Cloned (Comment) | Organism |
---|---|
the single copy gene is located on chromosome 4q13.3-q21.1 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dCTP | feedback inhibition, competitive versus phosphate donors | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | no Michaelis-Menten kinetics, but negative cooperativity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
nucleus | enzyme possesses a nuclear localization signal at the N-terminus | Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2'-deoxycytidine | Homo sapiens | - |
ADP + 2'-deoxycytidine 5'-phosphate | - |
? | |
UTP + 2'-deoxycytidine | Homo sapiens | - |
UDP + 2'-deoxycytidine 5'-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27707 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | posttranscriptional regulation of the enzyme | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
NTP + deoxycytidine = NDP + dCMP | substrate-enzyme interactions, bi bi random reaction mechanism with ATP, but ordered with UTP binding before the acceptor substrate, substrate binding site structures | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic mucosa | - |
Homo sapiens | - |
kidney | very low enzyme expression | Homo sapiens | - |
liver | very low enzyme expression | Homo sapiens | - |
lymphoid tissue | high enzyme expression | Homo sapiens | - |
additional information | tissue specific enzyme expression | Homo sapiens | - |
muscle | very low enzyme expression | Homo sapiens | - |
pancreas | very low enzyme expression | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
substrate specificity | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2',3'-dideoxycytidine | i.e. zalcitabine | Homo sapiens | ADP + 2',3'-dideoxycytidine 5'-phosphate | - |
? | |
ATP + 2'-deoxyadenosine | - |
Homo sapiens | ADP + 2'-deoxyadenosine 5'-phosphate | - |
? | |
ATP + 2'-deoxycytidine | - |
Homo sapiens | ADP + 2'-deoxycytidine 5'-phosphate | - |
? | |
ATP + 2'-deoxyguanosine | - |
Homo sapiens | ADP + 2'-deoxyguanosine 5'-phosphate | - |
? | |
ATP + 2-chloro-2'-deoxyadenosine | i.e. cladribine | Homo sapiens | ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate | - |
? | |
ATP + arabinosyl adenine | - |
Homo sapiens | ADP + arabinosyl adenine 5'-phosphate | - |
? | |
ATP + arabinosyl cytosine | i.e. cytosar | Homo sapiens | ADP + arabinosyl cytosine 5'-phosphate | - |
? | |
ATP + beta-L-2',3'-dideoxy-3'-thiacytidine | - |
Homo sapiens | ADP + beta-L-2',3'-dideoxy-3'-thiacytidine 5'-phosphate | - |
? | |
ATP + difluoro-arabinofuranosyl adenine | i.e. fludarabine | Homo sapiens | ADP + difluoro-arabinofuranosyl adenine 5'-phosphate | - |
? | |
ATP + difluorodeoxycytidine | i.e. gemcitabine | Homo sapiens | ADP + difluorodeoxycytidine 5'-phosphate | - |
? | |
additional information | substrate-enzyme interactions, overview, enzyme prefers nucleosides with sugars in the S-conformation, i.e C2'-endo-C3'-exo, binding of substrate induces conformational changes, the phosphate donor influences the acceptor substrate specificity, mechanism, overview | Homo sapiens | ? | - |
? | |
UTP + 2',3'-dideoxycytidine | i.e. zalcitabine | Homo sapiens | UDP + 2',3'-dideoxycytidine 5'-phosphate | - |
? | |
UTP + 2'-deoxyadenosine | - |
Homo sapiens | UDP + 2'-deoxyadenosine 5'-phosphate | - |
? | |
UTP + 2'-deoxycytidine | - |
Homo sapiens | UDP + 2'-deoxycytidine 5'-phosphate | - |
? | |
UTP + 2'-deoxyguanosine | - |
Homo sapiens | UDP + 2'-deoxyguanosine 5'-phosphate | - |
? | |
UTP + 2-chloro-2'-deoxyadenosine | i.e. cladribine | Homo sapiens | UDP + 2-chloro-2'-deoxyadenosine 5'-phosphate | - |
? | |
UTP + arabinosyl adenine | - |
Homo sapiens | UDP + arabinosyl adenine 5'-phosphate | - |
? | |
UTP + arabinosyl cytosine | i.e. cytosar | Homo sapiens | UDP + arabinosyl cytosine 5'-phosphate | - |
? | |
UTP + beta-L-2',3'-dideoxy-3'-thiacytidine | - |
Homo sapiens | UDP + beta-L-2',3'-dideoxy-3'-thiacytidine 5'-phosphate | - |
? | |
UTP + beta-L-dioxolane-cytidine | antitumor drug | Homo sapiens | UDP + beta-L-dioxolane-cytidine 5'-phosphate | - |
? | |
UTP + difluoro-arabinofuranosyl adenine | i.e. fludarabine | Homo sapiens | UDP + difluoro-arabinofuranosyl adenine 5'-phosphate | - |
? | |
UTP + difluorodeoxycytidine | i.e. gemcitabine | Homo sapiens | UDP + difluorodeoxycytidine 5'-phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | 3D-structure analysis, dCK structure model, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
dCK | - |
Homo sapiens |
NTP:deoxycytidine 5'-phosphotransferase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
additional information | enzyme lalso utilizes other nucleoside triphosphates as phosphate donors | Homo sapiens | |
UTP | - |
Homo sapiens |