Activating Compound | Comment | Organism | Structure |
---|---|---|---|
deoxyadenosine | activation, deoxycytidine as substrate, mitochondrial isozyme | Homo sapiens | |
deoxyguanosine | activation, deoxycytidine as substrate, mitochondrial isozyme | Homo sapiens | |
TTP | stimulation, cytosolic isozyme I | Homo sapiens | |
UDP | stimulation, mitochondrial isozyme | Homo sapiens | |
Uridine arabinoside | activation, deoxycytidine as substrate, mitochondrial isozyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cytosine arabinoside triphosphate | strong | Homo sapiens | |
dCMP | only cytosolic isozyme I; product inhibition, strong | Homo sapiens | |
dCTP | cytosine arabinoside as substrate; isozyme II | Homo sapiens | |
deoxyadenosine | cytosolic isozyme I, weak | Homo sapiens | |
deoxycytidine | cytosine arabinoside as substrate | Homo sapiens | |
deoxyguanosine | deoxyguanosine as substrate, cytosolic isozyme I, weak | Homo sapiens | |
deoxythymidine | weak | Homo sapiens | |
dGDP | not | Homo sapiens | |
dTTP | only mitochondrial isozyme; strong | Homo sapiens | |
dUDP | only cytosolic isozyme I; strong | Homo sapiens | |
GTP | not, deoxyadenosine as substrate | Homo sapiens | |
UDP | only cytosolic isozyme I; strong | Homo sapiens | |
Uridine arabinoside | weak, cytosolic isozyme I | Homo sapiens | |
UTP | not mitochondrial isozyme | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
cytosine arabinoside | deoxycytidine, cytosolic isozyme I, pH 7.5, 37°C | Homo sapiens | |
0.007 | - |
cytosine arabinoside | cytosolic isozyme I, pH 7.5, 37°C | Homo sapiens | |
0.014 | 0.0167 | deoxycytidine | pH 7.5, 37°C | Homo sapiens | |
0.014 | 0.0167 | deoxycytidine | mitochondrial isozyme, pH 7.5, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | 2 isozymes: I and II | Homo sapiens | 5829 | - |
mitochondrion | outer membrane | Homo sapiens | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
52000 | - |
1 * 52000, SDS-PAGE, mitochondrial isozyme | Homo sapiens |
70000 | - |
human cytoplasmic isozymes | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
affinity chromatography | Homo sapiens |
mitochondrial isozyme (extracted with digitonin) | Homo sapiens |
partial | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BG-1 cell | - |
Homo sapiens | - |
leukemia cell | from peripheral blood | Homo sapiens | - |
leukemia cell | from acute myeloid leukemia (AML) patients | Homo sapiens | - |
leukemia cell | ML-1 cells | Homo sapiens | - |
ML-1 cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.048 | - |
mitochondrial isozyme, pH 7.5, 37°C | Homo sapiens |
0.072 | - |
cytoplasmic isozyme I, pH 7.5, 37°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2'-deoxycytidine | best phosphate donor cytosolic isozyme II and mitochondrial isozyme | Homo sapiens | ADP + 5'-dCMP | - |
? | |
CTP + 2'-deoxycytidine | as good as GTP, UTP, dATP, mitochondrial isozyme | Homo sapiens | CDP + 2'-deoxy-CMP | - |
? | |
dGTP + 2'-deoxycytidine | cytosolic isozyme I | Homo sapiens | dGDP + 2'-deoxy-CMP | - |
? | |
dGTP + 2'-deoxycytidine | poor substrate of mitochondrial isozyme | Homo sapiens | dGDP + 2'-deoxy-CMP | - |
? | |
dUTP + 2'-deoxycytidine | best phosphate donor, cytosolic enzyme I, poor, mitochondrial isozyme | Homo sapiens | dUDP + 2'-deoxy-CMP | - |
? | |
GTP + 2'-deoxycytidine | as good as dGTP, dTTP or dUTP, cytosolic isozyme I | Homo sapiens | GDP + 2'-deoxy-CMP | - |
? | |
GTP + 2'-deoxycytidine | as good as CTP, dATP or UTP, mitochondrial isozyme | Homo sapiens | GDP + 2'-deoxy-CMP | - |
? | |
additional information | several isozymes: cytosolic deoxycytidine kinase I and II, plus mitochondrial isozyme | Homo sapiens | ? | - |
? | |
NTP + 2',2'-difluoro-2'-deoxycytidine | cytosolic isozyme I, not mitochondrial isozyme | Homo sapiens | NDP + 2',2'-difluoro-2'-deoxycytidine 5'-phosphate | - |
? | |
NTP + cytosine arabinoside | D-isomer | Homo sapiens | NDP + cytosine arabinoside 5'-monophosphate | - |
? | |
NTP + cytosine arabinoside | cytosolic isozyme I | Homo sapiens | NDP + cytosine arabinoside 5'-monophosphate | - |
? | |
NTP + cytosine arabinoside | no acceptor substrate for cytosolic isozyme II or mitochondrial isozyme | Homo sapiens | NDP + cytosine arabinoside 5'-monophosphate | - |
? | |
NTP + deoxyadenosine | cytosolic isozyme I | Homo sapiens | NDP + dAMP | - |
? | |
NTP + deoxyadenosine | not mitochondrial isozyme | Homo sapiens | NDP + dAMP | - |
? | |
NTP + deoxycytidine | no substrate: guanosine | Homo sapiens | NDP + dCMP | - |
? | |
NTP + deoxycytidine | poor substrate: arabinosyl-CTP | Homo sapiens | NDP + dCMP | - |
? | |
NTP + deoxycytidine | no substrate: uridine arabinoside, cytosine | Homo sapiens | NDP + dCMP | - |
? | |
NTP + deoxycytidine | no substrate: adenosine, uridine | Homo sapiens | NDP + dCMP | - |
? | |
NTP + deoxyguanosine | cytosolic isozyme I | Homo sapiens | NDP + dGMP | - |
? | |
NTP + deoxyguanosine | not mitochondrial isozyme | Homo sapiens | NDP + dGMP | - |
? | |
NTP + deoxythymidine | mitochondrial isozyme, better than deoxycytidine, not cytosolic isozyme I | Homo sapiens | NDP + dTMP | - |
? | |
NTP + deoxyuridine | mitochondrial isozyme, not cytosolic isozyme I | Homo sapiens | NDP + dUMP | - |
? | |
UTP + 2'-deoxycytidine | as good as CTP, GTP or dATP | Homo sapiens | UDP + 2'-deoxy-CMP | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 52000, SDS-PAGE, mitochondrial isozyme | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |