependent on
Phospholipid
significantly dependent on phospholipid when assayed with calf thymus H1 histone as a phosphate acceptor protein
Phospholipids
activate
Phospholipids
-
regulatory function for isozymes alpha, betaI, betaII, gamma, delta, epsilon, eta, and theta
Phospholipids
-
regulatory function for isozymes alpha, betaI, betaII, gamma, delta, epsilon, eta, and theta
thymeleatoxin
-
activates Ca2+-dependent PKC isozymes, reversal by chronic thymeleatoxin pretreatment of the effects of carbachol on glucose-induced Ca2+ oscillations and pulsatile 5-HT release, overview
thymeleatoxin
-
activates Na+,K+-ATPase activity at low concentration, but inhibits it at high concentration
additional information
-
the isozymes show varying activation requirements
-
additional information
-
PKC is activated by the addition of 0.03 mg/ml 10:0 1,2-didecanoyl-sn-glycero-3-phosphate, 0.01 mg/ml 1-oleoyl-2-acetoyl-sn-glycerol, and 0.6 mM CaCl2 (no CaCl2 for isoform PKC-delta) for 30 min at 37°C
-
additional information
cannot be activated by phorbol ester treatment of NIH 3T3 cells or insect cells, overexpressing the respective PKC isoenzyme
-
additional information
cannot be activated by phorbol ester treatment of NIH 3T3 cells or insect cells, overexpressing the respective PKC isoenzyme
-
additional information
-
cannot be activated by phorbol ester treatment of NIH 3T3 cells or insect cells, overexpressing the respective PKC isoenzyme
-
additional information
-
activation mechanism of isozymes, overview
-
additional information
-
Helicobacter pylori activates the enzyme in gastric epithelial cells
-
additional information
-
PKC activation is influenced by intracellular Ca2+ concentration and activity of the metabotropic glutamate receptor 5
-
additional information
-
no activation by 4alpha-phorbol 12-myristate 13-acetate
-
additional information
-
no activation by 4alpha-phorbol-12,13-didecanoate
-
additional information
-
not activated by 4alpha-phorbol
-
additional information
-
PKC isozymes are activated in gamma-ray-irradiated cells and bystander cells
-
additional information
PKC isozymes are activated in gamma-ray-irradiated cells and bystander cells
-
additional information
PKC isozymes are activated in gamma-ray-irradiated cells and bystander cells
-
additional information
the activation of PKCalpha isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1)
-
additional information
the activation of PKCalpha isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1)
-
additional information
the activation of PKCalpha isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1)
-
additional information
the activation of PKCalpha isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1)
-
additional information
the activation of PKCdelta isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1)
-
additional information
the activation of PKCdelta isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1)
-
additional information
the activation of PKCdelta isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1)
-
additional information
the activation of PKCdelta isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1)
-
additional information
the activation of PKCepsilon isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1)
-
additional information
the activation of PKCepsilon isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1)
-
additional information
the activation of PKCepsilon isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1)
-
additional information
the activation of PKCepsilon isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1)
-
additional information
-
after binding to alpha2beta1 integrin, human echovirus 1 activates PKCalpha, independent on the E336-mediated conformational changes in alpha2beta1
-
additional information
-
PKC activation can inhibit zinc transporter ZIP8 activity
-
additional information
-
autoregulation by a pseudosubstrate mechanism, overview
-
additional information
-
activation mechanism of isozymes, overview
-
additional information
-
PKC isozymes interacting proteins, overview
-
additional information
-
activation mechanism of isozymes PKCalpha and PKCgamma
-
additional information
-
F-actin, latrunculin B, and phalloidin do not modulate the initial steps of enzyme activation process in living nerve cells
-
additional information
-
phorbol 12-myristate 13-acetate and sugars activate PKC betaII activation and degradation via dephosphorylation and ubiquitinylation pathway
-
additional information
-
no activation by C2 ceramide or chronic insulin treatment
-
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0.000002 - 0.000829
(2R)-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
0.03
1,1'-(1,10-decanediyl)bis[1-amino isoquinolinium] diiodide
Homo sapiens
-
pH 7.4
0.014
1,1'-(1,10-decanediyl)bis[2-amino-1-methylbenzimidazolium] diiodide
Homo sapiens
-
pH 7.4
0.017
1,1'-(1,10-decanediyl)bis[2-methylbenzothiazolium] diiodide
Homo sapiens
-
pH 7.4
0.036
1,1'-(1,10-decanediyl)bis[2-methylbenzoxazolium] diiodide
Homo sapiens
-
pH 7.4
0.022
1,1'-(1,10-decanediyl)bis[2-methylquinolinium] diiodide
Homo sapiens
-
pH 7.4
0.007
1,1'-(1,10-decanediyl)bis[4-amino-2-methyl quinolinium] diiodide
Homo sapiens
-
pH 7.4
0.03
1,1'-(1,10-decanediyl)bis[4-aminoquinolinium] diiodide
Homo sapiens
-
pH 7.4
0.029
1,1'-(1,10-decanediyl)bis[4-N,N,dimethylaminoquinolinium] diiodide
Homo sapiens
-
pH 7.4
0.072
1,1'-(1,10-decanediyl)bis[quinolinium] diiodide
Homo sapiens
-
pH 7.4
0.112
1,1'-decane-1,10-diylbis(4-aminopyridinium) diiodide
Homo sapiens
-
pH 7.4
0.231
1,1'-decane-1,10-diylbis[4-(dimethylamino)pyridinium]
Homo sapiens
-
pH 7.4
0.03
1,6-bis[N-(1-methylquinolinium-2-methyl)amino]-hexane diiodide
Homo sapiens
-
pH 7.4
0.000004 - 0.000661
1-(1,4-diazepan-1-yl)-3-(pyridin-4-yl)-2,6-naphthyridine
0.000006 - 0.001
1-(piperazin-1-yl)-3-(pyridin-4-yl)-2,6-naphthyridine
0.000154
1-(tert-butyl)-3-(1-naphthyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Mus musculus
-
ATP analog-specific PKCdelta isoform, at pH 7.4 and 27°C
0.0026
1-(tert-butyl)-3-(2-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Mus musculus
-
ATP analog-specific PKCdelta isoform, at pH 7.4 and 27°C
0.000008 - 0.000865
1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]piperidin-3-amine
0.000000086
1-[3-chloro-6-(1,4-diazepan-1-yl)pyridin-2-yl]-7-ethoxy-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one
Homo sapiens
pH and temperature not specified in the publication
0.00000087
15-chloro-11-methyl-8,9,10,11-tetrahydro-7H-16,12-(azeno)-6-oxa-2,3,11,16a-tetraazacyclotetradeca[1,2,3-cd]inden-1(2H)-one
Homo sapiens
pH and temperature not specified in the publication
0.0000063
2-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)-6-(2-phenylpiperazin-1-yl)pyridine-3-carbonitrile
Homo sapiens
pH and temperature not specified in the publication
0.000081 - 0.001
2-([3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]amino)ethanol
0.000082 - 0.001
2-([3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]oxy)ethanamine
0.000052 - 0.001
2-methyl-N1-[3-(3-methylpyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
0.001
2-methyl-N1-[3-(pyridin-3-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.000009 - 0.000967
2-methyl-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
0.005
3-methoxybenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.000403 - 0.001
3-phenyl-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
3.59
4-amino-1,2-dimethylquinolinium
Homo sapiens
-
pH 7.4
0.117
4-amino-1-decyl-2-methylquinolinium iodide
Homo sapiens
-
pH 7.4
0.000735 - 0.001
4-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]piperazin-2-one
0.006
benzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.000221 - 0.0075
bisindolylmaleimide I
0.002
ethyl 2-amino-4-(1,3-benzodioxol-5-yl)thiophene-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.004
ethyl 2-amino-4-(2-fluoro-4-methoxyphenyl)thiophene-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.001
ethyl 2-amino-4-(4-aminophenyl)thiophene-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.002
ethyl 2-amino-4-(4-methoxyphenyl)thiophene-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0025
Gö 6983
Homo sapiens
-
pH not specified in the publication, 30°C
0.0000023 - 0.0000079
Gö-6976
Rattus norvegicus
-
IC50 of 2.3-7.9 nM
0.25
N,N,N,N',N',N'-hexaethyldecane-1,10-diaminium
Homo sapiens
-
pH 7.4
0.094
N-cyclohexa-1,3-dien-1-yl-N,N,N',N',N'-pentaphenyldecane-1,10-diaminium
Homo sapiens
-
pH 7.4
0.000079 - 0.001
N-methyl-N'-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
0.000024 - 0.001
N-methyl-N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
0.000027 - 0.001
N-[2-(pyridin-4-yl)pyrido[3,4-d]pyrimidin-4-yl]ethane-1,2-diamine
0.000005 - 0.0009
N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
0.00001 - 0.000779
N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,3-diamine
0.001
N-[3-(pyridin-4-yl)-2,7-naphthyridin-1-yl]ethane-1,2-diamine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.000743 - 0.001
N-[3-(pyridin-4-yl)isoquinolin-1-yl]ethane-1,2-diamine
0.000401 - 0.001
N-[7-(pyridin-4-yl)-1,6-naphthyridin-5-yl]ethane-1,2-diamine
0.000044 - 0.001
N-[7-(pyridin-4-yl)isoquinolin-5-yl]ethane-1,2-diamine
0.000862 - 0.001
N1-(3-[2-(propan-2-ylamino)pyridin-4-yl]-2,6-naphthyridin-1-yl)-2-methylpropane-1,2-diamine
0.00006 - 0.001
N1-[3-(2-aminopyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
0.000015 - 0.001
N1-[3-(3-chloropyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
0.000018 - 0.001
N1-[3-(3-fluoropyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
0.006
propan-2-yl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.016
propidiumiodide
Homo sapiens
-
pH 7.4
0.000008
Ro-31-8425
Homo sapiens
-
pH 7.3, 25°C
0.048
safranine O
Homo sapiens
-
pH 7.4
0.00023 - 0.00167
staurosporine
0.000002
(2R)-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000005
(2R)-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000008
(2R)-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000055
(2R)-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000378
(2R)-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000829
(2R)-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000004
1-(1,4-diazepan-1-yl)-3-(pyridin-4-yl)-2,6-naphthyridine
Homo sapiens
-
pH and temperature not specified in the publication
0.000007
1-(1,4-diazepan-1-yl)-3-(pyridin-4-yl)-2,6-naphthyridine
Homo sapiens
-
pH and temperature not specified in the publication
0.000063
1-(1,4-diazepan-1-yl)-3-(pyridin-4-yl)-2,6-naphthyridine
Homo sapiens
-
pH and temperature not specified in the publication
0.000077
1-(1,4-diazepan-1-yl)-3-(pyridin-4-yl)-2,6-naphthyridine
Homo sapiens
-
pH and temperature not specified in the publication
0.000433
1-(1,4-diazepan-1-yl)-3-(pyridin-4-yl)-2,6-naphthyridine
Homo sapiens
-
pH and temperature not specified in the publication
0.000661
1-(1,4-diazepan-1-yl)-3-(pyridin-4-yl)-2,6-naphthyridine
Homo sapiens
-
pH and temperature not specified in the publication
0.000006
1-(piperazin-1-yl)-3-(pyridin-4-yl)-2,6-naphthyridine
Homo sapiens
-
pH and temperature not specified in the publication
0.000008
1-(piperazin-1-yl)-3-(pyridin-4-yl)-2,6-naphthyridine
Homo sapiens
-
pH and temperature not specified in the publication
0.000031
1-(piperazin-1-yl)-3-(pyridin-4-yl)-2,6-naphthyridine
Homo sapiens
-
pH and temperature not specified in the publication
0.000109
1-(piperazin-1-yl)-3-(pyridin-4-yl)-2,6-naphthyridine
Homo sapiens
-
pH and temperature not specified in the publication
0.000823
1-(piperazin-1-yl)-3-(pyridin-4-yl)-2,6-naphthyridine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
1-(piperazin-1-yl)-3-(pyridin-4-yl)-2,6-naphthyridine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.000008
1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]piperidin-3-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.000013
1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]piperidin-3-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.000132
1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]piperidin-3-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.000214
1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]piperidin-3-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.000771
1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]piperidin-3-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.000865
1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]piperidin-3-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.000081
2-([3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]amino)ethanol
Homo sapiens
-
pH and temperature not specified in the publication
0.000188
2-([3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]amino)ethanol
Homo sapiens
-
pH and temperature not specified in the publication
0.000635
2-([3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]amino)ethanol
Homo sapiens
-
pH and temperature not specified in the publication
0.000743
2-([3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]amino)ethanol
Homo sapiens
-
pH and temperature not specified in the publication
0.001
2-([3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]amino)ethanol
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.000082
2-([3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]oxy)ethanamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00012
2-([3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]oxy)ethanamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000703
2-([3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]oxy)ethanamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000948
2-([3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]oxy)ethanamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
2-([3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]oxy)ethanamine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.000052
2-methyl-N1-[3-(3-methylpyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000133
2-methyl-N1-[3-(3-methylpyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000386
2-methyl-N1-[3-(3-methylpyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000738
2-methyl-N1-[3-(3-methylpyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
2-methyl-N1-[3-(3-methylpyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.000009
2-methyl-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000018
2-methyl-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000044
2-methyl-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000141
2-methyl-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000942
2-methyl-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000967
2-methyl-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000403
3-phenyl-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000452
3-phenyl-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000818
3-phenyl-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000932
3-phenyl-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
3-phenyl-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
3-phenyl-N1-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,2-diamine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.000735
4-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]piperazin-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000802
4-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]piperazin-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.001
4-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]piperazin-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.001
4-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]piperazin-2-one
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.000221
bisindolylmaleimide I
Mus musculus
-
ATP analog-specific PKCdelta isoform, at pH 7.4 and 27°C
0.0075
bisindolylmaleimide I
Homo sapiens
-
pH not specified in the publication, 30°C
0.000079
N-methyl-N'-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000093
N-methyl-N'-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000254
N-methyl-N'-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000997
N-methyl-N'-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N-methyl-N'-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.000024
N-methyl-N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000034
N-methyl-N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00035
N-methyl-N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000371
N-methyl-N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N-methyl-N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.000027
N-[2-(pyridin-4-yl)pyrido[3,4-d]pyrimidin-4-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000038
N-[2-(pyridin-4-yl)pyrido[3,4-d]pyrimidin-4-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000102
N-[2-(pyridin-4-yl)pyrido[3,4-d]pyrimidin-4-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N-[2-(pyridin-4-yl)pyrido[3,4-d]pyrimidin-4-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N-[2-(pyridin-4-yl)pyrido[3,4-d]pyrimidin-4-yl]ethane-1,2-diamine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.000005
N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00002
N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000077
N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000859
N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0009
N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00001
N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,3-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000013
N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,3-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000053
N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,3-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000097
N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,3-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000676
N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,3-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000779
N-[3-(pyridin-4-yl)-2,6-naphthyridin-1-yl]propane-1,3-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000743
N-[3-(pyridin-4-yl)isoquinolin-1-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000877
N-[3-(pyridin-4-yl)isoquinolin-1-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N-[3-(pyridin-4-yl)isoquinolin-1-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N-[3-(pyridin-4-yl)isoquinolin-1-yl]ethane-1,2-diamine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.000401
N-[7-(pyridin-4-yl)-1,6-naphthyridin-5-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000929
N-[7-(pyridin-4-yl)-1,6-naphthyridin-5-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N-[7-(pyridin-4-yl)-1,6-naphthyridin-5-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N-[7-(pyridin-4-yl)-1,6-naphthyridin-5-yl]ethane-1,2-diamine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.000044
N-[7-(pyridin-4-yl)isoquinolin-5-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000054
N-[7-(pyridin-4-yl)isoquinolin-5-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000157
N-[7-(pyridin-4-yl)isoquinolin-5-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000355
N-[7-(pyridin-4-yl)isoquinolin-5-yl]ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N-[7-(pyridin-4-yl)isoquinolin-5-yl]ethane-1,2-diamine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.000862
N1-(3-[2-(propan-2-ylamino)pyridin-4-yl]-2,6-naphthyridin-1-yl)-2-methylpropane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000961
N1-(3-[2-(propan-2-ylamino)pyridin-4-yl]-2,6-naphthyridin-1-yl)-2-methylpropane-1,2-diamine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.001
N1-(3-[2-(propan-2-ylamino)pyridin-4-yl]-2,6-naphthyridin-1-yl)-2-methylpropane-1,2-diamine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.00006
N1-[3-(2-aminopyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000147
N1-[3-(2-aminopyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000294
N1-[3-(2-aminopyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000378
N1-[3-(2-aminopyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000496
N1-[3-(2-aminopyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N1-[3-(2-aminopyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.000015
N1-[3-(3-chloropyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000047
N1-[3-(3-chloropyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000093
N1-[3-(3-chloropyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000221
N1-[3-(3-chloropyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N1-[3-(3-chloropyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.000018
N1-[3-(3-fluoropyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000062
N1-[3-(3-fluoropyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000124
N1-[3-(3-fluoropyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00014
N1-[3-(3-fluoropyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N1-[3-(3-fluoropyridin-4-yl)-2,6-naphthyridin-1-yl]-2-methylpropane-1,2-diamine
Homo sapiens
-
value higher than, pH and temperature not specified in the publication
0.00023
staurosporine
Homo sapiens
-
pH and temperature not specified in the publication
0.00167
staurosporine
Mus musculus
-
ATP analog-specific PKCdelta isoform, at pH 7.4 and 27°C
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