Protein Variants | Comment | Organism |
---|---|---|
additional information | depletion of CD38 cells results in enhanced levels of cell surface etheno-ADP-ribosylation on CD38 T cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CD38 | CD38, a potent ecto-NAD-glycohydrolase, controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins, CD38 decreases ART2-catalyzed ADP-ribosylation in trans by reducing the amount of ART substrate NAD+ | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | ART2 is attached to the cell surface by a glycosylphosphatidylinositol anchor in T-cells | Mus musculus | 9986 | - |
membrane | - |
Mus musculus | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
BALB/c and C57BL/6 mice, isozyme ART2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-lymphocyte | splenic lymphocyte subpopulations, ART2 is a T-cell-specific transferase, expression of CD38 and ART2 is inversely correlated on murine lymphocytes | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | CD38, a potent ecto-NAD-glycohydrolase, controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins, overview, the enzyme is a a GPI-anchored, toxin-related ADP-ribosylating ectoenzyme, ART2 can sense and translate the local concentration of ecto-NAD into corresponding levels of ADP-ribosylated cell surface proteins, whereas CD38 controls the level of cell surface protein ADP-ribosylation by limiting the substrate availability for ART2 | Mus musculus | ? | - |
? | |
P2X7 purinoceptor protein + NAD+ | isozyme ART2 | Mus musculus | Nomega-[(2'-phospho-ADP)-D-ribosyl]-P2X7 purinoceptor protein-L-arginine + nicotinamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADP-ribosyltransferase-2 | - |
Mus musculus |
ART2 | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |