Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine | i.e. pp2, inhibits Src family PTKs | Homo sapiens | |
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine | i.e. pp1, inhibits Src family PTKs | Homo sapiens | |
additional information | daidzein is no inhibitor of PTKs, no direct Src kinase inhibition by tyrphostin AG17, tyrphosptin AG879 and genistein | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens | |
Mn2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [aryl hydrocarbon receptor]-L-tyrosine | Homo sapiens | Src tyrosine kinases are involved in a signaling transduction pathway activating aryl hydrocarbon receptor AhR-mediated signalling by omeprazole or 2,3,7,8-tetrachlorodibenzo-4-dioxin TCDD ligand-binding, AhR phosphorylation at Tyr320, the omeprazole-dependent mechanism probably involves S318 and K316 | ADP + [aryl hydrocarbon receptor]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
hepatoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + KVEKIGEGTYGVVYK | synthetic peptide substrate | Homo sapiens | ADP + ? | - |
? | |
ATP + [aryl hydrocarbon receptor]-L-tyrosine | Src tyrosine kinases are involved in a signaling transduction pathway activating aryl hydrocarbon receptor AhR-mediated signalling by omeprazole or 2,3,7,8-tetrachlorodibenzo-4-dioxin TCDD ligand-binding, AhR phosphorylation at Tyr320, the omeprazole-dependent mechanism probably involves S318 and K316 | Homo sapiens | ADP + [aryl hydrocarbon receptor]-L-tyrosine phosphate | - |
? | |
ATP + [aryl hydrocarbon receptor]-L-tyrosine | in vivo assay utilizing Hep-G2 cells or H4IIE cells expressing AhR and Src kinase | Homo sapiens | ADP + [aryl hydrocarbon receptor]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C-SRC kinase | - |
Homo sapiens |
Protein tyrosine kinase | - |
Homo sapiens |
PTK | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |