Application | Comment | Organism |
---|---|---|
pharmacology | the enzyme is a pharmaceutical target for inhibitors in therapy of acute inflammatory responses, e.g. acute lung injury, ischemic brain injury, brain injury, spinal cord compression, stroke, and myocardial infarction, detailed overview | Mus musculus |
pharmacology | the enzyme is a pharmaceutical target for inhibitors in therapy of acute inflammatory responses, e.g. acute lung injury, ischemic brain injury, brain injury, spinal cord compression, stroke, and myocardial infarction, detailed overview | Homo sapiens |
pharmacology | the enzyme is a pharmaceutical target for inhibitors in therapy of acute inflammatory responses, e.g. acute lung injury, ischemic brain injury, brain injury, spinal cord compression, stroke, and myocardial infarction, detailed overview | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine | - |
Homo sapiens | |
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine | - |
Mus musculus | |
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine | - |
Rattus norvegicus | |
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine | - |
Homo sapiens | |
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine | - |
Mus musculus | |
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine | - |
Rattus norvegicus | |
AZM 475271 | - |
Homo sapiens | |
AZM 475271 | - |
Mus musculus | |
AZM 475271 | - |
Rattus norvegicus | |
CGP 76030 | - |
Homo sapiens | |
CGP 76030 | - |
Mus musculus | |
CGP 76030 | - |
Rattus norvegicus | |
CGP 77675 | - |
Homo sapiens | |
CGP 77675 | - |
Mus musculus | |
CGP 77675 | - |
Rattus norvegicus | |
M 475271 | - |
Homo sapiens | |
M 475271 | - |
Mus musculus | |
M 475271 | - |
Rattus norvegicus | |
SKI-606 | - |
Homo sapiens | |
SKI-606 | - |
Mus musculus | |
SKI-606 | - |
Rattus norvegicus | |
SU-6656 | - |
Homo sapiens | |
SU-6656 | - |
Mus musculus | |
SU-6656 | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | the NH2-terminal unique domain, the Src homology SH 4 region, is required for membrane attachment | Mus musculus | 16020 | - |
membrane | the NH2-terminal unique domain, the Src homology SH 4 region, is required for membrane attachment | Homo sapiens | 16020 | - |
membrane | the NH2-terminal unique domain, the Src homology SH 4 region, is required for membrane attachment | Rattus norvegicus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-catenin | Mus musculus | - |
ADP + phospho-tyrosinyl-beta-catenin | - |
? | |
ATP + beta-catenin | Homo sapiens | - |
ADP + phospho-tyrosinyl-beta-catenin | - |
? | |
ATP + beta-catenin | Rattus norvegicus | - |
ADP + phospho-tyrosinyl-beta-catenin | - |
? | |
ATP + Cas protein | Mus musculus | - |
ADP + phospho-tyrosinyl-Cas protein | - |
? | |
ATP + Cas protein | Homo sapiens | - |
ADP + phospho-tyrosinyl-Cas protein | - |
? | |
ATP + Cas protein | Rattus norvegicus | - |
ADP + phospho-tyrosinyl-Cas protein | - |
? | |
ATP + cortactin | Mus musculus | - |
ADP + phospho-tyrosinyl-cortactin | - |
? | |
ATP + cortactin | Homo sapiens | - |
ADP + phospho-tyrosinyl-cortactin | - |
? | |
ATP + cortactin | Rattus norvegicus | - |
ADP + phospho-tyrosinyl-cortactin | - |
? | |
ATP + ezrin | Mus musculus | - |
ADP + phospho-tyrosinyl-ezrin | - |
? | |
ATP + ezrin | Homo sapiens | - |
ADP + phospho-tyrosinyl-ezrin | - |
? | |
ATP + ezrin | Rattus norvegicus | - |
ADP + phospho-tyrosinyl-ezrin | - |
? | |
ATP + FAK | Mus musculus | - |
ADP + phospho-tyrosinyl-FAK | - |
? | |
ATP + FAK | Homo sapiens | - |
ADP + phospho-tyrosinyl-FAK | - |
? | |
ATP + FAK | Rattus norvegicus | - |
ADP + phospho-tyrosinyl-FAK | - |
? | |
ATP + p120 protein | Mus musculus | - |
ADP + phospho-tyrosinyl-p120 protein | - |
? | |
ATP + p120 protein | Homo sapiens | - |
ADP + phospho-tyrosinyl-p120 protein | - |
? | |
ATP + p120 protein | Rattus norvegicus | - |
ADP + phospho-tyrosinyl-p120 protein | - |
? | |
ATP + p190 GTPase | Mus musculus | - |
ADP + phospho-tyrosinyl-p190 GTPase | - |
? | |
ATP + p190 GTPase | Homo sapiens | - |
ADP + phospho-tyrosinyl-p190 GTPase | - |
? | |
ATP + p190 GTPase | Rattus norvegicus | - |
ADP + phospho-tyrosinyl-p190 GTPase | - |
? | |
ATP + paxillin | Mus musculus | - |
ADP + phospho-tyrosinyl-Shc paxillin | - |
? | |
ATP + paxillin | Homo sapiens | - |
ADP + phospho-tyrosinyl-Shc paxillin | - |
? | |
ATP + paxillin | Rattus norvegicus | - |
ADP + phospho-tyrosinyl-Shc paxillin | - |
? | |
ATP + plakoglobin | Mus musculus | - |
ADP + phospho-tyrosinyl-plakoglobin | - |
? | |
ATP + plakoglobin | Homo sapiens | - |
ADP + phospho-tyrosinyl-plakoglobin | - |
? | |
ATP + plakoglobin | Rattus norvegicus | - |
ADP + phospho-tyrosinyl-plakoglobin | - |
? | |
ATP + Rho protein | Mus musculus | - |
ADP + phospho-tyrosinyl-Rho protein | - |
? | |
ATP + Rho protein | Homo sapiens | - |
ADP + phospho-tyrosinyl-Rho protein | - |
? | |
ATP + Rho protein | Rattus norvegicus | - |
ADP + phospho-tyrosinyl-Rho protein | - |
? | |
ATP + Shc protein | Mus musculus | - |
ADP + phospho-tyrosinyl-Shc protein | - |
? | |
ATP + Shc protein | Homo sapiens | - |
ADP + phospho-tyrosinyl-Shc protein | - |
? | |
ATP + Shc protein | Rattus norvegicus | - |
ADP + phospho-tyrosinyl-Shc protein | - |
? | |
ATP + STAT3 | Mus musculus | - |
ADP + phospho-tyrosinyl-STAT3 | - |
? | |
ATP + STAT3 | Homo sapiens | - |
ADP + phospho-tyrosinyl-STAT3 | - |
? | |
ATP + STAT3 | Rattus norvegicus | - |
ADP + phospho-tyrosinyl-STAT3 | - |
? | |
additional information | Mus musculus | Src PTK plays a role in NF-kappaB activation in epithelial cells, Src PTKs are important in regulation of vascular permeability and acute inflammatory responses, and are essential for the recruitment and activation of monocytes, macrophages, neutrophils, and other immune cells, Src PTKs can also regulate the functional activity of these receptors and is involved in cell signaling, biological functions, cellular and molecular mechanisms, overview | ? | - |
? | |
additional information | Homo sapiens | Src PTK plays a role in NF-kappaB activation in epithelial cells, Src PTKs are important in regulation of vascular permeability and acute inflammatory responses, and are essential for the recruitment and activation of monocytes, macrophages, neutrophils, and other immune cells, Src PTKs can also regulate the functional activity of these receptors and is involved in cell signaling, biological functions, cellular and molecular mechanisms, overview | ? | - |
? | |
additional information | Rattus norvegicus | Src PTK plays a role in NF-kappaB activation in epithelial cells, Src PTKs are important in regulation of vascular permeability and acute inflammatory responses, and are essential for the recruitment and activation of monocytes, macrophages, neutrophils, and other immune cells, Src PTKs can also regulate the functional activity of these receptors and is involved in cell signaling, biological functions, cellular and molecular mechanisms, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | - |
Mus musculus | - |
epithelial cell | - |
Homo sapiens | - |
epithelial cell | - |
Rattus norvegicus | - |
granulocyte | - |
Mus musculus | - |
granulocyte | - |
Homo sapiens | - |
granulocyte | - |
Rattus norvegicus | - |
macrophage | - |
Mus musculus | - |
macrophage | - |
Homo sapiens | - |
macrophage | - |
Rattus norvegicus | - |
monocyte | - |
Mus musculus | - |
monocyte | - |
Homo sapiens | - |
monocyte | - |
Rattus norvegicus | - |
additional information | ubiquitous expression of Src, Fyn, Yes, and Yrk, while Blk, Fgr, Hck, Lck, and Lyn are expressed in more restricted patterns | Mus musculus | - |
additional information | ubiquitous expression of Src, Fyn, Yes, and Yrk, while Blk, Fgr, Hck, Lck, and Lyn are expressed in more restricted patterns | Homo sapiens | - |
additional information | ubiquitous expression of Src, Fyn, Yes, and Yrk, while Blk, Fgr, Hck, Lck, and Lyn are expressed in more restricted patterns | Rattus norvegicus | - |
neutrophil | - |
Mus musculus | - |
neutrophil | - |
Homo sapiens | - |
neutrophil | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-catenin | - |
Mus musculus | ADP + phospho-tyrosinyl-beta-catenin | - |
? | |
ATP + beta-catenin | - |
Homo sapiens | ADP + phospho-tyrosinyl-beta-catenin | - |
? | |
ATP + beta-catenin | - |
Rattus norvegicus | ADP + phospho-tyrosinyl-beta-catenin | - |
? | |
ATP + Cas protein | - |
Mus musculus | ADP + phospho-tyrosinyl-Cas protein | - |
? | |
ATP + Cas protein | - |
Homo sapiens | ADP + phospho-tyrosinyl-Cas protein | - |
? | |
ATP + Cas protein | - |
Rattus norvegicus | ADP + phospho-tyrosinyl-Cas protein | - |
? | |
ATP + cortactin | - |
Mus musculus | ADP + phospho-tyrosinyl-cortactin | - |
? | |
ATP + cortactin | - |
Homo sapiens | ADP + phospho-tyrosinyl-cortactin | - |
? | |
ATP + cortactin | - |
Rattus norvegicus | ADP + phospho-tyrosinyl-cortactin | - |
? | |
ATP + ezrin | - |
Mus musculus | ADP + phospho-tyrosinyl-ezrin | - |
? | |
ATP + ezrin | - |
Homo sapiens | ADP + phospho-tyrosinyl-ezrin | - |
? | |
ATP + ezrin | - |
Rattus norvegicus | ADP + phospho-tyrosinyl-ezrin | - |
? | |
ATP + FAK | - |
Mus musculus | ADP + phospho-tyrosinyl-FAK | - |
? | |
ATP + FAK | - |
Homo sapiens | ADP + phospho-tyrosinyl-FAK | - |
? | |
ATP + FAK | - |
Rattus norvegicus | ADP + phospho-tyrosinyl-FAK | - |
? | |
ATP + p120 protein | - |
Mus musculus | ADP + phospho-tyrosinyl-p120 protein | - |
? | |
ATP + p120 protein | - |
Homo sapiens | ADP + phospho-tyrosinyl-p120 protein | - |
? | |
ATP + p120 protein | - |
Rattus norvegicus | ADP + phospho-tyrosinyl-p120 protein | - |
? | |
ATP + p190 GTPase | - |
Mus musculus | ADP + phospho-tyrosinyl-p190 GTPase | - |
? | |
ATP + p190 GTPase | - |
Homo sapiens | ADP + phospho-tyrosinyl-p190 GTPase | - |
? | |
ATP + p190 GTPase | - |
Rattus norvegicus | ADP + phospho-tyrosinyl-p190 GTPase | - |
? | |
ATP + paxillin | - |
Mus musculus | ADP + phospho-tyrosinyl-Shc paxillin | - |
? | |
ATP + paxillin | - |
Homo sapiens | ADP + phospho-tyrosinyl-Shc paxillin | - |
? | |
ATP + paxillin | - |
Rattus norvegicus | ADP + phospho-tyrosinyl-Shc paxillin | - |
? | |
ATP + plakoglobin | - |
Mus musculus | ADP + phospho-tyrosinyl-plakoglobin | - |
? | |
ATP + plakoglobin | - |
Homo sapiens | ADP + phospho-tyrosinyl-plakoglobin | - |
? | |
ATP + plakoglobin | - |
Rattus norvegicus | ADP + phospho-tyrosinyl-plakoglobin | - |
? | |
ATP + Rho protein | - |
Mus musculus | ADP + phospho-tyrosinyl-Rho protein | - |
? | |
ATP + Rho protein | - |
Homo sapiens | ADP + phospho-tyrosinyl-Rho protein | - |
? | |
ATP + Rho protein | - |
Rattus norvegicus | ADP + phospho-tyrosinyl-Rho protein | - |
? | |
ATP + Shc protein | - |
Mus musculus | ADP + phospho-tyrosinyl-Shc protein | - |
? | |
ATP + Shc protein | - |
Homo sapiens | ADP + phospho-tyrosinyl-Shc protein | - |
? | |
ATP + Shc protein | - |
Rattus norvegicus | ADP + phospho-tyrosinyl-Shc protein | - |
? | |
ATP + STAT3 | - |
Mus musculus | ADP + phospho-tyrosinyl-STAT3 | - |
? | |
ATP + STAT3 | - |
Homo sapiens | ADP + phospho-tyrosinyl-STAT3 | - |
? | |
ATP + STAT3 | - |
Rattus norvegicus | ADP + phospho-tyrosinyl-STAT3 | - |
? | |
additional information | Src PTK plays a role in NF-kappaB activation in epithelial cells, Src PTKs are important in regulation of vascular permeability and acute inflammatory responses, and are essential for the recruitment and activation of monocytes, macrophages, neutrophils, and other immune cells, Src PTKs can also regulate the functional activity of these receptors and is involved in cell signaling, biological functions, cellular and molecular mechanisms, overview | Mus musculus | ? | - |
? | |
additional information | Src PTK plays a role in NF-kappaB activation in epithelial cells, Src PTKs are important in regulation of vascular permeability and acute inflammatory responses, and are essential for the recruitment and activation of monocytes, macrophages, neutrophils, and other immune cells, Src PTKs can also regulate the functional activity of these receptors and is involved in cell signaling, biological functions, cellular and molecular mechanisms, overview | Homo sapiens | ? | - |
? | |
additional information | Src PTK plays a role in NF-kappaB activation in epithelial cells, Src PTKs are important in regulation of vascular permeability and acute inflammatory responses, and are essential for the recruitment and activation of monocytes, macrophages, neutrophils, and other immune cells, Src PTKs can also regulate the functional activity of these receptors and is involved in cell signaling, biological functions, cellular and molecular mechanisms, overview | Rattus norvegicus | ? | - |
? | |
additional information | Src PTKs phosphorylate substrates in the cytosol or at the inner face of the plasma membrane, e.g. Shc, Rho GTPase-activating protein p190, and transcription factor STAT3, substrates at cell-matrix adhesions, e.g. cytoskeleton-associated proteins such as focal adhesion kinase FAK, Cas, paxillin, ezrin, and cortactin, and substrates at cell-cell adhesions, e.g. junctional proteins such as beta-catenin, p120, and plakoglobin | Mus musculus | ? | - |
? | |
additional information | Src PTKs phosphorylate substrates in the cytosol or at the inner face of the plasma membrane, e.g. Shc, Rho GTPase-activating protein p190, and transcription factor STAT3, substrates at cell-matrix adhesions, e.g. cytoskeleton-associated proteins such as focal adhesion kinase FAK, Cas, paxillin, ezrin, and cortactin, and substrates at cell-cell adhesions, e.g. junctional proteins such as beta-catenin, p120, and plakoglobin | Homo sapiens | ? | - |
? | |
additional information | Src PTKs phosphorylate substrates in the cytosol or at the inner face of the plasma membrane, e.g. Shc, Rho GTPase-activating protein p190, and transcription factor STAT3, substrates at cell-matrix adhesions, e.g. cytoskeleton-associated proteins such as focal adhesion kinase FAK, Cas, paxillin, ezrin, and cortactin, and substrates at cell-cell adhesions, e.g. junctional proteins such as beta-catenin, p120, and plakoglobin | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the NH2-terminal unique domain, the Src homology SH 4 region, is required for membrane attachment, SH4 is followed by the regulatory SH3 and SH2 domains, which are highly conserved and bind proline-rich and phosphotyrosyl regions, respectively | Mus musculus |
More | the NH2-terminal unique domain, the Src homology SH 4 region, is required for membrane attachment, SH4 is followed by the regulatory SH3 and SH2 domains, which are highly conserved and bind proline-rich and phosphotyrosyl regions, respectively | Homo sapiens |
More | the NH2-terminal unique domain, the Src homology SH 4 region, is required for membrane attachment, SH4 is followed by the regulatory SH3 and SH2 domains, which are highly conserved and bind proline-rich and phosphotyrosyl regions, respectively | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
Blk | - |
Mus musculus |
Blk | - |
Homo sapiens |
Blk | - |
Rattus norvegicus |
Fgr | - |
Mus musculus |
Fgr | - |
Homo sapiens |
Fgr | - |
Rattus norvegicus |
Fyn | - |
Mus musculus |
Fyn | - |
Homo sapiens |
Fyn | - |
Rattus norvegicus |
HCK | - |
Mus musculus |
HCK | - |
Homo sapiens |
HCK | - |
Rattus norvegicus |
Lck | - |
Mus musculus |
Lck | - |
Homo sapiens |
Lck | - |
Rattus norvegicus |
Lyn | - |
Mus musculus |
Lyn | - |
Homo sapiens |
Lyn | - |
Rattus norvegicus |
More | the enzyme belongs to the Src subfamily of the protein tyrosine kinase family | Mus musculus |
More | the enzyme belongs to the Src subfamily of the protein tyrosine kinase family | Homo sapiens |
More | the enzyme belongs to the Src subfamily of the protein tyrosine kinase family | Rattus norvegicus |
Src | - |
Mus musculus |
Src | - |
Homo sapiens |
Src | - |
Rattus norvegicus |
Yes | - |
Mus musculus |
Yes | - |
Homo sapiens |
Yes | - |
Rattus norvegicus |
yrk | - |
Mus musculus |
yrk | - |
Homo sapiens |
yrk | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
- |
Mus musculus | additional information | |
additional information | - |
- |
Homo sapiens | additional information | |
additional information | - |
- |
Rattus norvegicus | additional information |