Application | Comment | Organism |
---|---|---|
medicine | over-expression of Eph receptors on cancer cells is able to confer tumourigenic phenotypes such as proliferation and invasion, EphB4 could be a target for therapeutic intervention | Mammalia |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-([4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino)benzenesulfonamide | - |
Mammalia | |
2-([4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino)benzonitrile | - |
Mammalia | |
3-([4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino)benzenesulfonamide | - |
Mammalia | |
3-([4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino)benzonitrile | - |
Mammalia | |
4-([4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino)benzenesulfonamide | - |
Mammalia | |
4-([4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino)benzonitrile | - |
Mammalia | |
N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine | - |
Mammalia | |
N-(5-chloro-1,3-benzodioxol-4-yl)-N'-(3,4,5-trimethoxyphenyl)-1,3,5-triazine-2,4-diamine | - |
Mammalia | |
N-(5-chloro-1,3-benzodioxol-4-yl)-N'-(3,4,5-trimethoxyphenyl)pyrimidine-4,6-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(2-chlorophenyl)pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(2-fluorophenyl)pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(2-methoxyphenyl)pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(2-methylphenyl)pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(2-morpholin-4-ylphenyl)pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(3-chlorophenyl)pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(3-fluorophenyl)pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(3-methoxyphenyl)pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(3-methylphenyl)pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(3-morpholin-4-ylphenyl)pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(4-chlorophenyl)pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(4-fluorophenyl)pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(4-methoxyphenyl)pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(4-methylphenyl)pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(4-morpholin-4-ylphenyl)pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-phenylpyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-[2-(methylsulfonyl)phenyl]pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-[3-(methylsulfonyl)phenyl]pyrimidine-2,4-diamine | - |
Mammalia | |
N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-[4-(methylsulfonyl)phenyl]pyrimidine-2,4-diamine | - |
Mammalia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | Mammalia | - |
ADP + [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | - |
Mammalia | ADP + [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
EphB4 | - |
Mammalia |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00004 | - |
- |
Mammalia | 3-([4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino)benzenesulfonamide | |
0.00009 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-[3-(methylsulfonyl)phenyl]pyrimidine-2,4-diamine | |
0.00024 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine | |
0.0003 | - |
- |
Mammalia | 4-([4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino)benzenesulfonamide | |
0.00035 | - |
- |
Mammalia | N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine | |
0.00046 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(3-methylphenyl)pyrimidine-2,4-diamine | |
0.00055 | - |
- |
Mammalia | 3-([4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino)benzonitrile | |
0.00058 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(3-morpholin-4-ylphenyl)pyrimidine-2,4-diamine | |
0.00063 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-[4-(methylsulfonyl)phenyl]pyrimidine-2,4-diamine | |
0.00064 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(3-methoxyphenyl)pyrimidine-2,4-diamine | |
0.001 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(4-morpholin-4-ylphenyl)pyrimidine-2,4-diamine | |
0.00115 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(3-fluorophenyl)pyrimidine-2,4-diamine | |
0.00125 | - |
- |
Mammalia | 4-([4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino)benzonitrile | |
0.00133 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(3-chlorophenyl)pyrimidine-2,4-diamine | |
0.00155 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-phenylpyrimidine-2,4-diamine | |
0.0016 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(4-methylphenyl)pyrimidine-2,4-diamine | |
0.00194 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(4-methoxyphenyl)pyrimidine-2,4-diamine | |
0.0023 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(4-fluorophenyl)pyrimidine-2,4-diamine | |
0.00254 | - |
- |
Mammalia | N-(5-chloro-1,3-benzodioxol-4-yl)-N'-(3,4,5-trimethoxyphenyl)pyrimidine-4,6-diamine | |
0.00296 | - |
- |
Mammalia | N-(5-chloro-1,3-benzodioxol-4-yl)-N'-(3,4,5-trimethoxyphenyl)-1,3,5-triazine-2,4-diamine | |
0.00388 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(2-methoxyphenyl)pyrimidine-2,4-diamine | |
0.005 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(2-fluorophenyl)pyrimidine-2,4-diamine | |
0.006 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(4-chlorophenyl)pyrimidine-2,4-diamine | |
0.00785 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(2-morpholin-4-ylphenyl)pyrimidine-2,4-diamine | |
0.01132 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(2-chlorophenyl)pyrimidine-2,4-diamine | |
0.01396 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-(2-methylphenyl)pyrimidine-2,4-diamine | |
0.02049 | - |
- |
Mammalia | 2-([4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino)benzonitrile | |
0.0355 | - |
- |
Mammalia | 2-([4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino)benzenesulfonamide | |
0.041 | - |
- |
Mammalia | N4-(5-chloro-1,3-benzodioxol-4-yl)-N2-[2-(methylsulfonyl)phenyl]pyrimidine-2,4-diamine |