Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.10.2
-
RECOMMENDED NAME
GeneOntology No.
non-specific protein-tyrosine kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
CAS REGISTRY NUMBER
COMMENTARY hide
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Abelson leukaemia virus
-
-
-
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
genes wzc and etk
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-
Manually annotated by BRENDA team
ssp. catus
SwissProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
overproduced in Escherichia coli under the control of phage lambda promoter
SwissProt
Manually annotated by BRENDA team
MuSVts110
SwissProt
Manually annotated by BRENDA team
C57BL/6 mice
-
-
Manually annotated by BRENDA team
Mus musculus C57BL6J / 129Sv
hybrid C57BL6J/129Sv
-
-
Manually annotated by BRENDA team
clone ts159
SwissProt
Manually annotated by BRENDA team
New Zealand white rabbits
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-
Manually annotated by BRENDA team
strain PAO1 and strain ATCC 27853
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-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
AEEEIYGEFEAKKKK + ATP
? + ADP
show the reaction diagram
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + a [homeodomain-interacting protein kinase 2]-L-tyrosine
ADP + a [homeodomain-interacting protein kinase 2]-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + a [peptide]-L-tyrosine
ADP + a [peptide]-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
ATP + a [Tyr-2 peptide]-L-tyrosine
ADP + a [Tyr-2 peptide]-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + A-kinase anchor protein 8
?
show the reaction diagram
-
-
-
-
?
ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
show the reaction diagram
ATP + Akt tyrosine kinase
ADP + phosphotyrosinyl-Akt
show the reaction diagram
ATP + arsenate resistance protein ARS2
?
show the reaction diagram
-
-
-
-
?
ATP + ataxin 2 related protein
?
show the reaction diagram
-
-
-
-
?
ATP + Bad protein
ADP + phosphotyrosinyl Bad protein
show the reaction diagram
ATP + Bcl-2-associated transcription factor 1
?
show the reaction diagram
-
-
-
-
?
ATP + beta 1-integrin cytoplasmic domain peptide
ADP + ?
show the reaction diagram
-
-
-
-
?
ATP + beta-catenin
ADP + phospho-tyrosinyl-beta-catenin
show the reaction diagram
ATP + biotin-GGEAIYAAPFKK-amide
ADP + phosphorylated biotin-GGEAIYAAPFKK-amide
show the reaction diagram
-
a peptide with the preferred c-Abl substrate sequence carrying an Nterminal biotin
-
-
?
ATP + c-Src
?
show the reaction diagram
-
-
-
-
?
ATP + calponin 3
?
show the reaction diagram
-
-
-
-
?
ATP + Cas protein
ADP + phospho-tyrosinyl-Cas protein
show the reaction diagram
ATP + casein
ADP + phosphocasein
show the reaction diagram
-
serine/threonine kinase activity, and no tyrosine kinase activity
-
-
?
ATP + Cbp
? + ADP
show the reaction diagram
-
murine Csk binding protein, Cbp, amino acids 74-474, substrate used in kinase activity assay
-
-
?
ATP + cdc2
ADP + phosphorylated cdc2
show the reaction diagram
ATP + cdc2(6-20) peptide
?
show the reaction diagram
-
i.e. KVEKIGEGTYGVVYK, substrate of Src family kinases
-
-
?
ATP + chromosome 20 open reading frame 77
?
show the reaction diagram
-
-
-
-
?
ATP + cleavage and polyadenylation specific factor 5
?
show the reaction diagram
-
-
-
-
?
ATP + cofilin
ADP + phosphorylated cofilin
show the reaction diagram
ATP + cortactin
?
show the reaction diagram
-
-
-
-
?
ATP + cortactin
ADP + phospho-tyrosinyl-cortactin
show the reaction diagram
ATP + cyclin-associated cyclin-dependent kinase
ADP + phosphorylated cyclin-associated cyclin-dependent kinase
show the reaction diagram
ATP + EAIYAAPFAKKKG
ADP + EAI-pY-AAPFAKKKG
show the reaction diagram
-
-
-
-
?
ATP + EEEEY
ADP + EEEE(phospho)Y
show the reaction diagram
-
-
-
-
?
ATP + EEEEYIQ[dP]-8-hydroxy-5-(N,N-dimethylsulfonamido)-2-methylquinoline-G
ADP + EEEEYIQ[dP]-8-hydroxy-5-(N,N-dimethylsulfonamido)-2-methylquinoline-G phosphate
show the reaction diagram
-
Y7 Sox-based substrate, kinetic assay
-
-
?
ATP + EEEPQYEEIPI +
ADP + EEEPQpYEEIPI
show the reaction diagram
-
-
-
-
?
ATP + enolase
ADP + ?
show the reaction diagram
-
serine/threonine kinase activity, and no tyrosine kinase activity
-
-
?
ATP + epidermal growth factor receptor
ADP + phospho-L-tyrosinyl-epidermal growth factor receptor
show the reaction diagram
ATP + EQEDEPEGDYFEWLE
ADP + EQEDEPEGDpYFEWLE
show the reaction diagram
-
-
-
-
?
ATP + eukaryotic translation initiation factor 3, subunit 4
?
show the reaction diagram
-
-
-
-
?
ATP + ewing sarcoma breakpoint region 1
?
show the reaction diagram
-
-
-
-
?
ATP + ezrin
ADP + phospho-tyrosinyl-ezrin
show the reaction diagram
ATP + F peptide
ADP + phospho-L-tyrosinyl-F peptide
show the reaction diagram
-
i.e. biotin-Aca-AAAEEIFGEI-NH2
-
-
?
ATP + FAK
ADP + phospho-tyrosinyl-FAK
show the reaction diagram
ATP + FUS interacting protein (serine/arginine rich) 1
?
show the reaction diagram
-
-
-
-
?
ATP + FUS/TLS oncogene
?
show the reaction diagram
-
-
-
-
?
ATP + FUSE binding protein
?
show the reaction diagram
-
-
-
-
?
ATP + FUSE binding protein 2
?
show the reaction diagram
-
-
-
-
?
ATP + GAPEVIYATPGAKKK
ADP + GAPEVI-phosphotyrosinyl-ATPGAKKK
show the reaction diagram
-
consensus substrate
-
-
?
ATP + GGEAIYAAPFKK
ADP + GGEAIYAAPFKK phosphate
show the reaction diagram
-
kinase assay using biotinylated model substrate peptide
-
-
?
ATP + glycogen synthase kinase 3beta
ADP + phosphotyrosinyl glycogen synthase kinase 3beta
show the reaction diagram
ATP + heterogeneous nuclear ribonucleoprotein A3
?
show the reaction diagram
-
-
-
-
?
ATP + heterogeneous nuclear ribonucleoprotein AB
?
show the reaction diagram
-
-
-
-
?
ATP + heterogeneous nuclear ribonucleoprotein D-like
?
show the reaction diagram
-
-
-
-
?
ATP + heterogeneous nuclear ribonucleoprotein K
?
show the reaction diagram
-
-
-
-
?
ATP + histone
ADP + phosphorylated histone
show the reaction diagram
serine/threonine-specific kinase activity
-
-
?
ATP + homeobox prox 1
?
show the reaction diagram
-
-
-
-
?
ATP + IkappaBalpha-L-tyrosine
ADP + IkappaBalpha-L-tyrosine phosphate
show the reaction diagram
ATP + KVEKIGEGTYGVVYK
? + ADP
show the reaction diagram
-
substrate peptide used in kinase activity assay, derived from p34cdc2
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-
?
ATP + KVEKIGEGTYGVVYK
ADP + ?
show the reaction diagram
-
synthetic peptide substrate
-
-
?
ATP + lysozyme-L-tyrosine
ADP + lysozyme-L-tyrosine phosphate
show the reaction diagram
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substrate of Src, low activity with Csk or Chk
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?
ATP + myelin basic protein
ADP + ?
show the reaction diagram
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-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
ATP + myosin light chain
ADP + ?
show the reaction diagram
-
serine/threonine kinase activity, and no tyrosine kinase activity
-
-
?
ATP + NaV1.2 channel
ADP + phospho-L-tyrosinyl-NaV1.2 channel
show the reaction diagram
-
Y66 and Y1893, which are in consensus sequences appropriate for binding to the Fyn SH2 domain after phosphorylation, are both required for optimal binding and regulation by Fyn. Y730, which is located near the SH3-binding motif in LI-II, and Y1497 and Y1498 in the inactivation gate in LIII-IV, are also required for optimal regulation, but phosphorylation of these sites likely promotes fast inactivation
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-
?
ATP + NEFA-interacting nuclear protein
?
show the reaction diagram
-
-
-
-
?
ATP + NICE-4
?
show the reaction diagram
-
-
-
-
?
ATP + P1 peptide
ADP + phospho-L-tyrosinyl-P1 peptide
show the reaction diagram
-
i.e. biotin-Aca-AAAEEIpYGEI-NH2
-
-
?
ATP + p120 protein
ADP + phospho-tyrosinyl-p120 protein
show the reaction diagram
ATP + p190 GTPase
ADP + phospho-tyrosinyl-p190 GTPase
show the reaction diagram
ATP + p32-L-tyrosine
ADP + p32-L-tyrosine phosphate
show the reaction diagram
ATP + p34cdc2
ADP + phosphorylated p34cdc2
show the reaction diagram
ATP + PAK1
ADP + phospho-L-tyrosinyl-PAK1
show the reaction diagram
ATP + paxillin
ADP + phospho-tyrosinyl-Shc paxillin
show the reaction diagram
ATP + peptide
ADP + phospho-L-tyrosinyl-peptide
show the reaction diagram
-
PTKs phosphorylate substrates in a sequence-specific manner, relatively short peptide sequences determine selectivity, substrate specificity analysis using 144 different peptides, overview
-
-
?
ATP + PIKE-A
ADP + phosphotyrosinyl-PIKE-A
show the reaction diagram
ATP + plakoglobin
ADP + phospho-tyrosinyl-plakoglobin
show the reaction diagram
ATP + poly(Glu,Tyr)
? + ADP
show the reaction diagram
-
substrate used in the tyrosine kinase asssay
-
-
?
ATP + poly(Glu-Tyr)
? + ADP
show the reaction diagram
-
substrate used in the activity assay
-
-
?
ATP + poly(Glu4-Tyr)
ADP + poly(Glu-Tyr)-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + poly(Glu4-Tyr)
ADP + poly(Glu4-Tyr)-L-tyrosine phosphate
show the reaction diagram
ATP + poly-(Tyr-Glu)
ADP + phospho-poly-(Tyr-Glu)
show the reaction diagram
-
tyrosine kinase substrate, phosphoryated by Swe1p, Mps1p, Ime2p, and Hrr25p, but not by Ste7p, Rad53p, or Mck1p
-
-
?
ATP + proteasome activator subunit 3
?
show the reaction diagram
-
-
-
-
?
ATP + protein
?
show the reaction diagram
-
CSK phosphorylates other members of the src-family of tyrosine kinases at their regulatory carboxy-terminus. By regulating the activity of these kinases, CSK may play an important role in cell growth and development
-
-
?
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
ATP + protein tyrosine kinase Yes
ADP + phospho-L-tyrosinyl Yes
show the reaction diagram
-
Csk inactivates the enzyme substrate
-
-
?
ATP + RasGAP SH3-domain binding protein
?
show the reaction diagram
-
-
-
-
?
ATP + recombinant GST/beta3 integrin cytoplasmic tail peptide
ADP + ?
show the reaction diagram
-
-
-
-
?
ATP + Rho protein
ADP + phospho-tyrosinyl-Rho protein
show the reaction diagram