Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CHAPS | slight stimulation, deoxycytidine as substrate | Homo sapiens | |
sodium cholate | slight stimulation, deoxycytidine as substrate | Homo sapiens | |
Zwittergent 3-14 | slight stimulation, deoxycytidine as substrate | Homo sapiens |
General Stability | Organism |
---|---|
bovine serum albumin stabilizes | Homo sapiens |
dTTP, ATP or deoxycytidine stabilizes | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | deoxycytidine phosphorylating ability shows different inhibition pattern than deoxyadenosine activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + deoxycytidine | Homo sapiens | key anabolic enzyme for activation of purine or pyrimidine deoxynucleosides as well as cytidine arabinoside and other anti-tumor drugs | ADP + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukemia cell | from spleen | Homo sapiens | - |
spleen | - |
Homo sapiens | - |
Storage Stability | Organism |
---|---|
4°C, t1/2: 7 days with and t1/2: 72 h without bovine serum albumin | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2'-deoxycytidine | - |
Homo sapiens | ADP + 5'-dCMP | - |
? | |
ATP + deoxycytidine | key anabolic enzyme for activation of purine or pyrimidine deoxynucleosides as well as cytidine arabinoside and other anti-tumor drugs | Homo sapiens | ADP + ? | - |
? | |
additional information | multisubstrate enzyme, that also phosphorylates purine deoxyribonucleotides | Homo sapiens | ? | - |
? | |
additional information | enzyme exists in different conformational states with different substrate kinetic properties | Homo sapiens | ? | - |
? | |
NTP + deoxyadenosine | - |
Homo sapiens | NDP + dAMP | - |
? | |
NTP + deoxycytidine | - |
Homo sapiens | NDP + dCMP | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
- |
Homo sapiens |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | 55 | about half-maximal activity at 37°C and 55°C | Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
additional information | - |
temperature stability of deoxycytidine kinase activity differs appreciably from deoxyadenosine kinase activity | Homo sapiens |
37 | - |
at least 6 h stable | Homo sapiens |
54 | - |
inactivation | Homo sapiens |